Which Foods are Recommended for Marginal Zone Lymphoma?

Highlights

No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Marginal Zone Lymphoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Marginal Zone Lymphoma because of TBL1XR1 and CXCR4 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.

There is no one answer to this question for cancers such as Marginal Zone Lymphoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.

In short – the process to answer questions like “Should I Avoid eating fruit Date” or “Include fruit Mulberry in my diet” or “Should I reduce consumption of vegetable Endive” or “Can I take Cissus and Guggul supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.

RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO MARGINAL ZONE LYMPHOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.

The overall objective of personalized nutrition for Marginal Zone Lymphoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.

RECOMMENDATION: UPDATE YOUR NUTRITION FOR MARGINAL ZONE LYMPHOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.

About Marginal Zone Lymphoma

cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.

Following key highlights are derived from clinical data for Marginal Zone Lymphoma from cBioPortal. 50.0% of males and 50.0% of females were the distribution of gender in these clinical studies. From a patient sample size of 28; the top genes with mutations and other abnormalities for Marginal Zone Lymphoma include genes KMT2D, TBL1XR1, CXCR4, B2M and SPEN. The occurrence frequency distribution for these genes respectively is 15.4%, 15.4%, 7.7%, 7.7% and 7.7%. These tumor genetic details of Marginal Zone Lymphoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Marginal Zone Lymphoma.

Significance of Nutrition for Marginal Zone Lymphoma

All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Marginal Zone Lymphoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.

For example Date includes active ingredients Quercetin, Lupeol, Apigenin, Vitamin C, Gallic Acid and others. And Mulberry contains active ingredients Resveratrol, Morusin, Moracin P and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.

For cancers like Marginal Zone Lymphoma, activation or inhibition of selected biochemical pathways like RAS-RAF Signaling, Growth Factor Signaling, PI3K-AKT-MTOR Signaling, Oncogenic Histone Methylation plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Marginal Zone Lymphoma, while eating some other foods and supplements may not be recommended.

One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.

RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR MARGINAL ZONE LYMPHOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.

Foods for Marginal Zone Lymphoma undergoing chemotherapy treatment

In Marginal Zone Lymphoma – the genes KMT2D, TBL1XR1, CXCR4, B2M and SPEN have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Marginal Zone Lymphoma are RAS-RAF Signaling, Growth Factor Signaling, Notch Signaling and others. Herceptin is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers RAS-RAF Signaling, Growth Factor Signaling, Notch Signaling so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.

RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.

Eat more pulses, Scarlet Bean or Common Bean?

Pulses are an important part of many diets. The active ingredients contained in Scarlet Bean are Genistein, Vitamin C, Beta-sitosterol, Oleic Acid, Liquiritigenin among others. While the active ingredients contained in Common Bean are Delphinidin, Genistein, Apigenin, Vitamin C, Ferulic Acid and others.

Genistein can manipulate biochemical pathways Growth Factor Signaling, Cell Cycle and MYC Signaling. Vitamin C has biological action on biochemical pathways MAPK Signaling, PI3K-AKT-MTOR Signaling and Angiogenesis.

Apigenin can manipulate biochemical pathways Cell Junctions and PI3K-AKT-MTOR Signaling. Pelargonidin has biological action on biochemical pathways MYC Signaling, Cell Cycle and PI3K-AKT-MTOR Signaling. And so on.

When treating Marginal Zone Lymphoma with chemotherapy Herceptin – Foods like Scarlet Bean are recommended compared to Common Bean. This is because the active ingredients Apigenin and Pelargonidin in Common Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Genistein and Vitamin C contained in Scarlet Bean support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: SCARLET BEAN IS RECOMMENDED OVER COMMON BEAN FOR MARGINAL ZONE LYMPHOMA ON TREATMENT WITH CHEMOTHERAPY HERCEPTIN FOR SOME CONDITIONS.

Eat more vegetables, Cassava or Endive?

Vegetables are an important part of many diets. The active ingredients contained in Cassava are Vitamin C, Beta-sitosterol, Oleic Acid, Linolenic Acid, Vitamin A among others. While the active ingredients contained in Endive are Quercetin, Vitamin C, Oleic Acid, Linolenic Acid, Kaempferol and others.

Vitamin C can manipulate biochemical pathways Growth Factor Signaling, Cell Cycle and MYC Signaling. Beta-sitosterol has biological action on biochemical pathways RUNX Signaling, PI3K-AKT-MTOR Signaling and Angiogenesis.

