Which Foods are Recommended for Small Cell Lung Cancer?

Highlights

No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Small Cell Lung Cancer when undergoing chemotherapy or when you determine you have a genetic risk for developing Small Cell Lung Cancer because of FAT3 and RB1 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.

There is no one answer to this question for cancers such as Small Cell Lung Cancer which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.

In short – the process to answer questions like “Should I Avoid eating fruit Lingonberry” or “Include fruit Nance in my diet” or “Should I reduce consumption of vegetable Spinach” or “Can I take Neem Extract and Beta-sitosterol supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.

RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO SMALL CELL LUNG CANCER, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.

The overall objective of personalized nutrition for Small Cell Lung Cancer is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.

RECOMMENDATION: UPDATE YOUR NUTRITION FOR SMALL CELL LUNG CANCER, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.

About Small Cell Lung Cancer

cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.

Following key highlights are derived from clinical data for Small Cell Lung Cancer from cBioPortal. The patients enrolled in the studies for Small Cell Lung Cancer are in ages between 25 to 87 with an average age of 67. 58.0% of males and 42.0% of females were the distribution of gender in these clinical studies. From a patient sample size of 1060; the top genes with mutations and other abnormalities for Small Cell Lung Cancer include genes TP53, RB1, RYR2, KMT2D and FAT3. The occurrence frequency distribution for these genes respectively is 37.2%, 27.1%, 11.7%, 9.9% and 7.1%. These tumor genetic details of Small Cell Lung Cancer are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Small Cell Lung Cancer.

Significance of Nutrition for Small Cell Lung Cancer

All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Small Cell Lung Cancer. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.

For example Lingonberry includes active ingredients Quercetin, Resveratrol, Hyperoside, Linolenic Acid, Caffeic Acid and others. And Nance contains active ingredients Vitamin C, Betulin, Vitamin A and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.

For cancers like Small Cell Lung Cancer, activation or inhibition of selected biochemical pathways like Oncogenic Cancer Epigenetics, Chromatin Remodeling, PI3K-AKT-MTOR Signaling, Cell Cycle Checkpoints plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Small Cell Lung Cancer, while eating some other foods and supplements may not be recommended.

One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.

RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR SMALL CELL LUNG CANCER – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.

Foods for Small Cell Lung Cancer undergoing chemotherapy treatment

In Small Cell Lung Cancer – the genes TP53, RB1, RYR2, KMT2D and FAT3 have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Small Cell Lung Cancer are Oncogenic Cancer Epigenetics, Chromatin Remodeling, MAPK Signaling and others. Doxorubicin is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Oncogenic Cancer Epigenetics, Chromatin Remodeling, MAPK Signaling so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.

RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.

Eat more pulses, Common Pea or Pigeon Pea?

Pulses are an important part of many diets. The active ingredients contained in Common Pea are Beta-sitosterol, Lupeol, Daidzein, Linolenic Acid, Vitamin C among others. While the active ingredients contained in Pigeon Pea are Linolenic Acid, Vitamin C, Oleic Acid, Linoleic Acid, Genistein and others.

Beta-sitosterol can manipulate biochemical pathways DNA Repair, Cell Survival and Vitamin D Signaling. Vitamin C has biological action on biochemical pathways Epithelial to Mesenchymal Transition, Apoptosis and Oxidative Stress.

Genistein can manipulate biochemical pathways DNA Repair, Nutrient sensing and Oxidative Stress. Linolenic Acid has biological action on biochemical pathways Vitamin D Signaling and Oxidative Stress. And so on.

When treating Small Cell Lung Cancer with chemotherapy Doxorubicin – Foods like Common Pea are recommended compared to Pigeon Pea. This is because the active ingredients Genistein and Linolenic Acid in Pigeon Pea interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin C contained in Common Pea support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: COMMON PEA IS RECOMMENDED OVER PIGEON PEA FOR SMALL CELL LUNG CANCER ON TREATMENT WITH CHEMOTHERAPY DOXORUBICIN FOR SOME CONDITIONS.

Eat more vegetables, Cassava or Spinach?

Vegetables are an important part of many diets. The active ingredients contained in Cassava are Beta-sitosterol, Linolenic Acid, Vitamin C, Oleic Acid, Linoleic Acid among others. While the active ingredients contained in Spinach are Quercetin, Beta-sitosterol, Apigenin, Linolenic Acid, Vitamin C and others.

Vitamin C can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Apoptosis and Oxidative Stress. Beta-sitosterol has biological action on biochemical pathways DNA Repair, Cell Survival and Vitamin D Signaling.

Apigenin can manipulate biochemical pathways Epithelial to Mesenchymal Transition, DNA Repair and Vitamin D Signaling. Quercetin has biological action on biochemical pathways Oxidative Stress. And so on.

