Foods for Renal Angiomyolipoma!

Introduction

Foods for Renal Angiomyolipoma should be personalized for each individual and also must adapt when cancer treatment or tumor genetic change. The personalization and adaptation must consider all the active ingredients or bioactives contained in different foods with respect to cancer tissue biology, genetics, treatments, lifestyle conditions and diet preferences. Hence while nutrition is one of the very important decisions for a cancer patient and individual at risk of cancer to make – how to choose foods to eat is not an easy task.

When managing angiomyolipoma, a benign tumor composed of blood vessels, muscle, and fat, often found in the kidneys, diet can play a supportive role in overall health. Although there is no specific “angiomyolipoma diet,” patients are generally advised to maintain a balanced and healthy diet to support kidney health and overall well-being. This might include focusing on foods that are low in sodium and unhealthy fats, and rich in fruits, vegetables, whole grains, and lean proteins. It’s also important to consider any foods to avoid, particularly those that may exacerbate underlying conditions or interact with medications. For instance, patients with kidney-related issues might need to limit certain high-potassium foods. However, it’s crucial to remember that dietary needs can vary significantly from person to person, and what is beneficial for one individual might not be for another. Therefore, patients with angiomyolipoma should consult with their healthcare provider or a dietitian to create a personalized dietary plan that considers their specific health needs and treatment plan. This tailored approach ensures that the diet not only supports the management of angiomyolipoma but also promotes overall health and well-being.

For Renal Angiomyolipoma does it matter what vegetables, fruits, nuts, seeds one eats?

A very common nutrition question asked by cancer patients and individuals at-genetic risk of cancer is – for cancers like Renal Angiomyolipoma does it matter what foods I eat and which I do not? Or if I follow a plant-based diet is that enough for cancer like Renal Angiomyolipoma?

For example does it matter if vegetable Celery Stalks is consumed more compared to Cardoon? Does it make any difference if fruit Babassu Palm is preferred over Soursop? Also if similar choices are made for nuts/seeds like Common Walnut over Flaxseed and for pulses like Broad Bean over Catjang Pea. And if what I eat matters – then how does one identify foods which are recommended for Renal Angiomyolipoma and is it the same answer for everyone with the same diagnosis or genetic risk?

Yes! Foods you eat matters for Renal Angiomyolipoma!

Food recommendations may not be the same for everyone and can be different even for the same diagnosis and genetic risk.

All foods (vegetables, fruits, nuts, seeds, pulses, oils etc.) and nutritional supplements are made up of more than one active molecular ingredient or bio-actives in different proportions and quantities. Each active ingredient has a unique mechanism of action – which can be activation or inhibition of different biochemical pathways. Simply stated foods and supplements which are recommended are those which do not cause an increase of molecular drivers of cancer but reduce them. Else those foods should not be recommended. Foods contain multiple active ingredients – hence when evaluating foods and supplements you need to consider the impact of all active ingredients cumulatively rather than individually.

For example Babassu Palm contains active ingredients Apigenin, Curcumin, Lupeol, Psoralen, Phloretin. And Soursop contains active ingredients Apigenin, Emodin, Curcumin, Lupeol, Psoralen and possibly others.

A common mistake made when deciding and choosing foods to eat for Renal Angiomyolipoma – is to evaluate only selected active ingredients contained in foods and ignore the rest. Because different active ingredients contained in foods may have opposing effects on cancer drivers – you cannot cherry pick active ingredients in foods and supplements for making a nutrition decision for Renal Angiomyolipoma.

YES – FOOD CHOICES MATTER FOR CANCER. NUTRITION DECISIONS MUST CONSIDER ALL ACTIVE INGREDIENTS OF FOODS.

Skills Needed for Nutrition Personalization for Renal Angiomyolipoma?

Personalized nutrition for cancers like Renal Angiomyolipoma consists of recommended foods / supplements; not recommended foods / supplements with example recipes which prioritize use of recommended foods. An example of personalized nutrition can be seen at this link.

Deciding which foods are recommended or not is extremely complicated, requiring expertise in Renal Angiomyolipoma biology, food science, genetics, biochemistry along with good understanding of how cancer treatments work and associated vulnerabilities by which the treatments could stop being effective.

MINIMUM KNOWLEDGE EXPERTISE NEEDED FOR NUTRITION PERSONALIZATION FOR CANCER ARE: CANCER BIOLOGY, FOOD SCIENCE, CANCER TREATMENTS AND GENETICS.

Characteristics of cancers like Renal Angiomyolipoma

All cancers like Renal Angiomyolipoma can be characterized by a unique set of biochemical pathways – the signature pathways of Renal Angiomyolipoma. Biochemical pathways like Cell Cycle Checkpoints, Apoptosis, Nutrient sensing, DNA Repair are part of the signature definition of Renal Angiomyolipoma. Each individual’s cancer genetics can be different and hence their specific cancer signature could be unique.

