Highlights
No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Fibrothecoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Fibrothecoma because of BRIP1 and EPHA5 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.
There is no one answer to this question for cancers such as Fibrothecoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.
In short – the process to answer questions like “Should I Avoid eating fruit Fig” or “Include fruit Mulberry in my diet” or “Should I reduce consumption of vegetable Heart Of Palm” or “Can I take Lycopene and Mulberry supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.
RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO FIBROTHECOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.
The overall objective of personalized nutrition for Fibrothecoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.
RECOMMENDATION: UPDATE YOUR NUTRITION FOR FIBROTHECOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.
About Fibrothecoma
cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.
Following key highlights are derived from clinical data for Fibrothecoma from cBioPortal. The patients enrolled in the studies for Fibrothecoma are in ages between 7 to 84 with an average age of 54. 16.7% of males and 83.3% of females were the distribution of gender in these clinical studies. From a patient sample size of 36; the top genes with mutations and other abnormalities for Fibrothecoma include genes DNMT3A, BRIP1, EPHA5, FAT1 and MYD88. The occurrence frequency distribution for these genes respectively is 28.6%, 14.3%, 14.3%, 14.3% and 14.3%. These tumor genetic details of Fibrothecoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Fibrothecoma.
Significance of Nutrition for Fibrothecoma
All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Fibrothecoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.
For example Fig includes active ingredients Angelicin, Rutin, Psoralen, Lupeol, Bergapten and others. And Mulberry contains active ingredients Resveratrol, Morusin, Deoxynojirimycin and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.
For cancers like Fibrothecoma, activation or inhibition of selected biochemical pathways like Apoptosis, NFKB Signaling, Oncogenic Cancer Epigenetics, Oncogenic Histone Methylation plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Fibrothecoma, while eating some other foods and supplements may not be recommended.
One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.
RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR FIBROTHECOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.
Foods for Fibrothecoma undergoing chemotherapy treatment
In Fibrothecoma – the genes DNMT3A, BRIP1, EPHA5, FAT1 and MYD88 have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Fibrothecoma are Apoptosis, NFKB Signaling and others. Docetaxel is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Apoptosis, NFKB Signaling so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.
RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.
Eat more pulses, Scarlet Bean or Yellow Wax Bean?
Pulses are an important part of many diets. The active ingredients contained in Scarlet Bean are Linolenic Acid, Stigmasterol, Genistein, Linoleic Acid, Beta-sitosterol among others. While the active ingredients contained in Yellow Wax Bean are Ferulic Acid, Cianidanol, Palmitic Acid, Astragalin, Butyric Acid and others.
Stigmasterol can manipulate biochemical pathways Apoptosis. Genistein has biological action on biochemical pathways NFKB Signaling.
Palmitic Acid can manipulate biochemical pathways NFKB Signaling. Folic Acid has biological action on biochemical pathways Apoptosis. And so on.
When treating Fibrothecoma with chemotherapy Docetaxel – Foods like Scarlet Bean are recommended compared to Yellow Wax Bean. This is because the active ingredients Palmitic Acid and Folic Acid in Yellow Wax Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Stigmasterol and Genistein contained in Scarlet Bean support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: SCARLET BEAN IS RECOMMENDED OVER YELLOW WAX BEAN FOR FIBROTHECOMA ON TREATMENT WITH CHEMOTHERAPY DOCETAXEL FOR SOME CONDITIONS.
Eat more vegetables, Rhubarb or Heart Of Palm?
Vegetables are an important part of many diets. The active ingredients contained in Rhubarb are Gallic Acid, Vitamin E, Rutin, Chrysophanol, Linolenic Acid among others. While the active ingredients contained in Heart Of Palm are Palmitic Acid, Vitamin A, Vitamin C, Folic Acid and others.
Rutin can manipulate biochemical pathways NFKB Signaling and Apoptosis. Vitamin K has biological action on biochemical pathways NFKB Signaling.
Palmitic Acid can manipulate biochemical pathways NFKB Signaling. Folic Acid has biological action on biochemical pathways Apoptosis. And so on.
When treating Fibrothecoma with chemotherapy Docetaxel – Foods like Rhubarb are recommended compared to Heart Of Palm. This is because the active ingredients Palmitic Acid and Folic Acid in Heart Of Palm interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Rutin and Vitamin K contained in Rhubarb support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: RHUBARB IS RECOMMENDED OVER HEART OF PALM FOR FIBROTHECOMA ON TREATMENT WITH CHEMOTHERAPY DOCETAXEL FOR SOME CONDITIONS.
Eat more fruits, Mulberry or Fig?
Fruits are an important part of many diets. The active ingredients contained in Mulberry are Resveratrol, Morusin, Deoxynojirimycin among others. While the active ingredients contained in Fig are Angelicin, Rutin, Psoralen, Lupeol, Bergapten and others.
