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What Foods are Recommended for Cancer?
is a very common question. Personalized Nutrition Plans are foods and supplements which are personalized to a cancer indication, genes, any treatments and lifestyle conditions.

Foods for Cervical Squamous Cell Carcinoma!

Aug 4, 2023

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Introduction

Foods for Cervical Squamous Cell Carcinoma should be personalized for each individual and also must adapt when cancer treatment or tumor genetic change. The personalization and adaptation must consider all the active ingredients or bioactives contained in different foods with respect to cancer tissue biology, genetics, treatments, lifestyle conditions and diet preferences. Hence while nutrition is one of the very important decisions for a cancer patient and individual at risk of cancer to make – how to choose foods to eat is not an easy task.

Cervical squamous cell carcinoma, a significant subtype of cervical cancer, is characterized by the presence of malignant cells in the squamous cells of the cervix. Understanding this cancer’s pathology is crucial for effective treatment and management, as detailed in cervical squamous cell carcinoma pathology outlines. The classification of this cancer, including the in situ stage (early-stage cancer confined to the surface cells) and more advanced stages like stage 3 cervical squamous cell carcinoma, is critical for determining the appropriate course of action. This classification is also reflected in its ICD-10 coding, which is essential for medical documentation and treatment planning.

The staging of cervical squamous cell carcinoma plays a vital role in prognosis and treatment decisions. It can coexist with other types of cervical cancers, such as endocervical adenocarcinoma, posing a unique challenge in diagnosis and treatment. The treatment for cervical squamous cell carcinoma typically involves a combination of surgery, radiation therapy, and chemotherapy, tailored to the individual’s stage and overall health. Recognizing the symptoms of cervical squamous cell carcinoma early can lead to more effective management and better outcomes.

Non-keratinizing cervical squamous cell carcinoma is a specific histological type that has different characteristics from the more common keratinizing variant. In cases where there is a combination of cervical adenocarcinoma and squamous cell carcinoma, the treatment approach may vary. The squamous cell carcinoma cervical cancer survival rate depends on various factors, including the cancer’s stage at diagnosis and the effectiveness of the treatment regimen. With advancements in medical science, the treatment options and survival rates for squamous cell carcinoma in cervical cancer continue to improve, offering hope to those affected by this condition.



For Cervical Squamous Cell Carcinoma does it matter what vegetables, fruits, nuts, seeds one eats?

A very common nutrition question asked by cancer patients and individuals at-genetic risk of cancer is – for cancers like Cervical Squamous Cell Carcinoma does it matter what foods I eat and which I do not? Or if I follow a plant-based diet is that enough for cancer like Cervical Squamous Cell Carcinoma?

For example does it matter if vegetable New Zealand Spinach is consumed more compared to Garland Chrysanthemum? Does it make any difference if fruit Elderberry is preferred over Pomegranate? Also if similar choices are made for nuts/seeds like Butternut over European Chestnut and for pulses like Moth Bean over Catjang Pea. And if what I eat matters – then how does one identify foods which are recommended for Cervical Squamous Cell Carcinoma and is it the same answer for everyone with the same diagnosis or genetic risk?

Yes! Foods you eat matters for Cervical Squamous Cell Carcinoma!

Food recommendations may not be the same for everyone and can be different even for the same diagnosis and genetic risk.

All cancers like Cervical Squamous Cell Carcinoma can be characterized by a unique set of biochemical pathways - the signature pathways of Cervical Squamous Cell Carcinoma. Biochemical pathways like Cell Cycle, Growth Factor Signaling, PI3K-AKT-MTOR Signaling, Oncogenic Histone Methylation are part of the signature definition of Cervical Squamous Cell Carcinoma.

All foods (vegetables, fruits, nuts, seeds, pulses, oils etc.) and nutritional supplements are made up of more than one active molecular ingredient or bio-actives in different proportions and quantities. Each active ingredient has a unique mechanism of action – which can be activation or inhibition of different biochemical pathways. Simply stated foods and supplements which are recommended are those which do not cause an increase of molecular drivers of cancer but reduce them. Else those foods should not be recommended. Foods contain multiple active ingredients – hence when evaluating foods and supplements you need to consider the impact of all active ingredients cumulatively rather than individually.

