Highlights
No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Mucinous Cystic Neoplasm when undergoing chemotherapy or when you determine you have a genetic risk for developing Mucinous Cystic Neoplasm because of ALDH9A1 and GNAS gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.
There is no one answer to this question for cancers such as Mucinous Cystic Neoplasm which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.
In short – the process to answer questions like “Should I Avoid eating fruit Pummelo” or “Include fruit Quince in my diet” or “Should I reduce consumption of vegetable Celery” or “Can I take Senna and Buckthorn supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.
RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO MUCINOUS CYSTIC NEOPLASM, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.
The overall objective of personalized nutrition for Mucinous Cystic Neoplasm is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.
RECOMMENDATION: UPDATE YOUR NUTRITION FOR MUCINOUS CYSTIC NEOPLASM, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.
About Mucinous Cystic Neoplasm
cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.
Following key highlights are derived from clinical data for Mucinous Cystic Neoplasm from cBioPortal. The patients enrolled in the studies for Mucinous Cystic Neoplasm are in ages between 45 to 73 with an average age of 59. 8.3% of males and 91.7% of females were the distribution of gender in these clinical studies. From a patient sample size of 14; the top genes with mutations and other abnormalities for Mucinous Cystic Neoplasm include genes TP53, ALDH9A1, GNAS, MUC4 and KRAS. The occurrence frequency distribution for these genes respectively is 28.6%, 14.3%, 14.3%, 14.3% and 14.3%. These tumor genetic details of Mucinous Cystic Neoplasm are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Mucinous Cystic Neoplasm.
Significance of Nutrition for Mucinous Cystic Neoplasm
All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Mucinous Cystic Neoplasm. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.
For example Pummelo includes active ingredients Naringin, Beta-sitosterol, Linolenic Acid, Vitamin C, Oleic Acid and others. And Quince contains active ingredients Modified Citrus Pectin, Vitamin C, Quercitrin, Oleic Acid, Linoleic Acid and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.
For cancers like Mucinous Cystic Neoplasm, activation or inhibition of selected biochemical pathways like Notch Signaling, Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling, MAPK Signaling plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Mucinous Cystic Neoplasm, while eating some other foods and supplements may not be recommended.
One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.
RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR MUCINOUS CYSTIC NEOPLASM – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.
Foods for Mucinous Cystic Neoplasm undergoing chemotherapy treatment
In Mucinous Cystic Neoplasm – the genes TP53, ALDH9A1, GNAS, MUC4 and KRAS have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Mucinous Cystic Neoplasm are Notch Signaling, Cell Cycle Checkpoints, Apoptosis and others. Cisplatin is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Notch Signaling, Cell Cycle Checkpoints, Apoptosis so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.
RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.
Eat more pulses, Mung Bean or Moth Bean?
Pulses are an important part of many diets. The active ingredients contained in Mung Bean are Linolenic Acid, Vitamin C, Stigmasterol, Vitexin, Quercetin among others. While the active ingredients contained in Moth Bean are Beta-sitosterol, Linolenic Acid, Stigmasterol, Oleic Acid, Linoleic Acid and others.
Vitamin C can manipulate biochemical pathways WNT Beta Catenin Signaling, MAPK Signaling and Cell Cycle Checkpoints. Stigmasterol has biological action on biochemical pathways P53 Signaling, MYC Signaling and PI3K-AKT-MTOR Signaling.
Folic Acid can manipulate biochemical pathways MAPK Signaling, Cell Cycle Checkpoints and P53 Signaling. And so on.
When treating Mucinous Cystic Neoplasm with chemotherapy Cisplatin – Foods like Mung Bean are recommended compared to Moth Bean. This is because the active ingredients Folic Acid in Moth Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Stigmasterol contained in Mung Bean support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: MUNG BEAN IS RECOMMENDED OVER MOTH BEAN FOR MUCINOUS CYSTIC NEOPLASM ON TREATMENT WITH CHEMOTHERAPY CISPLATIN FOR SOME CONDITIONS.
Eat more vegetables, Arugula or Celery?
Vegetables are an important part of many diets. The active ingredients contained in Arugula are Esculin, Kaempferol, Vitamin A, Vitamin K, Erysolin among others. While the active ingredients contained in Celery are Apigenin, Linolenic Acid, Vitamin C, Cynaroside, Quercetin and others.
Kaempferol can manipulate biochemical pathways WNT Beta Catenin Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling. Vitamin A has biological action on biochemical pathways MYC Signaling, Apoptosis and WNT Beta Catenin Signaling.
Luteolin can manipulate biochemical pathways WNT Beta Catenin Signaling and MYC Signaling. Chrysin has biological action on biochemical pathways WNT Beta Catenin Signaling and MYC Signaling. And so on.
