Which Foods are Recommended for Sinonasal Adenocarcinoma?

Highlights

No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Sinonasal Adenocarcinoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Sinonasal Adenocarcinoma because of TCF3 and CTCF gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.

There is no one answer to this question for cancers such as Sinonasal Adenocarcinoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.

In short – the process to answer questions like “Should I Avoid eating fruit Strawberry” or “Include fruit Sapota in my diet” or “Should I reduce consumption of vegetable Japanese Pumpkin” or “Can I take Ginseng and Guggul supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.

RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO SINONASAL ADENOCARCINOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.

The overall objective of personalized nutrition for Sinonasal Adenocarcinoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.

RECOMMENDATION: UPDATE YOUR NUTRITION FOR SINONASAL ADENOCARCINOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.

About Sinonasal Adenocarcinoma

cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.

Following key highlights are derived from clinical data for Sinonasal Adenocarcinoma from cBioPortal. From a patient sample size of 4; the top genes with mutations and other abnormalities for Sinonasal Adenocarcinoma include genes ATRX, TCF3, ARID1A, BRAF and CTCF. The occurrence frequency distribution for these genes respectively is 25.0%, 25.0%, 25.0%, 25.0% and 25.0%. These tumor genetic details of Sinonasal Adenocarcinoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Sinonasal Adenocarcinoma.

Significance of Nutrition for Sinonasal Adenocarcinoma

All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Sinonasal Adenocarcinoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.

For example Strawberry includes active ingredients Ellagic Acid, Vitamin C, Pelargonidin, Beta-sitosterol, Salicylic Acid and others. And Sapota contains active ingredients Lycopene, Vitamin C, Beta-sitosterol, Linolenic Acid, Linoleic Acid and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.

For cancers like Sinonasal Adenocarcinoma, activation or inhibition of selected biochemical pathways like Notch Signaling, RUNX Signaling, Chromatin Remodeling, RAS-RAF Signaling plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Sinonasal Adenocarcinoma, while eating some other foods and supplements may not be recommended.

One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.

RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR SINONASAL ADENOCARCINOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.

Foods for Sinonasal Adenocarcinoma undergoing chemotherapy treatment

In Sinonasal Adenocarcinoma – the genes ATRX, TCF3, ARID1A, BRAF and CTCF have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Sinonasal Adenocarcinoma are Notch Signaling, RUNX Signaling and others. Radiation is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Notch Signaling, RUNX Signaling so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.

RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.

Eat more pulses, Lentils?

Pulses are an important part of many diets. The active ingredients contained in Lentils are Ellagic Acid, Vitamin C, Genistein, Isoliquiritigenin, Beta-sitosterol among others.

Ellagic Acid can manipulate biochemical pathways Oncogenic Cancer Epigenetics and RAS-RAF Signaling. Vitamin C has biological action on biochemical pathways WNT Beta Catenin Signaling, Oncogenic Cancer Epigenetics and RAS-RAF Signaling.

When treating Sinonasal Adenocarcinoma with chemotherapy Radiation – Foods like Lentils are recommended. This is because the active ingredients Ellagic Acid and Vitamin C contained in Lentils support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: LENTILS IS RECOMMENDED FOR SINONASAL ADENOCARCINOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Eat more vegetables, Squash or Japanese Pumpkin?

Vegetables are an important part of many diets. The active ingredients contained in Squash are Ellagic Acid, Vitamin E, Vitamin C, Beta-sitosterol, Linolenic Acid among others. While the active ingredients contained in Japanese Pumpkin are Vitamin E, Vitamin C, Palmitic Acid, Beta-sitosterol, Vitamin A and others.

Ellagic Acid can manipulate biochemical pathways Oncogenic Cancer Epigenetics and RAS-RAF Signaling. Vitamin E has biological action on biochemical pathways Notch Signaling, RUNX Signaling and RAS-RAF Signaling.

Palmitic Acid can manipulate biochemical pathways Chromatin Remodeling, Oncogenic Cancer Epigenetics and WNT Beta Catenin Signaling. Myristic Acid has biological action on biochemical pathways RAS-RAF Signaling and RUNX Signaling. And so on.

