Highlights
No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Renal Clear Cell Carcinoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Renal Clear Cell Carcinoma because of VHL and PBRM1 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.
There is no one answer to this question for cancers such as Renal Clear Cell Carcinoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.
In short – the process to answer questions like “Should I Avoid eating fruit Date” or “Include fruit Rowanberry in my diet” or “Should I reduce consumption of vegetable Kale” or “Can I take Cissus and Mayapple supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.
RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO RENAL CLEAR CELL CARCINOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.
The overall objective of personalized nutrition for Renal Clear Cell Carcinoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.
RECOMMENDATION: UPDATE YOUR NUTRITION FOR RENAL CLEAR CELL CARCINOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.
About Renal Clear Cell Carcinoma
cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.
Following key highlights are derived from clinical data for Renal Clear Cell Carcinoma from cBioPortal. The patients enrolled in the studies for Renal Clear Cell Carcinoma are in ages between 21 to 91 with an average age of 61. 69.8% of males and 30.2% of females were the distribution of gender in these clinical studies. From a patient sample size of 2174; the top genes with mutations and other abnormalities for Renal Clear Cell Carcinoma include genes VHL, PBRM1, MUC16, SETD2 and PRKDC. The occurrence frequency distribution for these genes respectively is 2.6%, 1.8%, 0.9%, 0.7% and 0.7%. These tumor genetic details of Renal Clear Cell Carcinoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Renal Clear Cell Carcinoma.
Significance of Nutrition for Renal Clear Cell Carcinoma
All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Renal Clear Cell Carcinoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.
For example Date includes active ingredients Quercetin, Gallic Acid, Apigenin, Protocatechuic Acid, Vitamin C and others. And Rowanberry contains active ingredients Quercetin, Chlorogenic Acid and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.
For cancers like Renal Clear Cell Carcinoma, activation or inhibition of selected biochemical pathways like Angiogenesis, Hypoxia, MAPK Signaling, PI3K-AKT-MTOR Signaling plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Renal Clear Cell Carcinoma, while eating some other foods and supplements may not be recommended.
One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.
RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR RENAL CLEAR CELL CARCINOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.
Foods for Renal Clear Cell Carcinoma undergoing chemotherapy treatment
In Renal Clear Cell Carcinoma – the genes VHL, PBRM1, MUC16, SETD2 and PRKDC have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Renal Clear Cell Carcinoma are Angiogenesis, Hypoxia, Extracellular Matrix Remodelling and others. Bevacizumab is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Angiogenesis, Hypoxia, Extracellular Matrix Remodelling so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.
RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.
Eat more pulses, Adzuki Bean or Pigeon Pea?
Pulses are an important part of many diets. The active ingredients contained in Adzuki Bean are Isoliquiritigenin, Genistein, Glucaric Acid, Folic Acid among others. While the active ingredients contained in Pigeon Pea are Vitamin C, Linolenic Acid, Genistein, Oleic Acid, Linoleic Acid and others.
Glucaric Acid can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Extracellular Matrix Remodelling and MYC Signaling. Isoliquiritigenin has biological action on biochemical pathways Chemokine Signaling, Growth Factor Signaling and TGFB Signaling.
Vitamin A can manipulate biochemical pathways Extracellular Matrix Remodelling, Notch Signaling and Focal Adhesion. Oleic Acid has biological action on biochemical pathways Epithelial to Mesenchymal Transition, Cytoskeletal Dynamics and Extracellular Matrix Remodelling. And so on.
When treating Renal Clear Cell Carcinoma with chemotherapy Bevacizumab – Foods like Adzuki Bean are recommended compared to Pigeon Pea. This is because the active ingredients Vitamin A and Oleic Acid in Pigeon Pea interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Glucaric Acid and Isoliquiritigenin contained in Adzuki Bean support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: ADZUKI BEAN IS RECOMMENDED OVER PIGEON PEA FOR RENAL CLEAR CELL CARCINOMA ON TREATMENT WITH CHEMOTHERAPY BEVACIZUMAB FOR SOME CONDITIONS.
Eat more vegetables, Kohlrabi or Kale?
