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What Foods are Recommended for Cancer?
is a very common question. Personalized Nutrition Plans are foods and supplements which are personalized to a cancer indication, genes, any treatments and lifestyle conditions.

Foods for Marginal Zone Lymphoma!

Jul 22, 2023

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Introduction

Foods for Marginal Zone Lymphoma should be personalized for each individual and also must adapt when cancer treatment or tumor genetic change. The personalization and adaptation must consider all the active ingredients or bioactives contained in different foods with respect to cancer tissue biology, genetics, treatments, lifestyle conditions and diet preferences. Hence while nutrition is one of the very important decisions for a cancer patient and individual at risk of cancer to make – how to choose foods to eat is not an easy task.



For Marginal Zone Lymphoma does it matter what vegetables, fruits, nuts, seeds one eats?

A very common nutrition question asked by cancer patients and individuals at-genetic risk of cancer is – for cancers like Marginal Zone Lymphoma does it matter what foods I eat and which I do not? Or if I follow a plant-based diet is that enough for cancer like Marginal Zone Lymphoma?

For example does it matter if vegetable Brussel Sprouts is consumed more compared to Mexican Groundcherry? Does it make any difference if fruit Pummelo is preferred over Black Mulberry? Also if similar choices are made for nuts/seeds like Common Hazelnut over Cashew Nut and for pulses like Broad Bean over Lentils. And if what I eat matters – then how does one identify foods which are recommended for Marginal Zone Lymphoma and is it the same answer for everyone with the same diagnosis or genetic risk?

Yes! Foods you eat matters for Marginal Zone Lymphoma!

Food recommendations may not be the same for everyone and can be different even for the same diagnosis and genetic risk.

All cancers like Marginal Zone Lymphoma can be characterized by a unique set of biochemical pathways - the signature pathways of Marginal Zone Lymphoma. Biochemical pathways like RAS-RAF Signaling, Growth Factor Signaling, PI3K-AKT-MTOR Signaling, Oncogenic Histone Methylation are part of the signature definition of Marginal Zone Lymphoma.

All foods (vegetables, fruits, nuts, seeds, pulses, oils etc.) and nutritional supplements are made up of more than one active molecular ingredient or bio-actives in different proportions and quantities. Each active ingredient has a unique mechanism of action – which can be activation or inhibition of different biochemical pathways. Simply stated foods and supplements which are recommended are those which do not cause an increase of molecular drivers of cancer but reduce them. Else those foods should not be recommended. Foods contain multiple active ingredients – hence when evaluating foods and supplements you need to consider the impact of all active ingredients cumulatively rather than individually.

For example Pummelo contains active ingredients Quercetin, Catechol, Lupeol, Apigenin, Phloretin. And Black Mulberry contains active ingredients Quercetin, Morusin, Catechol, Lupeol, Apigenin and possibly others.

A common mistake made when deciding and choosing foods to eat for Marginal Zone Lymphoma – is to evaluate only selected active ingredients contained in foods and ignore the rest. Because different active ingredients contained in foods may have opposing effects on cancer drivers – you cannot cherry pick active ingredients in foods and supplements for making a nutrition decision for Marginal Zone Lymphoma.

YES – FOOD CHOICES MATTER FOR CANCER. NUTRITION DECISIONS MUST CONSIDER ALL ACTIVE INGREDIENTS OF FOODS.

Skills Needed for Nutrition Personalization for Marginal Zone Lymphoma?

Personalized nutrition for cancers like Marginal Zone Lymphoma consists of recommended foods / supplements; not recommended foods / supplements with example recipes which prioritize use of recommended foods. An example of personalized nutrition can be seen at this link.

Deciding which foods are recommended or not is extremely complicated, requiring expertise in Marginal Zone Lymphoma biology, food science, genetics, biochemistry along with good understanding of how cancer treatments work and associated vulnerabilities by which the treatments could stop being effective.

MINIMUM KNOWLEDGE EXPERTISE NEEDED FOR NUTRITION PERSONALIZATION FOR CANCER ARE: CANCER BIOLOGY, FOOD SCIENCE, CANCER TREATMENTS AND GENETICS.

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.

Characteristics of cancers like Marginal Zone Lymphoma

All cancers like Marginal Zone Lymphoma can be characterized by a unique set of biochemical pathways – the signature pathways of Marginal Zone Lymphoma. Biochemical pathways like RAS-RAF Signaling, Growth Factor Signaling, PI3K-AKT-MTOR Signaling, Oncogenic Histone Methylation are part of the signature definition of Marginal Zone Lymphoma. Each individual’s cancer genetics can be different and hence their specific cancer signature could be unique.

The treatments which are effective for Marginal Zone Lymphoma need to be cognizant of the associated signature biochemical pathways for each cancer patient and individual at genetic risk. Therefore different treatments with different mechanisms of actions are effective for different patients. Similarly and for the same reasons foods and supplements need to be personalized for each individual. Hence some foods and supplements are recommended for Marginal Zone Lymphoma when taking cancer treatment Herceptin, and some foods and supplements are not recommended.

