Highlights
No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like High-grade Neuroepithelial Tumor when undergoing chemotherapy or when you determine you have a genetic risk for developing High-grade Neuroepithelial Tumor because of MYCN and NOTCH1 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.
There is no one answer to this question for cancers such as High-grade Neuroepithelial Tumor which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.
In short – the process to answer questions like “Should I Avoid eating fruit Graviola” or “Include fruit Blueberry in my diet” or “Should I reduce consumption of vegetable Japanese Pumpkin” or “Can I take Allspice and Bael supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.
RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO HIGH-GRADE NEUROEPITHELIAL TUMOR, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.
The overall objective of personalized nutrition for High-grade Neuroepithelial Tumor is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.
RECOMMENDATION: UPDATE YOUR NUTRITION FOR HIGH-GRADE NEUROEPITHELIAL TUMOR, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.
About High-grade Neuroepithelial Tumor
cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.
Following key highlights are derived from clinical data for High-grade Neuroepithelial Tumor from cBioPortal. The patients enrolled in the studies for High-grade Neuroepithelial Tumor are in ages between 1 to 74 with an average age of 30. 50.0% of males and 50.0% of females were the distribution of gender in these clinical studies. From a patient sample size of 26; the top genes with mutations and other abnormalities for High-grade Neuroepithelial Tumor include genes ASXL1, DNMT3A, MYCN and NOTCH1. The occurrence frequency distribution for these genes respectively is 25.0%, 25.0%, 25.0% and 25.0%. These tumor genetic details of High-grade Neuroepithelial Tumor are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of High-grade Neuroepithelial Tumor.
Significance of Nutrition for High-grade Neuroepithelial Tumor
All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of High-grade Neuroepithelial Tumor. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.
For example Graviola includes active ingredients Tangeretin, Chlorogenic Acid, Vitamin E, Vitamin C, Quercetin and others. And Blueberry contains active ingredients Eugenol, Chlorogenic Acid, Vitamin E, Vitamin C, Quercetin and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.
For cancers like High-grade Neuroepithelial Tumor, activation or inhibition of selected biochemical pathways like Oncogenic Cancer Epigenetics, Suppressive Histone Methylation, Notch Signaling, RUNX Signaling plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of High-grade Neuroepithelial Tumor, while eating some other foods and supplements may not be recommended.
One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.
RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR HIGH-GRADE NEUROEPITHELIAL TUMOR – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.
Foods for High-grade Neuroepithelial Tumor undergoing chemotherapy treatment
In High-grade Neuroepithelial Tumor – the genes ASXL1, DNMT3A, MYCN and NOTCH1 have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for High-grade Neuroepithelial Tumor are Oncogenic Cancer Epigenetics, Suppressive Histone Methylation and others. Radiation is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Oncogenic Cancer Epigenetics, Suppressive Histone Methylation so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.
RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.
Eat more pulses, Winged Bean or Hyacinth Bean?
Pulses are an important part of many diets. The active ingredients contained in Winged Bean are Vitamin C, Betulinic Acid, Linolenic Acid, Linoleic Acid, Oleic Acid among others. While the active ingredients contained in Hyacinth Bean are Vitamin C, Genistein, Myristic Acid, Palmitic Acid and others.
Betulinic Acid can manipulate biochemical pathways Oncogenic Cancer Epigenetics, RUNX Signaling and WNT Beta Catenin Signaling. Vitamin C has biological action on biochemical pathways Suppressive Histone Methylation, Oncogenic Cancer Epigenetics and WNT Beta Catenin Signaling.
Palmitic Acid can manipulate biochemical pathways Oncogenic Cancer Epigenetics and WNT Beta Catenin Signaling. Myristic Acid has biological action on biochemical pathways RUNX Signaling. And so on.
When treating High-grade Neuroepithelial Tumor with chemotherapy Radiation – Foods like Winged Bean are recommended compared to Hyacinth Bean. This is because the active ingredients Palmitic Acid and Myristic Acid in Hyacinth Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Betulinic Acid and Vitamin C contained in Winged Bean support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: WINGED BEAN IS RECOMMENDED OVER HYACINTH BEAN FOR HIGH-GRADE NEUROEPITHELIAL TUMOR ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Eat more vegetables, Beetroot or Japanese Pumpkin?
Vegetables are an important part of many diets. The active ingredients contained in Beetroot are Vitamin E, Vitamin C, Beta-sitosterol, Linolenic Acid, Linoleic Acid among others. While the active ingredients contained in Japanese Pumpkin are Vitamin E, Vitamin C, Beta-sitosterol, Myristic Acid, Vitamin A and others.