Vegetables are an important part of many diets. The active ingredients contained in Kohlrabi are Vitamin C, Linolenic Acid, Kaempferol, Brassinin, Sulforaphane among others. While the active ingredients contained in Kale are Vitamin C, Linolenic Acid, Kaempferol, Brassinin, Sulforaphane and others.
Vitamin C can manipulate biochemical pathways Epithelial to Mesenchymal Transition, MYC Signaling and WNT Beta Catenin Signaling. Brassinin has biological action on biochemical pathways Extracellular Matrix Remodelling, Chemokine Signaling and MAPK Signaling.
Vitamin A can manipulate biochemical pathways Extracellular Matrix Remodelling, Notch Signaling and Focal Adhesion. Linoleic Acid has biological action on biochemical pathways Epithelial to Mesenchymal Transition, Chemokine Signaling and TGFB Signaling. And so on.
When treating Renal Clear Cell Carcinoma with chemotherapy Bevacizumab – Foods like Kohlrabi are recommended compared to Kale. This is because the active ingredients Vitamin A and Linoleic Acid in Kale interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Brassinin contained in Kohlrabi support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: KOHLRABI IS RECOMMENDED OVER KALE FOR RENAL CLEAR CELL CARCINOMA ON TREATMENT WITH CHEMOTHERAPY BEVACIZUMAB FOR SOME CONDITIONS.
Eat more fruits, Rowanberry or Date?
Fruits are an important part of many diets. The active ingredients contained in Rowanberry are Quercetin, Chlorogenic Acid among others. While the active ingredients contained in Date are Quercetin, Gallic Acid, Apigenin, Protocatechuic Acid, Vitamin C and others.
Chlorogenic Acid can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Extracellular Matrix Remodelling and Chemokine Signaling. Quercetin has biological action on biochemical pathways Growth Factor Signaling, TGFB Signaling and EPHRIN Signaling.
Apigenin can manipulate biochemical pathways Epithelial to Mesenchymal Transition, WNT Beta Catenin Signaling and TGFB Signaling. Lupeol has biological action on biochemical pathways Cytoskeletal Dynamics. And so on.
When treating Renal Clear Cell Carcinoma with chemotherapy Bevacizumab – Foods like Rowanberry are recommended compared to Date. This is because the active ingredients Apigenin and Lupeol in Date interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Chlorogenic Acid and Quercetin contained in Rowanberry support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: ROWANBERRY IS RECOMMENDED OVER DATE FOR RENAL CLEAR CELL CARCINOMA ON TREATMENT WITH CHEMOTHERAPY BEVACIZUMAB FOR SOME CONDITIONS.
Eat more nuts, Pine Nut or Peanut?
Nuts are an important part of many diets. The active ingredients contained in Pine Nut are Vitamin E, Linolenic Acid, Beta-sitosterol, Oleic Acid, Linoleic Acid among others. While the active ingredients contained in Peanut are Quercetin, Vitamin E, Vitamin C, Linolenic Acid, Vanillic Acid and others.
Beta-sitosterol can manipulate biochemical pathways Epithelial to Mesenchymal Transition, MYC Signaling and WNT Beta Catenin Signaling. Vitamin K has biological action on biochemical pathways Cytokine Signaling, PI3K-AKT-MTOR Signaling and MYC Signaling.
Vitamin A can manipulate biochemical pathways Extracellular Matrix Remodelling, Notch Signaling and Focal Adhesion. Lecithin has biological action on biochemical pathways Chemokine Signaling, Cytoskeletal Dynamics and MYC Signaling. And so on.
When treating Renal Clear Cell Carcinoma with chemotherapy Bevacizumab – Foods like Pine Nut are recommended compared to Peanut. This is because the active ingredients Vitamin A and Lecithin in Peanut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin K contained in Pine Nut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: PINE NUT IS RECOMMENDED OVER PEANUT FOR RENAL CLEAR CELL CARCINOMA ON TREATMENT WITH CHEMOTHERAPY BEVACIZUMAB FOR SOME CONDITIONS.
