Highlights
No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Uterine Myxoid Leiomyosarcoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Uterine Myxoid Leiomyosarcoma because of RNF43 and CTNNB1 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.
There is no one answer to this question for cancers such as Uterine Myxoid Leiomyosarcoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.
In short – the process to answer questions like “Should I Avoid eating fruit Pear” or “Include fruit Squashberry in my diet” or “Should I reduce consumption of vegetable Tomato” or “Can I take Eucalyptus and Theaflavin supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.
RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO UTERINE MYXOID LEIOMYOSARCOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.
The overall objective of personalized nutrition for Uterine Myxoid Leiomyosarcoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.
RECOMMENDATION: UPDATE YOUR NUTRITION FOR UTERINE MYXOID LEIOMYOSARCOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.
About Uterine Myxoid Leiomyosarcoma
cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.
Following key highlights are derived from clinical data for Uterine Myxoid Leiomyosarcoma from cBioPortal. From a patient sample size of 5; the top genes with mutations and other abnormalities for Uterine Myxoid Leiomyosarcoma include genes CTNNB1, RNF43, ATM and FAT1. The occurrence frequency distribution for these genes respectively is 25.0%, 25.0%, 25.0% and 25.0%. These tumor genetic details of Uterine Myxoid Leiomyosarcoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Uterine Myxoid Leiomyosarcoma.
Significance of Nutrition for Uterine Myxoid Leiomyosarcoma
All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Uterine Myxoid Leiomyosarcoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.
For example Pear includes active ingredients Isorhamnetin, Beta-sitosterol, Isoliquiritigenin, Caffeic Acid, Vitamin C and others. And Squashberry contains active ingredients Vitamin A, Vitamin C and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.
For cancers like Uterine Myxoid Leiomyosarcoma, activation or inhibition of selected biochemical pathways like Adherens junction, Epithelial to Mesenchymal Transition, DNA Repair, Growth Factor Signaling plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Uterine Myxoid Leiomyosarcoma, while eating some other foods and supplements may not be recommended.
One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.
RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR UTERINE MYXOID LEIOMYOSARCOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.
Foods for Uterine Myxoid Leiomyosarcoma undergoing chemotherapy treatment
In Uterine Myxoid Leiomyosarcoma – the genes CTNNB1, RNF43, ATM and FAT1 have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Uterine Myxoid Leiomyosarcoma are Adherens junction, Epithelial to Mesenchymal Transition and others. Radiation is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Adherens junction, Epithelial to Mesenchymal Transition so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.
RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.
Eat more pulses, Common Bean or Lentils?
Pulses are an important part of many diets. The active ingredients contained in Common Bean are Vitamin A, Gamma-linolenic Acid, Ferulic Acid, Vitamin C, Esculin among others. While the active ingredients contained in Lentils are Beta-sitosterol, Isoliquiritigenin, Vitamin A, Vitamin C, Esculin and others.
Vitamin A can manipulate biochemical pathways Adherens junction, Epithelial to Mesenchymal Transition and WNT Beta Catenin Signaling. Gamma-linolenic Acid has biological action on biochemical pathways Adherens junction, Epithelial to Mesenchymal Transition and WNT Beta Catenin Signaling.
Isoliquiritigenin can manipulate biochemical pathways DNA Repair. Genistein has biological action on biochemical pathways DNA Repair. And so on.
When treating Uterine Myxoid Leiomyosarcoma with chemotherapy Radiation – Foods like Common Bean are recommended compared to Lentils. This is because the active ingredients Isoliquiritigenin and Genistein in Lentils interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin A and Gamma-linolenic Acid contained in Common Bean support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: COMMON BEAN IS RECOMMENDED OVER LENTILS FOR UTERINE MYXOID LEIOMYOSARCOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Eat more vegetables, Turnip or Tomato?