When treating Mucinous Cystic Neoplasm with chemotherapy Cisplatin – Foods like Arugula are recommended compared to Celery. This is because the active ingredients Luteolin and Chrysin in Celery interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Kaempferol and Vitamin A contained in Arugula support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: ARUGULA IS RECOMMENDED OVER CELERY FOR MUCINOUS CYSTIC NEOPLASM ON TREATMENT WITH CHEMOTHERAPY CISPLATIN FOR SOME CONDITIONS.
Eat more fruits, Quince or Pummelo?
Fruits are an important part of many diets. The active ingredients contained in Quince are Modified Citrus Pectin, Vitamin C, Quercitrin, Oleic Acid, Linoleic Acid among others. While the active ingredients contained in Pummelo are Naringin, Beta-sitosterol, Linolenic Acid, Vitamin C, Oleic Acid and others.
Quercitrin can manipulate biochemical pathways MAPK Signaling, Cell Cycle Checkpoints and P53 Signaling. Modified Citrus Pectin has biological action on biochemical pathways MYC Signaling, Apoptosis and PI3K-AKT-MTOR Signaling.
Naringetol can manipulate biochemical pathways WNT Beta Catenin Signaling. Hesperetin has biological action on biochemical pathways WNT Beta Catenin Signaling. And so on.
When treating Mucinous Cystic Neoplasm with chemotherapy Cisplatin – Foods like Quince are recommended compared to Pummelo. This is because the active ingredients Naringetol and Hesperetin in Pummelo interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Quercitrin and Modified Citrus Pectin contained in Quince support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: QUINCE IS RECOMMENDED OVER PUMMELO FOR MUCINOUS CYSTIC NEOPLASM ON TREATMENT WITH CHEMOTHERAPY CISPLATIN FOR SOME CONDITIONS.
Eat more nuts, Hazelnut or Macadamia Nut?
Nuts are an important part of many diets. The active ingredients contained in Hazelnut are Vitamin E, Linolenic Acid, Quercetin, Oleic Acid, Linoleic Acid among others. While the active ingredients contained in Macadamia Nut are Beta-sitosterol, Palmitic Acid, Lauric Acid, Myristic Acid, Folic Acid and others.
Vitamin E can manipulate biochemical pathways MAPK Signaling, Cell Cycle Checkpoints and P53 Signaling. Quercetin has biological action on biochemical pathways WNT Beta Catenin Signaling, MYC Signaling and PI3K-AKT-MTOR Signaling.
Palmitic Acid can manipulate biochemical pathways WNT Beta Catenin Signaling and MAPK Signaling. Lauric Acid has biological action on biochemical pathways MYC Signaling, PI3K-AKT-MTOR Signaling and MAPK Signaling. And so on.
When treating Mucinous Cystic Neoplasm with chemotherapy Cisplatin – Foods like Hazelnut are recommended compared to Macadamia Nut. This is because the active ingredients Palmitic Acid and Lauric Acid in Macadamia Nut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin E and Quercetin contained in Hazelnut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: HAZELNUT IS RECOMMENDED OVER MACADAMIA NUT FOR MUCINOUS CYSTIC NEOPLASM ON TREATMENT WITH CHEMOTHERAPY CISPLATIN FOR SOME CONDITIONS.
Foods for Genetic Risk of Mucinous Cystic Neoplasm
One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. ALDH9A1 and GNAS are two genes whose abnormalities are risk factors for Mucinous Cystic Neoplasm. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Mucinous Cystic Neoplasm can be used as a guide for coming up with a recommended personalized nutrition plan. For Mucinous Cystic Neoplasm gene ALDH9A1 has causative impact on biological pathways like Amino Acid Metabolism, Lipid Metabolism and Amino Acid Metabolism. And GNAS has a causative impact on biological pathways like G-protein-coupled Receptor Signaling, Reproductive Hormone Signaling and Gonadotropin-releasing hormone. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like ALDH9A1 and GNAS should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes ALDH9A1 and GNAS should be avoided.
Eat more pulses, Winged Bean or Chickpea?
The active ingredients contained in Winged Bean are Betulinic Acid, Oleic Acid, Linolenic Acid, Vitamin C, Vitamin A among others. While the active ingredients contained in Chickpea are Oleic Acid, Linolenic Acid, Genistein, Vitamin A, Folic Acid and others.
Betulinic Acid can manipulate biochemical pathways MAPK Signaling, MYC Signaling and Cell Cycle Checkpoints. Vitamin C has biological action on biochemical pathways RAS-RAF Signaling, PI3K-AKT-MTOR Signaling and MAPK Signaling.
Genistein can manipulate biochemical pathways G-protein-coupled Receptor Signaling. Folic Acid has biological action on biochemical pathways MAPK Signaling, Cell Cycle Checkpoints and RAS-RAF Signaling. And so on.
