Foods for Pleomorphic Rhabdomyosarcoma!

Introduction

Foods for Pleomorphic Rhabdomyosarcoma should be personalized for each individual and also must adapt when cancer treatment or tumor genetic change. The personalization and adaptation must consider all the active ingredients or bioactives contained in different foods with respect to cancer tissue biology, genetics, treatments, lifestyle conditions and diet preferences. Hence while nutrition is one of the very important decisions for a cancer patient and individual at risk of cancer to make – how to choose foods to eat is not an easy task.

Pleomorphic rhabdomyosarcoma, a rare and aggressive type of soft tissue sarcoma, is characterized by its diverse morphological features, as detailed in pathology outlines and histopathology. This cancer primarily affects adults and can occur in various locations, including the uterus, kidney, and liver. Radiology plays a crucial role in the diagnosis and staging of pleomorphic rhabdomyosarcoma, with stage 4 indicating advanced disease. Symptoms often depend on the tumor’s location but can include pain, swelling, or functional impairment of the affected organ. The ICD-10 classification for pleomorphic rhabdomyosarcoma provides a standardized coding for diagnosis and treatment tracking. Treatment typically involves a multimodal approach, including surgery, chemotherapy, and possibly radiation therapy. Chemotherapy regimens are tailored to the individual’s specific condition and disease stage. The prognosis for pleomorphic rhabdomyosarcoma is generally guarded, particularly for advanced stages, underscoring the importance of early detection and aggressive treatment. Immunohistochemistry (IHC) is often used to confirm the diagnosis, given the tumor’s variable appearance. Webpathology and other medical resources provide further information on this cancer’s gross pathology and molecular characteristics. Pleomorphic rhabdomyosarcoma is also known by other names, reflecting its diverse presentation. Understanding the meaning and implications of a pleomorphic rhabdomyosarcoma diagnosis is crucial for patients and healthcare providers in devising an effective treatment plan and managing the disease.

For Pleomorphic Rhabdomyosarcoma does it matter what vegetables, fruits, nuts, seeds one eats?

A very common nutrition question asked by cancer patients and individuals at-genetic risk of cancer is – for cancers like Pleomorphic Rhabdomyosarcoma does it matter what foods I eat and which I do not? Or if I follow a plant-based diet is that enough for cancer like Pleomorphic Rhabdomyosarcoma?

For example does it matter if vegetable Thistle is consumed more compared to Daikon Radish? Does it make any difference if fruit Pummelo is preferred over Grapefruit/pummelo Hybrid? Also if similar choices are made for nuts/seeds like Common Walnut over Japanese Chestnut and for pulses like Winged Bean over Catjang Pea. And if what I eat matters – then how does one identify foods which are recommended for Pleomorphic Rhabdomyosarcoma and is it the same answer for everyone with the same diagnosis or genetic risk?

Yes! Foods you eat matters for Pleomorphic Rhabdomyosarcoma!

Food recommendations may not be the same for everyone and can be different even for the same diagnosis and genetic risk.

All foods (vegetables, fruits, nuts, seeds, pulses, oils etc.) and nutritional supplements are made up of more than one active molecular ingredient or bio-actives in different proportions and quantities. Each active ingredient has a unique mechanism of action – which can be activation or inhibition of different biochemical pathways. Simply stated foods and supplements which are recommended are those which do not cause an increase of molecular drivers of cancer but reduce them. Else those foods should not be recommended. Foods contain multiple active ingredients – hence when evaluating foods and supplements you need to consider the impact of all active ingredients cumulatively rather than individually.

For example Pummelo contains active ingredients Apigenin, Curcumin, Lupeol, Lycopene, Naringin. And Grapefruit/pummelo Hybrid contains active ingredients Apigenin, Curcumin, Lupeol, Lycopene, Naringin and possibly others.