Vegetables are an important part of many diets. The active ingredients contained in Turnip are Indole-3-carbinol, Vitamin A, Vitamin C, Sulforaphane among others. While the active ingredients contained in Tomato are Lycopene, Solasodine, Lupeol, Isoquercitrin, Lutein and others.
Indole-3-carbinol can manipulate biochemical pathways DNA Repair, Adherens junction and Epithelial to Mesenchymal Transition. Vitamin A has biological action on biochemical pathways WNT Beta Catenin Signaling, Adherens junction and Epithelial to Mesenchymal Transition.
Rutin can manipulate biochemical pathways WNT Beta Catenin Signaling. Linoleic Acid has biological action on biochemical pathways Epithelial to Mesenchymal Transition. And so on.
When treating Uterine Myxoid Leiomyosarcoma with chemotherapy Radiation – Foods like Turnip are recommended compared to Tomato. This is because the active ingredients Rutin and Linoleic Acid in Tomato interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Indole-3-carbinol and Vitamin A contained in Turnip support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: TURNIP IS RECOMMENDED OVER TOMATO FOR UTERINE MYXOID LEIOMYOSARCOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Eat more fruits, Squashberry or Pear?
Fruits are an important part of many diets. The active ingredients contained in Squashberry are Vitamin A, Vitamin C among others. While the active ingredients contained in Pear are Isorhamnetin, Beta-sitosterol, Isoliquiritigenin, Caffeic Acid, Vitamin C and others.
Vitamin A can manipulate biochemical pathways Adherens junction, Epithelial to Mesenchymal Transition and WNT Beta Catenin Signaling. Vitamin C has biological action on biochemical pathways Adherens junction, Epithelial to Mesenchymal Transition and WNT Beta Catenin Signaling.
Isoliquiritigenin can manipulate biochemical pathways DNA Repair. Rutin has biological action on biochemical pathways WNT Beta Catenin Signaling. And so on.
When treating Uterine Myxoid Leiomyosarcoma with chemotherapy Radiation – Foods like Squashberry are recommended compared to Pear. This is because the active ingredients Isoliquiritigenin and Rutin in Pear interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin A and Vitamin C contained in Squashberry support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: SQUASHBERRY IS RECOMMENDED OVER PEAR FOR UTERINE MYXOID LEIOMYOSARCOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Eat more nuts, Walnut or Hazelnut?
Nuts are an important part of many diets. The active ingredients contained in Walnut are Juglone, Beta-sitosterol, Betulinic Acid, Urolithin B, Vitamin A among others. While the active ingredients contained in Hazelnut are Vitamin A, Quercetin, Linolenic Acid, Vitamin E, Linoleic Acid and others.
Juglone can manipulate biochemical pathways DNA Repair, Adherens junction and Epithelial to Mesenchymal Transition. Beta-sitosterol has biological action on biochemical pathways WNT Beta Catenin Signaling, Adherens junction and Epithelial to Mesenchymal Transition.
Quercetin can manipulate biochemical pathways DNA Repair. Vitamin E has biological action on biochemical pathways DNA Repair. And so on.
When treating Uterine Myxoid Leiomyosarcoma with chemotherapy Radiation – Foods like Walnut are recommended compared to Hazelnut. This is because the active ingredients Quercetin and Vitamin E in Hazelnut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Juglone and Beta-sitosterol contained in Walnut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: WALNUT IS RECOMMENDED OVER HAZELNUT FOR UTERINE MYXOID LEIOMYOSARCOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Foods for Genetic Risk of Uterine Myxoid Leiomyosarcoma
One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. RNF43 and CTNNB1 are two genes whose abnormalities are risk factors for Uterine Myxoid Leiomyosarcoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Uterine Myxoid Leiomyosarcoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Uterine Myxoid Leiomyosarcoma gene RNF43 has causative impact on biological pathways like . And CTNNB1 has a causative impact on biological pathways like Adherens junction, Androgen Signaling and Cytoskeletal Dynamics. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like RNF43 and CTNNB1 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes RNF43 and CTNNB1 should be avoided.
