Which Foods are Recommended for Renal Angiomyolipoma?

Highlights

No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Renal Angiomyolipoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Renal Angiomyolipoma because of TSC2 and TP53 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.

There is no one answer to this question for cancers such as Renal Angiomyolipoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.

In short – the process to answer questions like “Should I Avoid eating fruit Raspberry” or “Include fruit Graviola in my diet” or “Should I reduce consumption of vegetable Chicory” or “Can I take Buckthorn and Apigenin supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.

RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO RENAL ANGIOMYOLIPOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.

The overall objective of personalized nutrition for Renal Angiomyolipoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.

RECOMMENDATION: UPDATE YOUR NUTRITION FOR RENAL ANGIOMYOLIPOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.

About Renal Angiomyolipoma

cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.

Following key highlights are derived from clinical data for Renal Angiomyolipoma from cBioPortal. 50.0% of males and 50.0% of females were the distribution of gender in these clinical studies. From a patient sample size of 5; the top genes with mutations and other abnormalities for Renal Angiomyolipoma include genes TSC2, TP53 and ATRX. The occurrence frequency distribution for these genes respectively is 60.0%, 20.0% and 20.0%. These tumor genetic details of Renal Angiomyolipoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Renal Angiomyolipoma.

Renal angiomyolipoma (AML) is a benign, slow-growing tumor that occurs in the kidney. It is usually detected accidently through ultrasound or MRI done for another medical condition. It does not typically spread to other parts of the body and often does not cause any symptoms. In some cases, embolization or surgery may be required for the management of renal angiomyolipoma, especially if the tumor is causing symptoms or is at risk of hemorrhage. These tumors mostly affect women over 50 years of age. Rare symptoms of renal angiomyolipoma may include anemia, discomfort in the abdomen, back and sides, hematuria (blood in the urine), high blood pressure (hypertension) or urinary tract infections. Active surveillance and follow-up is crucial for the patients to detect any changes in the size or nature of the tumor and patients should be informed about the potential risk of hemorrhage. In addition, supportive care with optimal nutrition (foods and natural supplements) can help improve well-being of individuals diagnosed with renal angiomyolipoma. (Ref: https://www.ncbi.nlm.nih.gov/books/NBK585104/; https://my.clevelandclinic.org/health/diseases/22253-renal-angiomyolipoma )

Significance of Nutrition for Renal Angiomyolipoma

All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Renal Angiomyolipoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.

For example Raspberry includes active ingredients Vitamin C, Quercetin, Resveratrol, Ellagic Acid, Gallic Acid and others. And Graviola contains active ingredients Emodin, Lycopene, Vitamin E, Daidzein, Beta-sitosterol and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.

For cancers like Renal Angiomyolipoma, activation or inhibition of selected biochemical pathways like Cell Cycle Checkpoints, Apoptosis, Nutrient sensing, DNA Repair plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Renal Angiomyolipoma, while eating some other foods and supplements may not be recommended.

One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.

RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR RENAL ANGIOMYOLIPOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.

Foods for Renal Angiomyolipoma undergoing chemotherapy treatment

In Renal Angiomyolipoma – the genes TSC2, TP53 and ATRX have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Renal Angiomyolipoma are Cell Cycle Checkpoints, Apoptosis and others. Everolimus is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Cell Cycle Checkpoints, Apoptosis so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.

RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.

Eat more pulses, Hyacinth Bean or Soy Bean?

Pulses are an important part of many diets. The active ingredients contained in Hyacinth Bean are Vitamin C, Palmitic Acid, Genistein, Folic Acid, Myristic Acid among others. While the active ingredients contained in Soy Bean are Lupeol, Vitamin E, Daidzein, Beta-sitosterol, Stigmasterol and others.

Palmitic Acid can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Vitamin C has biological action on biochemical pathways Cell Cycle Checkpoints, Apoptosis and MYC Signaling.