A common mistake made when deciding and choosing foods to eat for Pleomorphic Rhabdomyosarcoma – is to evaluate only selected active ingredients contained in foods and ignore the rest. Because different active ingredients contained in foods may have opposing effects on cancer drivers – you cannot cherry pick active ingredients in foods and supplements for making a nutrition decision for Pleomorphic Rhabdomyosarcoma.

YES – FOOD CHOICES MATTER FOR CANCER. NUTRITION DECISIONS MUST CONSIDER ALL ACTIVE INGREDIENTS OF FOODS.

Skills Needed for Nutrition Personalization for Pleomorphic Rhabdomyosarcoma?

Personalized nutrition for cancers like Pleomorphic Rhabdomyosarcoma consists of recommended foods / supplements; not recommended foods / supplements with example recipes which prioritize use of recommended foods. An example of personalized nutrition can be seen at this link.

Deciding which foods are recommended or not is extremely complicated, requiring expertise in Pleomorphic Rhabdomyosarcoma biology, food science, genetics, biochemistry along with good understanding of how cancer treatments work and associated vulnerabilities by which the treatments could stop being effective.

MINIMUM KNOWLEDGE EXPERTISE NEEDED FOR NUTRITION PERSONALIZATION FOR CANCER ARE: CANCER BIOLOGY, FOOD SCIENCE, CANCER TREATMENTS AND GENETICS.

Characteristics of cancers like Pleomorphic Rhabdomyosarcoma

All cancers like Pleomorphic Rhabdomyosarcoma can be characterized by a unique set of biochemical pathways – the signature pathways of Pleomorphic Rhabdomyosarcoma. Biochemical pathways like Apoptosis, DNA Repair, Cell Cycle Checkpoints, Growth Factor Signaling are part of the signature definition of Pleomorphic Rhabdomyosarcoma. Each individual’s cancer genetics can be different and hence their specific cancer signature could be unique.

The treatments which are effective for Pleomorphic Rhabdomyosarcoma need to be cognizant of the associated signature biochemical pathways for each cancer patient and individual at genetic risk. Therefore different treatments with different mechanisms of actions are effective for different patients. Similarly and for the same reasons foods and supplements need to be personalized for each individual. Hence some foods and supplements are recommended for Pleomorphic Rhabdomyosarcoma when taking cancer treatment Epirubicin, and some foods and supplements are not recommended.

Sources like cBioPortal and many others provide population representative patient anonymized data from clinical trials for all cancer indications. This data consists of clinical trial study details like sample size / number of patients, age groups, gender, ethnicity, treatments, tumor site and any genetic mutations.

TP53, NR4A3, ARID1A, ATRX and CFTR are the top ranked reported genes for Pleomorphic Rhabdomyosarcoma. TP53 is reported in 50.0 % of the representative patients across all clinical trials. And NR4A3 is reported in 25.0 %. The combined population patient data cover ages from to . 28.6 % of the patient data are identified as men. The Pleomorphic Rhabdomyosarcoma biology along with reported genetics together define the population represented signature biochemical pathways for this cancer. If the individual cancer tumor genetics or genes contributing to the risk are also known then that should also be used for nutrition personalization.

NUTRITION CHOICES SHOULD MATCH WITH EACH INDIVIDUAL’S CANCER SIGNATURE.

Food and Supplements for Pleomorphic Rhabdomyosarcoma

For Cancer Patients

Cancer patients on treatment or on palliative care need to make decisions on food and supplements – for the needed dietary calories, for managing any treatment side effects and also for improved cancer management. All plant-based foods are not equal and choosing and prioritizing foods which are personalized and customized to ongoing cancer treatment is important and complicated. Here are some examples providing guidelines for making nutrition decisions.

Choose Vegetable THISTLE or DAIKON RADISH?

Vegetable Thistle contains many active ingredients or bioactives such as Apigenin, Curcumin, Lupeol, Lycopene, Phloretin. These active ingredients manipulate various biochemical pathways like Apoptosis and MYC Signaling and others. Thistle is recommended for Pleomorphic Rhabdomyosarcoma when ongoing cancer treatment is Epirubicin. This is because Thistle modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Epirubicin.

