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What Foods are Recommended for Cancer?
is a very common question. Personalized Nutrition Plans are foods and supplements which are personalized to a cancer indication, genes, any treatments and lifestyle conditions.

Which Foods are Recommended for Medullary Thyroid Cancer?

Sep 8, 2022

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Highlights

No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Medullary Thyroid Cancer when undergoing chemotherapy or when you determine you have a genetic risk for developing Medullary Thyroid Cancer because of RET and KMT2A gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.

There is no one answer to this question for cancers such as Medullary Thyroid Cancer which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.

In short – the process to answer questions like “Should I Avoid eating fruit Huckleberry” or “Include fruit Date in my diet” or “Should I reduce consumption of vegetable Chicory” or “Can I take Basil and Garlic supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.

RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO MEDULLARY THYROID CANCER, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.

The overall objective of personalized nutrition for Medullary Thyroid Cancer is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.

RECOMMENDATION: UPDATE YOUR NUTRITION FOR MEDULLARY THYROID CANCER, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.



About Medullary Thyroid Cancer

cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.

Following key highlights are derived from clinical data for Medullary Thyroid Cancer from cBioPortal. 55.3% of males and 44.7% of females were the distribution of gender in these clinical studies. From a patient sample size of 21; the top genes with mutations and other abnormalities for Medullary Thyroid Cancer include genes RET, KMT2A, EPHA3, ARID1A and BLM. The occurrence frequency distribution for these genes respectively is 16.7%, 5.6%, 5.6%, 5.6% and 5.6%. These tumor genetic details of Medullary Thyroid Cancer are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Medullary Thyroid Cancer.

Significance of Nutrition for Medullary Thyroid Cancer

All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Medullary Thyroid Cancer. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.

For example Huckleberry includes active ingredients Quercetin, Vitamin C, Resveratrol, P-coumaric Acid, Ferulic Acid and others. And Date contains active ingredients Apigenin, Quercetin, Vitamin C, Protocatechuic Acid, Lupeol and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.

For cancers like Medullary Thyroid Cancer, activation or inhibition of selected biochemical pathways like Growth Factor Signaling, Hypoxia, Chromatin Remodeling, Oncogenic Cancer Epigenetics plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Medullary Thyroid Cancer, while eating some other foods and supplements may not be recommended.

One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.

For cancers like Medullary Thyroid Cancer, activation or inhibition of selected biochemical pathways like Growth Factor Signaling, Hypoxia, Chromatin Remodeling, Oncogenic Cancer Epigenetics plays an important role in driving cancer growth.

RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR MEDULLARY THYROID CANCER – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.

Foods for Medullary Thyroid Cancer undergoing chemotherapy treatment

In Medullary Thyroid Cancer – the genes RET, KMT2A, EPHA3, ARID1A and BLM have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Medullary Thyroid Cancer are Growth Factor Signaling, Hypoxia, RAS-RAF Signaling and others. Cabozantinib is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Growth Factor Signaling, Hypoxia, RAS-RAF Signaling so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.

RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.

Eat more pulses, Mung Bean or Lima Bean?

Pulses are an important part of many diets. The active ingredients contained in Mung Bean are Quercetin, Vitamin C, Vitexin, Linolenic Acid, Oleic Acid among others. While the active ingredients contained in Lima Bean are Vitamin C, Oleic Acid, Linoleic Acid, Genistein, Vitamin A and others.

Quercetin can manipulate biochemical pathways RAS-RAF Signaling, P53 Signaling and MYC Signaling. Vitamin C has biological action on biochemical pathways Hypoxia, P53 Signaling and MYC Signaling.

Folic Acid can manipulate biochemical pathways P53 Signaling, MYC Signaling and RAS-RAF Signaling. And so on.

When treating Medullary Thyroid Cancer with chemotherapy Cabozantinib – Foods like Mung Bean are recommended compared to Lima Bean. This is because the active ingredients Folic Acid in Lima Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Quercetin and Vitamin C contained in Mung Bean support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: MUNG BEAN IS RECOMMENDED OVER LIMA BEAN FOR MEDULLARY THYROID CANCER ON TREATMENT WITH CHEMOTHERAPY CABOZANTINIB FOR SOME CONDITIONS.

Eat more vegetables, Arugula or Chicory?

Vegetables are an important part of many diets. The active ingredients contained in Arugula are Esculin, Kaempferol, Vitamin A, Vitamin K, Erysolin among others. While the active ingredients contained in Chicory are Apigenin, Quercetin, Esculin, Vitamin C, Protocatechuic Acid and others.

Kaempferol can manipulate biochemical pathways Hypoxia and RAS-RAF Signaling. Vitamin A has biological action on biochemical pathways MYC Signaling.