For example Elderberry contains active ingredients Curcumin, Quercetin, Apigenin, Lupeol, Formononetin. And Pomegranate contains active ingredients Ellagic Acid, Curcumin, Quercetin, Apigenin, Lupeol and possibly others.

A common mistake made when deciding and choosing foods to eat for Cervical Squamous Cell Carcinoma – is to evaluate only selected active ingredients contained in foods and ignore the rest. Because different active ingredients contained in foods may have opposing effects on cancer drivers – you cannot cherry pick active ingredients in foods and supplements for making a nutrition decision for Cervical Squamous Cell Carcinoma.

YES – FOOD CHOICES MATTER FOR CANCER. NUTRITION DECISIONS MUST CONSIDER ALL ACTIVE INGREDIENTS OF FOODS.

Skills Needed for Nutrition Personalization for Cervical Squamous Cell Carcinoma?

Personalized nutrition for cancers like Cervical Squamous Cell Carcinoma consists of recommended foods / supplements; not recommended foods / supplements with example recipes which prioritize use of recommended foods. An example of personalized nutrition can be seen at this link.

Deciding which foods are recommended or not is extremely complicated, requiring expertise in Cervical Squamous Cell Carcinoma biology, food science, genetics, biochemistry along with good understanding of how cancer treatments work and associated vulnerabilities by which the treatments could stop being effective.

MINIMUM KNOWLEDGE EXPERTISE NEEDED FOR NUTRITION PERSONALIZATION FOR CANCER ARE: CANCER BIOLOGY, FOOD SCIENCE, CANCER TREATMENTS AND GENETICS.

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.

Characteristics of cancers like Cervical Squamous Cell Carcinoma

All cancers like Cervical Squamous Cell Carcinoma can be characterized by a unique set of biochemical pathways – the signature pathways of Cervical Squamous Cell Carcinoma. Biochemical pathways like Cell Cycle, Growth Factor Signaling, PI3K-AKT-MTOR Signaling, Oncogenic Histone Methylation are part of the signature definition of Cervical Squamous Cell Carcinoma. Each individual’s cancer genetics can be different and hence their specific cancer signature could be unique.

The treatments which are effective for Cervical Squamous Cell Carcinoma need to be cognizant of the associated signature biochemical pathways for each cancer patient and individual at genetic risk. Therefore different treatments with different mechanisms of actions are effective for different patients. Similarly and for the same reasons foods and supplements need to be personalized for each individual. Hence some foods and supplements are recommended for Cervical Squamous Cell Carcinoma when taking cancer treatment Topotecan, and some foods and supplements are not recommended.

Sources like cBioPortal and many others provide population representative patient anonymized data from clinical trials for all cancer indications. This data consists of clinical trial study details like sample size / number of patients, age groups, gender, ethnicity, treatments, tumor site and any genetic mutations.

PIK3CA, KMT2D, FBXW7, KMT2C and TERT are the top ranked reported genes for Cervical Squamous Cell Carcinoma. PIK3CA is reported in 13.5 % of the representative patients across all clinical trials. And KMT2D is reported in 11.0 %. The combined population patient data cover ages from 21 to 58. 0.0 % of the patient data are identified as men. The Cervical Squamous Cell Carcinoma biology along with reported genetics together define the population represented signature biochemical pathways for this cancer. If the individual cancer tumor genetics or genes contributing to the risk are also known then that should also be used for nutrition personalization.

NUTRITION CHOICES SHOULD MATCH WITH EACH INDIVIDUAL’S CANCER SIGNATURE.

Foods for Cervical Squamous Cell Carcinoma!

Food and Supplements for Cervical Squamous Cell Carcinoma

For Cancer Patients

Cancer patients on treatment or on palliative care need to make decisions on food and supplements – for the needed dietary calories, for managing any treatment side effects and also for improved cancer management. All plant-based foods are not equal and choosing and prioritizing foods which are personalized and customized to ongoing cancer treatment is important and complicated. Here are some examples providing guidelines for making nutrition decisions.

Choose Vegetable NEW ZEALAND SPINACH or GARLAND CHRYSANTHEMUM?

