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What Foods are Recommended for Cancer?
is a very common question. Personalized Nutrition Plans are foods and supplements which are personalized to a cancer indication, genes, any treatments and lifestyle conditions.

Foods for Mucinous Cystic Neoplasm!

Jul 24, 2023

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Introduction

Foods for Mucinous Cystic Neoplasm should be personalized for each individual and also must adapt when cancer treatment or tumor genetic change. The personalization and adaptation must consider all the active ingredients or bioactives contained in different foods with respect to cancer tissue biology, genetics, treatments, lifestyle conditions and diet preferences. Hence while nutrition is one of the very important decisions for a cancer patient and individual at risk of cancer to make – how to choose foods to eat is not an easy task.

Mucinous cystic neoplasm (MCN) is a type of cyst-forming tumor that can occur in various organs, most commonly in the pancreas, liver, and ovary. In the pancreas, mucinous cystic neoplasm is characterized by distinctive features observable in radiology, often leading to a specific diagnosis and an ICD-10 code for standardized reporting. Similar radiological assessments are used for identifying MCN in the liver. The pathology outlines of these neoplasms provide crucial insights into their nature, including the presence of mucinous fluid and the potential for malignancy, as in the case of mucinous cystic neoplasm with an invasive adenocarcinoma. Symptoms can vary depending on the location of the neoplasm, with pancreatic MCNs often presenting with abdominal pain or discomfort. Treatment usually involves surgical resection, considering the potential for these neoplasms to progress to cancer, especially in contrast to IPMNs (intraductal papillary mucinous neoplasms), which are a different type of pancreatic cystic lesion. Liver mucinous cystic neoplasms may also require surgical intervention, guided by liver-specific pathology outlines. The prognosis for patients with mucinous cystic neoplasm depends on factors such as the size of the tumor, its location, and whether it has developed invasive characteristics. Early detection and accurate diagnosis are crucial for effective management and treatment of mucinous cystic neoplasms.



For Mucinous Cystic Neoplasm does it matter what vegetables, fruits, nuts, seeds one eats?

A very common nutrition question asked by cancer patients and individuals at-genetic risk of cancer is – for cancers like Mucinous Cystic Neoplasm does it matter what foods I eat and which I do not? Or if I follow a plant-based diet is that enough for cancer like Mucinous Cystic Neoplasm?

For example does it matter if vegetable New Zealand Spinach is consumed more compared to Arrowhead? Does it make any difference if fruit Pummelo is preferred over Purple Mangosteen? Also if similar choices are made for nuts/seeds like Butternut over European Chestnut and for pulses like Broad Bean over Lentils. And if what I eat matters – then how does one identify foods which are recommended for Mucinous Cystic Neoplasm and is it the same answer for everyone with the same diagnosis or genetic risk?

Yes! Foods you eat matters for Mucinous Cystic Neoplasm!

Food recommendations may not be the same for everyone and can be different even for the same diagnosis and genetic risk.

All cancers like Mucinous Cystic Neoplasm can be characterized by a unique set of biochemical pathways - the signature pathways of Mucinous Cystic Neoplasm. Biochemical pathways like MAPK Signaling, Focal Adhesion, PI3K-AKT-MTOR Signaling, Extracellular Matrix Remodelling are part of the signature definition of Mucinous Cystic Neoplasm.

All foods (vegetables, fruits, nuts, seeds, pulses, oils etc.) and nutritional supplements are made up of more than one active molecular ingredient or bio-actives in different proportions and quantities. Each active ingredient has a unique mechanism of action – which can be activation or inhibition of different biochemical pathways. Simply stated foods and supplements which are recommended are those which do not cause an increase of molecular drivers of cancer but reduce them. Else those foods should not be recommended. Foods contain multiple active ingredients – hence when evaluating foods and supplements you need to consider the impact of all active ingredients cumulatively rather than individually.

For example Pummelo contains active ingredients Curcumin, Apigenin, Lycopene, Protocatechuic Acid, Lupeol. And Purple Mangosteen contains active ingredients Curcumin, Apigenin, Lycopene, Protocatechuic Acid, Lupeol and possibly others.

