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What Foods are Recommended for Cancer?
is a very common question. Personalized Nutrition Plans are foods and supplements which are personalized to a cancer indication, genes, any treatments and lifestyle conditions.

Which Foods are Recommended for Urethral Squamous Cell Carcinoma

Sep 5, 2022

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Highlights

No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Urethral Squamous Cell Carcinoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Urethral Squamous Cell Carcinoma because of BLM and BRCA1 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.

There is no one answer to this question for cancers such as Urethral Squamous Cell Carcinoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.

In short – the process to answer questions like “Should I Avoid eating fruit Grape” or “Include fruit Currant in my diet” or “Should I reduce consumption of vegetable Chicory” or “Can I take Turmeric and Boldo supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.

RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO URETHRAL SQUAMOUS CELL CARCINOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.

The overall objective of personalized nutrition for Urethral Squamous Cell Carcinoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.

RECOMMENDATION: UPDATE YOUR NUTRITION FOR URETHRAL SQUAMOUS CELL CARCINOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.



About Urethral Squamous Cell Carcinoma

cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.

Following key highlights are derived from clinical data for Urethral Squamous Cell Carcinoma from cBioPortal. From a patient sample size of 4; the top genes with mutations and other abnormalities for Urethral Squamous Cell Carcinoma include genes BLM, BRCA1, CTCF, KMT2C and MAP3K13. The occurrence frequency distribution for these genes respectively is 50.0%, 50.0%, 50.0%, 50.0% and 50.0%. These tumor genetic details of Urethral Squamous Cell Carcinoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Urethral Squamous Cell Carcinoma.

Significance of Nutrition for Urethral Squamous Cell Carcinoma

All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Urethral Squamous Cell Carcinoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.

For example Grape includes active ingredients Delphinidin, Lupeol, Vitamin C, Salicylic Acid, Vitamin E and others. And Currant contains active ingredients Quercetin, Myricetin, Delphinidin, Vitamin C, Gallic Acid and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.

For cancers like Urethral Squamous Cell Carcinoma, activation or inhibition of selected biochemical pathways like RAS-RAF Signaling, DNA Repair, Oncogenic Histone Methylation, MAPK Signaling plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Urethral Squamous Cell Carcinoma, while eating some other foods and supplements may not be recommended.

One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.

For cancers like Urethral Squamous Cell Carcinoma, activation or inhibition of selected biochemical pathways like RAS-RAF Signaling, DNA Repair, Oncogenic Histone Methylation, MAPK Signaling plays an important role in driving cancer growth.

RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR URETHRAL SQUAMOUS CELL CARCINOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.

Foods for Urethral Squamous Cell Carcinoma undergoing chemotherapy treatment

In Urethral Squamous Cell Carcinoma – the genes BLM, BRCA1, CTCF, KMT2C and MAP3K13 have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Urethral Squamous Cell Carcinoma are RAS-RAF Signaling, DNA Repair and others. Radiation is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers RAS-RAF Signaling, DNA Repair so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.

RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.

Eat more pulses, Yellow Wax Bean or Adzuki Bean?

Pulses are an important part of many diets. The active ingredients contained in Yellow Wax Bean are Palmitic Acid, Ferulic Acid, Vitamin C, Folic Acid among others. While the active ingredients contained in Adzuki Bean are Isoliquiritigenin, Glucaric Acid, Folic Acid, Genistein and others.

Palmitic Acid can manipulate biochemical pathways DNA Repair and RAS-RAF Signaling. Ferulic Acid has biological action on biochemical pathways DNA Repair.

Genistein can manipulate biochemical pathways DNA Repair. Folic Acid has biological action on biochemical pathways RAS-RAF Signaling. And so on.

When treating Urethral Squamous Cell Carcinoma with chemotherapy Radiation – Foods like Yellow Wax Bean are recommended compared to Adzuki Bean. This is because the active ingredients Genistein and Folic Acid in Adzuki Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Palmitic Acid and Ferulic Acid contained in Yellow Wax Bean support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: YELLOW WAX BEAN IS RECOMMENDED OVER ADZUKI BEAN FOR URETHRAL SQUAMOUS CELL CARCINOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Eat more vegetables, Onion or Chicory?

Vegetables are an important part of many diets. The active ingredients contained in Onion are Quercetin, Myricetin, Delphinidin, Kaempferol, Protocatechuic Acid among others. While the active ingredients contained in Chicory are Quercetin, Delphinidin, Kaempferol, Luteolin, Protocatechuic Acid and others.