The treatments which are effective for Renal Angiomyolipoma need to be cognizant of the associated signature biochemical pathways for each cancer patient and individual at genetic risk. Therefore different treatments with different mechanisms of actions are effective for different patients. Similarly and for the same reasons foods and supplements need to be personalized for each individual. Hence some foods and supplements are recommended for Renal Angiomyolipoma when taking cancer treatment Everolimus, and some foods and supplements are not recommended.

Sources like cBioPortal and many others provide population representative patient anonymized data from clinical trials for all cancer indications. This data consists of clinical trial study details like sample size / number of patients, age groups, gender, ethnicity, treatments, tumor site and any genetic mutations.

TSC2, TP53 and ATRX are the top ranked reported genes for Renal Angiomyolipoma. TSC2 is reported in 60.0 % of the representative patients across all clinical trials. And TP53 is reported in 20.0 %. The combined population patient data cover ages from to . 50.0 % of the patient data are identified as men. The Renal Angiomyolipoma biology along with reported genetics together define the population represented signature biochemical pathways for this cancer. If the individual cancer tumor genetics or genes contributing to the risk are also known then that should also be used for nutrition personalization.

NUTRITION CHOICES SHOULD MATCH WITH EACH INDIVIDUAL’S CANCER SIGNATURE.

Food and Supplements for Renal Angiomyolipoma

For Cancer Patients

Cancer patients on treatment or on palliative care need to make decisions on food and supplements – for the needed dietary calories, for managing any treatment side effects and also for improved cancer management. All plant-based foods are not equal and choosing and prioritizing foods which are personalized and customized to ongoing cancer treatment is important and complicated. Here are some examples providing guidelines for making nutrition decisions.

Choose Vegetable CELERY STALKS or CARDOON?

Vegetable Celery Stalks contains many active ingredients or bioactives such as Apigenin, Curcumin, Lycopene, Lupeol, Phloretin. These active ingredients manipulate various biochemical pathways like MYC Signaling and others. Celery Stalks is recommended for Renal Angiomyolipoma when ongoing cancer treatment is Everolimus. This is because Celery Stalks modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Everolimus.

Some of the active ingredients or bioactives in vegetable Cardoon are Apigenin, Curcumin, Lycopene, Lupeol, Psoralen. These active ingredients manipulate various biochemical pathways like MYC Signaling and others. Cardoon is not recommended for Renal Angiomyolipoma when ongoing cancer treatment is Everolimus because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

VEGETABLE CELERY STALKS IS RECOMMENDED OVER CARDOON FOR Renal Angiomyolipoma AND TREATMENT Everolimus.

Choose Fruit SOURSOP or BABASSU PALM?

Fruit Soursop contains many active ingredients or bioactives such as Apigenin, Emodin, Curcumin, Lupeol, Psoralen. These active ingredients manipulate various biochemical pathways like MYC Signaling and others. Soursop is recommended for Renal Angiomyolipoma when ongoing cancer treatment is Everolimus. This is because Soursop modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Everolimus.

Some of the active ingredients or bioactives in fruit Babassu Palm are Apigenin, Curcumin, Lupeol, Psoralen, Phloretin. These active ingredients manipulate various biochemical pathways like MYC Signaling and others. Babassu Palm is not recommended for Renal Angiomyolipoma when ongoing cancer treatment is Everolimus because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

FRUIT SOURSOP IS RECOMMENDED OVER BABASSU PALM FOR Renal Angiomyolipoma AND TREATMENT Everolimus.

Choose Nut COMMON WALNUT or FLAXSEED?

Common Walnut contains many active ingredients or bioactives such as Curcumin, Lupeol, Psoralen, Phloretin, Daidzein. These active ingredients manipulate various biochemical pathways like MYC Signaling and others. Common Walnut is recommended for Renal Angiomyolipoma when ongoing cancer treatment is Everolimus. This is because Common Walnut modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Everolimus.

Some of the active ingredients or bioactives in Flaxseed are Apigenin, Curcumin, Lupeol, Psoralen, Phloretin. These active ingredients manipulate various biochemical pathways like MYC Signaling and others. Flaxseed is not recommended for Renal Angiomyolipoma when ongoing cancer treatment is Everolimus because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

COMMON WALNUT IS RECOMMENDED OVER FLAXSEED FOR Renal Angiomyolipoma AND TREATMENT Everolimus.

For Individuals with Genetic Risk of Cancer

The question asked by individuals who have genetic risk of Renal Angiomyolipoma or familial history is “What Should I Eat Differently from Before?” and how they should choose foods and supplements to manage risks of the disease. Since for cancer risk there is nothing actionable in terms of treatment – decisions of foods and supplements become important and one of the very few actionable things which can be done. All plant-based foods are not equal and based on identified genetics and pathway signature – the choices of food and supplements should be personalized.