Sources like cBioPortal and many others provide population representative patient anonymized data from clinical trials for all cancer indications. This data consists of clinical trial study details like sample size / number of patients, age groups, gender, ethnicity, treatments, tumor site and any genetic mutations.

KMT2D, TBL1XR1, CXCR4, B2M and SPEN are the top ranked reported genes for Marginal Zone Lymphoma. KMT2D is reported in 15.4 % of the representative patients across all clinical trials. And TBL1XR1 is reported in 15.4 %. The combined population patient data cover ages from to . 50.0 % of the patient data are identified as men. The Marginal Zone Lymphoma biology along with reported genetics together define the population represented signature biochemical pathways for this cancer. If the individual cancer tumor genetics or genes contributing to the risk are also known then that should also be used for nutrition personalization.

NUTRITION CHOICES SHOULD MATCH WITH EACH INDIVIDUAL’S CANCER SIGNATURE.

Foods for Marginal Zone Lymphoma!

Food and Supplements for Marginal Zone Lymphoma

For Cancer Patients

Cancer patients on treatment or on palliative care need to make decisions on food and supplements – for the needed dietary calories, for managing any treatment side effects and also for improved cancer management. All plant-based foods are not equal and choosing and prioritizing foods which are personalized and customized to ongoing cancer treatment is important and complicated. Here are some examples providing guidelines for making nutrition decisions.

Choose Vegetable BRUSSEL SPROUTS or MEXICAN GROUNDCHERRY?

Vegetable Brussel Sprouts contains many active ingredients or bioactives such as Catechol, Lupeol, Phloretin, Formononetin, Delphinidin. These active ingredients manipulate various biochemical pathways like MAPK Signaling, MYC Signaling, Growth Factor Signaling and PI3K-AKT-MTOR Signaling and others. Brussel Sprouts is recommended for Marginal Zone Lymphoma when ongoing cancer treatment is Herceptin. This is because Brussel Sprouts modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Herceptin.

Some of the active ingredients or bioactives in vegetable Mexican Groundcherry are Catechol, Lupeol, Apigenin, Phloretin, Formononetin. These active ingredients manipulate various biochemical pathways like PI3K-AKT-MTOR Signaling and others. Mexican Groundcherry is not recommended for Marginal Zone Lymphoma when ongoing cancer treatment is Herceptin because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

VEGETABLE BRUSSEL SPROUTS IS RECOMMENDED OVER MEXICAN GROUNDCHERRY FOR Marginal Zone Lymphoma AND TREATMENT Herceptin.

Choose Fruit BLACK MULBERRY or PUMMELO?

Fruit Black Mulberry contains many active ingredients or bioactives such as Quercetin, Morusin, Catechol, Lupeol, Apigenin. These active ingredients manipulate various biochemical pathways like MAPK Signaling, MYC Signaling, Cell Junctions and PI3K-AKT-MTOR Signaling and others. Black Mulberry is recommended for Marginal Zone Lymphoma when ongoing cancer treatment is Herceptin. This is because Black Mulberry modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Herceptin.

Some of the active ingredients or bioactives in fruit Pummelo are Quercetin, Catechol, Lupeol, Apigenin, Phloretin. These active ingredients manipulate various biochemical pathways like Notch Signaling and PI3K-AKT-MTOR Signaling and others. Pummelo is not recommended for Marginal Zone Lymphoma when ongoing cancer treatment is Herceptin because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

FRUIT BLACK MULBERRY IS RECOMMENDED OVER PUMMELO FOR Marginal Zone Lymphoma AND TREATMENT Herceptin.

Choose Nut COMMON HAZELNUT or CASHEW NUT?

Common Hazelnut contains many active ingredients or bioactives such as Quercetin, Catechol, Lupeol, Phloretin, Formononetin. These active ingredients manipulate various biochemical pathways like MAPK Signaling, Angiogenesis, Growth Factor Signaling and PI3K-AKT-MTOR Signaling and others. Common Hazelnut is recommended for Marginal Zone Lymphoma when ongoing cancer treatment is Herceptin. This is because Common Hazelnut modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Herceptin.

Some of the active ingredients or bioactives in Cashew Nut are Quercetin, Catechol, Lupeol, Phloretin, Formononetin. These active ingredients manipulate various biochemical pathways like MAPK Signaling and PI3K-AKT-MTOR Signaling and others. Cashew Nut is not recommended for Marginal Zone Lymphoma when ongoing cancer treatment is Herceptin because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

COMMON HAZELNUT IS RECOMMENDED OVER CASHEW NUT FOR Marginal Zone Lymphoma AND TREATMENT Herceptin.

For Individuals with Genetic Risk of Cancer

The question asked by individuals who have genetic risk of Marginal Zone Lymphoma or familial history is “What Should I Eat Differently from Before?” and how they should choose foods and supplements to manage risks of the disease. Since for cancer risk there is nothing actionable in terms of treatment – decisions of foods and supplements become important and one of the very few actionable things which can be done. All plant-based foods are not equal and based on identified genetics and pathway signature – the choices of food and supplements should be personalized.

