Highlights
No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Cervical Squamous Cell Carcinoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Cervical Squamous Cell Carcinoma because of FBXW7 and PIK3CA gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.
There is no one answer to this question for cancers such as Cervical Squamous Cell Carcinoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.
In short – the process to answer questions like “Should I Avoid eating fruit Strawberry” or “Include fruit Mulberry in my diet” or “Should I reduce consumption of vegetable Endive” or “Can I take Cissus and Mulberry supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.
RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO CERVICAL SQUAMOUS CELL CARCINOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.
The overall objective of personalized nutrition for Cervical Squamous Cell Carcinoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.
RECOMMENDATION: UPDATE YOUR NUTRITION FOR CERVICAL SQUAMOUS CELL CARCINOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.
About Cervical Squamous Cell Carcinoma
cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.
Following key highlights are derived from clinical data for Cervical Squamous Cell Carcinoma from cBioPortal. The patients enrolled in the studies for Cervical Squamous Cell Carcinoma are in ages between 21 to 58 with an average age of 39.From a patient sample size of 208; the top genes with mutations and other abnormalities for Cervical Squamous Cell Carcinoma include genes PIK3CA, KMT2D, FBXW7, KMT2C and TERT. The occurrence frequency distribution for these genes respectively is 13.5%, 11.0%, 7.1%, 6.5% and 5.8%. These tumor genetic details of Cervical Squamous Cell Carcinoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Cervical Squamous Cell Carcinoma.
Significance of Nutrition for Cervical Squamous Cell Carcinoma
All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Cervical Squamous Cell Carcinoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.
For example Strawberry includes active ingredients Ellagic Acid, Vitamin C, Lupeol, Beta-sitosterol, Fisetin and others. And Mulberry contains active ingredients Resveratrol, Morusin, Moracin P, Deoxynojirimycin and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.
For cancers like Cervical Squamous Cell Carcinoma, activation or inhibition of selected biochemical pathways like Angiogenesis, Hypoxia, PI3K-AKT-MTOR Signaling, Oncogenic Histone Methylation plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Cervical Squamous Cell Carcinoma, while eating some other foods and supplements may not be recommended.
One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.
RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR CERVICAL SQUAMOUS CELL CARCINOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.
Foods for Cervical Squamous Cell Carcinoma undergoing chemotherapy treatment
In Cervical Squamous Cell Carcinoma – the genes PIK3CA, KMT2D, FBXW7, KMT2C and TERT have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Cervical Squamous Cell Carcinoma are Angiogenesis, Hypoxia, Extracellular Matrix Remodelling and others. Bevacizumab is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Angiogenesis, Hypoxia, Extracellular Matrix Remodelling so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.
RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.
Eat more pulses, Adzuki Bean or Pigeon Pea?
Pulses are an important part of many diets. The active ingredients contained in Adzuki Bean are Isoliquiritigenin, Glucaric Acid, Genistein, Folic Acid among others. While the active ingredients contained in Pigeon Pea are Vitamin C, Linolenic Acid, Oleic Acid, Genistein, Vitamin A and others.
Glucaric Acid can manipulate biochemical pathways Epithelial to Mesenchymal Transition, MYC Signaling and MAPK Signaling. Isoliquiritigenin has biological action on biochemical pathways Chemokine Signaling, Growth Factor Signaling and TGFB Signaling.
Vitamin A can manipulate biochemical pathways Extracellular Matrix Remodelling, Notch Signaling and Focal Adhesion. Oleic Acid has biological action on biochemical pathways Epithelial to Mesenchymal Transition, Cytoskeletal Dynamics and Focal Adhesion. And so on.
When treating Cervical Squamous Cell Carcinoma with chemotherapy Bevacizumab – Foods like Adzuki Bean are recommended compared to Pigeon Pea. This is because the active ingredients Vitamin A and Oleic Acid in Pigeon Pea interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Glucaric Acid and Isoliquiritigenin contained in Adzuki Bean support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: ADZUKI BEAN IS RECOMMENDED OVER PIGEON PEA FOR CERVICAL SQUAMOUS CELL CARCINOMA ON TREATMENT WITH CHEMOTHERAPY BEVACIZUMAB FOR SOME CONDITIONS.
Eat more vegetables, Kohlrabi or Endive?
Vegetables are an important part of many diets. The active ingredients contained in Kohlrabi are Vitamin C, Beta-sitosterol, Brassinin, Linolenic Acid, Kaempferol among others. While the active ingredients contained in Endive are Quercetin, Vitamin C, Linolenic Acid, Kaempferol, Oleic Acid and others.
Vitamin C can manipulate biochemical pathways Epithelial to Mesenchymal Transition, MYC Signaling and WNT Beta Catenin Signaling. Brassinin has biological action on biochemical pathways Chemokine Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling.