When treating Small Cell Lung Cancer with chemotherapy Doxorubicin – Foods like Cassava are recommended compared to Spinach. This is because the active ingredients Apigenin and Quercetin in Spinach interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Beta-sitosterol contained in Cassava support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: CASSAVA IS RECOMMENDED OVER SPINACH FOR SMALL CELL LUNG CANCER ON TREATMENT WITH CHEMOTHERAPY DOXORUBICIN FOR SOME CONDITIONS.

Eat more fruits, Nance or Lingonberry?

Fruits are an important part of many diets. The active ingredients contained in Nance are Vitamin C, Betulin, Vitamin A among others. While the active ingredients contained in Lingonberry are Quercetin, Resveratrol, Hyperoside, Linolenic Acid, Caffeic Acid and others.

Vitamin C can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Apoptosis and Oxidative Stress. Betulin has biological action on biochemical pathways Cell Cycle, Post Translation Modification and Cell Survival.

Quercetin can manipulate biochemical pathways Oxidative Stress. Resveratrol has biological action on biochemical pathways P53 Signaling, DNA Repair and Oxidative Stress. And so on.

When treating Small Cell Lung Cancer with chemotherapy Doxorubicin – Foods like Nance are recommended compared to Lingonberry. This is because the active ingredients Quercetin and Resveratrol in Lingonberry interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Betulin contained in Nance support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: NANCE IS RECOMMENDED OVER LINGONBERRY FOR SMALL CELL LUNG CANCER ON TREATMENT WITH CHEMOTHERAPY DOXORUBICIN FOR SOME CONDITIONS.

Eat more nuts, Pecan Nut or Acorn?

Nuts are an important part of many diets. The active ingredients contained in Pecan Nut are Vitamin E, Linolenic Acid, Cianidanol, Oleic Acid, Delphinidin among others. While the active ingredients contained in Acorn are Quercetin, Beta-sitosterol, Vitamin C, Beta-carotene, Gallic Acid and others.

Vitamin E can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and Apoptosis. Cianidanol has biological action on biochemical pathways DNA Repair, Cell Survival and MYC Signaling.

Quercetin can manipulate biochemical pathways Oxidative Stress. Beta-carotene has biological action on biochemical pathways MAPK Signaling and Notch Signaling. And so on.

When treating Small Cell Lung Cancer with chemotherapy Doxorubicin – Foods like Pecan Nut are recommended compared to Acorn. This is because the active ingredients Quercetin and Beta-carotene in Acorn interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin E and Cianidanol contained in Pecan Nut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: PECAN NUT IS RECOMMENDED OVER ACORN FOR SMALL CELL LUNG CANCER ON TREATMENT WITH CHEMOTHERAPY DOXORUBICIN FOR SOME CONDITIONS.

Foods for Genetic Risk of Small Cell Lung Cancer

One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. FAT3 and RB1 are two genes whose abnormalities are risk factors for Small Cell Lung Cancer. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Small Cell Lung Cancer can be used as a guide for coming up with a recommended personalized nutrition plan. For Small Cell Lung Cancer gene FAT3 has causative impact on biological pathways like Adherens junction. And RB1 has a causative impact on biological pathways like Cell Cycle Checkpoints, DNA Repair and Cell Cycle. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like FAT3 and RB1 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes FAT3 and RB1 should be avoided.

Eat more pulses, Scarlet Bean or Common Bean?

The active ingredients contained in Scarlet Bean are Beta-sitosterol, Vitamin C, Oleic Acid, Linolenic Acid, Stigmasterol among others. While the active ingredients contained in Common Bean are Apigenin, Esculin, Vitamin C, Oleic Acid, P-coumaric Acid and others.

Beta-sitosterol can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Vitamin C has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and Apoptosis.

Ferulic Acid can manipulate biochemical pathways DNA Repair. Pelargonidin has biological action on biochemical pathways MYC Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling. And so on.

For genetic risk of Small Cell Lung Cancer due to abnormalities in genes FAT3 and RB1 – Foods like Scarlet Bean are recommended compared to Common Bean. This is because the active ingredients Ferulic Acid and Pelargonidin in Common Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin C contained in Scarlet Bean together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: SCARLET BEAN IS RECOMMENDED OVER COMMON BEAN FOR REDUCING THE GENETIC RISK OF SMALL CELL LUNG CANCER DUE TO GENES FAT3 AND RB1

Eat more vegetables, Giant Butterbur or Chicory?

The active ingredients contained in Giant Butterbur are Beta-sitosterol, Vitamin C, Vitamin B3, Melatonin, Kaempferol among others. While the active ingredients contained in Chicory are Apigenin, Esculin, Lupeol, Betulinic Acid, Protocatechuic Acid and others.

Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Beta-sitosterol has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and Apoptosis.

Quercetin can manipulate biochemical pathways DNA Repair. Gallic Acid has biological action on biochemical pathways DNA Repair. And so on.

