Highlights
No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Uterine Undifferentiated Carcinoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Uterine Undifferentiated Carcinoma because of NSD1 and ERBB3 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.
There is no one answer to this question for cancers such as Uterine Undifferentiated Carcinoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.
In short – the process to answer questions like “Should I Avoid eating fruit Lingonberry” or “Include fruit Blueberry in my diet” or “Should I reduce consumption of vegetable Yardlong Bean” or “Can I take Dim and Spirulina supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.
RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO UTERINE UNDIFFERENTIATED CARCINOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.
The overall objective of personalized nutrition for Uterine Undifferentiated Carcinoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.
RECOMMENDATION: UPDATE YOUR NUTRITION FOR UTERINE UNDIFFERENTIATED CARCINOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.
About Uterine Undifferentiated Carcinoma
cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.
Following key highlights are derived from clinical data for Uterine Undifferentiated Carcinoma from cBioPortal. From a patient sample size of 7; the top genes with mutations and other abnormalities for Uterine Undifferentiated Carcinoma include genes KMT2C, NSD1, TP53, ERBB3 and ERBB2. The occurrence frequency distribution for these genes respectively is 50.0%, 50.0%, 50.0%, 25.0% and 25.0%. These tumor genetic details of Uterine Undifferentiated Carcinoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Uterine Undifferentiated Carcinoma.
Significance of Nutrition for Uterine Undifferentiated Carcinoma
All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Uterine Undifferentiated Carcinoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.
For example Lingonberry includes active ingredients Resveratrol, Quercetin, Hyperoside, Vitamin C, Linolenic Acid and others. And Blueberry contains active ingredients Resveratrol, Quercetin, Eugenol, Pterostilbene, Vitamin E and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.
For cancers like Uterine Undifferentiated Carcinoma, activation or inhibition of selected biochemical pathways like Notch Signaling, Cell Cycle, PI3K-AKT-MTOR Signaling, Cell Cycle Checkpoints plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Uterine Undifferentiated Carcinoma, while eating some other foods and supplements may not be recommended.
One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.
RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR UTERINE UNDIFFERENTIATED CARCINOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.
Foods for Uterine Undifferentiated Carcinoma undergoing chemotherapy treatment
In Uterine Undifferentiated Carcinoma – the genes KMT2C, NSD1, TP53, ERBB3 and ERBB2 have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Uterine Undifferentiated Carcinoma are Notch Signaling, Cell Cycle, Apoptosis and others. Carboplatin is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Notch Signaling, Cell Cycle, Apoptosis so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.
RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.
Eat more pulses, Black-eyed Pea or Lima Bean?
Pulses are an important part of many diets. The active ingredients contained in Black-eyed Pea are Daidzein, Vitamin C, Beta-carotene, Linolenic Acid, Oleic Acid among others. While the active ingredients contained in Lima Bean are Vitamin C, Oleic Acid, Vitamin A, Linoleic Acid, Genistein and others.
Daidzein can manipulate biochemical pathways Angiogenesis, P53 Signaling and Cell Cycle Checkpoints. Vitamin C has biological action on biochemical pathways WNT Beta Catenin Signaling, Apoptosis and Cell Cycle.
Genistein can manipulate biochemical pathways DNA Repair. Oleic Acid has biological action on biochemical pathways Epithelial to Mesenchymal Transition. And so on.
When treating Uterine Undifferentiated Carcinoma with chemotherapy Carboplatin – Foods like Black-eyed Pea are recommended compared to Lima Bean. This is because the active ingredients Genistein and Oleic Acid in Lima Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Daidzein and Vitamin C contained in Black-eyed Pea support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: BLACK-EYED PEA IS RECOMMENDED OVER LIMA BEAN FOR UTERINE UNDIFFERENTIATED CARCINOMA ON TREATMENT WITH CHEMOTHERAPY CARBOPLATIN FOR SOME CONDITIONS.
Eat more vegetables, Arrowroot or Yardlong Bean?