Vegetable New Zealand Spinach contains many active ingredients or bioactives such as Curcumin, Quercetin, Apigenin, Lupeol, Formononetin. These active ingredients manipulate various biochemical pathways like NFKB Signaling, JAK-STAT Signaling, PI3K-AKT-MTOR Signaling and Cell Cycle and others. New Zealand Spinach is recommended for Cervical Squamous Cell Carcinoma when ongoing cancer treatment is Topotecan. This is because New Zealand Spinach modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Topotecan.

Some of the active ingredients or bioactives in vegetable Garland Chrysanthemum are Curcumin, Apigenin, Lupeol, Formononetin, Phloretin. These active ingredients manipulate various biochemical pathways like TGFB Signaling, Epithelial to Mesenchymal Transition and DNA Repair and others. Garland Chrysanthemum is not recommended for Cervical Squamous Cell Carcinoma when ongoing cancer treatment is Topotecan because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

VEGETABLE NEW ZEALAND SPINACH IS RECOMMENDED OVER GARLAND CHRYSANTHEMUM FOR Cervical Squamous Cell Carcinoma AND TREATMENT Topotecan.

Choose Fruit POMEGRANATE or ELDERBERRY?

Fruit Pomegranate contains many active ingredients or bioactives such as Ellagic Acid, Curcumin, Quercetin, Apigenin, Lupeol. These active ingredients manipulate various biochemical pathways like NFKB Signaling, JAK-STAT Signaling, PI3K-AKT-MTOR Signaling and Cell Cycle and others. Pomegranate is recommended for Cervical Squamous Cell Carcinoma when ongoing cancer treatment is Topotecan. This is because Pomegranate modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Topotecan.

Some of the active ingredients or bioactives in fruit Elderberry are Curcumin, Quercetin, Apigenin, Lupeol, Formononetin. These active ingredients manipulate various biochemical pathways like WNT Beta Catenin Signaling, TGFB Signaling and Epithelial to Mesenchymal Transition and others. Elderberry is not recommended for Cervical Squamous Cell Carcinoma when ongoing cancer treatment is Topotecan because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

FRUIT POMEGRANATE IS RECOMMENDED OVER ELDERBERRY FOR Cervical Squamous Cell Carcinoma AND TREATMENT Topotecan.

Choose Nut BUTTERNUT or EUROPEAN CHESTNUT?

Butternut contains many active ingredients or bioactives such as Curcumin, Apigenin, Lupeol, Formononetin, Phloretin. These active ingredients manipulate various biochemical pathways like NFKB Signaling, JAK-STAT Signaling, PI3K-AKT-MTOR Signaling and Cell Cycle and others. Butternut is recommended for Cervical Squamous Cell Carcinoma when ongoing cancer treatment is Topotecan. This is because Butternut modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Topotecan.

Some of the active ingredients or bioactives in European Chestnut are Ellagic Acid, Curcumin, Quercetin, Apigenin, Lupeol. These active ingredients manipulate various biochemical pathways like TGFB Signaling, Epithelial to Mesenchymal Transition and DNA Repair and others. European Chestnut is not recommended for Cervical Squamous Cell Carcinoma when ongoing cancer treatment is Topotecan because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

BUTTERNUT IS RECOMMENDED OVER EUROPEAN CHESTNUT FOR Cervical Squamous Cell Carcinoma AND TREATMENT Topotecan.

For Individuals with Genetic Risk of Cancer

The question asked by individuals who have genetic risk of Cervical Squamous Cell Carcinoma or familial history is “What Should I Eat Differently from Before?” and how they should choose foods and supplements to manage risks of the disease. Since for cancer risk there is nothing actionable in terms of treatment – decisions of foods and supplements become important and one of the very few actionable things which can be done. All plant-based foods are not equal and based on identified genetics and pathway signature – the choices of food and supplements should be personalized.

Choose Vegetable CAULIFLOWER or YAUTIA?

Vegetable Cauliflower contains many active ingredients or bioactives such as Curcumin, Formononetin, Lupeol, Daidzein, Catechol. These active ingredients manipulate various biochemical pathways like Angiogenesis, JAK-STAT Signaling, PI3K-AKT-MTOR Signaling and P53 Signaling and others. Cauliflower is recommended for risk of Cervical Squamous Cell Carcinoma when associated genetic risk is FBXW7. This is because Cauliflower increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in vegetable Yautia are Apigenin, Curcumin, Formononetin, Lupeol, Daidzein. These active ingredients manipulate various biochemical pathways like Cell Cycle Checkpoints and Oncogenic Cancer Epigenetics and others. Yautia is not recommended when risk of Cervical Squamous Cell Carcinoma when associated genetic risk is FBXW7 because it increases the signature pathways of it.