Oleic Acid can manipulate biochemical pathways Cell Junctions and Cytoskeletal Dynamics. Folic Acid has biological action on biochemical pathways MYC Signaling, RAS-RAF Signaling and MAPK Signaling. And so on.

When treating Marginal Zone Lymphoma with chemotherapy Herceptin – Foods like Cassava are recommended compared to Endive. This is because the active ingredients Oleic Acid and Folic Acid in Endive interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Beta-sitosterol contained in Cassava support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: CASSAVA IS RECOMMENDED OVER ENDIVE FOR MARGINAL ZONE LYMPHOMA ON TREATMENT WITH CHEMOTHERAPY HERCEPTIN FOR SOME CONDITIONS.

Eat more fruits, Mulberry or Date?

Fruits are an important part of many diets. The active ingredients contained in Mulberry are Resveratrol, Morusin, Moracin P among others. While the active ingredients contained in Date are Quercetin, Lupeol, Apigenin, Vitamin C, Gallic Acid and others.

Morusin can manipulate biochemical pathways Growth Factor Signaling, Cell Cycle and MYC Signaling. Resveratrol has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, Angiogenesis and RAS-RAF Signaling.

Apigenin can manipulate biochemical pathways Cell Junctions and PI3K-AKT-MTOR Signaling. Oleic Acid has biological action on biochemical pathways Cytoskeletal Dynamics and Cell Junctions. And so on.

When treating Marginal Zone Lymphoma with chemotherapy Herceptin – Foods like Mulberry are recommended compared to Date. This is because the active ingredients Apigenin and Oleic Acid in Date interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Morusin and Resveratrol contained in Mulberry support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: MULBERRY IS RECOMMENDED OVER DATE FOR MARGINAL ZONE LYMPHOMA ON TREATMENT WITH CHEMOTHERAPY HERCEPTIN FOR SOME CONDITIONS.

Eat more nuts, Pine Nut or Brazil Nut?

Nuts are an important part of many diets. The active ingredients contained in Pine Nut are Vitamin E, Beta-sitosterol, Oleic Acid, Linolenic Acid, Vitamin A among others. While the active ingredients contained in Brazil Nut are Vitamin E, Oleic Acid, Linolenic Acid, Folic Acid, Lecithin and others.

Beta-sitosterol can manipulate biochemical pathways Cell Cycle, MYC Signaling and RUNX Signaling. Vitamin K has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, MYC Signaling and Cell Cycle.

Lecithin can manipulate biochemical pathways Cell Junctions, Cytoskeletal Dynamics and MYC Signaling. Oleic Acid has biological action on biochemical pathways Cell Junctions and Cytoskeletal Dynamics. And so on.

When treating Marginal Zone Lymphoma with chemotherapy Herceptin – Foods like Pine Nut are recommended compared to Brazil Nut. This is because the active ingredients Lecithin and Oleic Acid in Brazil Nut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin K contained in Pine Nut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: PINE NUT IS RECOMMENDED OVER BRAZIL NUT FOR MARGINAL ZONE LYMPHOMA ON TREATMENT WITH CHEMOTHERAPY HERCEPTIN FOR SOME CONDITIONS.

Foods for Genetic Risk of Marginal Zone Lymphoma

One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. TBL1XR1 and CXCR4 are two genes whose abnormalities are risk factors for Marginal Zone Lymphoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Marginal Zone Lymphoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Marginal Zone Lymphoma gene TBL1XR1 has causative impact on biological pathways like Notch Signaling. And CXCR4 has a causative impact on biological pathways like Chemokine Signaling and Inflammation. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like TBL1XR1 and CXCR4 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes TBL1XR1 and CXCR4 should be avoided.

Eat more pulses, Common Pea or Pigeon Pea?

The active ingredients contained in Common Pea are Genistein, Vitamin C, Lupeol, Daidzein, Delphinidin among others. While the active ingredients contained in Pigeon Pea are Genistein, Vitamin C, Oleic Acid, Linolenic Acid, Linoleic Acid and others.

Vitamin C can manipulate biochemical pathways MYC Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling. Beta-sitosterol has biological action on biochemical pathways NFKB Signaling, Oncogenic Cancer Epigenetics and MYC Signaling.

Linolenic Acid can manipulate biochemical pathways C-type Lectin Receptor Signaling. Linoleic Acid has biological action on biochemical pathways Chemokine Signaling. And so on.