When treating Sinonasal Adenocarcinoma with chemotherapy Radiation – Foods like Squash are recommended compared to Japanese Pumpkin. This is because the active ingredients Palmitic Acid and Myristic Acid in Japanese Pumpkin interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Ellagic Acid and Vitamin E contained in Squash support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: SQUASH IS RECOMMENDED OVER JAPANESE PUMPKIN FOR SINONASAL ADENOCARCINOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Eat more fruits, Sapota or Strawberry?

Fruits are an important part of many diets. The active ingredients contained in Sapota are Lycopene, Vitamin C, Beta-sitosterol, Linolenic Acid, Linoleic Acid among others. While the active ingredients contained in Strawberry are Ellagic Acid, Vitamin C, Pelargonidin, Beta-sitosterol, Salicylic Acid and others.

Lycopene can manipulate biochemical pathways RAS-RAF Signaling and WNT Beta Catenin Signaling. Beta-sitosterol has biological action on biochemical pathways Oncogenic Cancer Epigenetics, RUNX Signaling and WNT Beta Catenin Signaling.

Fisetin can manipulate biochemical pathways WNT Beta Catenin Signaling. Pelargonidin has biological action on biochemical pathways WNT Beta Catenin Signaling. And so on.

When treating Sinonasal Adenocarcinoma with chemotherapy Radiation – Foods like Sapota are recommended compared to Strawberry. This is because the active ingredients Fisetin and Pelargonidin in Strawberry interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Lycopene and Beta-sitosterol contained in Sapota support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: SAPOTA IS RECOMMENDED OVER STRAWBERRY FOR SINONASAL ADENOCARCINOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Eat more nuts, Chestnut or Cashew Nut?

Nuts are an important part of many diets. The active ingredients contained in Chestnut are Ellagic Acid, Vitamin C, Quercetin, Linolenic Acid, Linoleic Acid among others. While the active ingredients contained in Cashew Nut are Vitamin C, Palmitic Acid, Beta-sitosterol, Myristic Acid and others.

Ellagic Acid can manipulate biochemical pathways Oncogenic Cancer Epigenetics and RAS-RAF Signaling. Vitamin A has biological action on biochemical pathways WNT Beta Catenin Signaling.

Palmitic Acid can manipulate biochemical pathways Chromatin Remodeling, Oncogenic Cancer Epigenetics and WNT Beta Catenin Signaling. Myristic Acid has biological action on biochemical pathways RAS-RAF Signaling and RUNX Signaling. And so on.

When treating Sinonasal Adenocarcinoma with chemotherapy Radiation – Foods like Chestnut are recommended compared to Cashew Nut. This is because the active ingredients Palmitic Acid and Myristic Acid in Cashew Nut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Ellagic Acid and Vitamin A contained in Chestnut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: CHESTNUT IS RECOMMENDED OVER CASHEW NUT FOR SINONASAL ADENOCARCINOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Foods for Genetic Risk of Sinonasal Adenocarcinoma

One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. TCF3 and CTCF are two genes whose abnormalities are risk factors for Sinonasal Adenocarcinoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Sinonasal Adenocarcinoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Sinonasal Adenocarcinoma gene TCF3 has causative impact on biological pathways like Noncoding RNA Signaling. And CTCF has a causative impact on biological pathways like Oncogenic Cancer Epigenetics. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like TCF3 and CTCF should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes TCF3 and CTCF should be avoided.

Eat more pulses, Mung Bean or Fava Bean?

The active ingredients contained in Mung Bean are Linolenic Acid, Stigmasterol, Vitamin C, Vitexin, Oleic Acid among others. While the active ingredients contained in Fava Bean are Daidzein, Beta-sitosterol, Linolenic Acid, P-coumaric Acid, Stigmasterol and others.

Stigmasterol can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Vitamin C has biological action on biochemical pathways Cell Cycle Checkpoints, Apoptosis and MYC Signaling.

Ferulic Acid can manipulate biochemical pathways DNA Repair. Quercetin has biological action on biochemical pathways DNA Repair. And so on.

