Which Foods are Recommended for Non-small Cell Lung Cancer?

Highlights

No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Non-small Cell Lung Cancer when undergoing chemotherapy or when you determine you have a genetic risk for developing Non-small Cell Lung Cancer because of LRP2 and CACNA1E gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.

There is no one answer to this question for cancers such as Non-small Cell Lung Cancer which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.

In short – the process to answer questions like “Should I Avoid eating fruit Sea Buckthorn” or “Include fruit Saskatoon Berry in my diet” or “Should I reduce consumption of vegetable Swede” or “Can I take D-limonene and Alpha Lipoic Acid supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.

RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO NON-SMALL CELL LUNG CANCER, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.

The overall objective of personalized nutrition for Non-small Cell Lung Cancer is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.

RECOMMENDATION: UPDATE YOUR NUTRITION FOR NON-SMALL CELL LUNG CANCER, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.

About Non-small Cell Lung Cancer

cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.

Following key highlights are derived from clinical data for Non-small Cell Lung Cancer from cBioPortal. The patients enrolled in the studies for Non-small Cell Lung Cancer are in ages between 37 to 88 with an average age of 65. 49.4% of males and 50.6% of females were the distribution of gender in these clinical studies. From a patient sample size of 152; the top genes with mutations and other abnormalities for Non-small Cell Lung Cancer include genes LRP2, CACNA1E, SI, TIAM1 and COL6A3. The occurrence frequency distribution for these genes respectively is 10.1%, 9.4%, 9.4%, 8.1% and 6.7%. These tumor genetic details of Non-small Cell Lung Cancer are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Non-small Cell Lung Cancer.

Significance of Nutrition for Non-small Cell Lung Cancer

All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Non-small Cell Lung Cancer. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.

For example Sea Buckthorn includes active ingredients Vitamin C, Linolenic Acid, Isorhamnetin, Beta-sitosterol, Oleic Acid and others. And Saskatoon Berry contains active ingredients Quercetin, Delphinidin and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.

For cancers like Non-small Cell Lung Cancer, activation or inhibition of selected biochemical pathways like RAS-RAF Signaling, Apoptosis, Small Molecule Transport, Extracellular Matrix Remodelling plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Non-small Cell Lung Cancer, while eating some other foods and supplements may not be recommended.

One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.

RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR NON-SMALL CELL LUNG CANCER – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.

Foods for Non-small Cell Lung Cancer undergoing chemotherapy treatment

In Non-small Cell Lung Cancer – the genes LRP2, CACNA1E, SI, TIAM1 and COL6A3 have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Non-small Cell Lung Cancer are RAS-RAF Signaling, Apoptosis, NFKB Signaling and others. Erlotinib is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers RAS-RAF Signaling, Apoptosis, NFKB Signaling so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.

RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.

Eat more pulses, Winged Bean or Lima Bean?

Pulses are an important part of many diets. The active ingredients contained in Winged Bean are Betulinic Acid, Vitamin C, Linolenic Acid, Oleic Acid, Linoleic Acid among others. While the active ingredients contained in Lima Bean are Vitamin C, Genistein, Oleic Acid, Linoleic Acid, Vitamin A and others.

Betulinic Acid can manipulate biochemical pathways Extracellular Matrix Remodelling, MAPK Signaling and WNT Beta Catenin Signaling. Vitamin C has biological action on biochemical pathways RAS-RAF Signaling, NFKB Signaling and P53 Signaling.

Vitamin A can manipulate biochemical pathways Extracellular Matrix Remodelling. Oleic Acid has biological action on biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and Extracellular Matrix Remodelling. And so on.

When treating Non-small Cell Lung Cancer with chemotherapy Erlotinib – Foods like Winged Bean are recommended compared to Lima Bean. This is because the active ingredients Vitamin A and Oleic Acid in Lima Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Betulinic Acid and Vitamin C contained in Winged Bean support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: WINGED BEAN IS RECOMMENDED OVER LIMA BEAN FOR NON-SMALL CELL LUNG CANCER ON TREATMENT WITH CHEMOTHERAPY ERLOTINIB FOR SOME CONDITIONS.

Eat more vegetables, Kohlrabi or Swede?

Vegetables are an important part of many diets. The active ingredients contained in Kohlrabi are Vitamin C, Linolenic Acid, Beta-sitosterol, Indole-3-carbinol, Sulforaphane among others. While the active ingredients contained in Swede are Lycopene, Linolenic Acid, Oleic Acid, Linoleic Acid, Folic Acid and others.

Vitamin C can manipulate biochemical pathways WNT Beta Catenin Signaling, MAPK Signaling and RAS-RAF Signaling. Brassinin has biological action on biochemical pathways Extracellular Matrix Remodelling, NFKB Signaling and P53 Signaling.