For genetic risk of Marginal Zone Lymphoma due to abnormalities in genes TBL1XR1 and CXCR4 – Foods like Common Pea are recommended compared to Pigeon Pea. This is because the active ingredients Linolenic Acid and Linoleic Acid in Pigeon Pea further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Common Pea together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: COMMON PEA IS RECOMMENDED OVER PIGEON PEA FOR REDUCING THE GENETIC RISK OF MARGINAL ZONE LYMPHOMA DUE TO GENES TBL1XR1 AND CXCR4

Eat more vegetables, Jicama or Lotus?

The active ingredients contained in Jicama are Vitamin C, Vitamin B3, Vitamin A, Beta-carotene, Folic Acid among others. While the active ingredients contained in Lotus are Quercetin, Vitamin C, Fisetin, Oleic Acid, Beta-sitosterol and others.

Vitamin C can manipulate biochemical pathways MYC Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling. Vitamin B3 has biological action on biochemical pathways NFKB Signaling, MYC Signaling and PI3K-AKT-MTOR Signaling.

Quercetin can manipulate biochemical pathways C-type Lectin Receptor Signaling. Fisetin has biological action on biochemical pathways MYC Signaling and C-type Lectin Receptor Signaling. And so on.

For genetic risk of Marginal Zone Lymphoma due to abnormalities in genes TBL1XR1 and CXCR4 – Foods like Jicama are recommended compared to Lotus. This is because the active ingredients Quercetin and Fisetin in Lotus further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Vitamin B3 contained in Jicama together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: JICAMA IS RECOMMENDED OVER LOTUS FOR REDUCING THE GENETIC RISK OF MARGINAL ZONE LYMPHOMA DUE TO GENES TBL1XR1 AND CXCR4

Eat more fruits, Blueberry or Roselle?

The active ingredients contained in Blueberry are Resveratrol, Quercetin, Gallic Acid, Myricetin, Hyperoside among others. While the active ingredients contained in Roselle are Vitamin C, Vitamin E, Oleic Acid, Beta-sitosterol, Linolenic Acid and others.

Gallic Acid can manipulate biochemical pathways NFKB Signaling, Chemokine Signaling and MYC Signaling. Vitamin C has biological action on biochemical pathways MAPK Signaling, PI3K-AKT-MTOR Signaling and Oncogenic Cancer Epigenetics.

Lutein can manipulate biochemical pathways NFKB Signaling. Linolenic Acid has biological action on biochemical pathways C-type Lectin Receptor Signaling. And so on.

For genetic risk of Marginal Zone Lymphoma due to abnormalities in genes TBL1XR1 and CXCR4 – Foods like Blueberry are recommended compared to Roselle. This is because the active ingredients Lutein and Linolenic Acid in Roselle further promote the effects of genes on the biochemical pathways. While the active ingredients Gallic Acid and Vitamin C contained in Blueberry together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: BLUEBERRY IS RECOMMENDED OVER ROSELLE FOR REDUCING THE GENETIC RISK OF MARGINAL ZONE LYMPHOMA DUE TO GENES TBL1XR1 AND CXCR4

Eat more nuts, Almond or Cashew Nut?

The active ingredients contained in Almond are Quercetin, Vitamin E, Oleic Acid, Beta-sitosterol, Linolenic Acid among others. While the active ingredients contained in Cashew Nut are Gallic Acid, Vitamin C, Beta-sitosterol, Butyric Acid, Vitamin K and others.

Beta-sitosterol can manipulate biochemical pathways MYC Signaling, NFKB Signaling and Oncogenic Cancer Epigenetics. Vitamin E has biological action on biochemical pathways Chemokine Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling.

Myristic Acid can manipulate biochemical pathways Chemokine Signaling, MYC Signaling and MAPK Signaling. Lauric Acid has biological action on biochemical pathways NFKB Signaling, PI3K-AKT-MTOR Signaling and MYC Signaling. And so on.

For genetic risk of Marginal Zone Lymphoma due to abnormalities in genes TBL1XR1 and CXCR4 – Foods like Almond are recommended compared to Cashew Nut. This is because the active ingredients Myristic Acid and Lauric Acid in Cashew Nut further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin E contained in Almond together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: ALMOND IS RECOMMENDED OVER CASHEW NUT FOR REDUCING THE GENETIC RISK OF MARGINAL ZONE LYMPHOMA DUE TO GENES TBL1XR1 AND CXCR4

In Summary

An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.

“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.

The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.

You can get started NOW and design a personalized nutrition plan for Marginal Zone Lymphoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

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