Luteolin can manipulate biochemical pathways MYC Signaling. Esculetin has biological action on biochemical pathways Hypoxia. And so on.

When treating Medullary Thyroid Cancer with chemotherapy Cabozantinib – Foods like Arugula are recommended compared to Chicory. This is because the active ingredients Luteolin and Esculetin in Chicory interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Kaempferol and Vitamin A contained in Arugula support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: ARUGULA IS RECOMMENDED OVER CHICORY FOR MEDULLARY THYROID CANCER ON TREATMENT WITH CHEMOTHERAPY CABOZANTINIB FOR SOME CONDITIONS.

Which Foods are Recommended for Medullary Thyroid Cancer?

Eat more fruits, Date or Huckleberry?

Fruits are an important part of many diets. The active ingredients contained in Date are Apigenin, Quercetin, Vitamin C, Protocatechuic Acid, Lupeol among others. While the active ingredients contained in Huckleberry are Quercetin, Vitamin C, Resveratrol, P-coumaric Acid, Ferulic Acid and others.

Apigenin can manipulate biochemical pathways RAS-RAF Signaling, P53 Signaling and MYC Signaling. Quercetin has biological action on biochemical pathways Hypoxia, EPHRIN Signaling and RAS-RAF Signaling.

Resveratrol can manipulate biochemical pathways P53 Signaling. Pelargonidin has biological action on biochemical pathways MYC Signaling. And so on.

When treating Medullary Thyroid Cancer with chemotherapy Cabozantinib – Foods like Date are recommended compared to Huckleberry. This is because the active ingredients Resveratrol and Pelargonidin in Huckleberry interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Apigenin and Quercetin contained in Date support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: DATE IS RECOMMENDED OVER HUCKLEBERRY FOR MEDULLARY THYROID CANCER ON TREATMENT WITH CHEMOTHERAPY CABOZANTINIB FOR SOME CONDITIONS.

Eat more nuts, Almond or Chestnut?

Nuts are an important part of many diets. The active ingredients contained in Almond are Quercetin, Vitamin E, Linolenic Acid, Beta-sitosterol, Vitamin B3 among others. While the active ingredients contained in Chestnut are Quercetin, Vitamin C, Ellagic Acid, Linolenic Acid, Oleic Acid and others.

Beta-sitosterol can manipulate biochemical pathways P53 Signaling, MYC Signaling and Hypoxia. Quercetin has biological action on biochemical pathways RAS-RAF Signaling, EPHRIN Signaling and P53 Signaling.

Ellagic Acid can manipulate biochemical pathways MYC Signaling. Folic Acid has biological action on biochemical pathways P53 Signaling, RAS-RAF Signaling and MYC Signaling. And so on.

When treating Medullary Thyroid Cancer with chemotherapy Cabozantinib – Foods like Almond are recommended compared to Chestnut. This is because the active ingredients Ellagic Acid and Folic Acid in Chestnut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Quercetin contained in Almond support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: ALMOND IS RECOMMENDED OVER CHESTNUT FOR MEDULLARY THYROID CANCER ON TREATMENT WITH CHEMOTHERAPY CABOZANTINIB FOR SOME CONDITIONS.

Foods for Genetic Risk of Medullary Thyroid Cancer

One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. RET and KMT2A are two genes whose abnormalities are risk factors for Medullary Thyroid Cancer. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Medullary Thyroid Cancer can be used as a guide for coming up with a recommended personalized nutrition plan. For Medullary Thyroid Cancer gene RET has causative impact on biological pathways like MAPK Signaling, PI3K-AKT-MTOR Signaling and Growth Factor Signaling. And KMT2A has a causative impact on biological pathways like Amino Acid Metabolism and Oncogenic Histone Methylation. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like RET and KMT2A should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes RET and KMT2A should be avoided.

Eat more pulses, Yellow Wax Bean or Soy Bean?

The active ingredients contained in Yellow Wax Bean are Vitamin C, Palmitic Acid, Ferulic Acid, Cianidanol, Butyric Acid among others. While the active ingredients contained in Soy Bean are Lupeol, Quercetin, Daidzein, Beta-sitosterol, Vitamin E and others.

Palmitic Acid can manipulate biochemical pathways MYC Signaling, Apoptosis and Cell Cycle Checkpoints. Vitamin A has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, MYC Signaling and Apoptosis.

Aescin can manipulate biochemical pathways Cell Cycle Checkpoints. Lecithin has biological action on biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. And so on.