Vitamin C can manipulate biochemical pathways Oncogenic Cancer Epigenetics, Suppressive Histone Methylation and WNT Beta Catenin Signaling. Vitamin E has biological action on biochemical pathways Notch Signaling and RUNX Signaling.
Palmitic Acid can manipulate biochemical pathways Oncogenic Cancer Epigenetics and WNT Beta Catenin Signaling. Myristic Acid has biological action on biochemical pathways RUNX Signaling. And so on.
When treating High-grade Neuroepithelial Tumor with chemotherapy Radiation – Foods like Beetroot are recommended compared to Japanese Pumpkin. This is because the active ingredients Palmitic Acid and Myristic Acid in Japanese Pumpkin interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Vitamin E contained in Beetroot support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: BEETROOT IS RECOMMENDED OVER JAPANESE PUMPKIN FOR HIGH-GRADE NEUROEPITHELIAL TUMOR ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Eat more fruits, Blueberry or Graviola?
Fruits are an important part of many diets. The active ingredients contained in Blueberry are Eugenol, Chlorogenic Acid, Vitamin E, Vitamin C, Quercetin among others. While the active ingredients contained in Graviola are Tangeretin, Chlorogenic Acid, Vitamin E, Vitamin C, Quercetin and others.
Chlorogenic Acid can manipulate biochemical pathways Oncogenic Cancer Epigenetics, Notch Signaling and RUNX Signaling. Vitamin C has biological action on biochemical pathways Suppressive Histone Methylation, WNT Beta Catenin Signaling and Oncogenic Cancer Epigenetics.
Fisetin can manipulate biochemical pathways WNT Beta Catenin Signaling. Vitexin has biological action on biochemical pathways WNT Beta Catenin Signaling. And so on.
When treating High-grade Neuroepithelial Tumor with chemotherapy Radiation – Foods like Blueberry are recommended compared to Graviola. This is because the active ingredients Fisetin and Vitexin in Graviola interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Chlorogenic Acid and Vitamin C contained in Blueberry support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: BLUEBERRY IS RECOMMENDED OVER GRAVIOLA FOR HIGH-GRADE NEUROEPITHELIAL TUMOR ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Eat more nuts, Hazelnut or Macadamia Nut?
Nuts are an important part of many diets. The active ingredients contained in Hazelnut are Vitamin E, Quercetin, Linolenic Acid, Linoleic Acid, Oleic Acid among others. While the active ingredients contained in Macadamia Nut are Beta-sitosterol, Myristic Acid, Palmitic Acid and others.
Vitamin E can manipulate biochemical pathways Notch Signaling and RUNX Signaling. Quercetin has biological action on biochemical pathways Oncogenic Cancer Epigenetics, Suppressive Histone Methylation and WNT Beta Catenin Signaling.
Myristic Acid can manipulate biochemical pathways RUNX Signaling. Palmitic Acid has biological action on biochemical pathways Oncogenic Cancer Epigenetics and WNT Beta Catenin Signaling. And so on.
When treating High-grade Neuroepithelial Tumor with chemotherapy Radiation – Foods like Hazelnut are recommended compared to Macadamia Nut. This is because the active ingredients Myristic Acid and Palmitic Acid in Macadamia Nut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin E and Quercetin contained in Hazelnut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: HAZELNUT IS RECOMMENDED OVER MACADAMIA NUT FOR HIGH-GRADE NEUROEPITHELIAL TUMOR ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Foods for Genetic Risk of High-grade Neuroepithelial Tumor
One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. MYCN and NOTCH1 are two genes whose abnormalities are risk factors for High-grade Neuroepithelial Tumor. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of High-grade Neuroepithelial Tumor can be used as a guide for coming up with a recommended personalized nutrition plan. For High-grade Neuroepithelial Tumor gene MYCN has causative impact on biological pathways like Focal Adhesion and Cell Cycle. And NOTCH1 has a causative impact on biological pathways like Notch Signaling and RUNX Signaling. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like MYCN and NOTCH1 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes MYCN and NOTCH1 should be avoided.
Eat more pulses, Mung Bean or Lima Bean?
The active ingredients contained in Mung Bean are Linolenic Acid, Vitamin C, Oleic Acid, Stigmasterol, Vitexin among others. While the active ingredients contained in Lima Bean are Vitamin C, Oleic Acid, Genistein, Linoleic Acid, Vitamin A and others.
Vitamin C can manipulate biochemical pathways Cell Cycle Checkpoints, Apoptosis and WNT Beta Catenin Signaling. Stigmasterol has biological action on biochemical pathways MYC Signaling, PI3K-AKT-MTOR Signaling and Apoptosis.
Vitamin A can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways Apoptosis, MYC Signaling and Cell Cycle Checkpoints. And so on.
