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What Foods are Recommended for Cancer?
is a very common question. Personalized Nutrition Plans are foods and supplements which are personalized to a cancer indication, genes, any treatments and lifestyle conditions.

Foods for High-grade Neuroepithelial Tumor!

Jul 19, 2023

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Introduction

Foods for High-grade Neuroepithelial Tumor should be personalized for each individual and also must adapt when cancer treatment or tumor genetic change. The personalization and adaptation must consider all the active ingredients or bioactives contained in different foods with respect to cancer tissue biology, genetics, treatments, lifestyle conditions and diet preferences. Hence while nutrition is one of the very important decisions for a cancer patient and individual at risk of cancer to make – how to choose foods to eat is not an easy task.



For High-grade Neuroepithelial Tumor does it matter what vegetables, fruits, nuts, seeds one eats?

A very common nutrition question asked by cancer patients and individuals at-genetic risk of cancer is – for cancers like High-grade Neuroepithelial Tumor does it matter what foods I eat and which I do not? Or if I follow a plant-based diet is that enough for cancer like High-grade Neuroepithelial Tumor?

For example does it matter if vegetable Sweet Potato is consumed more compared to American Pokeweed? Does it make any difference if fruit Pummelo is preferred over Mango? Also if similar choices are made for nuts/seeds like Pistachio over Hickory Nut and for pulses like Green Bean over Adzuki Bean. And if what I eat matters – then how does one identify foods which are recommended for High-grade Neuroepithelial Tumor and is it the same answer for everyone with the same diagnosis or genetic risk?

Yes! Foods you eat matters for High-grade Neuroepithelial Tumor!

Food recommendations may not be the same for everyone and can be different even for the same diagnosis and genetic risk.

All cancers like High-grade Neuroepithelial Tumor can be characterized by a unique set of biochemical pathways - the signature pathways of High-grade Neuroepithelial Tumor. Biochemical pathways like Oncogenic Cancer Epigenetics, Suppressive Histone Methylation, Notch Signaling, Amino Acid Metabolism are part of the signature definition of High-grade Neuroepithelial Tumor.

All foods (vegetables, fruits, nuts, seeds, pulses, oils etc.) and nutritional supplements are made up of more than one active molecular ingredient or bio-actives in different proportions and quantities. Each active ingredient has a unique mechanism of action – which can be activation or inhibition of different biochemical pathways. Simply stated foods and supplements which are recommended are those which do not cause an increase of molecular drivers of cancer but reduce them. Else those foods should not be recommended. Foods contain multiple active ingredients – hence when evaluating foods and supplements you need to consider the impact of all active ingredients cumulatively rather than individually.

For example Pummelo contains active ingredients Curcumin, Quercetin, Genistein, Isoliquiritigenin, Lupeol. And Mango contains active ingredients Curcumin, Vitamin C, Quercetin, Genistein, Isoliquiritigenin and possibly others.

A common mistake made when deciding and choosing foods to eat for High-grade Neuroepithelial Tumor – is to evaluate only selected active ingredients contained in foods and ignore the rest. Because different active ingredients contained in foods may have opposing effects on cancer drivers – you cannot cherry pick active ingredients in foods and supplements for making a nutrition decision for High-grade Neuroepithelial Tumor.

YES – FOOD CHOICES MATTER FOR CANCER. NUTRITION DECISIONS MUST CONSIDER ALL ACTIVE INGREDIENTS OF FOODS.

Skills Needed for Nutrition Personalization for High-grade Neuroepithelial Tumor?

Personalized nutrition for cancers like High-grade Neuroepithelial Tumor consists of recommended foods / supplements; not recommended foods / supplements with example recipes which prioritize use of recommended foods. An example of personalized nutrition can be seen at this link.

Deciding which foods are recommended or not is extremely complicated, requiring expertise in High-grade Neuroepithelial Tumor biology, food science, genetics, biochemistry along with good understanding of how cancer treatments work and associated vulnerabilities by which the treatments could stop being effective.

MINIMUM KNOWLEDGE EXPERTISE NEEDED FOR NUTRITION PERSONALIZATION FOR CANCER ARE: CANCER BIOLOGY, FOOD SCIENCE, CANCER TREATMENTS AND GENETICS.

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.

Characteristics of cancers like High-grade Neuroepithelial Tumor

All cancers like High-grade Neuroepithelial Tumor can be characterized by a unique set of biochemical pathways – the signature pathways of High-grade Neuroepithelial Tumor. Biochemical pathways like Oncogenic Cancer Epigenetics, Suppressive Histone Methylation, Notch Signaling, Amino Acid Metabolism are part of the signature definition of High-grade Neuroepithelial Tumor. Each individual’s cancer genetics can be different and hence their specific cancer signature could be unique.

The treatments which are effective for High-grade Neuroepithelial Tumor need to be cognizant of the associated signature biochemical pathways for each cancer patient and individual at genetic risk. Therefore different treatments with different mechanisms of actions are effective for different patients. Similarly and for the same reasons foods and supplements need to be personalized for each individual. Hence some foods and supplements are recommended for High-grade Neuroepithelial Tumor when taking cancer treatment Pembrolizumab, and some foods and supplements are not recommended.