Oleic Acid can manipulate biochemical pathways Extracellular Matrix Remodelling, Epithelial to Mesenchymal Transition and NFKB Signaling. Linoleic Acid has biological action on biochemical pathways Growth Factor Signaling, TGFB Signaling and Extracellular Matrix Remodelling. And so on.

When treating Non-small Cell Lung Cancer with chemotherapy Erlotinib – Foods like Kohlrabi are recommended compared to Swede. This is because the active ingredients Oleic Acid and Linoleic Acid in Swede interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Brassinin contained in Kohlrabi support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: KOHLRABI IS RECOMMENDED OVER SWEDE FOR NON-SMALL CELL LUNG CANCER ON TREATMENT WITH CHEMOTHERAPY ERLOTINIB FOR SOME CONDITIONS.

Eat more fruits, Saskatoon Berry or Sea Buckthorn?

Fruits are an important part of many diets. The active ingredients contained in Saskatoon Berry are Quercetin, Delphinidin among others. While the active ingredients contained in Sea Buckthorn are Vitamin C, Linolenic Acid, Isorhamnetin, Beta-sitosterol, Oleic Acid and others.

Delphinidin can manipulate biochemical pathways Extracellular Matrix Remodelling, MAPK Signaling and RAS-RAF Signaling. Quercetin has biological action on biochemical pathways WNT Beta Catenin Signaling, NFKB Signaling and P53 Signaling.

Vitamin A can manipulate biochemical pathways Extracellular Matrix Remodelling. Oleic Acid has biological action on biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and Extracellular Matrix Remodelling. And so on.

When treating Non-small Cell Lung Cancer with chemotherapy Erlotinib – Foods like Saskatoon Berry are recommended compared to Sea Buckthorn. This is because the active ingredients Vitamin A and Oleic Acid in Sea Buckthorn interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Delphinidin and Quercetin contained in Saskatoon Berry support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: SASKATOON BERRY IS RECOMMENDED OVER SEA BUCKTHORN FOR NON-SMALL CELL LUNG CANCER ON TREATMENT WITH CHEMOTHERAPY ERLOTINIB FOR SOME CONDITIONS.

Eat more nuts, Pistachio or Macadamia Nut?

Nuts are an important part of many diets. The active ingredients contained in Pistachio are Resveratrol, Vitamin E, Linolenic Acid, Beta-sitosterol, Oleic Acid among others. While the active ingredients contained in Macadamia Nut are Beta-sitosterol, Palmitic Acid, Lauric Acid, Myristic Acid, Folic Acid and others.

Beta-sitosterol can manipulate biochemical pathways WNT Beta Catenin Signaling, NFKB Signaling and P53 Signaling. Resveratrol has biological action on biochemical pathways Extracellular Matrix Remodelling, RAS-RAF Signaling and MYC Signaling.

Palmitic Acid can manipulate biochemical pathways Extracellular Matrix Remodelling, MAPK Signaling and WNT Beta Catenin Signaling. Lauric Acid has biological action on biochemical pathways NFKB Signaling, MYC Signaling and PI3K-AKT-MTOR Signaling. And so on.

When treating Non-small Cell Lung Cancer with chemotherapy Erlotinib – Foods like Pistachio are recommended compared to Macadamia Nut. This is because the active ingredients Palmitic Acid and Lauric Acid in Macadamia Nut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Resveratrol contained in Pistachio support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: PISTACHIO IS RECOMMENDED OVER MACADAMIA NUT FOR NON-SMALL CELL LUNG CANCER ON TREATMENT WITH CHEMOTHERAPY ERLOTINIB FOR SOME CONDITIONS.

Foods for Genetic Risk of Non-small Cell Lung Cancer

One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. LRP2 and CACNA1E are two genes whose abnormalities are risk factors for Non-small Cell Lung Cancer. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Non-small Cell Lung Cancer can be used as a guide for coming up with a recommended personalized nutrition plan. For Non-small Cell Lung Cancer gene LRP2 has causative impact on biological pathways like . And CACNA1E has a causative impact on biological pathways like MAPK Signaling. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like LRP2 and CACNA1E should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes LRP2 and CACNA1E should be avoided.

Eat more pulses, Mung Bean or Pigeon Pea?

The active ingredients contained in Mung Bean are Quercetin, Vitamin C, Kaempferol, Linolenic Acid, Oleic Acid among others. While the active ingredients contained in Pigeon Pea are Vitamin C, Linolenic Acid, Oleic Acid, Linoleic Acid, Genistein and others.