For genetic risk of Medullary Thyroid Cancer due to abnormalities in genes RET and KMT2A – Foods like Yellow Wax Bean are recommended compared to Soy Bean. This is because the active ingredients Aescin and Lecithin in Soy Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Palmitic Acid and Vitamin A contained in Yellow Wax Bean together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: YELLOW WAX BEAN IS RECOMMENDED OVER SOY BEAN FOR REDUCING THE GENETIC RISK OF MEDULLARY THYROID CANCER DUE TO GENES RET AND KMT2A

Eat more vegetables, Giant Butterbur or Radish?

The active ingredients contained in Giant Butterbur are Beta-sitosterol, Vitamin C, Kaempferol, Vitamin B3, Melatonin among others. While the active ingredients contained in Radish are Quercetin, Beta-sitosterol, Vitamin C, Oleic Acid, Linolenic Acid and others.

Vitamin C can manipulate biochemical pathways Cell Cycle Checkpoints, RAS-RAF Signaling and MYC Signaling. Beta-sitosterol has biological action on biochemical pathways Apoptosis, PI3K-AKT-MTOR Signaling and MYC Signaling.

Pelargonidin can manipulate biochemical pathways MYC Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways RAS-RAF Signaling, Apoptosis and Cell Cycle Checkpoints. And so on.

For genetic risk of Medullary Thyroid Cancer due to abnormalities in genes RET and KMT2A – Foods like Giant Butterbur are recommended compared to Radish. This is because the active ingredients Pelargonidin and Folic Acid in Radish further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Giant Butterbur together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: GIANT BUTTERBUR IS RECOMMENDED OVER RADISH FOR REDUCING THE GENETIC RISK OF MEDULLARY THYROID CANCER DUE TO GENES RET AND KMT2A

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.

Eat more fruits, Orange or Strawberry?

The active ingredients contained in Orange are D-limonene, Linalool, Modified Citrus Pectin, Vitamin C, Oleic Acid among others. While the active ingredients contained in Strawberry are Lupeol, Beta-sitosterol, Ellagic Acid, Vitamin C, Oleic Acid and others.

D-limonene can manipulate biochemical pathways Cell Cycle Checkpoints, RAS-RAF Signaling and MYC Signaling. Vitamin C has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, Apoptosis and Cell Cycle Checkpoints.

Fisetin can manipulate biochemical pathways MYC Signaling. Ellagic Acid has biological action on biochemical pathways MYC Signaling. And so on.

For genetic risk of Medullary Thyroid Cancer due to abnormalities in genes RET and KMT2A – Foods like Orange are recommended compared to Strawberry. This is because the active ingredients Fisetin and Ellagic Acid in Strawberry further promote the effects of genes on the biochemical pathways. While the active ingredients D-limonene and Vitamin C contained in Orange together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: ORANGE IS RECOMMENDED OVER STRAWBERRY FOR REDUCING THE GENETIC RISK OF MEDULLARY THYROID CANCER DUE TO GENES RET AND KMT2A

Eat more nuts, Walnut or Macadamia Nut?

The active ingredients contained in Walnut are D-limonene, Protocatechuic Acid, Quercetin, Betulinic Acid, Myricetin among others. While the active ingredients contained in Macadamia Nut are Beta-sitosterol, Palmitic Acid, Lauric Acid, Myristic Acid, Folic Acid and others.

D-limonene can manipulate biochemical pathways Cell Cycle Checkpoints, RAS-RAF Signaling and MYC Signaling. Myricetin has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, EPHRIN Signaling and Apoptosis.

Lauric Acid can manipulate biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. Myristic Acid has biological action on biochemical pathways Apoptosis, Cell Cycle Checkpoints and RAS-RAF Signaling. And so on.

For genetic risk of Medullary Thyroid Cancer due to abnormalities in genes RET and KMT2A – Foods like Walnut are recommended compared to Macadamia Nut. This is because the active ingredients Lauric Acid and Myristic Acid in Macadamia Nut further promote the effects of genes on the biochemical pathways. While the active ingredients D-limonene and Myricetin contained in Walnut together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: WALNUT IS RECOMMENDED OVER MACADAMIA NUT FOR REDUCING THE GENETIC RISK OF MEDULLARY THYROID CANCER DUE TO GENES RET AND KMT2A


In Summary

An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.

“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.

The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.

You can get started NOW and design a personalized nutrition plan for Medullary Thyroid Cancer by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

sample-report


References

Personalized Nutrition for Cancer!

Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.


Scientifically Reviewed by: Dr. Cogle

Christopher R. Cogle, M.D. is a tenured professor at the University of Florida, Chief Medical Officer of Florida Medicaid, and Director of the Florida Health Policy Leadership Academy at the Bob Graham Center for Public Service.

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