Eat more pulses, Yellow Wax Bean or Pigeon Pea?
The active ingredients contained in Yellow Wax Bean are Ferulic Acid, Vitamin C, Cianidanol, Palmitic Acid, Vitamin A among others. While the active ingredients contained in Pigeon Pea are Vitamin C, Linolenic Acid, Oleic Acid, Vitamin A, Linoleic Acid and others.
Palmitic Acid can manipulate biochemical pathways Cell Cycle Checkpoints, RAS-RAF Signaling and Apoptosis. Vitamin A has biological action on biochemical pathways Epithelial to Mesenchymal Transition, WNT Beta Catenin Signaling and PI3K-AKT-MTOR Signaling.
Oleic Acid can manipulate biochemical pathways Epithelial to Mesenchymal Transition. Linoleic Acid has biological action on biochemical pathways Epithelial to Mesenchymal Transition. And so on.
For genetic risk of Uterine Myxoid Leiomyosarcoma due to abnormalities in genes RNF43 and CTNNB1 – Foods like Yellow Wax Bean are recommended compared to Pigeon Pea. This is because the active ingredients Oleic Acid and Linoleic Acid in Pigeon Pea further promote the effects of genes on the biochemical pathways. While the active ingredients Palmitic Acid and Vitamin A contained in Yellow Wax Bean together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: YELLOW WAX BEAN IS RECOMMENDED OVER PIGEON PEA FOR REDUCING THE GENETIC RISK OF UTERINE MYXOID LEIOMYOSARCOMA DUE TO GENES RNF43 AND CTNNB1
Eat more vegetables, Cassava or Carob?
The active ingredients contained in Cassava are Beta-sitosterol, Vitamin C, Linolenic Acid, Oleic Acid, Vitamin A among others. While the active ingredients contained in Carob are Quercetin, Phloroglucinol, Myricetin, Palmitic Acid, Gallic Acid and others.
Vitamin C can manipulate biochemical pathways Cell Cycle Checkpoints, Epithelial to Mesenchymal Transition and RAS-RAF Signaling. Beta-sitosterol has biological action on biochemical pathways Apoptosis, WNT Beta Catenin Signaling and PI3K-AKT-MTOR Signaling.
Folic Acid can manipulate biochemical pathways Cell Cycle Checkpoints, RAS-RAF Signaling and Apoptosis. And so on.
For genetic risk of Uterine Myxoid Leiomyosarcoma due to abnormalities in genes RNF43 and CTNNB1 – Foods like Cassava are recommended compared to Carob. This is because the active ingredients Folic Acid in Carob further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Cassava together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: CASSAVA IS RECOMMENDED OVER CAROB FOR REDUCING THE GENETIC RISK OF UTERINE MYXOID LEIOMYOSARCOMA DUE TO GENES RNF43 AND CTNNB1
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
Eat more fruits, Kiwi or Pummelo?
The active ingredients contained in Kiwi are Quercetin, Vitamin C, Fisetin, Vitamin A, Chlorogenic Acid among others. While the active ingredients contained in Pummelo are Naringin, Beta-sitosterol, Vitamin C, Linolenic Acid, Naringenin and others.
Vitamin C can manipulate biochemical pathways Cell Cycle Checkpoints, Epithelial to Mesenchymal Transition and RAS-RAF Signaling. Fisetin has biological action on biochemical pathways PI3K-AKT-MTOR Signaling and Cell Cycle Checkpoints.
Naringetol can manipulate biochemical pathways WNT Beta Catenin Signaling. Hesperetin has biological action on biochemical pathways WNT Beta Catenin Signaling. And so on.