Vitamin A can manipulate biochemical pathways Extracellular Matrix Remodelling, Notch Signaling and Focal Adhesion. Oleic Acid has biological action on biochemical pathways Epithelial to Mesenchymal Transition, Cytoskeletal Dynamics and Focal Adhesion. And so on.
When treating Cervical Squamous Cell Carcinoma with chemotherapy Bevacizumab – Foods like Kohlrabi are recommended compared to Endive. This is because the active ingredients Vitamin A and Oleic Acid in Endive interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Brassinin contained in Kohlrabi support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: KOHLRABI IS RECOMMENDED OVER ENDIVE FOR CERVICAL SQUAMOUS CELL CARCINOMA ON TREATMENT WITH CHEMOTHERAPY BEVACIZUMAB FOR SOME CONDITIONS.
Eat more fruits, Mulberry or Strawberry?
Fruits are an important part of many diets. The active ingredients contained in Mulberry are Resveratrol, Morusin, Moracin P, Deoxynojirimycin among others. While the active ingredients contained in Strawberry are Ellagic Acid, Vitamin C, Lupeol, Beta-sitosterol, Fisetin and others.
Morusin can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Extracellular Matrix Remodelling and Growth Factor Signaling. Deoxynojirimycin has biological action on biochemical pathways Epithelial to Mesenchymal Transition.
Fisetin can manipulate biochemical pathways Epithelial to Mesenchymal Transition and MYC Signaling. Ellagic Acid has biological action on biochemical pathways Epithelial to Mesenchymal Transition and MYC Signaling. And so on.
When treating Cervical Squamous Cell Carcinoma with chemotherapy Bevacizumab – Foods like Mulberry are recommended compared to Strawberry. This is because the active ingredients Fisetin and Ellagic Acid in Strawberry interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Morusin and Deoxynojirimycin contained in Mulberry support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: MULBERRY IS RECOMMENDED OVER STRAWBERRY FOR CERVICAL SQUAMOUS CELL CARCINOMA ON TREATMENT WITH CHEMOTHERAPY BEVACIZUMAB FOR SOME CONDITIONS.
Eat more nuts, Pine Nut or Pumpkin Seeds?
Nuts are an important part of many diets. The active ingredients contained in Pine Nut are Beta-sitosterol, Vitamin E, Linolenic Acid, Oleic Acid, Vitamin A among others. While the active ingredients contained in Pumpkin Seeds are Cucurbitacin I, Beta-sitosterol, Gamma-linolenic Acid, Linolenic Acid, Salicylic Acid and others.
Beta-sitosterol can manipulate biochemical pathways Epithelial to Mesenchymal Transition, MYC Signaling and WNT Beta Catenin Signaling. Vitamin K has biological action on biochemical pathways PI3K-AKT-MTOR Signaling and MYC Signaling.
Lecithin can manipulate biochemical pathways Chemokine Signaling, Cytoskeletal Dynamics and MYC Signaling. Cucurbitacin I has biological action on biochemical pathways EPHRIN Signaling and MYC Signaling. And so on.
When treating Cervical Squamous Cell Carcinoma with chemotherapy Bevacizumab – Foods like Pine Nut are recommended compared to Pumpkin Seeds. This is because the active ingredients Lecithin and Cucurbitacin I in Pumpkin Seeds interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin K contained in Pine Nut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: PINE NUT IS RECOMMENDED OVER PUMPKIN SEEDS FOR CERVICAL SQUAMOUS CELL CARCINOMA ON TREATMENT WITH CHEMOTHERAPY BEVACIZUMAB FOR SOME CONDITIONS.
Foods for Genetic Risk of Cervical Squamous Cell Carcinoma
One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. FBXW7 and PIK3CA are two genes whose abnormalities are risk factors for Cervical Squamous Cell Carcinoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Cervical Squamous Cell Carcinoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Cervical Squamous Cell Carcinoma gene FBXW7 has causative impact on biological pathways like Antigen Presentation and Post Translation Modification. And PIK3CA has a causative impact on biological pathways like Angiogenesis and Hematopoiesis. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like FBXW7 and PIK3CA should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes FBXW7 and PIK3CA should be avoided.
Eat more pulses, Common Pea or Soy Bean?
The active ingredients contained in Common Pea are Lupeol, Daidzein, Beta-sitosterol, Vitamin C, Oleic Acid among others. While the active ingredients contained in Soy Bean are Lupeol, Quercetin, Daidzein, Vitamin E, Beta-sitosterol and others.
Beta-sitosterol can manipulate biochemical pathways Apoptosis, Cell Cycle and MYC Signaling. Vitamin C has biological action on biochemical pathways P53 Signaling, Cell Cycle Checkpoints and MAPK Signaling.