Quercetin can manipulate biochemical pathways DNA Repair and RAS-RAF Signaling. Myricetin has biological action on biochemical pathways RAS-RAF Signaling.

Apigenin can manipulate biochemical pathways DNA Repair. Folic Acid has biological action on biochemical pathways RAS-RAF Signaling. And so on.

When treating Urethral Squamous Cell Carcinoma with chemotherapy Radiation – Foods like Onion are recommended compared to Chicory. This is because the active ingredients Apigenin and Folic Acid in Chicory interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Quercetin and Myricetin contained in Onion support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: ONION IS RECOMMENDED OVER CHICORY FOR URETHRAL SQUAMOUS CELL CARCINOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Which Foods are Recommended for Urethral Squamous Cell Carcinoma?

Eat more fruits, Currant or Grape?

Fruits are an important part of many diets. The active ingredients contained in Currant are Quercetin, Myricetin, Delphinidin, Vitamin C, Gallic Acid among others. While the active ingredients contained in Grape are Delphinidin, Lupeol, Vitamin C, Salicylic Acid, Vitamin E and others.

Delphinidin can manipulate biochemical pathways RAS-RAF Signaling. Vitamin C has biological action on biochemical pathways RAS-RAF Signaling.

Resveratrol can manipulate biochemical pathways DNA Repair. Pterostilbene has biological action on biochemical pathways DNA Repair. And so on.

When treating Urethral Squamous Cell Carcinoma with chemotherapy Radiation – Foods like Currant are recommended compared to Grape. This is because the active ingredients Resveratrol and Pterostilbene in Grape interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Delphinidin and Vitamin C contained in Currant support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: CURRANT IS RECOMMENDED OVER GRAPE FOR URETHRAL SQUAMOUS CELL CARCINOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Eat more nuts, Almond or Acorn?

Nuts are an important part of many diets. The active ingredients contained in Almond are Quercetin, Salicylic Acid, Vitamin E among others. While the active ingredients contained in Acorn are Quercetin, Vitamin C, Beta-carotene, Gallic Acid, Folic Acid and others.

Quercetin can manipulate biochemical pathways DNA Repair and RAS-RAF Signaling. Salicylic Acid has biological action on biochemical pathways RAS-RAF Signaling.

Folic Acid can manipulate biochemical pathways RAS-RAF Signaling. And so on.

When treating Urethral Squamous Cell Carcinoma with chemotherapy Radiation – Foods like Almond are recommended compared to Acorn. This is because the active ingredients Folic Acid in Acorn interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Quercetin and Salicylic Acid contained in Almond support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: ALMOND IS RECOMMENDED OVER ACORN FOR URETHRAL SQUAMOUS CELL CARCINOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Foods for Genetic Risk of Urethral Squamous Cell Carcinoma

One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. BLM and BRCA1 are two genes whose abnormalities are risk factors for Urethral Squamous Cell Carcinoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Urethral Squamous Cell Carcinoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Urethral Squamous Cell Carcinoma gene BLM has causative impact on biological pathways like DNA Repair, DNA Repair and Post Translation Modification. And BRCA1 has a causative impact on biological pathways like Androgen Signaling, DNA Repair and Cell Cycle. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like BLM and BRCA1 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes BLM and BRCA1 should be avoided.

Eat more pulses, Winged Bean or Fava Bean?

The active ingredients contained in Winged Bean are Oleic Acid, Betulinic Acid, Vitamin C, Linolenic Acid, Linoleic Acid among others. While the active ingredients contained in Fava Bean are Quercetin, Genistein, Oleic Acid, Daidzein, Cianidanol and others.

Betulinic Acid can manipulate biochemical pathways Cell Cycle Checkpoints, P53 Signaling and MYC Signaling. Vitamin C has biological action on biochemical pathways RAS-RAF Signaling, Oncogenic Cancer Epigenetics and PI3K-AKT-MTOR Signaling.

Vitamin A can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. And so on.

For genetic risk of Urethral Squamous Cell Carcinoma due to abnormalities in genes BLM and BRCA1 – Foods like Winged Bean are recommended compared to Fava Bean. This is because the active ingredients Vitamin A in Fava Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Betulinic Acid and Vitamin C contained in Winged Bean together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: WINGED BEAN IS RECOMMENDED OVER FAVA BEAN FOR REDUCING THE GENETIC RISK OF URETHRAL SQUAMOUS CELL CARCINOMA DUE TO GENES BLM AND BRCA1

Eat more vegetables, Giant Butterbur or Jute?