Choose Vegetable GIANT BUTTERBUR or CHINESE BROCCOLI?

Vegetable Giant Butterbur contains many active ingredients or bioactives such as Apigenin, Curcumin, Lupeol, Daidzein, Formononetin. These active ingredients manipulate various biochemical pathways like Cell Cycle, P53 Signaling, DNA Repair and MYC Signaling and others. Giant Butterbur is recommended for risk of Renal Angiomyolipoma when associated genetic risk is ATRX. This is because Giant Butterbur increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in vegetable Chinese Broccoli are Apigenin, Curcumin, Lupeol, Daidzein, Formononetin. These active ingredients manipulate various biochemical pathways like DNA Repair and Oxidative Stress and others. Chinese Broccoli is not recommended when risk of Renal Angiomyolipoma when associated genetic risk is ATRX because it increases the signature pathways of it.

VEGETABLE GIANT BUTTERBUR IS RECOMMENDED OVER CHINESE BROCCOLI FOR ATRX GENETIC RISK OF CANCER.

Choose Fruit NANCE or GRAPEFRUIT?

Fruit Nance contains many active ingredients or bioactives such as Apigenin, Curcumin, Lupeol, Daidzein, Formononetin. These active ingredients manipulate various biochemical pathways like Cell Cycle, P53 Signaling, DNA Repair and MYC Signaling and others. Nance is recommended for risk of Renal Angiomyolipoma when associated genetic risk is ATRX. This is because Nance increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in fruit Grapefruit are Curcumin, Lupeol, Daidzein, Formononetin, Beta-sitosterol. These active ingredients manipulate various biochemical pathways like Oxidative Stress and others. Grapefruit is not recommended when risk of Renal Angiomyolipoma when associated genetic risk is ATRX because it increases the signature pathways of it.

FRUIT NANCE IS RECOMMENDED OVER GRAPEFRUIT FOR ATRX GENETIC RISK OF CANCER.

Choose Nut COMMON HAZELNUT or EUROPEAN CHESTNUT?

Common Hazelnut contains many active ingredients or bioactives such as Curcumin, Lupeol, Daidzein, Formononetin, Beta-sitosterol. These active ingredients manipulate various biochemical pathways like DNA Repair, Cell Cycle, P53 Signaling and MAPK Signaling and others. Common Hazelnut is recommended for risk of Renal Angiomyolipoma when associated genetic risk is ATRX. This is because Common Hazelnut increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in European Chestnut are Apigenin, Curcumin, Ellagic Acid, Lupeol, Daidzein. These active ingredients manipulate various biochemical pathways like DNA Repair and Oxidative Stress and others. European Chestnut is not recommended when risk of Renal Angiomyolipoma when associated genetic risk is ATRX because it increases the signature pathways of it.

COMMON HAZELNUT IS RECOMMENDED OVER EUROPEAN CHESTNUT FOR ATRX GENETIC RISK OF CANCER.

In Conclusion

Foods and Supplements chosen are important decisions for cancers like Renal Angiomyolipoma. Renal Angiomyolipoma patients and individuals with genetic-risk always have this question: “What foods and nutritional supplements are recommended for me and which are not?” There is a common belief which is a misconception that all plant-based foods could be beneficial or not but would not be harmful. Certain foods and supplements can interfere with cancer treatments or promote molecular pathway drivers of cancer.

There are different types of cancer indications like Renal Angiomyolipoma, each with different tumor genetics with further genomic variations across each individual. Further every cancer treatment and chemotherapy has a unique mechanism of action. Each food like Celery Stalks contains various bioactives in different quantities, which have an impact on different and distinct sets of biochemical pathways. The definition of personalized nutrition is individualized food recommendations for the cancer indication, treatments, genetics, lifestyle and other factors. Nutrition personalization decisions for cancer require knowledge of cancer biology, food science and an understanding of different chemotherapy treatments. Finally when there are treatment changes or new genomics is identified – the nutrition personalization needs re-evaluation.

The addon nutrition personalization solution makes the decision making easy and removes all the guesswork in answering the question, “What foods should I choose or not choose for Renal Angiomyolipoma?”. The addon multi-disciplinary team includes cancer physicians, clinical scientists, software engineers and data scientists.

References

• Msk Impact 2017
• Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients.
• Paederia foetida induces anticancer activity by modulating chromatin modification enzymes and altering pro-inflammatory cytokine gene expression in human prostate cancer cells.
• Induction of colon and cervical cancer cell death by cinnamic acid derivatives is mediated through the inhibition of Histone Deacetylases (HDAC).
• https://www.ncbi.nlm.nih.gov/books/NBK585104
• https://my.clevelandclinic.org/health/diseases/22253-renal-angiomyolipoma