For genetic risk of Sinonasal Adenocarcinoma due to abnormalities in genes TCF3 and CTCF – Foods like Mung Bean are recommended compared to Fava Bean. This is because the active ingredients Ferulic Acid and Quercetin in Fava Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Stigmasterol and Vitamin C contained in Mung Bean together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: MUNG BEAN IS RECOMMENDED OVER FAVA BEAN FOR REDUCING THE GENETIC RISK OF SINONASAL ADENOCARCINOMA DUE TO GENES TCF3 AND CTCF

Eat more vegetables, Artichoke or Beetroot?

The active ingredients contained in Artichoke are Apigenin, Vitamin C, Cynaroside, Luteolin, Chlorogenic Acid among others. While the active ingredients contained in Beetroot are Vitamin E, Beta-sitosterol, Linolenic Acid, Vitamin C, Linoleic Acid and others.

Vitamin K can manipulate biochemical pathways MYC Signaling and Cell Cycle Checkpoints. Apigenin has biological action on biochemical pathways DNA Repair, Apoptosis and P53 Signaling.

Folic Acid can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. And so on.

For genetic risk of Sinonasal Adenocarcinoma due to abnormalities in genes TCF3 and CTCF – Foods like Artichoke are recommended compared to Beetroot. This is because the active ingredients Folic Acid in Beetroot further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin K and Apigenin contained in Artichoke together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: ARTICHOKE IS RECOMMENDED OVER BEETROOT FOR REDUCING THE GENETIC RISK OF SINONASAL ADENOCARCINOMA DUE TO GENES TCF3 AND CTCF

Eat more fruits, Cherimoya or Huckleberry?

The active ingredients contained in Cherimoya are Beta-sitosterol, Linolenic Acid, Stigmasterol, Vitamin C, Oleic Acid among others. While the active ingredients contained in Huckleberry are Resveratrol, P-coumaric Acid, Vitamin C, Ferulic Acid, Quercetin and others.

Beta-sitosterol can manipulate biochemical pathways Cell Cycle Checkpoints, RUNX Signaling and Apoptosis. Stigmasterol has biological action on biochemical pathways MYC Signaling, P53 Signaling and Apoptosis.

Resveratrol can manipulate biochemical pathways P53 Signaling. Ferulic Acid has biological action on biochemical pathways DNA Repair. And so on.

For genetic risk of Sinonasal Adenocarcinoma due to abnormalities in genes TCF3 and CTCF – Foods like Cherimoya are recommended compared to Huckleberry. This is because the active ingredients Resveratrol and Ferulic Acid in Huckleberry further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Stigmasterol contained in Cherimoya together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: CHERIMOYA IS RECOMMENDED OVER HUCKLEBERRY FOR REDUCING THE GENETIC RISK OF SINONASAL ADENOCARCINOMA DUE TO GENES TCF3 AND CTCF

Eat more nuts, Hazelnut or Macadamia Nut?

The active ingredients contained in Hazelnut are Vitamin E, Linolenic Acid, Oleic Acid, Linoleic Acid, Quercetin among others. While the active ingredients contained in Macadamia Nut are Beta-sitosterol, Palmitic Acid, Lauric Acid, Folic Acid, Myristic Acid and others.

Vitamin E can manipulate biochemical pathways Cell Cycle Checkpoints, RUNX Signaling and Apoptosis. Vitamin A has biological action on biochemical pathways MYC Signaling, Apoptosis and Cell Cycle Checkpoints.

Palmitic Acid can manipulate biochemical pathways DNA Repair and Chromatin Remodeling. Lauric Acid has biological action on biochemical pathways MYC Signaling. And so on.

For genetic risk of Sinonasal Adenocarcinoma due to abnormalities in genes TCF3 and CTCF – Foods like Hazelnut are recommended compared to Macadamia Nut. This is because the active ingredients Palmitic Acid and Lauric Acid in Macadamia Nut further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin E and Vitamin A contained in Hazelnut together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: HAZELNUT IS RECOMMENDED OVER MACADAMIA NUT FOR REDUCING THE GENETIC RISK OF SINONASAL ADENOCARCINOMA DUE TO GENES TCF3 AND CTCF

In Summary

An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.

“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.

The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.

You can get started NOW and design a personalized nutrition plan for Sinonasal Adenocarcinoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

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