Vegetables are an important part of many diets. The active ingredients contained in Arrowroot are Quercetin, Vitamin C, Beta-carotene, Protocatechuic Acid, Vanillic Acid among others. While the active ingredients contained in Yardlong Bean are Vitamin C, Linolenic Acid, Oleic Acid, Vitamin A, Linoleic Acid and others.
Quercetin can manipulate biochemical pathways Angiogenesis, P53 Signaling and WNT Beta Catenin Signaling. Vitamin C has biological action on biochemical pathways Cell Cycle Checkpoints, Apoptosis and Cell Cycle.
Oleic Acid can manipulate biochemical pathways Epithelial to Mesenchymal Transition. Linoleic Acid has biological action on biochemical pathways Angiogenesis, TGFB Signaling and Epithelial to Mesenchymal Transition. And so on.
When treating Uterine Undifferentiated Carcinoma with chemotherapy Carboplatin – Foods like Arrowroot are recommended compared to Yardlong Bean. This is because the active ingredients Oleic Acid and Linoleic Acid in Yardlong Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Quercetin and Vitamin C contained in Arrowroot support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: ARROWROOT IS RECOMMENDED OVER YARDLONG BEAN FOR UTERINE UNDIFFERENTIATED CARCINOMA ON TREATMENT WITH CHEMOTHERAPY CARBOPLATIN FOR SOME CONDITIONS.
Eat more fruits, Blueberry or Lingonberry?
Fruits are an important part of many diets. The active ingredients contained in Blueberry are Resveratrol, Quercetin, Eugenol, Pterostilbene, Vitamin E among others. While the active ingredients contained in Lingonberry are Resveratrol, Quercetin, Hyperoside, Vitamin C, Linolenic Acid and others.
Vitamin C can manipulate biochemical pathways Angiogenesis, P53 Signaling and WNT Beta Catenin Signaling. Cianidanol has biological action on biochemical pathways Cell Cycle Checkpoints, Apoptosis and PI3K-AKT-MTOR Signaling.
Resveratrol can manipulate biochemical pathways P53 Signaling and DNA Repair. Caffeic Acid has biological action on biochemical pathways TGFB Signaling. And so on.
When treating Uterine Undifferentiated Carcinoma with chemotherapy Carboplatin – Foods like Blueberry are recommended compared to Lingonberry. This is because the active ingredients Resveratrol and Caffeic Acid in Lingonberry interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Cianidanol contained in Blueberry support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: BLUEBERRY IS RECOMMENDED OVER LINGONBERRY FOR UTERINE UNDIFFERENTIATED CARCINOMA ON TREATMENT WITH CHEMOTHERAPY CARBOPLATIN FOR SOME CONDITIONS.
Eat more nuts, Brazil Nut or Walnut?
Nuts are an important part of many diets. The active ingredients contained in Brazil Nut are Vitamin E, Linolenic Acid, Oleic Acid, Lecithin, Folic Acid among others. While the active ingredients contained in Walnut are Ellagic Acid, Quercetin, Beta-sitosterol, Betulinic Acid, Vitamin E and others.
Vitamin E can manipulate biochemical pathways Angiogenesis, P53 Signaling and DNA Repair. Linolenic Acid has biological action on biochemical pathways WNT Beta Catenin Signaling, Cell Cycle Checkpoints and Apoptosis.
Ellagic Acid can manipulate biochemical pathways Epithelial to Mesenchymal Transition, MYC Signaling and Cell Cycle Checkpoints. Juglone has biological action on biochemical pathways DNA Repair. And so on.
When treating Uterine Undifferentiated Carcinoma with chemotherapy Carboplatin – Foods like Brazil Nut are recommended compared to Walnut. This is because the active ingredients Ellagic Acid and Juglone in Walnut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin E and Linolenic Acid contained in Brazil Nut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: BRAZIL NUT IS RECOMMENDED OVER WALNUT FOR UTERINE UNDIFFERENTIATED CARCINOMA ON TREATMENT WITH CHEMOTHERAPY CARBOPLATIN FOR SOME CONDITIONS.