A common mistake made when deciding and choosing foods to eat for Mucinous Cystic Neoplasm – is to evaluate only selected active ingredients contained in foods and ignore the rest. Because different active ingredients contained in foods may have opposing effects on cancer drivers – you cannot cherry pick active ingredients in foods and supplements for making a nutrition decision for Mucinous Cystic Neoplasm.

YES – FOOD CHOICES MATTER FOR CANCER. NUTRITION DECISIONS MUST CONSIDER ALL ACTIVE INGREDIENTS OF FOODS.

Skills Needed for Nutrition Personalization for Mucinous Cystic Neoplasm?

Personalized nutrition for cancers like Mucinous Cystic Neoplasm consists of recommended foods / supplements; not recommended foods / supplements with example recipes which prioritize use of recommended foods. An example of personalized nutrition can be seen at this link.

Deciding which foods are recommended or not is extremely complicated, requiring expertise in Mucinous Cystic Neoplasm biology, food science, genetics, biochemistry along with good understanding of how cancer treatments work and associated vulnerabilities by which the treatments could stop being effective.

MINIMUM KNOWLEDGE EXPERTISE NEEDED FOR NUTRITION PERSONALIZATION FOR CANCER ARE: CANCER BIOLOGY, FOOD SCIENCE, CANCER TREATMENTS AND GENETICS.

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.

Characteristics of cancers like Mucinous Cystic Neoplasm

All cancers like Mucinous Cystic Neoplasm can be characterized by a unique set of biochemical pathways – the signature pathways of Mucinous Cystic Neoplasm. Biochemical pathways like MAPK Signaling, Focal Adhesion, PI3K-AKT-MTOR Signaling, Extracellular Matrix Remodelling are part of the signature definition of Mucinous Cystic Neoplasm. Each individual’s cancer genetics can be different and hence their specific cancer signature could be unique.

The treatments which are effective for Mucinous Cystic Neoplasm need to be cognizant of the associated signature biochemical pathways for each cancer patient and individual at genetic risk. Therefore different treatments with different mechanisms of actions are effective for different patients. Similarly and for the same reasons foods and supplements need to be personalized for each individual. Hence some foods and supplements are recommended for Mucinous Cystic Neoplasm when taking cancer treatment Epirubicin, and some foods and supplements are not recommended.

Sources like cBioPortal and many others provide population representative patient anonymized data from clinical trials for all cancer indications. This data consists of clinical trial study details like sample size / number of patients, age groups, gender, ethnicity, treatments, tumor site and any genetic mutations.

TP53, ALDH9A1, GNAS, MUC4 and KRAS are the top ranked reported genes for Mucinous Cystic Neoplasm. TP53 is reported in 28.6 % of the representative patients across all clinical trials. And ALDH9A1 is reported in 14.3 %. The combined population patient data cover ages from 45 to 73. 8.3 % of the patient data are identified as men. The Mucinous Cystic Neoplasm biology along with reported genetics together define the population represented signature biochemical pathways for this cancer. If the individual cancer tumor genetics or genes contributing to the risk are also known then that should also be used for nutrition personalization.

NUTRITION CHOICES SHOULD MATCH WITH EACH INDIVIDUAL’S CANCER SIGNATURE.

Foods for Mucinous Cystic Neoplasm!

Food and Supplements for Mucinous Cystic Neoplasm

For Cancer Patients

Cancer patients on treatment or on palliative care need to make decisions on food and supplements – for the needed dietary calories, for managing any treatment side effects and also for improved cancer management. All plant-based foods are not equal and choosing and prioritizing foods which are personalized and customized to ongoing cancer treatment is important and complicated. Here are some examples providing guidelines for making nutrition decisions.

Choose Vegetable NEW ZEALAND SPINACH or ARROWHEAD?

Vegetable New Zealand Spinach contains many active ingredients or bioactives such as Curcumin, Apigenin, Lycopene, Protocatechuic Acid, Lupeol. These active ingredients manipulate various biochemical pathways like MAPK Signaling, Post Translation Modification, Focal Adhesion and MYC Signaling and others. New Zealand Spinach is recommended for Mucinous Cystic Neoplasm when ongoing cancer treatment is Epirubicin. This is because New Zealand Spinach modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Epirubicin.