Morusin can manipulate biochemical pathways NFKB Signaling and Apoptosis. Deoxynojirimycin has biological action on biochemical pathways Apoptosis.
Palmitic Acid can manipulate biochemical pathways NFKB Signaling. Myristic Acid has biological action on biochemical pathways Apoptosis. And so on.
When treating Fibrothecoma with chemotherapy Docetaxel – Foods like Mulberry are recommended compared to Fig. This is because the active ingredients Palmitic Acid and Myristic Acid in Fig interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Morusin and Deoxynojirimycin contained in Mulberry support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: MULBERRY IS RECOMMENDED OVER FIG FOR FIBROTHECOMA ON TREATMENT WITH CHEMOTHERAPY DOCETAXEL FOR SOME CONDITIONS.
Eat more nuts, Pistachio or Cashew Nut?
Nuts are an important part of many diets. The active ingredients contained in Pistachio are Resveratrol, Vitamin E, Linolenic Acid, Stigmasterol, Linoleic Acid among others. While the active ingredients contained in Cashew Nut are Gallic Acid, Beta-sitosterol, Palmitic Acid, Myristic Acid, Butyric Acid and others.
Beta-sitosterol can manipulate biochemical pathways NFKB Signaling and Apoptosis. Resveratrol has biological action on biochemical pathways NFKB Signaling.
Palmitic Acid can manipulate biochemical pathways NFKB Signaling. Myristic Acid has biological action on biochemical pathways Apoptosis. And so on.
When treating Fibrothecoma with chemotherapy Docetaxel – Foods like Pistachio are recommended compared to Cashew Nut. This is because the active ingredients Palmitic Acid and Myristic Acid in Cashew Nut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Resveratrol contained in Pistachio support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: PISTACHIO IS RECOMMENDED OVER CASHEW NUT FOR FIBROTHECOMA ON TREATMENT WITH CHEMOTHERAPY DOCETAXEL FOR SOME CONDITIONS.
Foods for Genetic Risk of Fibrothecoma
One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. BRIP1 and EPHA5 are two genes whose abnormalities are risk factors for Fibrothecoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Fibrothecoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Fibrothecoma gene BRIP1 has causative impact on biological pathways like DNA Repair and DNA Repair. And EPHA5 has a causative impact on biological pathways like . Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like BRIP1 and EPHA5 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes BRIP1 and EPHA5 should be avoided.
Eat more pulses, Common Pea or Soy Bean?
The active ingredients contained in Common Pea are Lupeol, Daidzein, Beta-sitosterol, Vitamin C, Linolenic Acid among others. While the active ingredients contained in Soy Bean are Lupeol, Vitamin E, Daidzein, Beta-sitosterol, Vitamin C and others.
Beta-sitosterol can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Vitamin C has biological action on biochemical pathways Cell Cycle Checkpoints, MAPK Signaling and PI3K-AKT-MTOR Signaling.
Aescin can manipulate biochemical pathways Cell Cycle Checkpoints. Lecithin has biological action on biochemical pathways MYC Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling. And so on.
For genetic risk of Fibrothecoma due to abnormalities in genes BRIP1 and EPHA5 – Foods like Common Pea are recommended compared to Soy Bean. This is because the active ingredients Aescin and Lecithin in Soy Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin C contained in Common Pea together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: COMMON PEA IS RECOMMENDED OVER SOY BEAN FOR REDUCING THE GENETIC RISK OF FIBROTHECOMA DUE TO GENES BRIP1 AND EPHA5
Eat more vegetables, Cassava or Bell Pepper?
The active ingredients contained in Cassava are Beta-sitosterol, Vitamin C, Linolenic Acid, Oleic Acid, Linoleic Acid among others. While the active ingredients contained in Bell Pepper are Vitamin E, Vitamin C, Linolenic Acid, Oleic Acid, P-coumaric Acid and others.
Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Beta-sitosterol has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and Oncogenic Cancer Epigenetics.
Capsaicin can manipulate biochemical pathways MAPK Signaling. Folic Acid has biological action on biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. And so on.
For genetic risk of Fibrothecoma due to abnormalities in genes BRIP1 and EPHA5 – Foods like Cassava are recommended compared to Bell Pepper. This is because the active ingredients Capsaicin and Folic Acid in Bell Pepper further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Cassava together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: CASSAVA IS RECOMMENDED OVER BELL PEPPER FOR REDUCING THE GENETIC RISK OF FIBROTHECOMA DUE TO GENES BRIP1 AND EPHA5
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
Eat more fruits, Feijoa or Cranberry?
The active ingredients contained in Feijoa are Lycopene, Vitamin C, Casuarinin, Folic Acid among others. While the active ingredients contained in Cranberry are Ellagic Acid, Hyperoside, Vitamin C, Quercetin, P-coumaric Acid and others.
Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Lycopene has biological action on biochemical pathways Cell Cycle Checkpoints, MAPK Signaling and PI3K-AKT-MTOR Signaling.
Ellagic Acid can manipulate biochemical pathways MYC Signaling. Myricetin has biological action on biochemical pathways Oncogenic Cancer Epigenetics. And so on.
For genetic risk of Fibrothecoma due to abnormalities in genes BRIP1 and EPHA5 – Foods like Feijoa are recommended compared to Cranberry. This is because the active ingredients Ellagic Acid and Myricetin in Cranberry further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Lycopene contained in Feijoa together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: FEIJOA IS RECOMMENDED OVER CRANBERRY FOR REDUCING THE GENETIC RISK OF FIBROTHECOMA DUE TO GENES BRIP1 AND EPHA5
Eat more nuts, Almond or Peanut?
The active ingredients contained in Almond are Vitamin E, Beta-sitosterol, Linolenic Acid, Oleic Acid, Stigmasterol among others. While the active ingredients contained in Peanut are Vitamin E, Beta-sitosterol, Vitamin C, Linolenic Acid, Oleic Acid and others.
Beta-sitosterol can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Vitamin E has biological action on biochemical pathways Cell Cycle Checkpoints, MAPK Signaling and PI3K-AKT-MTOR Signaling.
Lecithin can manipulate biochemical pathways MYC Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways Apoptosis, P53 Signaling and Cell Cycle Checkpoints. And so on.
For genetic risk of Fibrothecoma due to abnormalities in genes BRIP1 and EPHA5 – Foods like Almond are recommended compared to Peanut. This is because the active ingredients Lecithin and Folic Acid in Peanut further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin E contained in Almond together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: ALMOND IS RECOMMENDED OVER PEANUT FOR REDUCING THE GENETIC RISK OF FIBROTHECOMA DUE TO GENES BRIP1 AND EPHA5
In Summary
An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.
“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.
The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.
You can get started NOW and design a personalized nutrition plan for Fibrothecoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
References
- Msk Ch 2020
- Cancer therapy shapes the fitness landscape of clonal hematopoiesis.
- Stigmasterol exhibits potent antitumor effects in human gastric cancer cells mediated via inhibition of cell migration, cell cycle arrest, mitochondrial mediated apoptosis and inhibition of JAK/STAT signalling pathway.
- Effect of flavonoids on androgen and glucocorticoid receptors based on in vitro reporter gene assay.
- Quercetin protects against obesity-induced skeletal muscle inflammation and atrophy.
- Effects of folate deficiency on gene expression in the apoptosis and cancer pathways in colon cancer cells.
- The clam”: indications and complications.”
- Intake of mulberry 1-deoxynojirimycin prevents colorectal cancer in mice.
- Saturated fatty acids modulate cell response to DNA damage: implication for their role in tumorigenesis.
- Rutin Attenuates Hepatotoxicity in High-Cholesterol-Diet-Fed Rats.
- Research progress on the anticancer effects of vitamin K2.
- Paederia foetida induces anticancer activity by modulating chromatin modification enzymes and altering pro-inflammatory cytokine gene expression in human prostate cancer cells.
- Spongiapyridine and related spongians isolated from an Indonesian Spongia sp.
- The synergy of Vitamin C with decitabine activates TET2 in leukemic cells and significantly improves overall survival in elderly patients with acute myeloid leukemia.
- The recruitment of Raf-1 to membranes is mediated by direct interaction with phosphatidic acid and is independent of association with Ras.
- Lycopene metabolite, apo-10′-lycopenoic acid, inhibits diethylnitrosamine-initiated, high fat diet-promoted hepatic inflammation and tumorigenesis in mice.
- Identification of ellagic acid as potent inhibitor of protein kinase CK2: a successful example of a virtual screening application.
- Triggering of transient receptor potential vanilloid type 1 (TRPV1) by capsaicin induces Fas/CD95-mediated apoptosis of urothelial cancer cells in an ATM-dependent manner.
- Gamma- and delta-tocotrienols exert a more potent anticancer effect than alpha-tocopheryl succinate on breast cancer cell lines irrespective of HER-2/neu expression.
- HyperFoods: Machine intelligent mapping of cancer-beating molecules in foods.
- Determination of 1-deoxynojirimycin in mulberry leaves using hydrophilic interaction chromatography with evaporative light scattering detection.
- 1-Deoxynojirimycin in Mulberry (Morus indica L.) Leaves Ameliorates Stable Angina Pectoris in Patients With Coronary Heart Disease by Improving Antioxidant and Anti-inflammatory Capacities.
- Effects of mulberry leaf extract rich in 1-deoxynojirimycin on blood lipid profiles in humans.
- Effect of sodium nitrate loading on electrolyte transport by the renal tubule.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.