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What Foods are Recommended for Cancer?
is a very common question. Personalized Nutrition Plans are foods and supplements which are personalized to a cancer indication, genes, any treatments and lifestyle conditions.

Which Foods are Recommended for Spindle Cell Rhabdomyosarcoma?

Sep 7, 2022

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Highlights

No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Spindle Cell Rhabdomyosarcoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Spindle Cell Rhabdomyosarcoma because of MYOD1 and TCF3 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.

There is no one answer to this question for cancers such as Spindle Cell Rhabdomyosarcoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.

In short – the process to answer questions like “Should I Avoid eating fruit Coconut” or “Include fruit Naranjilla in my diet” or “Should I reduce consumption of vegetable Cauliflower” or “Can I take Diosmin and Dim supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.

RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO SPINDLE CELL RHABDOMYOSARCOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.

The overall objective of personalized nutrition for Spindle Cell Rhabdomyosarcoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.

RECOMMENDATION: UPDATE YOUR NUTRITION FOR SPINDLE CELL RHABDOMYOSARCOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.



About Spindle Cell Rhabdomyosarcoma

cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.

Following key highlights are derived from clinical data for Spindle Cell Rhabdomyosarcoma from cBioPortal. 55.6% of males and 44.4% of females were the distribution of gender in these clinical studies. From a patient sample size of 18; the top genes with mutations and other abnormalities for Spindle Cell Rhabdomyosarcoma include genes MYOD1, TP53, PIK3CA, TCF3 and ATM. The occurrence frequency distribution for these genes respectively is 55.6%, 22.2%, 22.2%, 11.1% and 11.1%. These tumor genetic details of Spindle Cell Rhabdomyosarcoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Spindle Cell Rhabdomyosarcoma.

Significance of Nutrition for Spindle Cell Rhabdomyosarcoma

All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Spindle Cell Rhabdomyosarcoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.

For example Coconut includes active ingredients Beta-sitosterol, Vitamin E, Palmitic Acid, Capric Acid, Lauric Acid and others. And Naranjilla contains active ingredients Beta-carotene, Zeaxanthin, Vitamin A and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.

For cancers like Spindle Cell Rhabdomyosarcoma, activation or inhibition of selected biochemical pathways like Cell Cycle Checkpoints, Apoptosis, PI3K-AKT-MTOR Signaling, Inositol Phosphate Signaling plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Spindle Cell Rhabdomyosarcoma, while eating some other foods and supplements may not be recommended.

One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.

For cancers like Spindle Cell Rhabdomyosarcoma, activation or inhibition of selected biochemical pathways like Cell Cycle Checkpoints, Apoptosis, PI3K-AKT-MTOR Signaling, Inositol Phosphate Signaling plays an important role in driving cancer growth.

RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR SPINDLE CELL RHABDOMYOSARCOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.

Foods for Spindle Cell Rhabdomyosarcoma undergoing chemotherapy treatment

In Spindle Cell Rhabdomyosarcoma – the genes MYOD1, TP53, PIK3CA, TCF3 and ATM have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Spindle Cell Rhabdomyosarcoma are Cell Cycle Checkpoints, Apoptosis, DNA Repair and others. Doxorubicin is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Cell Cycle Checkpoints, Apoptosis, DNA Repair so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.

RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.

Eat more pulses, Mung Bean or Adzuki Bean?

Pulses are an important part of many diets. The active ingredients contained in Mung Bean are Vitamin C, Stigmasterol, Linolenic Acid, Oleic Acid, Vitexin among others. While the active ingredients contained in Adzuki Bean are Isoliquiritigenin, Glucaric Acid, Genistein, Folic Acid and others.

Vitamin C can manipulate biochemical pathways Cell Cycle Checkpoints, P53 Signaling and MYC Signaling. Stigmasterol has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, Oxidative Stress and Apoptosis.

Isoliquiritigenin can manipulate biochemical pathways Oxidative Stress. Genistein has biological action on biochemical pathways DNA Repair and Oxidative Stress. And so on.

When treating Spindle Cell Rhabdomyosarcoma with chemotherapy Doxorubicin – Foods like Mung Bean are recommended compared to Adzuki Bean. This is because the active ingredients Isoliquiritigenin and Genistein in Adzuki Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Stigmasterol contained in Mung Bean support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: MUNG BEAN IS RECOMMENDED OVER ADZUKI BEAN FOR SPINDLE CELL RHABDOMYOSARCOMA ON TREATMENT WITH CHEMOTHERAPY DOXORUBICIN FOR SOME CONDITIONS.

Eat more vegetables, Cabbage or Cauliflower?

Vegetables are an important part of many diets. The active ingredients contained in Cabbage are Benzyl Isothiocyanate, Beta-sitosterol, Vitamin C, Brassinin, Quercetin among others. While the active ingredients contained in Cauliflower are Beta-sitosterol, Vitamin C, Brassinin, Linolenic Acid, Oleic Acid and others.