Foods for Genetic Risk of Uterine Undifferentiated Carcinoma
One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. NSD1 and ERBB3 are two genes whose abnormalities are risk factors for Uterine Undifferentiated Carcinoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Uterine Undifferentiated Carcinoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Uterine Undifferentiated Carcinoma gene NSD1 has causative impact on biological pathways like Oncogenic Histone Methylation, Chromatin Remodeling and Amino Acid Metabolism. And ERBB3 has a causative impact on biological pathways like Growth Factor Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like NSD1 and ERBB3 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes NSD1 and ERBB3 should be avoided.
Eat more pulses, Winged Bean or Pigeon Pea?
The active ingredients contained in Winged Bean are Betulinic Acid, Vitamin C, Linolenic Acid, Oleic Acid, Vitamin A among others. While the active ingredients contained in Pigeon Pea are Vitamin C, Linolenic Acid, Oleic Acid, Genistein, Vitamin A and others.
Betulinic Acid can manipulate biochemical pathways Oncogenic Cancer Epigenetics, Cell Cycle Checkpoints and Apoptosis. Vitamin C has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, Growth Factor Signaling and MYC Signaling.
Linoleic Acid can manipulate biochemical pathways Growth Factor Signaling. Folic Acid has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, MYC Signaling and Cell Cycle Checkpoints. And so on.
For genetic risk of Uterine Undifferentiated Carcinoma due to abnormalities in genes NSD1 and ERBB3 – Foods like Winged Bean are recommended compared to Pigeon Pea. This is because the active ingredients Linoleic Acid and Folic Acid in Pigeon Pea further promote the effects of genes on the biochemical pathways. While the active ingredients Betulinic Acid and Vitamin C contained in Winged Bean together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: WINGED BEAN IS RECOMMENDED OVER PIGEON PEA FOR REDUCING THE GENETIC RISK OF UTERINE UNDIFFERENTIATED CARCINOMA DUE TO GENES NSD1 AND ERBB3
Eat more vegetables, Cassava or Swede?
The active ingredients contained in Cassava are Beta-sitosterol, Vitamin C, Linolenic Acid, Oleic Acid, Vitamin A among others. While the active ingredients contained in Swede are Lycopene, Linolenic Acid, Oleic Acid, Linoleic Acid, Folic Acid and others.
Vitamin C can manipulate biochemical pathways Oncogenic Cancer Epigenetics, Cell Cycle Checkpoints and Apoptosis. Beta-sitosterol has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, MYC Signaling and Oncogenic Cancer Epigenetics.
Linoleic Acid can manipulate biochemical pathways Growth Factor Signaling. Folic Acid has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, MYC Signaling and Cell Cycle Checkpoints. And so on.
For genetic risk of Uterine Undifferentiated Carcinoma due to abnormalities in genes NSD1 and ERBB3 – Foods like Cassava are recommended compared to Swede. This is because the active ingredients Linoleic Acid and Folic Acid in Swede further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Cassava together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: CASSAVA IS RECOMMENDED OVER SWEDE FOR REDUCING THE GENETIC RISK OF UTERINE UNDIFFERENTIATED CARCINOMA DUE TO GENES NSD1 AND ERBB3
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
Eat more fruits, Currant or Date?
The active ingredients contained in Currant are Delphinidin, Beta-sitosterol, Cianidanol, Vitamin C, Linolenic Acid among others. While the active ingredients contained in Date are Apigenin, Lupeol, Beta-sitosterol, Vitamin C, Protocatechuic Acid and others.
Delphinidin can manipulate biochemical pathways PI3K-AKT-MTOR Signaling, Growth Factor Signaling and MYC Signaling. Cianidanol has biological action on biochemical pathways Cell Cycle Checkpoints, Apoptosis and PI3K-AKT-MTOR Signaling.
Ferulic Acid can manipulate biochemical pathways Growth Factor Signaling. Linoleic Acid has biological action on biochemical pathways Growth Factor Signaling. And so on.