Some of the active ingredients or bioactives in vegetable Daikon Radish are Apigenin, Curcumin, Lupeol, Stigmasterol, Phloretin. These active ingredients manipulate various biochemical pathways like MYC Signaling and others. Daikon Radish is not recommended for Pleomorphic Rhabdomyosarcoma when ongoing cancer treatment is Epirubicin because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

VEGETABLE THISTLE IS RECOMMENDED OVER DAIKON RADISH FOR Pleomorphic Rhabdomyosarcoma AND TREATMENT Epirubicin.

Choose Fruit GRAPEFRUIT/PUMMELO HYBRID or PUMMELO?

Fruit Grapefruit/pummelo Hybrid contains many active ingredients or bioactives such as Apigenin, Curcumin, Lupeol, Lycopene, Naringin. These active ingredients manipulate various biochemical pathways like Apoptosis and MYC Signaling and others. Grapefruit/pummelo Hybrid is recommended for Pleomorphic Rhabdomyosarcoma when ongoing cancer treatment is Epirubicin. This is because Grapefruit/pummelo Hybrid modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Epirubicin.

Some of the active ingredients or bioactives in fruit Pummelo are Apigenin, Curcumin, Lupeol, Lycopene, Naringin. These active ingredients manipulate various biochemical pathways like MYC Signaling and others. Pummelo is not recommended for Pleomorphic Rhabdomyosarcoma when ongoing cancer treatment is Epirubicin because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

FRUIT GRAPEFRUIT/PUMMELO HYBRID IS RECOMMENDED OVER PUMMELO FOR Pleomorphic Rhabdomyosarcoma AND TREATMENT Epirubicin.

Choose Nut COMMON WALNUT or JAPANESE CHESTNUT?

Common Walnut contains many active ingredients or bioactives such as Curcumin, Lupeol, Juglone, Daidzein, Phloretin. These active ingredients manipulate various biochemical pathways like Apoptosis and MYC Signaling and others. Common Walnut is recommended for Pleomorphic Rhabdomyosarcoma when ongoing cancer treatment is Epirubicin. This is because Common Walnut modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Epirubicin.

Some of the active ingredients or bioactives in Japanese Chestnut are Apigenin, Curcumin, Lupeol, Lycopene, Stigmasterol. These active ingredients manipulate various biochemical pathways like MYC Signaling and others. Japanese Chestnut is not recommended for Pleomorphic Rhabdomyosarcoma when ongoing cancer treatment is Epirubicin because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

COMMON WALNUT IS RECOMMENDED OVER JAPANESE CHESTNUT FOR Pleomorphic Rhabdomyosarcoma AND TREATMENT Epirubicin.

For Individuals with Genetic Risk of Cancer

The question asked by individuals who have genetic risk of Pleomorphic Rhabdomyosarcoma or familial history is “What Should I Eat Differently from Before?” and how they should choose foods and supplements to manage risks of the disease. Since for cancer risk there is nothing actionable in terms of treatment – decisions of foods and supplements become important and one of the very few actionable things which can be done. All plant-based foods are not equal and based on identified genetics and pathway signature – the choices of food and supplements should be personalized.

Choose Vegetable GIANT BUTTERBUR or GARLAND CHRYSANTHEMUM?

Vegetable Giant Butterbur contains many active ingredients or bioactives such as Curcumin, Apigenin, Lupeol, Beta-sitosterol, Phloretin. These active ingredients manipulate various biochemical pathways like Cell Cycle, TGFB Signaling, P53 Signaling and DNA Repair and others. Giant Butterbur is recommended for risk of Pleomorphic Rhabdomyosarcoma when associated genetic risk is ARID1A. This is because Giant Butterbur increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in vegetable Garland Chrysanthemum are Curcumin, Apigenin, Lupeol, Beta-sitosterol, Phloretin. These active ingredients manipulate various biochemical pathways like WNT Beta Catenin Signaling and Oncogenic Cancer Epigenetics and others. Garland Chrysanthemum is not recommended when risk of Pleomorphic Rhabdomyosarcoma when associated genetic risk is ARID1A because it increases the signature pathways of it.

