Which Foods are Recommended for Salivary Gland Cancer?

Highlights

No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Salivary Gland Cancer when undergoing chemotherapy or when you determine you have a genetic risk for developing Salivary Gland Cancer because of PPM1D and ASXL1 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.

There is no one answer to this question for cancers such as Salivary Gland Cancer which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.

In short – the process to answer questions like “Should I Avoid eating fruit Cranberry” or “Include fruit Naranjilla in my diet” or “Should I reduce consumption of vegetable Swede” or “Can I take Dim and Birch supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.

RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO SALIVARY GLAND CANCER, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.

The overall objective of personalized nutrition for Salivary Gland Cancer is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.

RECOMMENDATION: UPDATE YOUR NUTRITION FOR SALIVARY GLAND CANCER, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.

About Salivary Gland Cancer

cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.

Following key highlights are derived from clinical data for Salivary Gland Cancer from cBioPortal. The patients enrolled in the studies for Salivary Gland Cancer are in ages between 1 to 98 with an average age of 58. 60.1% of males and 39.9% of females were the distribution of gender in these clinical studies. From a patient sample size of 220; the top genes with mutations and other abnormalities for Salivary Gland Cancer include genes DNMT3A, PPM1D, ASXL1, TERT and TET2. The occurrence frequency distribution for these genes respectively is 40.4%, 5.8%, 5.8%, 3.8% and 3.8%. These tumor genetic details of Salivary Gland Cancer are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Salivary Gland Cancer.

Significance of Nutrition for Salivary Gland Cancer

All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Salivary Gland Cancer. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.

For example Cranberry includes active ingredients Ellagic Acid, Quercetin, Hyperoside, Vitamin C, P-coumaric Acid and others. And Naranjilla contains active ingredients Beta-carotene, Zeaxanthin, Vitamin A and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.

For cancers like Salivary Gland Cancer, activation or inhibition of selected biochemical pathways like Cell Cycle Checkpoints, Cell Cycle, Oncogenic Cancer Epigenetics, PI3K-AKT-MTOR Signaling plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Salivary Gland Cancer, while eating some other foods and supplements may not be recommended.

One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.

RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR SALIVARY GLAND CANCER – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.

Foods for Salivary Gland Cancer undergoing chemotherapy treatment

In Salivary Gland Cancer – the genes DNMT3A, PPM1D, ASXL1, TERT and TET2 have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Salivary Gland Cancer are Cell Cycle Checkpoints, Cell Cycle, Hippo Signaling and others. Cyclophosphamide is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Cell Cycle Checkpoints, Cell Cycle, Hippo Signaling so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.

RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.

Eat more pulses, Common Pea or Pigeon Pea?

Pulses are an important part of many diets. The active ingredients contained in Common Pea are Lupeol, Daidzein, Vitamin C, Beta-sitosterol, Genistein among others. While the active ingredients contained in Pigeon Pea are Vitamin C, Genistein, Vitamin A, Oleic Acid, Linolenic Acid and others.

Vitamin C can manipulate biochemical pathways Growth Factor Signaling, Cell Cycle and MYC Signaling. Beta-sitosterol has biological action on biochemical pathways Vitamin D Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling.

Genistein can manipulate biochemical pathways Hippo Signaling, DNA Repair and Oxidative Stress. Linolenic Acid has biological action on biochemical pathways Vitamin D Signaling and Oxidative Stress. And so on.

When treating Salivary Gland Cancer with chemotherapy Cyclophosphamide – Foods like Common Pea are recommended compared to Pigeon Pea. This is because the active ingredients Genistein and Linolenic Acid in Pigeon Pea interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Beta-sitosterol contained in Common Pea support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: COMMON PEA IS RECOMMENDED OVER PIGEON PEA FOR SALIVARY GLAND CANCER ON TREATMENT WITH CHEMOTHERAPY CYCLOPHOSPHAMIDE FOR SOME CONDITIONS.

Eat more vegetables, Giant Butterbur or Swede?

Vegetables are an important part of many diets. The active ingredients contained in Giant Butterbur are Vitamin C, Beta-sitosterol, Vitamin A, Melatonin, Vitamin B3 among others. While the active ingredients contained in Swede are Lycopene, Oleic Acid, Linolenic Acid, Linoleic Acid, Folic Acid and others.

Vitamin C can manipulate biochemical pathways Growth Factor Signaling, Cell Cycle and MYC Signaling. Beta-sitosterol has biological action on biochemical pathways Vitamin D Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling.

Lycopene can manipulate biochemical pathways Oxidative Stress. Linolenic Acid has biological action on biochemical pathways Vitamin D Signaling and Oxidative Stress. And so on.