Aescin can manipulate biochemical pathways Cell Cycle Checkpoints. Lecithin has biological action on biochemical pathways MYC Signaling. And so on.

When treating Renal Angiomyolipoma with chemotherapy Everolimus – Foods like Hyacinth Bean are recommended compared to Soy Bean. This is because the active ingredients Aescin and Lecithin in Soy Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Palmitic Acid and Vitamin C contained in Hyacinth Bean support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: HYACINTH BEAN IS RECOMMENDED OVER SOY BEAN FOR RENAL ANGIOMYOLIPOMA ON TREATMENT WITH CHEMOTHERAPY EVEROLIMUS FOR SOME CONDITIONS.

Eat more vegetables, Arugula or Chicory?

Vegetables are an important part of many diets. The active ingredients contained in Arugula are Esculin, Vitamin A, Kaempferol, Vitamin K, Erysolin among others. While the active ingredients contained in Chicory are Apigenin, Esculin, Lupeol, Betulinic Acid, Linolenic Acid and others.

Vitamin A can manipulate biochemical pathways Apoptosis, MYC Signaling and Cell Cycle Checkpoints. Kaempferol has biological action on biochemical pathways Cell Cycle Checkpoints.

Luteolin can manipulate biochemical pathways MYC Signaling. Folic Acid has biological action on biochemical pathways Apoptosis, P53 Signaling and Cell Cycle Checkpoints. And so on.

When treating Renal Angiomyolipoma with chemotherapy Everolimus – Foods like Arugula are recommended compared to Chicory. This is because the active ingredients Luteolin and Folic Acid in Chicory interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin A and Kaempferol contained in Arugula support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: ARUGULA IS RECOMMENDED OVER CHICORY FOR RENAL ANGIOMYOLIPOMA ON TREATMENT WITH CHEMOTHERAPY EVEROLIMUS FOR SOME CONDITIONS.

Eat more fruits, Graviola or Raspberry?

Fruits are an important part of many diets. The active ingredients contained in Graviola are Emodin, Lycopene, Vitamin E, Daidzein, Beta-sitosterol among others. While the active ingredients contained in Raspberry are Vitamin C, Quercetin, Resveratrol, Ellagic Acid, Gallic Acid and others.

Emodin can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Cinnamic Acid has biological action on biochemical pathways Cell Cycle Checkpoints, Apoptosis and MYC Signaling.

Ellagic Acid can manipulate biochemical pathways MYC Signaling. Resveratrol has biological action on biochemical pathways P53 Signaling. And so on.

When treating Renal Angiomyolipoma with chemotherapy Everolimus – Foods like Graviola are recommended compared to Raspberry. This is because the active ingredients Ellagic Acid and Resveratrol in Raspberry interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Emodin and Cinnamic Acid contained in Graviola support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: GRAVIOLA IS RECOMMENDED OVER RASPBERRY FOR RENAL ANGIOMYOLIPOMA ON TREATMENT WITH CHEMOTHERAPY EVEROLIMUS FOR SOME CONDITIONS.

Eat more nuts, Hazelnut or Chestnut?

Nuts are an important part of many diets. The active ingredients contained in Hazelnut are Vitamin E, Linolenic Acid, Oleic Acid, Linoleic Acid, Quercetin among others. While the active ingredients contained in Chestnut are Linolenic Acid, Vitamin C, Oleic Acid, Linoleic Acid, Quercetin and others.

Vitamin E can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Quercetin has biological action on biochemical pathways Cell Cycle Checkpoints, Apoptosis and MYC Signaling.

Ellagic Acid can manipulate biochemical pathways MYC Signaling. Folic Acid has biological action on biochemical pathways Apoptosis, P53 Signaling and Cell Cycle Checkpoints. And so on.