Choose Vegetable CAULIFLOWER or SAVOY CABBAGE?

Vegetable Cauliflower contains many active ingredients or bioactives such as Curcumin, Daidzein, Lupeol, Formononetin, Beta-sitosterol. These active ingredients manipulate various biochemical pathways like RAS-RAF Signaling, MYC Signaling, NFKB Signaling and PI3K-AKT-MTOR Signaling and others. Cauliflower is recommended for risk of Marginal Zone Lymphoma when associated genetic risk is B2M. This is because Cauliflower increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in vegetable Savoy Cabbage are Curcumin, Lycopene, Daidzein, Lupeol, Formononetin. These active ingredients manipulate various biochemical pathways like Cell Cycle Checkpoints and NFKB Signaling and others. Savoy Cabbage is not recommended when risk of Marginal Zone Lymphoma when associated genetic risk is B2M because it increases the signature pathways of it.

VEGETABLE CAULIFLOWER IS RECOMMENDED OVER SAVOY CABBAGE FOR B2M GENETIC RISK OF CANCER.

Choose Fruit RABBITEYE BLUEBERRY or MUSCADINE GRAPE?

Fruit Rabbiteye Blueberry contains many active ingredients or bioactives such as Quercetin, Linalool, Eugenol, Ferulic Acid, Epicatechin. These active ingredients manipulate various biochemical pathways like MYC Signaling, NFKB Signaling, Chemokine Signaling and PI3K-AKT-MTOR Signaling and others. Rabbiteye Blueberry is recommended for risk of Marginal Zone Lymphoma when associated genetic risk is B2M. This is because Rabbiteye Blueberry increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in fruit Muscadine Grape are Apigenin, Curcumin, Ellagic Acid, Daidzein, Lupeol. These active ingredients manipulate various biochemical pathways like Oncogenic Cancer Epigenetics and Inflammation and others. Muscadine Grape is not recommended when risk of Marginal Zone Lymphoma when associated genetic risk is B2M because it increases the signature pathways of it.

FRUIT RABBITEYE BLUEBERRY IS RECOMMENDED OVER MUSCADINE GRAPE FOR B2M GENETIC RISK OF CANCER.

Choose Nut BUTTERNUT or FLAXSEED?

Butternut contains many active ingredients or bioactives such as Apigenin, Curcumin, Lycopene, Daidzein, Lupeol. These active ingredients manipulate various biochemical pathways like RAS-RAF Signaling, NFKB Signaling, Inflammation and PI3K-AKT-MTOR Signaling and others. Butternut is recommended for risk of Marginal Zone Lymphoma when associated genetic risk is B2M. This is because Butternut increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in Flaxseed are Apigenin, Curcumin, Daidzein, Lupeol, Formononetin. These active ingredients manipulate various biochemical pathways like NFKB Signaling, Oncogenic Cancer Epigenetics and PI3K-AKT-MTOR Signaling and others. Flaxseed is not recommended when risk of Marginal Zone Lymphoma when associated genetic risk is B2M because it increases the signature pathways of it.

BUTTERNUT IS RECOMMENDED OVER FLAXSEED FOR B2M GENETIC RISK OF CANCER.


In Conclusion

Foods and Supplements chosen are important decisions for cancers like Marginal Zone Lymphoma. Marginal Zone Lymphoma patients and individuals with genetic-risk always have this question: “What foods and nutritional supplements are recommended for me and which are not?” There is a common belief which is a misconception that all plant-based foods could be beneficial or not but would not be harmful. Certain foods and supplements can interfere with cancer treatments or promote molecular pathway drivers of cancer.

There are different types of cancer indications like Marginal Zone Lymphoma, each with different tumor genetics with further genomic variations across each individual. Further every cancer treatment and chemotherapy has a unique mechanism of action. Each food like Brussel Sprouts contains various bioactives in different quantities, which have an impact on different and distinct sets of biochemical pathways. The definition of personalized nutrition is individualized food recommendations for the cancer indication, treatments, genetics, lifestyle and other factors. Nutrition personalization decisions for cancer require knowledge of cancer biology, food science and an understanding of different chemotherapy treatments. Finally when there are treatment changes or new genomics is identified – the nutrition personalization needs re-evaluation.

The addon nutrition personalization solution makes the decision making easy and removes all the guesswork in answering the question, “What foods should I choose or not choose for Marginal Zone Lymphoma?”. The addon multi-disciplinary team includes cancer physicians, clinical scientists, software engineers and data scientists.


Personalized Nutrition for Cancer!

Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.

References

Scientifically Reviewed by: Dr. Cogle

Christopher R. Cogle, M.D. is a tenured professor at the University of Florida, Chief Medical Officer of Florida Medicaid, and Director of the Florida Health Policy Leadership Academy at the Bob Graham Center for Public Service.

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