For genetic risk of Uterine Myxoid Leiomyosarcoma due to abnormalities in genes RNF43 and CTNNB1 – Foods like Kiwi are recommended compared to Pummelo. This is because the active ingredients Naringetol and Hesperetin in Pummelo further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Fisetin contained in Kiwi together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: KIWI IS RECOMMENDED OVER PUMMELO FOR REDUCING THE GENETIC RISK OF UTERINE MYXOID LEIOMYOSARCOMA DUE TO GENES RNF43 AND CTNNB1
Eat more nuts, Brazil Nut or Macadamia Nut?
The active ingredients contained in Brazil Nut are Vitamin E, Linolenic Acid, Oleic Acid, Lecithin, Folic Acid among others. While the active ingredients contained in Macadamia Nut are Beta-sitosterol, Palmitic Acid, Lauric Acid, Myristic Acid, Folic Acid and others.
Linolenic Acid can manipulate biochemical pathways Cell Cycle Checkpoints, Epithelial to Mesenchymal Transition and Apoptosis.
Lauric Acid can manipulate biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. Myristic Acid has biological action on biochemical pathways Cell Cycle Checkpoints, RAS-RAF Signaling and Apoptosis. And so on.
For genetic risk of Uterine Myxoid Leiomyosarcoma due to abnormalities in genes RNF43 and CTNNB1 – Foods like Brazil Nut are recommended compared to Macadamia Nut. This is because the active ingredients Lauric Acid and Myristic Acid in Macadamia Nut further promote the effects of genes on the biochemical pathways. While the active ingredients Linolenic Acid contained in Brazil Nut together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: BRAZIL NUT IS RECOMMENDED OVER MACADAMIA NUT FOR REDUCING THE GENETIC RISK OF UTERINE MYXOID LEIOMYOSARCOMA DUE TO GENES RNF43 AND CTNNB1
In Summary
An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.
“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.
The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.
You can get started NOW and design a personalized nutrition plan for Uterine Myxoid Leiomyosarcoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
References
- Msk Impact 2017
- Genomic Landscape of Uterine Sarcomas Defined Through Prospective Clinical Sequencing.
- Retinol decreases beta-catenin protein levels in retinoic acid-resistant colon cancer cell lines.
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- Vitamin C enhances epigenetic modifications induced by 5-azacytidine and cell cycle arrest in the hepatocellular carcinoma cell lines HLE and Huh7.
- Indole-3-carbinol inhibits prostate cancer cell migration via degradation of beta-catenin.
- Role of phospholipase D in migration and invasion induced by linoleic acid in breast cancer cells.
- Mechanism of Juglone-Induced Cell Cycle Arrest and Apoptosis in Ishikawa Human Endometrial Cancer Cells.
- β-Sitosterol and Gemcitabine Exhibit Synergistic Anti-pancreatic Cancer Activity by Modulating Apoptosis and Inhibiting Epithelial-Mesenchymal Transition by Deactivating Akt/GSK-3β Signaling.
- [Basic formulation of the tasks of special education in rehabilitating the physically handicapped].
- Inhibitory effect of tocotrienol on eukaryotic DNA polymerase lambda and angiogenesis.
- Functional lipidomics: Palmitic acid impairs hepatocellular carcinoma development by modulating membrane fluidity and glucose metabolism.
- Oleic acid-induced ANGPTL4 enhances head and neck squamous cell carcinoma anoikis resistance and metastasis via up-regulation of fibronectin.
- Crystal structure of a human cyclin-dependent kinase 6 complex with a flavonol inhibitor, fisetin.
- Effects of folate deficiency on gene expression in the apoptosis and cancer pathways in colon cancer cells.
- α-Linolenic acid inhibits the migration of human triple-negative breast cancer cells by attenuating Twist1 expression and suppressing Twist1-mediated epithelial-mesenchymal transition.
- Clinical pharmacodynamics of antihistamines.
- Saturated fatty acids modulate cell response to DNA damage: implication for their role in tumorigenesis.
- HyperFoods: Machine intelligent mapping of cancer-beating molecules in foods.
- Fisetin: a dietary antioxidant for health promotion.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.