Highlights
No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Pleomorphic Rhabdomyosarcoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Pleomorphic Rhabdomyosarcoma because of NR4A3 and CFTR gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.
There is no one answer to this question for cancers such as Pleomorphic Rhabdomyosarcoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.
In short – the process to answer questions like “Should I Avoid eating fruit Raspberry” or “Include fruit Date in my diet” or “Should I reduce consumption of vegetable Chicory” or “Can I take Dim and Vitamin E supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.
RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO PLEOMORPHIC RHABDOMYOSARCOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.
The overall objective of personalized nutrition for Pleomorphic Rhabdomyosarcoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.
RECOMMENDATION: UPDATE YOUR NUTRITION FOR PLEOMORPHIC RHABDOMYOSARCOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.
About Pleomorphic Rhabdomyosarcoma
cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.
Following key highlights are derived from clinical data for Pleomorphic Rhabdomyosarcoma from cBioPortal. 28.6% of males and 71.4% of females were the distribution of gender in these clinical studies. From a patient sample size of 7; the top genes with mutations and other abnormalities for Pleomorphic Rhabdomyosarcoma include genes TP53, NR4A3, ARID1A, ATRX and CFTR. The occurrence frequency distribution for these genes respectively is 50.0%, 25.0%, 25.0%, 25.0% and 25.0%. These tumor genetic details of Pleomorphic Rhabdomyosarcoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Pleomorphic Rhabdomyosarcoma.
Significance of Nutrition for Pleomorphic Rhabdomyosarcoma
All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Pleomorphic Rhabdomyosarcoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.
For example Raspberry includes active ingredients Ellagic Acid, Vitamin C, Resveratrol, Quercetin, Salicylic Acid and others. And Date contains active ingredients Apigenin, Lupeol, Vitamin C, Protocatechuic Acid, Beta-sitosterol and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.
For cancers like Pleomorphic Rhabdomyosarcoma, activation or inhibition of selected biochemical pathways like Cell Cycle Checkpoints, Angiogenesis, Apoptosis, Growth Factor Signaling plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Pleomorphic Rhabdomyosarcoma, while eating some other foods and supplements may not be recommended.
One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.
RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR PLEOMORPHIC RHABDOMYOSARCOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.
Foods for Pleomorphic Rhabdomyosarcoma undergoing chemotherapy treatment
In Pleomorphic Rhabdomyosarcoma – the genes TP53, NR4A3, ARID1A, ATRX and CFTR have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Pleomorphic Rhabdomyosarcoma are Cell Cycle Checkpoints, Angiogenesis, DNA Repair and others. Cyclophosphamide is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Cell Cycle Checkpoints, Angiogenesis, DNA Repair so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.
RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.
Eat more pulses, Mung Bean or Fava Bean?
Pulses are an important part of many diets. The active ingredients contained in Mung Bean are Vitamin C, Vitexin, Stigmasterol, Linolenic Acid, Oleic Acid among others. While the active ingredients contained in Fava Bean are Vitamin C, Daidzein, P-coumaric Acid, Beta-sitosterol, Stigmasterol and others.
Vitamin C can manipulate biochemical pathways Angiogenesis, MYC Signaling and Cell Cycle Checkpoints. Stigmasterol has biological action on biochemical pathways Angiogenesis, MYC Signaling and Cell Cycle Checkpoints.
Folic Acid can manipulate biochemical pathways MYC Signaling and Cell Cycle Checkpoints. And so on.
When treating Pleomorphic Rhabdomyosarcoma with chemotherapy Cyclophosphamide – Foods like Mung Bean are recommended compared to Fava Bean. This is because the active ingredients Folic Acid in Fava Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Stigmasterol contained in Mung Bean support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: MUNG BEAN IS RECOMMENDED OVER FAVA BEAN FOR PLEOMORPHIC RHABDOMYOSARCOMA ON TREATMENT WITH CHEMOTHERAPY CYCLOPHOSPHAMIDE FOR SOME CONDITIONS.
Eat more vegetables, Rhubarb or Chicory?
Vegetables are an important part of many diets. The active ingredients contained in Rhubarb are Emodin, Rhein, Vitamin E, Vitamin C, Chrysophanol among others. While the active ingredients contained in Chicory are Apigenin, Esculin, Lupeol, Protocatechuic Acid, Vitamin C and others.
Rutin can manipulate biochemical pathways Angiogenesis and MYC Signaling. Vitamin K has biological action on biochemical pathways Cell Cycle Checkpoints and MYC Signaling.
Luteolin can manipulate biochemical pathways MYC Signaling. Folic Acid has biological action on biochemical pathways Cell Cycle Checkpoints and MYC Signaling. And so on.
When treating Pleomorphic Rhabdomyosarcoma with chemotherapy Cyclophosphamide – Foods like Rhubarb are recommended compared to Chicory. This is because the active ingredients Luteolin and Folic Acid in Chicory interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Rutin and Vitamin K contained in Rhubarb support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: RHUBARB IS RECOMMENDED OVER CHICORY FOR PLEOMORPHIC RHABDOMYOSARCOMA ON TREATMENT WITH CHEMOTHERAPY CYCLOPHOSPHAMIDE FOR SOME CONDITIONS.