When treating Renal Angiomyolipoma with chemotherapy Everolimus – Foods like Hazelnut are recommended compared to Chestnut. This is because the active ingredients Ellagic Acid and Folic Acid in Chestnut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin E and Quercetin contained in Hazelnut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: HAZELNUT IS RECOMMENDED OVER CHESTNUT FOR RENAL ANGIOMYOLIPOMA ON TREATMENT WITH CHEMOTHERAPY EVEROLIMUS FOR SOME CONDITIONS.

Foods for Genetic Risk of Renal Angiomyolipoma

One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. TSC2 and TP53 are two genes whose abnormalities are risk factors for Renal Angiomyolipoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Renal Angiomyolipoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Renal Angiomyolipoma gene TSC2 has causative impact on biological pathways like Nutrient sensing, Autophagy and PI3K-AKT-MTOR Signaling. And TP53 has a causative impact on biological pathways like Cell Cycle Checkpoints and Apoptosis. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like TSC2 and TP53 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes TSC2 and TP53 should be avoided.

Eat more pulses, Mung Bean or Pigeon Pea?

The active ingredients contained in Mung Bean are Quercetin, Vitamin C, Linolenic Acid, Oleic Acid, Stigmasterol among others. While the active ingredients contained in Pigeon Pea are Vitamin C, Linolenic Acid, Oleic Acid, Linoleic Acid, Genistein and others.

Quercetin can manipulate biochemical pathways Cell Cycle Checkpoints, RAS-RAF Signaling and EPHRIN Signaling. Vitamin C has biological action on biochemical pathways Apoptosis, PI3K-AKT-MTOR Signaling and MYC Signaling.

Folic Acid can manipulate biochemical pathways Cell Cycle Checkpoints, RAS-RAF Signaling and Apoptosis. And so on.

For genetic risk of Renal Angiomyolipoma due to abnormalities in genes TSC2 and TP53 – Foods like Mung Bean are recommended compared to Pigeon Pea. This is because the active ingredients Folic Acid in Pigeon Pea further promote the effects of genes on the biochemical pathways. While the active ingredients Quercetin and Vitamin C contained in Mung Bean together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: MUNG BEAN IS RECOMMENDED OVER PIGEON PEA FOR REDUCING THE GENETIC RISK OF RENAL ANGIOMYOLIPOMA DUE TO GENES TSC2 AND TP53

Eat more vegetables, Giant Butterbur or Carob?

The active ingredients contained in Giant Butterbur are Beta-sitosterol, Vitamin C, Vitamin B3, Kaempferol, Melatonin among others. While the active ingredients contained in Carob are Quercetin, Myricetin, Palmitic Acid, Gallic Acid, Phloroglucinol and others.

Vitamin C can manipulate biochemical pathways Cell Cycle Checkpoints, RAS-RAF Signaling and Apoptosis. Beta-sitosterol has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, MYC Signaling and P53 Signaling.

Folic Acid can manipulate biochemical pathways Cell Cycle Checkpoints, RAS-RAF Signaling and Apoptosis. And so on.

For genetic risk of Renal Angiomyolipoma due to abnormalities in genes TSC2 and TP53 – Foods like Giant Butterbur are recommended compared to Carob. This is because the active ingredients Folic Acid in Carob further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Giant Butterbur together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: GIANT BUTTERBUR IS RECOMMENDED OVER CAROB FOR REDUCING THE GENETIC RISK OF RENAL ANGIOMYOLIPOMA DUE TO GENES TSC2 AND TP53

Eat more fruits, Date or Cranberry?

The active ingredients contained in Date are Apigenin, Lupeol, Protocatechuic Acid, Quercetin, Beta-sitosterol among others. While the active ingredients contained in Cranberry are Ellagic Acid, Resveratrol, Hyperoside, Quercetin, Myricetin and others.

Apigenin can manipulate biochemical pathways Cell Cycle Checkpoints, RAS-RAF Signaling and EPHRIN Signaling. Lupeol has biological action on biochemical pathways Apoptosis, PI3K-AKT-MTOR Signaling and MYC Signaling.