Foods for Genetic Risk of Renal Clear Cell Carcinoma
One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. VHL and PBRM1 are two genes whose abnormalities are risk factors for Renal Clear Cell Carcinoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Renal Clear Cell Carcinoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Renal Clear Cell Carcinoma gene VHL has causative impact on biological pathways like Angiogenesis, Carbohydrate Metabolism and Hypoxia. And PBRM1 has a causative impact on biological pathways like Chromatin Remodeling. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like VHL and PBRM1 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes VHL and PBRM1 should be avoided.
Eat more pulses, Common Bean or Yellow Wax Bean?
The active ingredients contained in Common Bean are Folic Acid, Kaempferol, Vitamin C, Apigenin, Pelargonidin among others. While the active ingredients contained in Yellow Wax Bean are Folic Acid, Vitamin C, Astragalin, Palmitic Acid, Vitamin A and others.
Kaempferol can manipulate biochemical pathways Hypoxia. Vitamin C has biological action on biochemical pathways Hypoxia.
Palmitic Acid can manipulate biochemical pathways TGFB Signaling and Energy Metabolism. Vitamin A has biological action on biochemical pathways Extracellular Matrix Remodelling and TGFB Signaling. And so on.
For genetic risk of Renal Clear Cell Carcinoma due to abnormalities in genes VHL and PBRM1 – Foods like Common Bean are recommended compared to Yellow Wax Bean. This is because the active ingredients Palmitic Acid and Vitamin A in Yellow Wax Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Kaempferol and Vitamin C contained in Common Bean together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: COMMON BEAN IS RECOMMENDED OVER YELLOW WAX BEAN FOR REDUCING THE GENETIC RISK OF RENAL CLEAR CELL CARCINOMA DUE TO GENES VHL AND PBRM1
Eat more vegetables, Arrowroot or Lettuce?
The active ingredients contained in Arrowroot are Quercetin, Vitamin C, Chlorogenic Acid, Vanillic Acid, Beta-carotene among others. While the active ingredients contained in Lettuce are Quercetin, Caffeic Acid, Folic Acid, Vitamin C, Chlorogenic Acid and others.
Quercetin can manipulate biochemical pathways Cytokine Signaling, TGFB Signaling and Hypoxia. Vitamin C has biological action on biochemical pathways Hypoxia.
Vitamin A can manipulate biochemical pathways TGFB Signaling and Extracellular Matrix Remodelling. Caffeic Acid has biological action on biochemical pathways TGFB Signaling. And so on.
For genetic risk of Renal Clear Cell Carcinoma due to abnormalities in genes VHL and PBRM1 – Foods like Arrowroot are recommended compared to Lettuce. This is because the active ingredients Vitamin A and Caffeic Acid in Lettuce further promote the effects of genes on the biochemical pathways. While the active ingredients Quercetin and Vitamin C contained in Arrowroot together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: ARROWROOT IS RECOMMENDED OVER LETTUCE FOR REDUCING THE GENETIC RISK OF RENAL CLEAR CELL CARCINOMA DUE TO GENES VHL AND PBRM1
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
Eat more fruits, Saskatoon Berry or Malus (crab Apple)?
The active ingredients contained in Saskatoon Berry are Quercetin, Delphinidin among others. While the active ingredients contained in Malus (crab Apple) are Vitamin C, Linolenic Acid, Linoleic Acid, Oleic Acid and others.
Delphinidin can manipulate biochemical pathways Hypoxia. Quercetin has biological action on biochemical pathways Cytokine Signaling, TGFB Signaling and Hypoxia.
Linoleic Acid can manipulate biochemical pathways TGFB Signaling. Oleic Acid has biological action on biochemical pathways DNA Repair. And so on.
For genetic risk of Renal Clear Cell Carcinoma due to abnormalities in genes VHL and PBRM1 – Foods like Saskatoon Berry are recommended compared to Malus (crab Apple). This is because the active ingredients Linoleic Acid and Oleic Acid in Malus (crab Apple) further promote the effects of genes on the biochemical pathways. While the active ingredients Delphinidin and Quercetin contained in Saskatoon Berry together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: SASKATOON BERRY IS RECOMMENDED OVER MALUS (CRAB APPLE) FOR REDUCING THE GENETIC RISK OF RENAL CLEAR CELL CARCINOMA DUE TO GENES VHL AND PBRM1
Eat more nuts, Acorn or Hazelnut?