When treating Salivary Gland Cancer with chemotherapy Cyclophosphamide – Foods like Giant Butterbur are recommended compared to Swede. This is because the active ingredients Lycopene and Linolenic Acid in Swede interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Beta-sitosterol contained in Giant Butterbur support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: GIANT BUTTERBUR IS RECOMMENDED OVER SWEDE FOR SALIVARY GLAND CANCER ON TREATMENT WITH CHEMOTHERAPY CYCLOPHOSPHAMIDE FOR SOME CONDITIONS.

Eat more fruits, Naranjilla or Cranberry?

Fruits are an important part of many diets. The active ingredients contained in Naranjilla are Beta-carotene, Zeaxanthin, Vitamin A among others. While the active ingredients contained in Cranberry are Ellagic Acid, Quercetin, Hyperoside, Vitamin C, P-coumaric Acid and others.

Beta-carotene can manipulate biochemical pathways DNA Repair, Cell Cycle and MYC Signaling. Vitamin A has biological action on biochemical pathways Vitamin D Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling.

Ellagic Acid can manipulate biochemical pathways MYC Signaling and Vitamin D Signaling. Quercetin has biological action on biochemical pathways Oxidative Stress. And so on.

When treating Salivary Gland Cancer with chemotherapy Cyclophosphamide – Foods like Naranjilla are recommended compared to Cranberry. This is because the active ingredients Ellagic Acid and Quercetin in Cranberry interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-carotene and Vitamin A contained in Naranjilla support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: NARANJILLA IS RECOMMENDED OVER CRANBERRY FOR SALIVARY GLAND CANCER ON TREATMENT WITH CHEMOTHERAPY CYCLOPHOSPHAMIDE FOR SOME CONDITIONS.

Eat more nuts, Pecan Nut or Pumpkin Seeds?

Nuts are an important part of many diets. The active ingredients contained in Pecan Nut are Vitamin E, Delphinidin, Vitamin A, Oleic Acid, Linolenic Acid among others. While the active ingredients contained in Pumpkin Seeds are Beta-sitosterol, Salicylic Acid, Oleic Acid, Linolenic Acid, Stigmasterol and others.

Vitamin E can manipulate biochemical pathways Growth Factor Signaling, Cell Cycle and DNA Repair. Delphinidin has biological action on biochemical pathways MYC Signaling, PI3K-AKT-MTOR Signaling and Growth Factor Signaling.

Gamma-linolenic Acid can manipulate biochemical pathways Vitamin D Signaling and Oxidative Stress. Lecithin has biological action on biochemical pathways MYC Signaling, JAK-STAT Signaling and PI3K-AKT-MTOR Signaling. And so on.

When treating Salivary Gland Cancer with chemotherapy Cyclophosphamide – Foods like Pecan Nut are recommended compared to Pumpkin Seeds. This is because the active ingredients Gamma-linolenic Acid and Lecithin in Pumpkin Seeds interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin E and Delphinidin contained in Pecan Nut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: PECAN NUT IS RECOMMENDED OVER PUMPKIN SEEDS FOR SALIVARY GLAND CANCER ON TREATMENT WITH CHEMOTHERAPY CYCLOPHOSPHAMIDE FOR SOME CONDITIONS.

Foods for Genetic Risk of Salivary Gland Cancer

One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. PPM1D and ASXL1 are two genes whose abnormalities are risk factors for Salivary Gland Cancer. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Salivary Gland Cancer can be used as a guide for coming up with a recommended personalized nutrition plan. For Salivary Gland Cancer gene PPM1D has causative impact on biological pathways like DNA Repair. And ASXL1 has a causative impact on biological pathways like Oncogenic Cancer Epigenetics and Suppressive Histone Methylation. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like PPM1D and ASXL1 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes PPM1D and ASXL1 should be avoided.

Eat more pulses, Scarlet Bean or Common Bean?

The active ingredients contained in Scarlet Bean are Vitamin C, Beta-sitosterol, Linolenic Acid, Stigmasterol, Genistein among others. While the active ingredients contained in Common Bean are Apigenin, Esculin, Vitamin C, Linolenic Acid, Ferulic Acid and others.

Vitamin C can manipulate biochemical pathways Apoptosis, Suppressive Histone Methylation and MYC Signaling. Beta-sitosterol has biological action on biochemical pathways Oncogenic Cancer Epigenetics, Cell Cycle Checkpoints and Apoptosis.