Quercetin can manipulate biochemical pathways Cell Cycle Checkpoints, P53 Signaling and PI3K-AKT-MTOR Signaling. Vitamin C has biological action on biochemical pathways Cell Cycle, P53 Signaling and Cell Cycle Checkpoints.

Folic Acid can manipulate biochemical pathways P53 Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling. And so on.

For genetic risk of Non-small Cell Lung Cancer due to abnormalities in genes LRP2 and CACNA1E – Foods like Mung Bean are recommended compared to Pigeon Pea. This is because the active ingredients Folic Acid in Pigeon Pea further promote the effects of genes on the biochemical pathways. While the active ingredients Quercetin and Vitamin C contained in Mung Bean together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: MUNG BEAN IS RECOMMENDED OVER PIGEON PEA FOR REDUCING THE GENETIC RISK OF NON-SMALL CELL LUNG CANCER DUE TO GENES LRP2 AND CACNA1E

Eat more vegetables, Artichoke or Parsnip?

The active ingredients contained in Artichoke are Apigenin, Vitamin C, Cynaroside, Luteolin, Chlorogenic Acid among others. While the active ingredients contained in Parsnip are Quercetin, Ferulic Acid, Bergapten, Vitamin C, P-coumaric Acid and others.

Vitamin K can manipulate biochemical pathways Cell Cycle Checkpoints, Cell Cycle and PI3K-AKT-MTOR Signaling. Apigenin has biological action on biochemical pathways P53 Signaling, EPHRIN Signaling and Cell Cycle Checkpoints.

Imperatorin can manipulate biochemical pathways Small Molecule Transport. Folic Acid has biological action on biochemical pathways P53 Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling. And so on.

For genetic risk of Non-small Cell Lung Cancer due to abnormalities in genes LRP2 and CACNA1E – Foods like Artichoke are recommended compared to Parsnip. This is because the active ingredients Imperatorin and Folic Acid in Parsnip further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin K and Apigenin contained in Artichoke together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: ARTICHOKE IS RECOMMENDED OVER PARSNIP FOR REDUCING THE GENETIC RISK OF NON-SMALL CELL LUNG CANCER DUE TO GENES LRP2 AND CACNA1E

Eat more fruits, Date or Elderberry?

The active ingredients contained in Date are Apigenin, Quercetin, Lupeol, Beta-sitosterol, Ferulic Acid among others. While the active ingredients contained in Elderberry are Quercetin, Lupeol, Betulinic Acid, Vitamin C, Kaempferol and others.

Apigenin can manipulate biochemical pathways Cell Cycle Checkpoints, P53 Signaling and PI3K-AKT-MTOR Signaling. Quercetin has biological action on biochemical pathways EPHRIN Signaling, Cell Cycle and Small Molecule Transport.

Rutin can manipulate biochemical pathways Extracellular Matrix Remodelling. Isorhamnetin has biological action on biochemical pathways Small Molecule Transport. And so on.

For genetic risk of Non-small Cell Lung Cancer due to abnormalities in genes LRP2 and CACNA1E – Foods like Date are recommended compared to Elderberry. This is because the active ingredients Rutin and Isorhamnetin in Elderberry further promote the effects of genes on the biochemical pathways. While the active ingredients Apigenin and Quercetin contained in Date together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: DATE IS RECOMMENDED OVER ELDERBERRY FOR REDUCING THE GENETIC RISK OF NON-SMALL CELL LUNG CANCER DUE TO GENES LRP2 AND CACNA1E

Eat more nuts, Almond or Brazil Nut?

The active ingredients contained in Almond are Quercetin, Vitamin E, Beta-sitosterol, Linolenic Acid, Oleic Acid among others. While the active ingredients contained in Brazil Nut are Vitamin E, Linolenic Acid, Oleic Acid, Lecithin, Folic Acid and others.

Beta-sitosterol can manipulate biochemical pathways P53 Signaling, Cell Cycle Checkpoints and Cell Cycle. Quercetin has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, EPHRIN Signaling and Small Molecule Transport.

Lecithin can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways P53 Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling. And so on.

For genetic risk of Non-small Cell Lung Cancer due to abnormalities in genes LRP2 and CACNA1E – Foods like Almond are recommended compared to Brazil Nut. This is because the active ingredients Lecithin and Folic Acid in Brazil Nut further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Quercetin contained in Almond together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: ALMOND IS RECOMMENDED OVER BRAZIL NUT FOR REDUCING THE GENETIC RISK OF NON-SMALL CELL LUNG CANCER DUE TO GENES LRP2 AND CACNA1E

In Summary

An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.

“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.

The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.

You can get started NOW and design a personalized nutrition plan for Non-small Cell Lung Cancer by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

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