Sources like cBioPortal and many others provide population representative patient anonymized data from clinical trials for all cancer indications. This data consists of clinical trial study details like sample size / number of patients, age groups, gender, ethnicity, treatments, tumor site and any genetic mutations.

ASXL1, DNMT3A, MYCN and NOTCH1 are the top ranked reported genes for High-grade Neuroepithelial Tumor. ASXL1 is reported in 25.0 % of the representative patients across all clinical trials. And DNMT3A is reported in 25.0 %. The combined population patient data cover ages from 1 to 74. 50.0 % of the patient data are identified as men. The High-grade Neuroepithelial Tumor biology along with reported genetics together define the population represented signature biochemical pathways for this cancer. If the individual cancer tumor genetics or genes contributing to the risk are also known then that should also be used for nutrition personalization.

NUTRITION CHOICES SHOULD MATCH WITH EACH INDIVIDUAL’S CANCER SIGNATURE.

Foods for High grade Neuroepithelial Tumor!

Food and Supplements for High-grade Neuroepithelial Tumor

For Cancer Patients

Cancer patients on treatment or on palliative care need to make decisions on food and supplements – for the needed dietary calories, for managing any treatment side effects and also for improved cancer management. All plant-based foods are not equal and choosing and prioritizing foods which are personalized and customized to ongoing cancer treatment is important and complicated. Here are some examples providing guidelines for making nutrition decisions.

Choose Vegetable SWEET POTATO or AMERICAN POKEWEED

Vegetable Sweet Potato contains many active ingredients or bioactives such as Curcumin, Beta-carotene, Vitamin C, Quercetin, Isoliquiritigenin. These active ingredients manipulate various biochemical pathways like WNT Beta Catenin Signaling and Oncogenic Cancer Epigenetics and others. Sweet Potato is recommended for High-grade Neuroepithelial Tumor when ongoing cancer treatment is Pembrolizumab. This is because Sweet Potato modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Pembrolizumab.

Some of the active ingredients or bioactives in vegetable American Pokeweed are Curcumin, Beta-carotene, Quercetin, Genistein, Isoliquiritigenin. These active ingredients manipulate various biochemical pathways like WNT Beta Catenin Signaling and others. American Pokeweed is not recommended for High-grade Neuroepithelial Tumor when ongoing cancer treatment is Pembrolizumab because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

VEGETABLE SWEET POTATO IS RECOMMENDED OVER AMERICAN POKEWEED FOR High-grade Neuroepithelial Tumor AND TREATMENT Pembrolizumab.

Choose Fruit MANGO or PUMMELO

Fruit Mango contains many active ingredients or bioactives such as Curcumin, Vitamin C, Quercetin, Genistein, Isoliquiritigenin. These active ingredients manipulate various biochemical pathways like WNT Beta Catenin Signaling and Oncogenic Cancer Epigenetics and others. Mango is recommended for High-grade Neuroepithelial Tumor when ongoing cancer treatment is Pembrolizumab. This is because Mango modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Pembrolizumab.

Some of the active ingredients or bioactives in fruit Pummelo are Curcumin, Quercetin, Genistein, Isoliquiritigenin, Lupeol. These active ingredients manipulate various biochemical pathways like WNT Beta Catenin Signaling and others. Pummelo is not recommended for High-grade Neuroepithelial Tumor when ongoing cancer treatment is Pembrolizumab because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

FRUIT MANGO IS RECOMMENDED OVER PUMMELO FOR High-grade Neuroepithelial Tumor AND TREATMENT Pembrolizumab.

Choose Nut PISTACHIO or HICKORY NUT

Pistachio contains many active ingredients or bioactives such as Curcumin, Quercetin, Genistein, Isoliquiritigenin, Lupeol. These active ingredients manipulate various biochemical pathways like WNT Beta Catenin Signaling and Oncogenic Cancer Epigenetics and others. Pistachio is recommended for High-grade Neuroepithelial Tumor when ongoing cancer treatment is Pembrolizumab. This is because Pistachio modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Pembrolizumab.

Some of the active ingredients or bioactives in Hickory Nut are Curcumin, Genistein, Isoliquiritigenin, Lupeol, Beta-sitosterol. These active ingredients manipulate various biochemical pathways like WNT Beta Catenin Signaling and others. Hickory Nut is not recommended for High-grade Neuroepithelial Tumor when ongoing cancer treatment is Pembrolizumab because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

PISTACHIO IS RECOMMENDED OVER HICKORY NUT FOR High-grade Neuroepithelial Tumor AND TREATMENT Pembrolizumab.

For Individuals with Genetic Risk of Cancer

The question asked by individuals who have genetic risk of High-grade Neuroepithelial Tumor or familial history is “What Should I Eat Differently from Before?” and how they should choose foods and supplements to manage risks of the disease. Since for cancer risk there is nothing actionable in terms of treatment – decisions of foods and supplements become important and one of the very few actionable things which can be done. All plant-based foods are not equal and based on identified genetics and pathway signature – the choices of food and supplements should be personalized.