VEGETABLE GIANT BUTTERBUR IS RECOMMENDED OVER GARLAND CHRYSANTHEMUM FOR ARID1A GENETIC RISK OF CANCER.

Choose Fruit JAVA PLUM or LIME?

Fruit Java Plum contains many active ingredients or bioactives such as Curcumin, Apigenin, Ellagic Acid, Lupeol, Beta-sitosterol. These active ingredients manipulate various biochemical pathways like Cell Cycle, TGFB Signaling, P53 Signaling and DNA Repair and others. Java Plum is recommended for risk of Pleomorphic Rhabdomyosarcoma when associated genetic risk is ARID1A. This is because Java Plum increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in fruit Lime are Curcumin, Lupeol, Beta-sitosterol, Phloretin, Lycopene. These active ingredients manipulate various biochemical pathways like TGFB Signaling and WNT Beta Catenin Signaling and others. Lime is not recommended when risk of Pleomorphic Rhabdomyosarcoma when associated genetic risk is ARID1A because it increases the signature pathways of it.

FRUIT JAVA PLUM IS RECOMMENDED OVER LIME FOR ARID1A GENETIC RISK OF CANCER.

Choose Nut BUTTERNUT or EUROPEAN CHESTNUT?

Butternut contains many active ingredients or bioactives such as Curcumin, Apigenin, Lupeol, Beta-sitosterol, Phloretin. These active ingredients manipulate various biochemical pathways like DNA Repair, Cell Cycle, P53 Signaling and MAPK Signaling and others. Butternut is recommended for risk of Pleomorphic Rhabdomyosarcoma when associated genetic risk is ARID1A. This is because Butternut increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in European Chestnut are Curcumin, Apigenin, Ellagic Acid, Lupeol, Beta-sitosterol. These active ingredients manipulate various biochemical pathways like Epithelial to Mesenchymal Transition, WNT Beta Catenin Signaling and Oncogenic Cancer Epigenetics and others. European Chestnut is not recommended when risk of Pleomorphic Rhabdomyosarcoma when associated genetic risk is ARID1A because it increases the signature pathways of it.

BUTTERNUT IS RECOMMENDED OVER EUROPEAN CHESTNUT FOR ARID1A GENETIC RISK OF CANCER.

In Conclusion

Foods and Supplements chosen are important decisions for cancers like Pleomorphic Rhabdomyosarcoma. Pleomorphic Rhabdomyosarcoma patients and individuals with genetic-risk always have this question: “What foods and nutritional supplements are recommended for me and which are not?” There is a common belief which is a misconception that all plant-based foods could be beneficial or not but would not be harmful. Certain foods and supplements can interfere with cancer treatments or promote molecular pathway drivers of cancer.

There are different types of cancer indications like Pleomorphic Rhabdomyosarcoma, each with different tumor genetics with further genomic variations across each individual. Further every cancer treatment and chemotherapy has a unique mechanism of action. Each food like Thistle contains various bioactives in different quantities, which have an impact on different and distinct sets of biochemical pathways. The definition of personalized nutrition is individualized food recommendations for the cancer indication, treatments, genetics, lifestyle and other factors. Nutrition personalization decisions for cancer require knowledge of cancer biology, food science and an understanding of different chemotherapy treatments. Finally when there are treatment changes or new genomics is identified – the nutrition personalization needs re-evaluation.

The addon nutrition personalization solution makes the decision making easy and removes all the guesswork in answering the question, “What foods should I choose or not choose for Pleomorphic Rhabdomyosarcoma?”. The addon multi-disciplinary team includes cancer physicians, clinical scientists, software engineers and data scientists.

References

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