Aescin can manipulate biochemical pathways Cell Cycle Checkpoints. Lecithin has biological action on biochemical pathways MYC Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling. And so on.
For genetic risk of Cervical Squamous Cell Carcinoma due to abnormalities in genes FBXW7 and PIK3CA – Foods like Common Pea are recommended compared to Soy Bean. This is because the active ingredients Aescin and Lecithin in Soy Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin C contained in Common Pea together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: COMMON PEA IS RECOMMENDED OVER SOY BEAN FOR REDUCING THE GENETIC RISK OF CERVICAL SQUAMOUS CELL CARCINOMA DUE TO GENES FBXW7 AND PIK3CA
Eat more vegetables, Arugula or Bell Pepper?
The active ingredients contained in Arugula are Esculin, Kaempferol, Vitamin A, Vitamin K, Erysolin among others. While the active ingredients contained in Bell Pepper are Vitamin E, Capsaicin, Vitamin C, Oleic Acid, Linolenic Acid and others.
Kaempferol can manipulate biochemical pathways RAS-RAF Signaling, Cell Cycle Checkpoints and Cell Cycle. Vitamin K has biological action on biochemical pathways MYC Signaling, PI3K-AKT-MTOR Signaling and Cell Cycle Checkpoints.
Capsaicin can manipulate biochemical pathways MAPK Signaling. Folic Acid has biological action on biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. And so on.
For genetic risk of Cervical Squamous Cell Carcinoma due to abnormalities in genes FBXW7 and PIK3CA – Foods like Arugula are recommended compared to Bell Pepper. This is because the active ingredients Capsaicin and Folic Acid in Bell Pepper further promote the effects of genes on the biochemical pathways. While the active ingredients Kaempferol and Vitamin K contained in Arugula together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: ARUGULA IS RECOMMENDED OVER BELL PEPPER FOR REDUCING THE GENETIC RISK OF CERVICAL SQUAMOUS CELL CARCINOMA DUE TO GENES FBXW7 AND PIK3CA
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
Eat more fruits, Feijoa or Grape?
The active ingredients contained in Feijoa are Lycopene, Vitamin C, Casuarinin, Folic Acid among others. While the active ingredients contained in Grape are Lupeol, Vitamin E, Resveratrol, Beta-sitosterol, Pterostilbene and others.
Vitamin C can manipulate biochemical pathways Apoptosis, Cell Cycle and MYC Signaling. Lycopene has biological action on biochemical pathways P53 Signaling, Cell Cycle Checkpoints and MAPK Signaling.
Resveratrol can manipulate biochemical pathways P53 Signaling. Pelargonidin has biological action on biochemical pathways MYC Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling. And so on.
For genetic risk of Cervical Squamous Cell Carcinoma due to abnormalities in genes FBXW7 and PIK3CA – Foods like Feijoa are recommended compared to Grape. This is because the active ingredients Resveratrol and Pelargonidin in Grape further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Lycopene contained in Feijoa together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: FEIJOA IS RECOMMENDED OVER GRAPE FOR REDUCING THE GENETIC RISK OF CERVICAL SQUAMOUS CELL CARCINOMA DUE TO GENES FBXW7 AND PIK3CA
Eat more nuts, Pecan Nut or Brazil Nut?
The active ingredients contained in Pecan Nut are Vitamin E, Cianidanol, Oleic Acid, Linolenic Acid, Linoleic Acid among others. While the active ingredients contained in Brazil Nut are Vitamin E, Oleic Acid, Linolenic Acid, Lecithin, Folic Acid and others.
Vitamin E can manipulate biochemical pathways Apoptosis, Cell Cycle and MYC Signaling. Cianidanol has biological action on biochemical pathways P53 Signaling, Cell Cycle Checkpoints and MAPK Signaling.
Lecithin can manipulate biochemical pathways MYC Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways Apoptosis, P53 Signaling and Cell Cycle Checkpoints. And so on.
For genetic risk of Cervical Squamous Cell Carcinoma due to abnormalities in genes FBXW7 and PIK3CA – Foods like Pecan Nut are recommended compared to Brazil Nut. This is because the active ingredients Lecithin and Folic Acid in Brazil Nut further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin E and Cianidanol contained in Pecan Nut together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: PECAN NUT IS RECOMMENDED OVER BRAZIL NUT FOR REDUCING THE GENETIC RISK OF CERVICAL SQUAMOUS CELL CARCINOMA DUE TO GENES FBXW7 AND PIK3CA
In Summary
An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.
“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.
The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.
You can get started NOW and design a personalized nutrition plan for Cervical Squamous Cell Carcinoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
References
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Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.