Ellagic Acid can manipulate biochemical pathways MYC Signaling and Cell Cycle Checkpoints. Resveratrol has biological action on biochemical pathways P53 Signaling. And so on.

For genetic risk of Renal Angiomyolipoma due to abnormalities in genes TSC2 and TP53 – Foods like Date are recommended compared to Cranberry. This is because the active ingredients Ellagic Acid and Resveratrol in Cranberry further promote the effects of genes on the biochemical pathways. While the active ingredients Apigenin and Lupeol contained in Date together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: DATE IS RECOMMENDED OVER CRANBERRY FOR REDUCING THE GENETIC RISK OF RENAL ANGIOMYOLIPOMA DUE TO GENES TSC2 AND TP53

Eat more nuts, Almond or Brazil Nut?

The active ingredients contained in Almond are Quercetin, Vitamin E, Beta-sitosterol, Linolenic Acid, Oleic Acid among others. While the active ingredients contained in Brazil Nut are Vitamin E, Linolenic Acid, Oleic Acid, Lecithin, Folic Acid and others.

Beta-sitosterol can manipulate biochemical pathways Cell Cycle Checkpoints, Apoptosis and PI3K-AKT-MTOR Signaling. Quercetin has biological action on biochemical pathways RAS-RAF Signaling, EPHRIN Signaling and MYC Signaling.

Lecithin can manipulate biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways Cell Cycle Checkpoints, RAS-RAF Signaling and Apoptosis. And so on.

For genetic risk of Renal Angiomyolipoma due to abnormalities in genes TSC2 and TP53 – Foods like Almond are recommended compared to Brazil Nut. This is because the active ingredients Lecithin and Folic Acid in Brazil Nut further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Quercetin contained in Almond together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: ALMOND IS RECOMMENDED OVER BRAZIL NUT FOR REDUCING THE GENETIC RISK OF RENAL ANGIOMYOLIPOMA DUE TO GENES TSC2 AND TP53

In Summary

An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.

“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.

The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.

You can get started NOW and design a personalized nutrition plan for Renal Angiomyolipoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

References

• Msk Impact 2017
• Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients.
• A redox-resistant sirtuin-1 mutant protects against hepatic metabolic and oxidant stress.
• Vitamin C enhances epigenetic modifications induced by 5-azacytidine and cell cycle arrest in the hepatocellular carcinoma cell lines HLE and Huh7.
• The recruitment of Raf-1 to membranes is mediated by direct interaction with phosphatidic acid and is independent of association with Ras.
• Comparison of Myo-Monitor centric position to centric relation and centric occlusion.
• Induction of colon and cervical cancer cell death by cinnamic acid derivatives is mediated through the inhibition of Histone Deacetylases (HDAC).
• Indeno[1,2-b]indole derivatives as a novel class of potent human protein kinase CK2 inhibitors.
• Resveratrol, a remarkable inhibitor of ribonucleotide reductase.
• Transcriptional activation of the cyclin-dependent kinase inhibitor p21 by PML/RARalpha.
• Crystal structure of a human cyclin-dependent kinase 6 complex with a flavonol inhibitor, fisetin.
• Effects of folate deficiency on gene expression in the apoptosis and cancer pathways in colon cancer cells.
• Gamma- and delta-tocotrienols exert a more potent anticancer effect than alpha-tocopheryl succinate on breast cancer cell lines irrespective of HER-2/neu expression.
• Isotretinoin in the treatment of systemic sclerosis.
• β-Sitosterol targets Trx/Trx1 reductase to induce apoptosis in A549 cells via ROS mediated mitochondrial dysregulation and p53 activation.
• HyperFoods: Machine intelligent mapping of cancer-beating molecules in foods.
• HyperFoods/food_compound_original.csv at master • warcraft12321/HyperFoods • GitHub