Vitamin C can manipulate biochemical pathways Cell Cycle Checkpoints, P53 Signaling and MYC Signaling. Glucaric Acid has biological action on biochemical pathways Apoptosis, NFKB Signaling and PI3K-AKT-MTOR Signaling.

Brassinin can manipulate biochemical pathways Oxidative Stress. Citric Acid has biological action on biochemical pathways Oxidative Stress. And so on.

When treating Spindle Cell Rhabdomyosarcoma with chemotherapy Doxorubicin – Foods like Cabbage are recommended compared to Cauliflower. This is because the active ingredients Brassinin and Citric Acid in Cauliflower interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Glucaric Acid contained in Cabbage support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: CABBAGE IS RECOMMENDED OVER CAULIFLOWER FOR SPINDLE CELL RHABDOMYOSARCOMA ON TREATMENT WITH CHEMOTHERAPY DOXORUBICIN FOR SOME CONDITIONS.

Which Foods are Recommended for Spindle Cell Rhabdomyosarcoma?

Eat more fruits, Naranjilla or Coconut?

Fruits are an important part of many diets. The active ingredients contained in Naranjilla are Beta-carotene, Zeaxanthin, Vitamin A among others. While the active ingredients contained in Coconut are Beta-sitosterol, Vitamin E, Palmitic Acid, Capric Acid, Lauric Acid and others.

Beta-carotene can manipulate biochemical pathways Cell Cycle Checkpoints, NFKB Signaling and P53 Signaling. Vitamin A has biological action on biochemical pathways MYC Signaling, PI3K-AKT-MTOR Signaling and Oxidative Stress.

Palmitic Acid can manipulate biochemical pathways NFKB Signaling. Lauric Acid has biological action on biochemical pathways MYC Signaling, PI3K-AKT-MTOR Signaling and NFKB Signaling. And so on.

When treating Spindle Cell Rhabdomyosarcoma with chemotherapy Doxorubicin – Foods like Naranjilla are recommended compared to Coconut. This is because the active ingredients Palmitic Acid and Lauric Acid in Coconut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-carotene and Vitamin A contained in Naranjilla support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: NARANJILLA IS RECOMMENDED OVER COCONUT FOR SPINDLE CELL RHABDOMYOSARCOMA ON TREATMENT WITH CHEMOTHERAPY DOXORUBICIN FOR SOME CONDITIONS.

Eat more nuts, Brazil Nut?

Nuts are an important part of many diets. The active ingredients contained in Brazil Nut are Vitamin E, Linolenic Acid, Oleic Acid, Lecithin, Folic Acid among others.

Lecithin can manipulate biochemical pathways Oxidative Stress. Vitamin E has biological action on biochemical pathways Cell Cycle Checkpoints, NFKB Signaling and P53 Signaling.

When treating Spindle Cell Rhabdomyosarcoma with chemotherapy Doxorubicin – Foods like Brazil Nut are recommended. This is because the active ingredients Lecithin and Vitamin E contained in Brazil Nut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: BRAZIL NUT IS RECOMMENDED FOR SPINDLE CELL RHABDOMYOSARCOMA ON TREATMENT WITH CHEMOTHERAPY DOXORUBICIN FOR SOME CONDITIONS.

Foods for Genetic Risk of Spindle Cell Rhabdomyosarcoma

One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. MYOD1 and TCF3 are two genes whose abnormalities are risk factors for Spindle Cell Rhabdomyosarcoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Spindle Cell Rhabdomyosarcoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Spindle Cell Rhabdomyosarcoma gene MYOD1 has causative impact on biological pathways like Sirtuin Signaling and TGFB Signaling. And TCF3 has a causative impact on biological pathways like Noncoding RNA Signaling. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like MYOD1 and TCF3 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes MYOD1 and TCF3 should be avoided.

Eat more pulses, Lentils or Common Bean?

The active ingredients contained in Lentils are Ellagic Acid, Esculin, Vitamin C, Daidzein, Beta-sitosterol among others. While the active ingredients contained in Common Bean are Apigenin, Esculin, Vitamin C, Linolenic Acid, Ferulic Acid and others.

Ellagic Acid can manipulate biochemical pathways Cell Cycle Checkpoints, RAS-RAF Signaling and Oncogenic Cancer Epigenetics. Esculin has biological action on biochemical pathways PI3K-AKT-MTOR Signaling and Cell Cycle Checkpoints.

Pelargonidin can manipulate biochemical pathways WNT Beta Catenin Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling. And so on.