For genetic risk of Uterine Undifferentiated Carcinoma due to abnormalities in genes NSD1 and ERBB3 – Foods like Currant are recommended compared to Date. This is because the active ingredients Ferulic Acid and Linoleic Acid in Date further promote the effects of genes on the biochemical pathways. While the active ingredients Delphinidin and Cianidanol contained in Currant together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: CURRANT IS RECOMMENDED OVER DATE FOR REDUCING THE GENETIC RISK OF UTERINE UNDIFFERENTIATED CARCINOMA DUE TO GENES NSD1 AND ERBB3
Eat more nuts, Hazelnut or Macadamia Nut?
The active ingredients contained in Hazelnut are Vitamin E, Linolenic Acid, Oleic Acid, Quercetin, Vitamin A among others. While the active ingredients contained in Macadamia Nut are Beta-sitosterol, Palmitic Acid, Lauric Acid, Myristic Acid, Folic Acid and others.
Vitamin E can manipulate biochemical pathways Cell Cycle Checkpoints, Apoptosis and PI3K-AKT-MTOR Signaling. Quercetin has biological action on biochemical pathways Oncogenic Cancer Epigenetics, Growth Factor Signaling and MYC Signaling.
Palmitic Acid can manipulate biochemical pathways PI3K-AKT-MTOR Signaling, Oncogenic Cancer Epigenetics and Growth Factor Signaling. Lauric Acid has biological action on biochemical pathways MYC Signaling, PI3K-AKT-MTOR Signaling and Growth Factor Signaling. And so on.
For genetic risk of Uterine Undifferentiated Carcinoma due to abnormalities in genes NSD1 and ERBB3 – Foods like Hazelnut are recommended compared to Macadamia Nut. This is because the active ingredients Palmitic Acid and Lauric Acid in Macadamia Nut further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin E and Quercetin contained in Hazelnut together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: HAZELNUT IS RECOMMENDED OVER MACADAMIA NUT FOR REDUCING THE GENETIC RISK OF UTERINE UNDIFFERENTIATED CARCINOMA DUE TO GENES NSD1 AND ERBB3
In Summary
An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.
“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.
The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.
You can get started NOW and design a personalized nutrition plan for Uterine Undifferentiated Carcinoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
References
- Ucec Msk 2018
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- Oleic acid-induced ANGPTL4 enhances head and neck squamous cell carcinoma anoikis resistance and metastasis via up-regulation of fibronectin.
- Cytotoxicity and apoptosis induction in human breast adenocarcinoma MCF-7 cells by (+)-cyanidan-3-ol.
- Resveratrol, a remarkable inhibitor of ribonucleotide reductase.
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- gamma-Tocotrienol inhibits ErbB3-dependent PI3K/Akt mitogenic signalling in neoplastic mammary epithelial cells.
- α-Linolenic acid inhibits the migration of human triple-negative breast cancer cells by attenuating Twist1 expression and suppressing Twist1-mediated epithelial-mesenchymal transition.
- Identification of ellagic acid as potent inhibitor of protein kinase CK2: a successful example of a virtual screening application.
- Mechanism of Juglone-Induced Cell Cycle Arrest and Apoptosis in Ishikawa Human Endometrial Cancer Cells.
- Betulinic acid induces DNA damage and apoptosis in SiHa cells.
- Effects of folate deficiency on gene expression in the apoptosis and cancer pathways in colon cancer cells.
- Delphinidin inhibits a broad spectrum of receptor tyrosine kinases of the ErbB and VEGFR family.
- Modulation of HER2 expression by ferulic acid on human breast cancer MCF7 cells.
- Paederia foetida induces anticancer activity by modulating chromatin modification enzymes and altering pro-inflammatory cytokine gene expression in human prostate cancer cells.
- Functional lipidomics: Palmitic acid impairs hepatocellular carcinoma development by modulating membrane fluidity and glucose metabolism.
- Clinical pharmacodynamics of antihistamines.
- HyperFoods: Machine intelligent mapping of cancer-beating molecules in foods.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.