Pelargonidin can manipulate biochemical pathways MYC Signaling and Cell Cycle Checkpoints. Folic Acid has biological action on biochemical pathways Apoptosis, MYC Signaling and Cell Cycle Checkpoints. And so on.

For genetic risk of Salivary Gland Cancer due to abnormalities in genes PPM1D and ASXL1 – Foods like Scarlet Bean are recommended compared to Common Bean. This is because the active ingredients Pelargonidin and Folic Acid in Common Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Scarlet Bean together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: SCARLET BEAN IS RECOMMENDED OVER COMMON BEAN FOR REDUCING THE GENETIC RISK OF SALIVARY GLAND CANCER DUE TO GENES PPM1D AND ASXL1

Eat more vegetables, Cassava or Heart Of Palm?

The active ingredients contained in Cassava are Vitamin C, Beta-sitosterol, Linolenic Acid, Oleic Acid, Linoleic Acid among others. While the active ingredients contained in Heart Of Palm are Vitamin C, Palmitic Acid, Vitamin A, Folic Acid and others.

Vitamin C can manipulate biochemical pathways Apoptosis, Suppressive Histone Methylation and MYC Signaling. Beta-sitosterol has biological action on biochemical pathways Oncogenic Cancer Epigenetics, Cell Cycle Checkpoints and Apoptosis.

Palmitic Acid can manipulate biochemical pathways Oncogenic Cancer Epigenetics and mRNA Splicing. Folic Acid has biological action on biochemical pathways MYC Signaling, Cell Cycle Checkpoints and Apoptosis. And so on.

For genetic risk of Salivary Gland Cancer due to abnormalities in genes PPM1D and ASXL1 – Foods like Cassava are recommended compared to Heart Of Palm. This is because the active ingredients Palmitic Acid and Folic Acid in Heart Of Palm further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Cassava together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: CASSAVA IS RECOMMENDED OVER HEART OF PALM FOR REDUCING THE GENETIC RISK OF SALIVARY GLAND CANCER DUE TO GENES PPM1D AND ASXL1

Eat more fruits, Feijoa or Graviola?

The active ingredients contained in Feijoa are Lycopene, Vitamin C, Casuarinin, Folic Acid among others. While the active ingredients contained in Graviola are Emodin, Lycopene, Vitamin C, Beta-sitosterol, Daidzein and others.

Vitamin C can manipulate biochemical pathways Apoptosis, Suppressive Histone Methylation and MYC Signaling. Casuarinin has biological action on biochemical pathways Cell Cycle Checkpoints, MYC Signaling and Apoptosis.

Fisetin can manipulate biochemical pathways MYC Signaling. Myricetin has biological action on biochemical pathways Oncogenic Cancer Epigenetics. And so on.

For genetic risk of Salivary Gland Cancer due to abnormalities in genes PPM1D and ASXL1 – Foods like Feijoa are recommended compared to Graviola. This is because the active ingredients Fisetin and Myricetin in Graviola further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Casuarinin contained in Feijoa together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: FEIJOA IS RECOMMENDED OVER GRAVIOLA FOR REDUCING THE GENETIC RISK OF SALIVARY GLAND CANCER DUE TO GENES PPM1D AND ASXL1

Eat more nuts, Pistachio or Chestnut?

The active ingredients contained in Pistachio are Beta-sitosterol, Vitamin E, Stigmasterol, Linolenic Acid, Oleic Acid among others. While the active ingredients contained in Chestnut are Vitamin C, Linolenic Acid, Quercetin, Oleic Acid, Linoleic Acid and others.

Beta-sitosterol can manipulate biochemical pathways Apoptosis, Oncogenic Cancer Epigenetics and Cell Cycle Checkpoints. Vitamin E has biological action on biochemical pathways MYC Signaling, Cell Cycle Checkpoints and Apoptosis.

Ellagic Acid can manipulate biochemical pathways MYC Signaling and Cell Cycle Checkpoints. Folic Acid has biological action on biochemical pathways Apoptosis, MYC Signaling and Cell Cycle Checkpoints. And so on.

For genetic risk of Salivary Gland Cancer due to abnormalities in genes PPM1D and ASXL1 – Foods like Pistachio are recommended compared to Chestnut. This is because the active ingredients Ellagic Acid and Folic Acid in Chestnut further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin E contained in Pistachio together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: PISTACHIO IS RECOMMENDED OVER CHESTNUT FOR REDUCING THE GENETIC RISK OF SALIVARY GLAND CANCER DUE TO GENES PPM1D AND ASXL1

In Summary

An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.

“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.

The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.

You can get started NOW and design a personalized nutrition plan for Salivary Gland Cancer by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

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