The active ingredients contained in Giant Butterbur are Vitamin C, Beta-sitosterol, Melatonin, Vitamin B3, Kaempferol among others. While the active ingredients contained in Jute are Quercetin, Oleic Acid, Vitamin C, Linolenic Acid, Vitamin B3 and others.

Vitamin C can manipulate biochemical pathways Cell Cycle Checkpoints, RAS-RAF Signaling and P53 Signaling. Beta-sitosterol has biological action on biochemical pathways MYC Signaling, Oncogenic Cancer Epigenetics and PI3K-AKT-MTOR Signaling.

Vitamin A can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways Cell Cycle Checkpoints, RAS-RAF Signaling and P53 Signaling. And so on.

For genetic risk of Urethral Squamous Cell Carcinoma due to abnormalities in genes BLM and BRCA1 – Foods like Giant Butterbur are recommended compared to Jute. This is because the active ingredients Vitamin A and Folic Acid in Jute further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Giant Butterbur together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: GIANT BUTTERBUR IS RECOMMENDED OVER JUTE FOR REDUCING THE GENETIC RISK OF URETHRAL SQUAMOUS CELL CARCINOMA DUE TO GENES BLM AND BRCA1

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.

Eat more fruits, Persimmon or Peach?

The active ingredients contained in Persimmon are Quercetin, Lupeol, Betulinic Acid, Lycopene, Vitamin C among others. While the active ingredients contained in Peach are Oleic Acid, Modified Citrus Pectin, Vitamin C, Beta-sitosterol, Linolenic Acid and others.

Lycopene can manipulate biochemical pathways Cell Cycle Checkpoints, RAS-RAF Signaling and P53 Signaling. Vitamin C has biological action on biochemical pathways MYC Signaling, Oncogenic Cancer Epigenetics and PI3K-AKT-MTOR Signaling.

Fisetin can manipulate biochemical pathways MYC Signaling. Vitamin A has biological action on biochemical pathways PI3K-AKT-MTOR Signaling. And so on.

For genetic risk of Urethral Squamous Cell Carcinoma due to abnormalities in genes BLM and BRCA1 – Foods like Persimmon are recommended compared to Peach. This is because the active ingredients Fisetin and Vitamin A in Peach further promote the effects of genes on the biochemical pathways. While the active ingredients Lycopene and Vitamin C contained in Persimmon together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: PERSIMMON IS RECOMMENDED OVER PEACH FOR REDUCING THE GENETIC RISK OF URETHRAL SQUAMOUS CELL CARCINOMA DUE TO GENES BLM AND BRCA1

Eat more nuts, Hazelnut or Macadamia Nut?

The active ingredients contained in Hazelnut are Quercetin, Vitamin E, Oleic Acid, Linolenic Acid, Linoleic Acid among others. While the active ingredients contained in Macadamia Nut are Beta-sitosterol, Palmitic Acid, Lauric Acid, Myristic Acid, Folic Acid and others.

Quercetin can manipulate biochemical pathways Cell Cycle Checkpoints, RAS-RAF Signaling and P53 Signaling. Vitamin E has biological action on biochemical pathways MYC Signaling, PI3K-AKT-MTOR Signaling and Growth Factor Signaling.

Lauric Acid can manipulate biochemical pathways MYC Signaling, Growth Factor Signaling and PI3K-AKT-MTOR Signaling. Myristic Acid has biological action on biochemical pathways Cell Cycle Checkpoints, RAS-RAF Signaling and P53 Signaling. And so on.

For genetic risk of Urethral Squamous Cell Carcinoma due to abnormalities in genes BLM and BRCA1 – Foods like Hazelnut are recommended compared to Macadamia Nut. This is because the active ingredients Lauric Acid and Myristic Acid in Macadamia Nut further promote the effects of genes on the biochemical pathways. While the active ingredients Quercetin and Vitamin E contained in Hazelnut together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: HAZELNUT IS RECOMMENDED OVER MACADAMIA NUT FOR REDUCING THE GENETIC RISK OF URETHRAL SQUAMOUS CELL CARCINOMA DUE TO GENES BLM AND BRCA1


In Summary

An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.

“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.

The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.

You can get started NOW and design a personalized nutrition plan for Urethral Squamous Cell Carcinoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

sample-report


References

Personalized Nutrition for Cancer!

Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.


Scientifically Reviewed by: Dr. Cogle

Christopher R. Cogle, M.D. is a tenured professor at the University of Florida, Chief Medical Officer of Florida Medicaid, and Director of the Florida Health Policy Leadership Academy at the Bob Graham Center for Public Service.

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