Choose Vegetable BITTER GOURD or POTATO

Vegetable Bitter Gourd contains many active ingredients or bioactives such as Apigenin, Curcumin, Lupeol, Daidzein, Beta-sitosterol. These active ingredients manipulate various biochemical pathways like Cell Cycle Checkpoints, Cell Cycle, Apoptosis and PI3K-AKT-MTOR Signaling and others. Bitter Gourd is recommended for risk of High-grade Neuroepithelial Tumor when associated genetic risk is ASXL1. This is because Bitter Gourd increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in vegetable Potato are Curcumin, Quercetin, Lupeol, Daidzein, Beta-sitosterol. These active ingredients manipulate various biochemical pathways like WNT Beta Catenin Signaling, Stem Cell Signaling and PI3K-AKT-MTOR Signaling and others. Potato is not recommended when risk of High-grade Neuroepithelial Tumor when associated genetic risk is ASXL1 because it increases the signature pathways of it.

VEGETABLE BITTER GOURD IS RECOMMENDED OVER POTATO FOR ASXL1 GENETIC RISK OF CANCER.

Choose Fruit JAVA PLUM or ALASKA BLUEBERRY

Fruit Java Plum contains many active ingredients or bioactives such as Apigenin, Curcumin, Lupeol, Ellagic Acid, Daidzein. These active ingredients manipulate various biochemical pathways like Apoptosis, MYC Signaling, Focal Adhesion and PI3K-AKT-MTOR Signaling and others. Java Plum is recommended for risk of High-grade Neuroepithelial Tumor when associated genetic risk is ASXL1. This is because Java Plum increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in fruit Alaska Blueberry are Apigenin, Curcumin, Lupeol, Daidzein, Beta-sitosterol. These active ingredients manipulate various biochemical pathways like Oncogenic Cancer Epigenetics, WNT Beta Catenin Signaling and Stem Cell Signaling and others. Alaska Blueberry is not recommended when risk of High-grade Neuroepithelial Tumor when associated genetic risk is ASXL1 because it increases the signature pathways of it.

FRUIT JAVA PLUM IS RECOMMENDED OVER ALASKA BLUEBERRY FOR ASXL1 GENETIC RISK OF CANCER.

Choose Nut BUTTERNUT or PUMPKIN SEEDS

Butternut contains many active ingredients or bioactives such as Apigenin, Curcumin, Lupeol, Daidzein, Lycopene. These active ingredients manipulate various biochemical pathways like Cell Cycle Checkpoints, Stem Cell Signaling, Focal Adhesion and PI3K-AKT-MTOR Signaling and others. Butternut is recommended for risk of High-grade Neuroepithelial Tumor when associated genetic risk is ASXL1. This is because Butternut increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in Pumpkin Seeds are Beta-sitosterol, Stigmasterol, Linolenic Acid, Oleic Acid, Salicylic Acid. These active ingredients manipulate various biochemical pathways like MYC Signaling and PI3K-AKT-MTOR Signaling and others. Pumpkin Seeds is not recommended when risk of High-grade Neuroepithelial Tumor when associated genetic risk is ASXL1 because it increases the signature pathways of it.

BUTTERNUT IS RECOMMENDED OVER PUMPKIN SEEDS FOR ASXL1 GENETIC RISK OF CANCER.


In Conclusion

Foods and Supplements chosen are important decisions for cancers like High-grade Neuroepithelial Tumor. High-grade Neuroepithelial Tumor patients and individuals with genetic-risk always have this question: “What foods and nutritional supplements are recommended for me and which are not?” There is a common belief which is a misconception that all plant-based foods could be beneficial or not but would not be harmful. Certain foods and supplements can interfere with cancer treatments or promote molecular pathway drivers of cancer.

There are different types of cancer indications like High-grade Neuroepithelial Tumor, each with different tumor genetics with further genomic variations across each individual. Further every cancer treatment and chemotherapy has a unique mechanism of action. Each food like Sweet Potato contains various bioactives in different quantities, which have an impact on different and distinct sets of biochemical pathways. The definition of personalized nutrition is individualized food recommendations for the cancer indication, treatments, genetics, lifestyle and other factors. Nutrition personalization decisions for cancer require knowledge of cancer biology, food science and an understanding of different chemotherapy treatments. Finally when there are treatment changes or new genomics is identified – the nutrition personalization needs re-evaluation.

The addon nutrition personalization solution makes the decision making easy and removes all the guesswork in answering the question, “What foods should I choose or not choose for High-grade Neuroepithelial Tumor?”. The addon multi-disciplinary team includes cancer physicians, clinical scientists, software engineers and data scientists.


Personalized Nutrition for Cancer!

Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.

References

Scientifically Reviewed by: Dr. Cogle

Christopher R. Cogle, M.D. is a tenured professor at the University of Florida, Chief Medical Officer of Florida Medicaid, and Director of the Florida Health Policy Leadership Academy at the Bob Graham Center for Public Service.

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