For genetic risk of Spindle Cell Rhabdomyosarcoma due to abnormalities in genes MYOD1 and TCF3 – Foods like Lentils are recommended compared to Common Bean. This is because the active ingredients Pelargonidin and Folic Acid in Common Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Ellagic Acid and Esculin contained in Lentils together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: LENTILS IS RECOMMENDED OVER COMMON BEAN FOR REDUCING THE GENETIC RISK OF SPINDLE CELL RHABDOMYOSARCOMA DUE TO GENES MYOD1 AND TCF3

Eat more vegetables, Giant Butterbur or Radish?

The active ingredients contained in Giant Butterbur are Vitamin C, Beta-sitosterol, Vitamin B3, Melatonin, Kaempferol among others. While the active ingredients contained in Radish are Vitamin C, Beta-sitosterol, Isorhamnetin, Quercetin, Linolenic Acid and others.

Vitamin C can manipulate biochemical pathways RAS-RAF Signaling, Cell Cycle Checkpoints and WNT Beta Catenin Signaling. Beta-sitosterol has biological action on biochemical pathways RUNX Signaling, Oncogenic Cancer Epigenetics and PI3K-AKT-MTOR Signaling.

Pelargonidin can manipulate biochemical pathways WNT Beta Catenin Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling. And so on.

For genetic risk of Spindle Cell Rhabdomyosarcoma due to abnormalities in genes MYOD1 and TCF3 – Foods like Giant Butterbur are recommended compared to Radish. This is because the active ingredients Pelargonidin and Folic Acid in Radish further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Giant Butterbur together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: GIANT BUTTERBUR IS RECOMMENDED OVER RADISH FOR REDUCING THE GENETIC RISK OF SPINDLE CELL RHABDOMYOSARCOMA DUE TO GENES MYOD1 AND TCF3

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.

Eat more fruits, Quince or Strawberry?

The active ingredients contained in Quince are Vitamin C, Chlorogenic Acid, Oleic Acid, Quercitrin, Linoleic Acid among others. While the active ingredients contained in Strawberry are Ellagic Acid, Lupeol, Vitamin C, Beta-sitosterol, Linolenic Acid and others.

Quercitrin can manipulate biochemical pathways Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling. Vitamin C has biological action on biochemical pathways RAS-RAF Signaling, WNT Beta Catenin Signaling and Oncogenic Cancer Epigenetics.

Fisetin can manipulate biochemical pathways WNT Beta Catenin Signaling. Pelargonidin has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and WNT Beta Catenin Signaling. And so on.

For genetic risk of Spindle Cell Rhabdomyosarcoma due to abnormalities in genes MYOD1 and TCF3 – Foods like Quince are recommended compared to Strawberry. This is because the active ingredients Fisetin and Pelargonidin in Strawberry further promote the effects of genes on the biochemical pathways. While the active ingredients Quercitrin and Vitamin C contained in Quince together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: QUINCE IS RECOMMENDED OVER STRAWBERRY FOR REDUCING THE GENETIC RISK OF SPINDLE CELL RHABDOMYOSARCOMA DUE TO GENES MYOD1 AND TCF3

Eat more nuts, Almond or Cashew Nut?

The active ingredients contained in Almond are Vitamin E, Beta-sitosterol, Quercetin, Linolenic Acid, Oleic Acid among others. While the active ingredients contained in Cashew Nut are Vitamin C, Beta-sitosterol, Palmitic Acid, Butyric Acid, Gallic Acid and others.

Beta-sitosterol can manipulate biochemical pathways Cell Cycle Checkpoints, WNT Beta Catenin Signaling and RUNX Signaling. Vitamin E has biological action on biochemical pathways RAS-RAF Signaling, PI3K-AKT-MTOR Signaling and Notch Signaling.

Palmitic Acid can manipulate biochemical pathways WNT Beta Catenin Signaling, Chromatin Remodeling and Oncogenic Cancer Epigenetics. Lauric Acid has biological action on biochemical pathways PI3K-AKT-MTOR Signaling. And so on.

For genetic risk of Spindle Cell Rhabdomyosarcoma due to abnormalities in genes MYOD1 and TCF3 – Foods like Almond are recommended compared to Cashew Nut. This is because the active ingredients Palmitic Acid and Lauric Acid in Cashew Nut further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin E contained in Almond together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: ALMOND IS RECOMMENDED OVER CASHEW NUT FOR REDUCING THE GENETIC RISK OF SPINDLE CELL RHABDOMYOSARCOMA DUE TO GENES MYOD1 AND TCF3


In Summary

An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.

“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.

The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.

You can get started NOW and design a personalized nutrition plan for Spindle Cell Rhabdomyosarcoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

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References

Personalized Nutrition for Cancer!

Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.


Scientifically Reviewed by: Dr. Cogle

Christopher R. Cogle, M.D. is a tenured professor at the University of Florida, Chief Medical Officer of Florida Medicaid, and Director of the Florida Health Policy Leadership Academy at the Bob Graham Center for Public Service.

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