For genetic risk of High-grade Neuroepithelial Tumor due to abnormalities in genes MYCN and NOTCH1 – Foods like Mung Bean are recommended compared to Lima Bean. This is because the active ingredients Vitamin A and Folic Acid in Lima Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Stigmasterol contained in Mung Bean together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: MUNG BEAN IS RECOMMENDED OVER LIMA BEAN FOR REDUCING THE GENETIC RISK OF HIGH-GRADE NEUROEPITHELIAL TUMOR DUE TO GENES MYCN AND NOTCH1
Eat more vegetables, Amaranth or Carrot?
The active ingredients contained in Amaranth are Beta-sitosterol, Linolenic Acid, Vitamin C, Oleic Acid, Stigmasterol among others. While the active ingredients contained in Carrot are Lupeol, Vitamin E, D-limonene, Eugenol, Linalool and others.
Beta-sitosterol can manipulate biochemical pathways Cell Cycle Checkpoints, RUNX Signaling and Apoptosis. Vitamin C has biological action on biochemical pathways WNT Beta Catenin Signaling, PI3K-AKT-MTOR Signaling and MYC Signaling.
Osthole can manipulate biochemical pathways WNT Beta Catenin Signaling. Beta-carotene has biological action on biochemical pathways DNA Repair, PI3K-AKT-MTOR Signaling and Notch Signaling. And so on.
For genetic risk of High-grade Neuroepithelial Tumor due to abnormalities in genes MYCN and NOTCH1 – Foods like Amaranth are recommended compared to Carrot. This is because the active ingredients Osthole and Beta-carotene in Carrot further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin C contained in Amaranth together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: AMARANTH IS RECOMMENDED OVER CARROT FOR REDUCING THE GENETIC RISK OF HIGH-GRADE NEUROEPITHELIAL TUMOR DUE TO GENES MYCN AND NOTCH1
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
Eat more fruits, Cherimoya or Cloudberry?
The active ingredients contained in Cherimoya are Beta-sitosterol, Linolenic Acid, Vitamin C, Oleic Acid, Stigmasterol among others. While the active ingredients contained in Cloudberry are Ellagic Acid, Vitamin C, Urolithin B, Vitamin A and others.
Beta-sitosterol can manipulate biochemical pathways Cell Cycle Checkpoints, RUNX Signaling and Apoptosis. Stigmasterol has biological action on biochemical pathways MYC Signaling, PI3K-AKT-MTOR Signaling and Apoptosis.
Vitamin A can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Ellagic Acid has biological action on biochemical pathways MYC Signaling and WNT Beta Catenin Signaling. And so on.
For genetic risk of High-grade Neuroepithelial Tumor due to abnormalities in genes MYCN and NOTCH1 – Foods like Cherimoya are recommended compared to Cloudberry. This is because the active ingredients Vitamin A and Ellagic Acid in Cloudberry further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Stigmasterol contained in Cherimoya together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: CHERIMOYA IS RECOMMENDED OVER CLOUDBERRY FOR REDUCING THE GENETIC RISK OF HIGH-GRADE NEUROEPITHELIAL TUMOR DUE TO GENES MYCN AND NOTCH1
Eat more nuts, Almond or Chestnut?
The active ingredients contained in Almond are Vitamin E, Beta-sitosterol, Linolenic Acid, Oleic Acid, Stigmasterol among others. While the active ingredients contained in Chestnut are Linolenic Acid, Ellagic Acid, Vitamin C, Oleic Acid, Quercetin and others.
Beta-sitosterol can manipulate biochemical pathways Cell Cycle Checkpoints, RUNX Signaling and Apoptosis. Vitamin E has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, MYC Signaling and Notch Signaling.
Ellagic Acid can manipulate biochemical pathways MYC Signaling and WNT Beta Catenin Signaling. Gallic Acid has biological action on biochemical pathways DNA Repair. And so on.
For genetic risk of High-grade Neuroepithelial Tumor due to abnormalities in genes MYCN and NOTCH1 – Foods like Almond are recommended compared to Chestnut. This is because the active ingredients Ellagic Acid and Gallic Acid in Chestnut further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin E contained in Almond together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: ALMOND IS RECOMMENDED OVER CHESTNUT FOR REDUCING THE GENETIC RISK OF HIGH-GRADE NEUROEPITHELIAL TUMOR DUE TO GENES MYCN AND NOTCH1
In Summary
An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.
“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.
The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.
You can get started NOW and design a personalized nutrition plan for High-grade Neuroepithelial Tumor by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
References
- Msk Ch 2020
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- Gallic acid provokes DNA damage and suppresses DNA repair gene expression in human prostate cancer PC-3 cells.
- HyperFoods: Machine intelligent mapping of cancer-beating molecules in foods.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.