Which Foods are Recommended for Seminoma?

Highlights

No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Seminoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Seminoma because of KIT and RAC1 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.

There is no one answer to this question for cancers such as Seminoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.

In short – the process to answer questions like “Should I Avoid eating fruit Peach” or “Include fruit Raspberry in my diet” or “Should I reduce consumption of vegetable Chinese Mustard” or “Can I take Lavender and Sesamin supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.

RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO SEMINOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.

The overall objective of personalized nutrition for Seminoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.

RECOMMENDATION: UPDATE YOUR NUTRITION FOR SEMINOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.

About Seminoma

cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.

Following key highlights are derived from clinical data for Seminoma from cBioPortal. The patients enrolled in the studies for Seminoma are in ages between 19 to 65 with an average age of 35.From a patient sample size of 289; the top genes with mutations and other abnormalities for Seminoma include genes KIT, KRAS, RAC1, NRAS and PIK3CA. The occurrence frequency distribution for these genes respectively is 10.1%, 6.7%, 2.8%, 2.8% and 1.7%. These tumor genetic details of Seminoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Seminoma.

Seminoma is a malignant germ cell tumor that most commonly affects the seminiferous tubules of the testis. Incidence of seminoma is high among young men aged 15-34 years. It accounts for less than 1% of all male tumors, but its incidence is rising, and testicular seminoma is the most common subtype of testicular cancer in the United States. Seminoma usually presents as a nodule or a painless swelling of the testis and may cause a dull ache or a heavy sensation in the lower abdomen or scrotum. Cases of advanced disease with metastases could present with cough, anorexia, nausea, vomiting, gastrointestinal hemorrhage, bone pain and other symptoms. Combination chemotherapy regimens are used for the treatment of advanced stage seminoma. It is a treatable and curable cancer with high 5-year survival rates for localized and regional seminoma at 96-99% (if diagnosed early), but decreases to 73% for advanced disease that has spread. Supportive care with the right nutrition (food and natural supplements) aligned with the stage of the disease and treatment plan can help improve patients’ well-being. (Ref: https://www.ncbi.nlm.nih.gov/books/NBK560513/)

Significance of Nutrition for Seminoma

All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Seminoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.

For example Peach includes active ingredients Fisetin, Beta-sitosterol, Modified Citrus Pectin, Oleic Acid, Vitamin C and others. And Raspberry contains active ingredients Quercetin, Ellagic Acid, Resveratrol, Vitamin C, Gallic Acid and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.

For cancers like Seminoma, activation or inhibition of selected biochemical pathways like Cell Cycle, C-type Lectin Receptor Signaling, PI3K-AKT-MTOR Signaling, MAPK Signaling plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Seminoma, while eating some other foods and supplements may not be recommended.

One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.

RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR SEMINOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.

Foods for Seminoma undergoing chemotherapy treatment

In Seminoma – the genes KIT, KRAS, RAC1, NRAS and PIK3CA have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Seminoma are Cell Cycle, C-type Lectin Receptor Signaling, RUNX Signaling and others. Cisplatin is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Cell Cycle, C-type Lectin Receptor Signaling, RUNX Signaling so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.

RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.

Eat more pulses, Scarlet Bean or Moth Bean?

Pulses are an important part of many diets. The active ingredients contained in Scarlet Bean are Beta-sitosterol, Oleic Acid, Vitamin C, Stigmasterol, Linolenic Acid among others. While the active ingredients contained in Moth Bean are Beta-sitosterol, Oleic Acid, Stigmasterol, Linolenic Acid, Linoleic Acid and others.

Beta-sitosterol can manipulate biochemical pathways Inositol Phosphate Signaling, Apoptosis and Cell Cycle. Vitamin C has biological action on biochemical pathways MYC Signaling, P53 Signaling and Cell Cycle Checkpoints.

Vitamin A can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Linolenic Acid has biological action on biochemical pathways Oxidative Stress. And so on.

When treating Seminoma with chemotherapy Cisplatin – Foods like Scarlet Bean are recommended compared to Moth Bean. This is because the active ingredients Vitamin A and Linolenic Acid in Moth Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin C contained in Scarlet Bean support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: SCARLET BEAN IS RECOMMENDED OVER MOTH BEAN FOR SEMINOMA ON TREATMENT WITH CHEMOTHERAPY CISPLATIN FOR SOME CONDITIONS.

Eat more vegetables, Jicama or Chinese Mustard?

Vegetables are an important part of many diets. The active ingredients contained in Jicama are Vitamin C, Beta-carotene, Vitamin B3, Vitamin A, Folic Acid among others. While the active ingredients contained in Chinese Mustard are Quercetin, Indole-3-carbinol, Isorhamnetin, Vitamin A, Kaempferol and others.