Some of the active ingredients or bioactives in vegetable Arrowhead are Curcumin, Apigenin, Lycopene, Protocatechuic Acid, Lupeol. These active ingredients manipulate various biochemical pathways like WNT Beta Catenin Signaling and others. Arrowhead is not recommended for Mucinous Cystic Neoplasm when ongoing cancer treatment is Epirubicin because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

VEGETABLE NEW ZEALAND SPINACH IS RECOMMENDED OVER ARROWHEAD FOR Mucinous Cystic Neoplasm AND TREATMENT Epirubicin.

Choose Fruit PURPLE MANGOSTEEN or PUMMELO?

Fruit Purple Mangosteen contains many active ingredients or bioactives such as Curcumin, Apigenin, Lycopene, Protocatechuic Acid, Lupeol. These active ingredients manipulate various biochemical pathways like MAPK Signaling, Post Translation Modification, Focal Adhesion and PI3K-AKT-MTOR Signaling and others. Purple Mangosteen is recommended for Mucinous Cystic Neoplasm when ongoing cancer treatment is Epirubicin. This is because Purple Mangosteen modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Epirubicin.

Some of the active ingredients or bioactives in fruit Pummelo are Curcumin, Apigenin, Lycopene, Protocatechuic Acid, Lupeol. These active ingredients manipulate various biochemical pathways like WNT Beta Catenin Signaling and others. Pummelo is not recommended for Mucinous Cystic Neoplasm when ongoing cancer treatment is Epirubicin because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

FRUIT PURPLE MANGOSTEEN IS RECOMMENDED OVER PUMMELO FOR Mucinous Cystic Neoplasm AND TREATMENT Epirubicin.

Choose Nut BUTTERNUT or EUROPEAN CHESTNUT?

Butternut contains many active ingredients or bioactives such as Curcumin, Apigenin, Lycopene, Protocatechuic Acid, Juglone. These active ingredients manipulate various biochemical pathways like MAPK Signaling, Post Translation Modification, Focal Adhesion and MYC Signaling and others. Butternut is recommended for Mucinous Cystic Neoplasm when ongoing cancer treatment is Epirubicin. This is because Butternut modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Epirubicin.

Some of the active ingredients or bioactives in European Chestnut are Curcumin, Apigenin, Protocatechuic Acid, Ellagic Acid, Lupeol. These active ingredients manipulate various biochemical pathways like WNT Beta Catenin Signaling and others. European Chestnut is not recommended for Mucinous Cystic Neoplasm when ongoing cancer treatment is Epirubicin because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

BUTTERNUT IS RECOMMENDED OVER EUROPEAN CHESTNUT FOR Mucinous Cystic Neoplasm AND TREATMENT Epirubicin.

For Individuals with Genetic Risk of Cancer

The question asked by individuals who have genetic risk of Mucinous Cystic Neoplasm or familial history is “What Should I Eat Differently from Before?” and how they should choose foods and supplements to manage risks of the disease. Since for cancer risk there is nothing actionable in terms of treatment – decisions of foods and supplements become important and one of the very few actionable things which can be done. All plant-based foods are not equal and based on identified genetics and pathway signature – the choices of food and supplements should be personalized.

Choose Vegetable GIANT BUTTERBUR or SWAMP CABBAGE?

Vegetable Giant Butterbur contains many active ingredients or bioactives such as Curcumin, Apigenin, Lycopene, Lupeol, Daidzein. These active ingredients manipulate various biochemical pathways like MAPK Signaling, PI3K-AKT-MTOR Signaling, RAS-RAF Signaling and Oxidative Stress and others. Giant Butterbur is recommended for risk of Mucinous Cystic Neoplasm when associated genetic risk is ALDH9A1. This is because Giant Butterbur increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in vegetable Swamp Cabbage are Curcumin, Lycopene, Lupeol, Daidzein, Formononetin. These active ingredients manipulate various biochemical pathways like MAPK Signaling and Oxidative Stress and others. Swamp Cabbage is not recommended when risk of Mucinous Cystic Neoplasm when associated genetic risk is ALDH9A1 because it increases the signature pathways of it.