The active ingredients contained in Acorn are Quercetin, Folic Acid, Vitamin C, Beta-carotene, Vitamin B3 among others. While the active ingredients contained in Hazelnut are Quercetin, Folic Acid, Linolenic Acid, Vitamin E, Linoleic Acid and others.
Quercetin can manipulate biochemical pathways Cytokine Signaling, TGFB Signaling and Hypoxia. Vitamin C has biological action on biochemical pathways Hypoxia.
Vitamin E can manipulate biochemical pathways DNA Repair. Vitamin A has biological action on biochemical pathways TGFB Signaling and Extracellular Matrix Remodelling. And so on.
For genetic risk of Renal Clear Cell Carcinoma due to abnormalities in genes VHL and PBRM1 – Foods like Acorn are recommended compared to Hazelnut. This is because the active ingredients Vitamin E and Vitamin A in Hazelnut further promote the effects of genes on the biochemical pathways. While the active ingredients Quercetin and Vitamin C contained in Acorn together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: ACORN IS RECOMMENDED OVER HAZELNUT FOR REDUCING THE GENETIC RISK OF RENAL CLEAR CELL CARCINOMA DUE TO GENES VHL AND PBRM1
In Summary
An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.
“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.
The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.
You can get started NOW and design a personalized nutrition plan for Renal Clear Cell Carcinoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
References
- Tmb Mskcc 2018
- Integrated molecular analysis of clear-cell renal cell carcinoma.
- Preventive effects of butyric acid, nicotinamide, calcium glucarate alone or in combination during the 7, 12-dimethylbenz (a) anthracene induced mouse skin tumorigenesis via modulation of K-Ras-PI3K-AKTpathway and associated micro RNAs.
- Effects of isoliquiritigenin on ovarian cancer cells.
- Retinoic acid, GABA-ergic, and TGF-beta signaling systems are involved in human cleft palate fibroblast phenotype.
- Anti-cancer targeting telomerase inhibitors: β-rubromycin and oleic acid.
- Chlorogenic acid inhibits proliferation and induces apoptosis in A498 human kidney cancer cells via inactivating PI3K/Akt/mTOR signalling pathway.
- Docking studies on isoform-specific inhibition of phosphoinositide-3-kinases.
- Crystal structure of a human cyclin-dependent kinase 6 complex with a flavonol inhibitor, fisetin.
- Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors.
- Regulated function of the prolyl-4-hydroxylase domain (PHD) oxygen sensor proteins.
- Brassinin inhibits STAT3 signaling pathway through modulation of PIAS-3 and SOCS-3 expression and sensitizes human lung cancer xenograft in nude mice to paclitaxel.
- Activation of PPAR gamma and delta by conjugated linoleic acid mediates protection from experimental inflammatory bowel disease.
- Reactive oxygen species-mediated activation of AMP-activated protein kinase and c-Jun N-terminal kinase plays a critical role in beta-sitosterol-induced apoptosis in multiple myeloma U266 cells.
- Vitamin K protects against 7,12-dimethylbenz(A)anthracene induced hepatotoxicity in Wistar rats.
- New concepts in phospholipase D signaling in inflammation and cancer.
- Flavonoids as receptor tyrosine kinase FLT3 inhibitors.
- Acanthoic acid modulates lipogenesis in nonalcoholic fatty liver disease via FXR/LXRs-dependent manner.
- Delphinidin inhibits angiogenesis through the suppression of HIF-1α and VEGF expression in A549 lung cancer cells.
- Synthesis and structure-activity relationship analysis of caffeic acid amides as selective matrix metalloproteinase inhibitors.
- Inhibitory effect of tocotrienol on eukaryotic DNA polymerase lambda and angiogenesis.
- HyperFoods: Machine intelligent mapping of cancer-beating molecules in foods.
- HyperFoods/food_compound_original.csv at master · warcraft12321/HyperFoods · GitHub
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.