Vitamin C can manipulate biochemical pathways Apoptosis, Cell Cycle and MYC Signaling. Beta-carotene has biological action on biochemical pathways DNA Repair, P53 Signaling and Cell Cycle Checkpoints.

Vitamin A can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Quercetin has biological action on biochemical pathways Oxidative Stress. And so on.

When treating Seminoma with chemotherapy Cisplatin – Foods like Jicama are recommended compared to Chinese Mustard. This is because the active ingredients Vitamin A and Quercetin in Chinese Mustard interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Beta-carotene contained in Jicama support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: JICAMA IS RECOMMENDED OVER CHINESE MUSTARD FOR SEMINOMA ON TREATMENT WITH CHEMOTHERAPY CISPLATIN FOR SOME CONDITIONS.

Eat more fruits, Raspberry or Peach?

Fruits are an important part of many diets. The active ingredients contained in Raspberry are Quercetin, Ellagic Acid, Resveratrol, Vitamin C, Gallic Acid among others. While the active ingredients contained in Peach are Fisetin, Beta-sitosterol, Modified Citrus Pectin, Oleic Acid, Vitamin C and others.

Ellagic Acid can manipulate biochemical pathways Apoptosis, JAK-STAT Signaling and Cell Cycle. Vitamin C has biological action on biochemical pathways MYC Signaling, P53 Signaling and Cell Cycle Checkpoints.

Citric Acid can manipulate biochemical pathways Oxidative Stress. Fisetin has biological action on biochemical pathways MYC Signaling and Oxidative Stress. And so on.

When treating Seminoma with chemotherapy Cisplatin – Foods like Raspberry are recommended compared to Peach. This is because the active ingredients Citric Acid and Fisetin in Peach interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Ellagic Acid and Vitamin C contained in Raspberry support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: RASPBERRY IS RECOMMENDED OVER PEACH FOR SEMINOMA ON TREATMENT WITH CHEMOTHERAPY CISPLATIN FOR SOME CONDITIONS.

Eat more nuts, Pine Nut or Brazil Nut?

Nuts are an important part of many diets. The active ingredients contained in Pine Nut are Vitamin E, Beta-sitosterol, Oleic Acid, Linolenic Acid, Linoleic Acid among others. While the active ingredients contained in Brazil Nut are Vitamin E, Oleic Acid, Linolenic Acid, Lecithin, Folic Acid and others.

Beta-sitosterol can manipulate biochemical pathways Inositol Phosphate Signaling, Apoptosis and Cell Cycle. Vitamin K has biological action on biochemical pathways MYC Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling.

Lecithin can manipulate biochemical pathways MYC Signaling, JAK-STAT Signaling and MAPK Signaling. Vitamin E has biological action on biochemical pathways Oxidative Stress. And so on.

When treating Seminoma with chemotherapy Cisplatin – Foods like Pine Nut are recommended compared to Brazil Nut. This is because the active ingredients Lecithin and Vitamin E in Brazil Nut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin K contained in Pine Nut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: PINE NUT IS RECOMMENDED OVER BRAZIL NUT FOR SEMINOMA ON TREATMENT WITH CHEMOTHERAPY CISPLATIN FOR SOME CONDITIONS.

Foods for Genetic Risk of Seminoma

One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. KIT and RAC1 are two genes whose abnormalities are risk factors for Seminoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Seminoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Seminoma gene KIT has causative impact on biological pathways like MAPK Signaling, Growth Factor Signaling and PI3K-AKT-MTOR Signaling. And RAC1 has a causative impact on biological pathways like Cytoskeletal Dynamics, Adherens junction and Angiogenesis. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like KIT and RAC1 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes KIT and RAC1 should be avoided.

Eat more pulses, Common Pea or Pigeon Pea?

The active ingredients contained in Common Pea are Daidzein, Lupeol, Beta-sitosterol, Oleic Acid, Vitamin C among others. While the active ingredients contained in Pigeon Pea are Oleic Acid, Vitamin C, Linolenic Acid, Linoleic Acid, Genistein and others.

Beta-sitosterol can manipulate biochemical pathways MYC Signaling, Apoptosis and PI3K-AKT-MTOR Signaling. Vitamin C has biological action on biochemical pathways MAPK Signaling, Oxidative Stress and RAS-RAF Signaling.

Genistein can manipulate biochemical pathways Oxidative Stress. Vitamin A has biological action on biochemical pathways PI3K-AKT-MTOR Signaling. And so on.

For genetic risk of Seminoma due to abnormalities in genes KIT and RAC1 – Foods like Common Pea are recommended compared to Pigeon Pea. This is because the active ingredients Genistein and Vitamin A in Pigeon Pea further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin C contained in Common Pea together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: COMMON PEA IS RECOMMENDED OVER PIGEON PEA FOR REDUCING THE GENETIC RISK OF SEMINOMA DUE TO GENES KIT AND RAC1

Eat more vegetables, Cassava or Chicory?