For genetic risk of Small Cell Lung Cancer due to abnormalities in genes FAT3 and RB1 – Foods like Giant Butterbur are recommended compared to Chicory. This is because the active ingredients Quercetin and Gallic Acid in Chicory further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Giant Butterbur together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: GIANT BUTTERBUR IS RECOMMENDED OVER CHICORY FOR REDUCING THE GENETIC RISK OF SMALL CELL LUNG CANCER DUE TO GENES FAT3 AND RB1

Eat more fruits, Kiwi or Cranberry?

The active ingredients contained in Kiwi are Vitamin C, Chlorogenic Acid, Quercetin, Fisetin, Vitamin A among others. While the active ingredients contained in Cranberry are Resveratrol, Vitamin C, Hyperoside, Ellagic Acid, P-coumaric Acid and others.

Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Chlorogenic Acid has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, MYC Signaling and Apoptosis.

Resveratrol can manipulate biochemical pathways P53 Signaling. Ellagic Acid has biological action on biochemical pathways MYC Signaling and Cell Cycle Checkpoints. And so on.

For genetic risk of Small Cell Lung Cancer due to abnormalities in genes FAT3 and RB1 – Foods like Kiwi are recommended compared to Cranberry. This is because the active ingredients Resveratrol and Ellagic Acid in Cranberry further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Chlorogenic Acid contained in Kiwi together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: KIWI IS RECOMMENDED OVER CRANBERRY FOR REDUCING THE GENETIC RISK OF SMALL CELL LUNG CANCER DUE TO GENES FAT3 AND RB1

Eat more nuts, Hazelnut or Chestnut?

The active ingredients contained in Hazelnut are Vitamin E, Oleic Acid, Linolenic Acid, Linoleic Acid, Quercetin among others. While the active ingredients contained in Chestnut are Vitamin C, Oleic Acid, Ellagic Acid, Linolenic Acid, Linoleic Acid and others.

Vitamin E can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Vitamin A has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and MYC Signaling.

Ellagic Acid can manipulate biochemical pathways MYC Signaling and Cell Cycle Checkpoints. Gallic Acid has biological action on biochemical pathways DNA Repair. And so on.

For genetic risk of Small Cell Lung Cancer due to abnormalities in genes FAT3 and RB1 – Foods like Hazelnut are recommended compared to Chestnut. This is because the active ingredients Ellagic Acid and Gallic Acid in Chestnut further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin E and Vitamin A contained in Hazelnut together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: HAZELNUT IS RECOMMENDED OVER CHESTNUT FOR REDUCING THE GENETIC RISK OF SMALL CELL LUNG CANCER DUE TO GENES FAT3 AND RB1

In Summary

An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.

“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.

The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.

You can get started NOW and design a personalized nutrition plan for Small Cell Lung Cancer by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

References

• Lung Msk Pdx
• Molecular Evolution Patterns in Metastatic Lymph Nodes Reflect the Differential Treatment Response of Advanced Primary Lung Cancer.
• β-Sitosterol targets Trx/Trx1 reductase to induce apoptosis in A549 cells via ROS mediated mitochondrial dysregulation and p53 activation.
• Vitamin C enhances epigenetic modifications induced by 5-azacytidine and cell cycle arrest in the hepatocellular carcinoma cell lines HLE and Huh7.
• Peroxisome proliferator-activated receptor gamma (PPARgamma ) as a molecular target for the soy phytoestrogen genistein.
• Alpha-linolenic acid confers protection on mice renal cells against cisplatin-induced nephrotoxicity.
• Trends in congenital heart disease in Dallas County births. 1971-1984.
• [Basic formulation of the tasks of special education in rehabilitating the physically handicapped].
• Resveratrol, a remarkable inhibitor of ribonucleotide reductase.
• Flavones: an important scaffold for medicinal chemistry.
• Gamma- and delta-tocotrienols exert a more potent anticancer effect than alpha-tocopheryl succinate on breast cancer cell lines irrespective of HER-2/neu expression.
• (+)-Catechin inhibits tumour angiogenesis and regulates the production of nitric oxide and TNF-alpha in LPS-stimulated macrophages.
• Growth stimulation of human pulmonary adenocarcinoma cells and small airway epithelial cells by beta-carotene via activation of cAMP, PKA, CREB and ERK1/2.
• Legionella pneumophila serogroup 12 pneumonia in a renal transplant recipient: case report and environmental observations.
• Pelargonidin suppresses adipogenesis in 3T3-L1 cells through inhibition of PPAR-γ signaling pathway.
• Chlorogenic acid inhibits proliferation and induces apoptosis in A498 human kidney cancer cells via inactivating PI3K/Akt/mTOR signalling pathway.
• Indeno[1,2-b]indole derivatives as a novel class of potent human protein kinase CK2 inhibitors.
• Gallic acid provokes DNA damage and suppresses DNA repair gene expression in human prostate cancer PC-3 cells.
• Transcriptional activation of the cyclin-dependent kinase inhibitor p21 by PML/RARalpha.
• HyperFoods: Machine intelligent mapping of cancer-beating molecules in foods.
• Phenolic Profiles, Antioxidant Capacities, and Inhibitory Effects on Digestive Enzymes of Different Kiwifruits.