VEGETABLE GIANT BUTTERBUR IS RECOMMENDED OVER SWAMP CABBAGE FOR ALDH9A1 GENETIC RISK OF CANCER.

Choose Fruit RED RASPBERRY or JUJUBE?

Fruit Red Raspberry contains many active ingredients or bioactives such as Curcumin, Ellagic Acid, Quercetin, Lupeol, Daidzein. These active ingredients manipulate various biochemical pathways like MAPK Signaling, PI3K-AKT-MTOR Signaling, RAS-RAF Signaling and Oxidative Stress and others. Red Raspberry is recommended for risk of Mucinous Cystic Neoplasm when associated genetic risk is ALDH9A1. This is because Red Raspberry increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in fruit Jujube are Curcumin, Apigenin, Quercetin, Lycopene, Lupeol. These active ingredients manipulate various biochemical pathways like MAPK Signaling, Oxidative Stress and PI3K-AKT-MTOR Signaling and others. Jujube is not recommended when risk of Mucinous Cystic Neoplasm when associated genetic risk is ALDH9A1 because it increases the signature pathways of it.

FRUIT RED RASPBERRY IS RECOMMENDED OVER JUJUBE FOR ALDH9A1 GENETIC RISK OF CANCER.

Choose Nut COMMON HAZELNUT or BRAZIL NUT?

Common Hazelnut contains many active ingredients or bioactives such as Curcumin, Quercetin, Lycopene, Lupeol, Daidzein. These active ingredients manipulate various biochemical pathways like MAPK Signaling, PI3K-AKT-MTOR Signaling, RAS-RAF Signaling and Oxidative Stress and others. Common Hazelnut is recommended for risk of Mucinous Cystic Neoplasm when associated genetic risk is ALDH9A1. This is because Common Hazelnut increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in Brazil Nut are Curcumin, Ellagic Acid, Lupeol, Daidzein, Formononetin. These active ingredients manipulate various biochemical pathways like MAPK Signaling and PI3K-AKT-MTOR Signaling and others. Brazil Nut is not recommended when risk of Mucinous Cystic Neoplasm when associated genetic risk is ALDH9A1 because it increases the signature pathways of it.

COMMON HAZELNUT IS RECOMMENDED OVER BRAZIL NUT FOR ALDH9A1 GENETIC RISK OF CANCER.


In Conclusion

Foods and Supplements chosen are important decisions for cancers like Mucinous Cystic Neoplasm. Mucinous Cystic Neoplasm patients and individuals with genetic-risk always have this question: “What foods and nutritional supplements are recommended for me and which are not?” There is a common belief which is a misconception that all plant-based foods could be beneficial or not but would not be harmful. Certain foods and supplements can interfere with cancer treatments or promote molecular pathway drivers of cancer.

There are different types of cancer indications like Mucinous Cystic Neoplasm, each with different tumor genetics with further genomic variations across each individual. Further every cancer treatment and chemotherapy has a unique mechanism of action. Each food like New Zealand Spinach contains various bioactives in different quantities, which have an impact on different and distinct sets of biochemical pathways. The definition of personalized nutrition is individualized food recommendations for the cancer indication, treatments, genetics, lifestyle and other factors. Nutrition personalization decisions for cancer require knowledge of cancer biology, food science and an understanding of different chemotherapy treatments. Finally when there are treatment changes or new genomics is identified – the nutrition personalization needs re-evaluation.

The addon nutrition personalization solution makes the decision making easy and removes all the guesswork in answering the question, “What foods should I choose or not choose for Mucinous Cystic Neoplasm?”. The addon multi-disciplinary team includes cancer physicians, clinical scientists, software engineers and data scientists.


Personalized Nutrition for Cancer!

Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.

References

Scientifically Reviewed by: Dr. Cogle

Christopher R. Cogle, M.D. is a tenured professor at the University of Florida, Chief Medical Officer of Florida Medicaid, and Director of the Florida Health Policy Leadership Academy at the Bob Graham Center for Public Service.

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