Eat more fruits, Date or Raspberry?
Fruits are an important part of many diets. The active ingredients contained in Date are Apigenin, Lupeol, Vitamin C, Protocatechuic Acid, Beta-sitosterol among others. While the active ingredients contained in Raspberry are Ellagic Acid, Vitamin C, Resveratrol, Quercetin, Salicylic Acid and others.
Apigenin can manipulate biochemical pathways MYC Signaling and Cell Cycle Checkpoints. Lupeol has biological action on biochemical pathways Angiogenesis, MYC Signaling and Cell Cycle Checkpoints.
Ellagic Acid can manipulate biochemical pathways MYC Signaling. Resveratrol has biological action on biochemical pathways DNA Repair. And so on.
When treating Pleomorphic Rhabdomyosarcoma with chemotherapy Cyclophosphamide – Foods like Date are recommended compared to Raspberry. This is because the active ingredients Ellagic Acid and Resveratrol in Raspberry interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Apigenin and Lupeol contained in Date support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: DATE IS RECOMMENDED OVER RASPBERRY FOR PLEOMORPHIC RHABDOMYOSARCOMA ON TREATMENT WITH CHEMOTHERAPY CYCLOPHOSPHAMIDE FOR SOME CONDITIONS.
Eat more nuts, Almond or Brazil Nut?
Nuts are an important part of many diets. The active ingredients contained in Almond are Vitamin E, Beta-sitosterol, Linolenic Acid, Stigmasterol, Oleic Acid among others. While the active ingredients contained in Brazil Nut are Vitamin E, Linolenic Acid, Oleic Acid, Lecithin, Folic Acid and others.
Beta-sitosterol can manipulate biochemical pathways Angiogenesis, MYC Signaling and Cell Cycle Checkpoints. Vitamin E has biological action on biochemical pathways Angiogenesis, MYC Signaling and Cell Cycle Checkpoints.
Lecithin can manipulate biochemical pathways MYC Signaling. Folic Acid has biological action on biochemical pathways Cell Cycle Checkpoints and MYC Signaling. And so on.
When treating Pleomorphic Rhabdomyosarcoma with chemotherapy Cyclophosphamide – Foods like Almond are recommended compared to Brazil Nut. This is because the active ingredients Lecithin and Folic Acid in Brazil Nut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin E contained in Almond support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: ALMOND IS RECOMMENDED OVER BRAZIL NUT FOR PLEOMORPHIC RHABDOMYOSARCOMA ON TREATMENT WITH CHEMOTHERAPY CYCLOPHOSPHAMIDE FOR SOME CONDITIONS.
Foods for Genetic Risk of Pleomorphic Rhabdomyosarcoma
One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. NR4A3 and CFTR are two genes whose abnormalities are risk factors for Pleomorphic Rhabdomyosarcoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Pleomorphic Rhabdomyosarcoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Pleomorphic Rhabdomyosarcoma gene NR4A3 has causative impact on biological pathways like Angiogenesis. And CFTR has a causative impact on biological pathways like Nutrient sensing, Cytoskeletal Dynamics and Cell Junctions. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like NR4A3 and CFTR should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes NR4A3 and CFTR should be avoided.
Eat more pulses, Hyacinth Bean or Soy Bean?
The active ingredients contained in Hyacinth Bean are Palmitic Acid, Vitamin C, Genistein, Folic Acid, Myristic Acid among others. While the active ingredients contained in Soy Bean are Lupeol, Vitamin E, Beta-sitosterol, Daidzein, Vitamin C and others.
Palmitic Acid can manipulate biochemical pathways Cell Cycle Checkpoints, RAS-RAF Signaling and P53 Signaling. Vitamin C has biological action on biochemical pathways Angiogenesis, MYC Signaling and Apoptosis.
Aescin can manipulate biochemical pathways Cell Cycle Checkpoints. Lecithin has biological action on biochemical pathways MYC Signaling. And so on.
For genetic risk of Pleomorphic Rhabdomyosarcoma due to abnormalities in genes NR4A3 and CFTR – Foods like Hyacinth Bean are recommended compared to Soy Bean. This is because the active ingredients Aescin and Lecithin in Soy Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Palmitic Acid and Vitamin C contained in Hyacinth Bean together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: HYACINTH BEAN IS RECOMMENDED OVER SOY BEAN FOR REDUCING THE GENETIC RISK OF PLEOMORPHIC RHABDOMYOSARCOMA DUE TO GENES NR4A3 AND CFTR
Eat more vegetables, Giant Butterbur or Celery?
The active ingredients contained in Giant Butterbur are Beta-sitosterol, Vitamin C, Vitamin B3, Melatonin, Kaempferol among others. While the active ingredients contained in Celery are Apigenin, Vitamin C, Linolenic Acid, Quercetin, Cynaroside and others.
Vitamin C can manipulate biochemical pathways Angiogenesis, Cell Cycle Checkpoints and RAS-RAF Signaling. Beta-sitosterol has biological action on biochemical pathways P53 Signaling, MYC Signaling and Apoptosis.