VEGETABLE CAULIFLOWER IS RECOMMENDED OVER YAUTIA FOR FBXW7 GENETIC RISK OF CANCER.

Choose Fruit NANCE or PUMMELO?

Fruit Nance contains many active ingredients or bioactives such as Apigenin, Curcumin, Formononetin, Lupeol, Daidzein. These active ingredients manipulate various biochemical pathways like PI3K-AKT-MTOR Signaling, Hypoxia and P53 Signaling and others. Nance is recommended for risk of Cervical Squamous Cell Carcinoma when associated genetic risk is FBXW7. This is because Nance increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in fruit Pummelo are Apigenin, Quercetin, Curcumin, Formononetin, Lupeol. These active ingredients manipulate various biochemical pathways like Cell Cycle Checkpoints and Notch Signaling and others. Pummelo is not recommended when risk of Cervical Squamous Cell Carcinoma when associated genetic risk is FBXW7 because it increases the signature pathways of it.

FRUIT NANCE IS RECOMMENDED OVER PUMMELO FOR FBXW7 GENETIC RISK OF CANCER.

Choose Nut COMMON WALNUT or CHESTNUT?

Common Walnut contains many active ingredients or bioactives such as Quercetin, Curcumin, Ellagic Acid, Formononetin, Lupeol. These active ingredients manipulate various biochemical pathways like Angiogenesis, RAS-RAF Signaling, JAK-STAT Signaling and PI3K-AKT-MTOR Signaling and others. Common Walnut is recommended for risk of Cervical Squamous Cell Carcinoma when associated genetic risk is FBXW7. This is because Common Walnut increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in Chestnut are Apigenin, Curcumin, Ellagic Acid, Formononetin, Lupeol. These active ingredients manipulate various biochemical pathways like PI3K-AKT-MTOR Signaling and Oncogenic Cancer Epigenetics and others. Chestnut is not recommended when risk of Cervical Squamous Cell Carcinoma when associated genetic risk is FBXW7 because it increases the signature pathways of it.

COMMON WALNUT IS RECOMMENDED OVER CHESTNUT FOR FBXW7 GENETIC RISK OF CANCER.


In Conclusion

Foods and Supplements chosen are important decisions for cancers like Cervical Squamous Cell Carcinoma. Cervical Squamous Cell Carcinoma patients and individuals with genetic-risk always have this question: “What foods and nutritional supplements are recommended for me and which are not?” There is a common belief which is a misconception that all plant-based foods could be beneficial or not but would not be harmful. Certain foods and supplements can interfere with cancer treatments or promote molecular pathway drivers of cancer.

There are different types of cancer indications like Cervical Squamous Cell Carcinoma, each with different tumor genetics with further genomic variations across each individual. Further every cancer treatment and chemotherapy has a unique mechanism of action. Each food like New Zealand Spinach contains various bioactives in different quantities, which have an impact on different and distinct sets of biochemical pathways. The definition of personalized nutrition is individualized food recommendations for the cancer indication, treatments, genetics, lifestyle and other factors. Nutrition personalization decisions for cancer require knowledge of cancer biology, food science and an understanding of different chemotherapy treatments. Finally when there are treatment changes or new genomics is identified – the nutrition personalization needs re-evaluation.

The addon nutrition personalization solution makes the decision making easy and removes all the guesswork in answering the question, “What foods should I choose or not choose for Cervical Squamous Cell Carcinoma?”. The addon multi-disciplinary team includes cancer physicians, clinical scientists, software engineers and data scientists.


Personalized Nutrition for Cancer!

Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.

References

Scientifically Reviewed by: Dr. Cogle

Christopher R. Cogle, M.D. is a tenured professor at the University of Florida, Chief Medical Officer of Florida Medicaid, and Director of the Florida Health Policy Leadership Academy at the Bob Graham Center for Public Service.

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