For genetic risk of Mucinous Cystic Neoplasm due to abnormalities in genes ALDH9A1 and GNAS – Foods like Winged Bean are recommended compared to Chickpea. This is because the active ingredients Genistein and Folic Acid in Chickpea further promote the effects of genes on the biochemical pathways. While the active ingredients Betulinic Acid and Vitamin C contained in Winged Bean together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: WINGED BEAN IS RECOMMENDED OVER CHICKPEA FOR REDUCING THE GENETIC RISK OF MUCINOUS CYSTIC NEOPLASM DUE TO GENES ALDH9A1 AND GNAS
Eat more vegetables, Cassava or Carob?
The active ingredients contained in Cassava are Oleic Acid, Beta-sitosterol, Linolenic Acid, Vitamin C, Vitamin A among others. While the active ingredients contained in Carob are Quercetin, Myricetin, Phloroglucinol, Gallic Acid, Palmitic Acid and others.
Vitamin C can manipulate biochemical pathways MAPK Signaling, Cell Cycle Checkpoints and RAS-RAF Signaling. Beta-sitosterol has biological action on biochemical pathways MYC Signaling, PI3K-AKT-MTOR Signaling and Cell Cycle Checkpoints.
Palmitic Acid can manipulate biochemical pathways MAPK Signaling and DNA Repair. Gallic Acid has biological action on biochemical pathways DNA Repair. And so on.
For genetic risk of Mucinous Cystic Neoplasm due to abnormalities in genes ALDH9A1 and GNAS – Foods like Cassava are recommended compared to Carob. This is because the active ingredients Palmitic Acid and Gallic Acid in Carob further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Cassava together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: CASSAVA IS RECOMMENDED OVER CAROB FOR REDUCING THE GENETIC RISK OF MUCINOUS CYSTIC NEOPLASM DUE TO GENES ALDH9A1 AND GNAS
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
Eat more fruits, Orange or Date?
The active ingredients contained in Orange are D-limonene, Modified Citrus Pectin, Linalool, Glucaric Acid, Hesperidin among others. While the active ingredients contained in Date are Apigenin, Protocatechuic Acid, Lupeol, Oleic Acid, Beta-sitosterol and others.
D-limonene can manipulate biochemical pathways MAPK Signaling, Cell Cycle Checkpoints and RAS-RAF Signaling. Glucaric Acid has biological action on biochemical pathways MYC Signaling, PI3K-AKT-MTOR Signaling and MAPK Signaling.
Ferulic Acid can manipulate biochemical pathways DNA Repair. Gallic Acid has biological action on biochemical pathways DNA Repair. And so on.
For genetic risk of Mucinous Cystic Neoplasm due to abnormalities in genes ALDH9A1 and GNAS – Foods like Orange are recommended compared to Date. This is because the active ingredients Ferulic Acid and Gallic Acid in Date further promote the effects of genes on the biochemical pathways. While the active ingredients D-limonene and Glucaric Acid contained in Orange together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: ORANGE IS RECOMMENDED OVER DATE FOR REDUCING THE GENETIC RISK OF MUCINOUS CYSTIC NEOPLASM DUE TO GENES ALDH9A1 AND GNAS
Eat more nuts, Almond or Cashew Nut?
The active ingredients contained in Almond are Oleic Acid, Beta-sitosterol, Vitamin E, Quercetin, Linolenic Acid among others. While the active ingredients contained in Cashew Nut are Beta-sitosterol, Vitamin C, Gallic Acid, Palmitic Acid, Butyric Acid and others.
Beta-sitosterol can manipulate biochemical pathways MYC Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling. Vitamin E has biological action on biochemical pathways MAPK Signaling, MYC Signaling and Cell Cycle Checkpoints.
Palmitic Acid can manipulate biochemical pathways MAPK Signaling and DNA Repair. Lauric Acid has biological action on biochemical pathways MYC Signaling, PI3K-AKT-MTOR Signaling and MAPK Signaling. And so on.
For genetic risk of Mucinous Cystic Neoplasm due to abnormalities in genes ALDH9A1 and GNAS – Foods like Almond are recommended compared to Cashew Nut. This is because the active ingredients Palmitic Acid and Lauric Acid in Cashew Nut further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin E contained in Almond together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: ALMOND IS RECOMMENDED OVER CASHEW NUT FOR REDUCING THE GENETIC RISK OF MUCINOUS CYSTIC NEOPLASM DUE TO GENES ALDH9A1 AND GNAS
In Summary
An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.
“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.
The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.
You can get started NOW and design a personalized nutrition plan for Mucinous Cystic Neoplasm by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
References
- Pact Jhu 2011
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Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.