Luteolin can manipulate biochemical pathways MYC Signaling. Chrysin has biological action on biochemical pathways MYC Signaling. And so on.
For genetic risk of Pleomorphic Rhabdomyosarcoma due to abnormalities in genes NR4A3 and CFTR – Foods like Giant Butterbur are recommended compared to Celery. This is because the active ingredients Luteolin and Chrysin in Celery further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Giant Butterbur together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: GIANT BUTTERBUR IS RECOMMENDED OVER CELERY FOR REDUCING THE GENETIC RISK OF PLEOMORPHIC RHABDOMYOSARCOMA DUE TO GENES NR4A3 AND CFTR
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
Eat more fruits, Star Fruit or Cranberry?
The active ingredients contained in Star Fruit are Beta-sitosterol, Vitamin C, Linolenic Acid, Oleic Acid, Linoleic Acid among others. While the active ingredients contained in Cranberry are Ellagic Acid, Hyperoside, Vitamin C, P-coumaric Acid, Quercetin and others.
Vitamin C can manipulate biochemical pathways Angiogenesis, Cell Cycle Checkpoints and RAS-RAF Signaling. Beta-sitosterol has biological action on biochemical pathways P53 Signaling, MYC Signaling and Apoptosis.
Ellagic Acid can manipulate biochemical pathways MYC Signaling. Resveratrol has biological action on biochemical pathways P53 Signaling. And so on.
For genetic risk of Pleomorphic Rhabdomyosarcoma due to abnormalities in genes NR4A3 and CFTR – Foods like Star Fruit are recommended compared to Cranberry. This is because the active ingredients Ellagic Acid and Resveratrol in Cranberry further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Star Fruit together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: STAR FRUIT IS RECOMMENDED OVER CRANBERRY FOR REDUCING THE GENETIC RISK OF PLEOMORPHIC RHABDOMYOSARCOMA DUE TO GENES NR4A3 AND CFTR
Eat more nuts, Pistachio or Chestnut?
The active ingredients contained in Pistachio are Vitamin E, Beta-sitosterol, Stigmasterol, Linolenic Acid, Oleic Acid among others. While the active ingredients contained in Chestnut are Ellagic Acid, Vitamin C, Linolenic Acid, Quercetin, Linoleic Acid and others.
Beta-sitosterol can manipulate biochemical pathways Angiogenesis, Cell Cycle Checkpoints and P53 Signaling. Vitamin E has biological action on biochemical pathways MYC Signaling, Apoptosis and Angiogenesis.
Ellagic Acid can manipulate biochemical pathways MYC Signaling. Folic Acid has biological action on biochemical pathways Cell Cycle Checkpoints, RAS-RAF Signaling and P53 Signaling. And so on.
For genetic risk of Pleomorphic Rhabdomyosarcoma due to abnormalities in genes NR4A3 and CFTR – Foods like Pistachio are recommended compared to Chestnut. This is because the active ingredients Ellagic Acid and Folic Acid in Chestnut further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin E contained in Pistachio together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: PISTACHIO IS RECOMMENDED OVER CHESTNUT FOR REDUCING THE GENETIC RISK OF PLEOMORPHIC RHABDOMYOSARCOMA DUE TO GENES NR4A3 AND CFTR
In Summary
An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.
“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.
The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.
You can get started NOW and design a personalized nutrition plan for Pleomorphic Rhabdomyosarcoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
References
- Pan Origimed 2020
- Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients.
- Vitamin C enhances epigenetic modifications induced by 5-azacytidine and cell cycle arrest in the hepatocellular carcinoma cell lines HLE and Huh7.
- Stigmasterol isolated from marine microalgae Navicula incerta induces apoptosis in human hepatoma HepG2 cells.
- Effects of folate deficiency on gene expression in the apoptosis and cancer pathways in colon cancer cells.
- Crystal structure of a human cyclin-dependent kinase 6 complex with a flavonol inhibitor, fisetin.
- Isotretinoin in the treatment of systemic sclerosis.
- Identification of ellagic acid as potent inhibitor of protein kinase CK2: a successful example of a virtual screening application.
- Vitamin E and rutin synergistically inhibit expression of vascular endothelial growth factor through down-regulation of binding activity of activator protein-1 in human promyelocytic leukemia (HL-60) cells.
- Research progress on the anticancer effects of vitamin K2.
- β-Sitosterol targets Trx/Trx1 reductase to induce apoptosis in A549 cells via ROS mediated mitochondrial dysregulation and p53 activation.
- Gamma- and delta-tocotrienols exert a more potent anticancer effect than alpha-tocopheryl succinate on breast cancer cell lines irrespective of HER-2/neu expression.
- The recruitment of Raf-1 to membranes is mediated by direct interaction with phosphatidic acid and is independent of association with Ras.
- A redox-resistant sirtuin-1 mutant protects against hepatic metabolic and oxidant stress.
- Resveratrol, a remarkable inhibitor of ribonucleotide reductase.
- HyperFoods: Machine intelligent mapping of cancer-beating molecules in foods.
- HyperFoods/food_compound_original.csv at master · warcraft12321/HyperFoods · GitHub
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.