The active ingredients contained in Cassava are Beta-sitosterol, Oleic Acid, Vitamin C, Linolenic Acid, Linoleic Acid among others. While the active ingredients contained in Chicory are Protocatechuic Acid, Apigenin, Lupeol, Betulinic Acid, Quercetin and others.

Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and MAPK Signaling. Beta-sitosterol has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, Oxidative Stress and MYC Signaling.

Vitamin A can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Protocatechuic Acid has biological action on biochemical pathways Oxidative Stress. And so on.

For genetic risk of Seminoma due to abnormalities in genes KIT and RAC1 – Foods like Cassava are recommended compared to Chicory. This is because the active ingredients Vitamin A and Protocatechuic Acid in Chicory further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Cassava together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: CASSAVA IS RECOMMENDED OVER CHICORY FOR REDUCING THE GENETIC RISK OF SEMINOMA DUE TO GENES KIT AND RAC1

Eat more fruits, Feijoa or Lingonberry?

The active ingredients contained in Feijoa are Lycopene, Vitamin C, Casuarinin, Folic Acid among others. While the active ingredients contained in Lingonberry are Resveratrol, Quercetin, Hyperoside, Oleic Acid, Vitamin C and others.

Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and MAPK Signaling. Lycopene has biological action on biochemical pathways Cytoskeletal Dynamics, PI3K-AKT-MTOR Signaling and RAS-RAF Signaling.

Quercetin can manipulate biochemical pathways Cell Junctions and Oxidative Stress. Hyperoside has biological action on biochemical pathways Oxidative Stress. And so on.

For genetic risk of Seminoma due to abnormalities in genes KIT and RAC1 – Foods like Feijoa are recommended compared to Lingonberry. This is because the active ingredients Quercetin and Hyperoside in Lingonberry further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Lycopene contained in Feijoa together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: FEIJOA IS RECOMMENDED OVER LINGONBERRY FOR REDUCING THE GENETIC RISK OF SEMINOMA DUE TO GENES KIT AND RAC1

Eat more nuts, Pecan Nut or Acorn?

The active ingredients contained in Pecan Nut are Cianidanol, Vitamin E, Oleic Acid, Delphinidin, Linolenic Acid among others. While the active ingredients contained in Acorn are Quercetin, Beta-sitosterol, Vitamin C, Gallic Acid, Quercitrin and others.

Cianidanol can manipulate biochemical pathways MYC Signaling, Apoptosis and MAPK Signaling. Delphinidin has biological action on biochemical pathways RAS-RAF Signaling, PI3K-AKT-MTOR Signaling and MYC Signaling.

Quercetin can manipulate biochemical pathways Cell Junctions and Oxidative Stress. Gallic Acid has biological action on biochemical pathways Cell Junctions and Oxidative Stress. And so on.

For genetic risk of Seminoma due to abnormalities in genes KIT and RAC1 – Foods like Pecan Nut are recommended compared to Acorn. This is because the active ingredients Quercetin and Gallic Acid in Acorn further promote the effects of genes on the biochemical pathways. While the active ingredients Cianidanol and Delphinidin contained in Pecan Nut together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: PECAN NUT IS RECOMMENDED OVER ACORN FOR REDUCING THE GENETIC RISK OF SEMINOMA DUE TO GENES KIT AND RAC1

In Summary

An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.

“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.

The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.

You can get started NOW and design a personalized nutrition plan for Seminoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

References

• Gct Msk 2016
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• Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH.
• Vitamin A regulates Akt signaling through the phospholipid fatty acid composition.
• Alpha-linolenic acid confers protection on mice renal cells against cisplatin-induced nephrotoxicity.
• Indeno[1,2-b]indole derivatives as a novel class of potent human protein kinase CK2 inhibitors.
• Crystal structure of a human cyclin-dependent kinase 6 complex with a flavonol inhibitor, fisetin.
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• Small-molecule inhibitors of NADPH oxidase 4.
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• Antimetastatic effects and mechanisms of apo-8′-lycopenal, an enzymatic metabolite of lycopene, against human hepatocarcinoma SK-Hep-1 cells.
• Hyperoside Induces Breast Cancer Cells Apoptosis via ROS-Mediated NF-κB Signaling Pathway.
• Inhibitory effect of Hibiscus protocatechuic acid on tumor promotion in mouse skin.
• Molecular docking analysis of Cianidanol fromGinkgo biloba with HER2+ breast cancer target.
• Delphinidin inhibits a broad spectrum of receptor tyrosine kinases of the ErbB and VEGFR family.
• Cardioprotective effect of gallic acid on cardiac troponin-T, cardiac marker enzymes, lipid peroxidation products and antioxidants in experimentally induced myocardial infarction in Wistar rats.
• Fisetin: a dietary antioxidant for health promotion.