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What Foods are Recommended for Cancer?
is a very common question. Personalized Nutrition Plans are foods and supplements which are personalized to a cancer indication, genes, any treatments and lifestyle conditions.

Foods for Salivary Adenocarcinoma!

Jul 29, 2023

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Introduction

Foods for Salivary Adenocarcinoma should be personalized for each individual and also must adapt when cancer treatment or tumor genetic change. The personalization and adaptation must consider all the active ingredients or bioactives contained in different foods with respect to cancer tissue biology, genetics, treatments, lifestyle conditions and diet preferences. Hence while nutrition is one of the very important decisions for a cancer patient and individual at risk of cancer to make – how to choose foods to eat is not an easy task.



For Salivary Adenocarcinoma does it matter what vegetables, fruits, nuts, seeds one eats?

A very common nutrition question asked by cancer patients and individuals at-genetic risk of cancer is – for cancers like Salivary Adenocarcinoma does it matter what foods I eat and which I do not? Or if I follow a plant-based diet is that enough for cancer like Salivary Adenocarcinoma?

For example does it matter if vegetable Celery Stalks is consumed more compared to Shallot? Does it make any difference if fruit Mammee Apple is preferred over Soursop? Also if similar choices are made for nuts/seeds like Walnut over Flaxseed and for pulses like Yardlong Bean over Catjang Pea. And if what I eat matters – then how does one identify foods which are recommended for Salivary Adenocarcinoma and is it the same answer for everyone with the same diagnosis or genetic risk?

Yes! Foods you eat matters for Salivary Adenocarcinoma!

Food recommendations may not be the same for everyone and can be different even for the same diagnosis and genetic risk.

All cancers like Salivary Adenocarcinoma can be characterized by a unique set of biochemical pathways - the signature pathways of Salivary Adenocarcinoma. Biochemical pathways like Apoptosis, Chromatin Remodeling, Cell Cycle Checkpoints, Epithelial to Mesenchymal Transition are part of the signature definition of Salivary Adenocarcinoma.

All foods (vegetables, fruits, nuts, seeds, pulses, oils etc.) and nutritional supplements are made up of more than one active molecular ingredient or bio-actives in different proportions and quantities. Each active ingredient has a unique mechanism of action – which can be activation or inhibition of different biochemical pathways. Simply stated foods and supplements which are recommended are those which do not cause an increase of molecular drivers of cancer but reduce them. Else those foods should not be recommended. Foods contain multiple active ingredients – hence when evaluating foods and supplements you need to consider the impact of all active ingredients cumulatively rather than individually.

For example Mammee Apple contains active ingredients Apigenin, Curcumin, Lupeol, Lycopene, Phloretin. And Soursop contains active ingredients Apigenin, Emodin, Curcumin, Lupeol, Phloretin and possibly others.

A common mistake made when deciding and choosing foods to eat for Salivary Adenocarcinoma – is to evaluate only selected active ingredients contained in foods and ignore the rest. Because different active ingredients contained in foods may have opposing effects on cancer drivers – you cannot cherry pick active ingredients in foods and supplements for making a nutrition decision for Salivary Adenocarcinoma.

YES – FOOD CHOICES MATTER FOR CANCER. NUTRITION DECISIONS MUST CONSIDER ALL ACTIVE INGREDIENTS OF FOODS.

Skills Needed for Nutrition Personalization for Salivary Adenocarcinoma?

Personalized nutrition for cancers like Salivary Adenocarcinoma consists of recommended foods / supplements; not recommended foods / supplements with example recipes which prioritize use of recommended foods. An example of personalized nutrition can be seen at this link.

Deciding which foods are recommended or not is extremely complicated, requiring expertise in Salivary Adenocarcinoma biology, food science, genetics, biochemistry along with good understanding of how cancer treatments work and associated vulnerabilities by which the treatments could stop being effective.

MINIMUM KNOWLEDGE EXPERTISE NEEDED FOR NUTRITION PERSONALIZATION FOR CANCER ARE: CANCER BIOLOGY, FOOD SCIENCE, CANCER TREATMENTS AND GENETICS.

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.

Characteristics of cancers like Salivary Adenocarcinoma

All cancers like Salivary Adenocarcinoma can be characterized by a unique set of biochemical pathways – the signature pathways of Salivary Adenocarcinoma. Biochemical pathways like Apoptosis, Chromatin Remodeling, Cell Cycle Checkpoints, Epithelial to Mesenchymal Transition are part of the signature definition of Salivary Adenocarcinoma. Each individual’s cancer genetics can be different and hence their specific cancer signature could be unique.

The treatments which are effective for Salivary Adenocarcinoma need to be cognizant of the associated signature biochemical pathways for each cancer patient and individual at genetic risk. Therefore different treatments with different mechanisms of actions are effective for different patients. Similarly and for the same reasons foods and supplements need to be personalized for each individual. Hence some foods and supplements are recommended for Salivary Adenocarcinoma when taking cancer treatment Taxol, and some foods and supplements are not recommended.

Sources like cBioPortal and many others provide population representative patient anonymized data from clinical trials for all cancer indications. This data consists of clinical trial study details like sample size / number of patients, age groups, gender, ethnicity, treatments, tumor site and any genetic mutations.

ARID1A, TP53, PIK3R1 and KDM6A are the top ranked reported genes for Salivary Adenocarcinoma. ARID1A is reported in 50.0 % of the representative patients across all clinical trials. And TP53 is reported in 50.0 %. The combined population patient data cover ages from 54 to 89. 25.0 % of the patient data are identified as men. The Salivary Adenocarcinoma biology along with reported genetics together define the population represented signature biochemical pathways for this cancer. If the individual cancer tumor genetics or genes contributing to the risk are also known then that should also be used for nutrition personalization.

NUTRITION CHOICES SHOULD MATCH WITH EACH INDIVIDUAL’S CANCER SIGNATURE.

Foods for Salivary Adenocarcinoma!

Food and Supplements for Salivary Adenocarcinoma

For Cancer Patients

Cancer patients on treatment or on palliative care need to make decisions on food and supplements – for the needed dietary calories, for managing any treatment side effects and also for improved cancer management. All plant-based foods are not equal and choosing and prioritizing foods which are personalized and customized to ongoing cancer treatment is important and complicated. Here are some examples providing guidelines for making nutrition decisions.

Choose Vegetable CELERY STALKS or SHALLOT?

Vegetable Celery Stalks contains many active ingredients or bioactives such as Apigenin, Curcumin, Lycopene, Lupeol, Linalool. These active ingredients manipulate various biochemical pathways like Apoptosis and MYC Signaling and others. Celery Stalks is recommended for Salivary Adenocarcinoma when ongoing cancer treatment is Taxol. This is because Celery Stalks modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Taxol.

Some of the active ingredients or bioactives in vegetable Shallot are Apigenin, Curcumin, Lupeol, Phloretin, Daidzein. These active ingredients manipulate various biochemical pathways like MYC Signaling and others. Shallot is not recommended for Salivary Adenocarcinoma when ongoing cancer treatment is Taxol because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

VEGETABLE CELERY STALKS IS RECOMMENDED OVER SHALLOT FOR Salivary Adenocarcinoma AND TREATMENT Taxol.

Choose Fruit SOURSOP or MAMMEE APPLE?

Fruit Soursop contains many active ingredients or bioactives such as Apigenin, Emodin, Curcumin, Lupeol, Phloretin. These active ingredients manipulate various biochemical pathways like Apoptosis and MYC Signaling and others. Soursop is recommended for Salivary Adenocarcinoma when ongoing cancer treatment is Taxol. This is because Soursop modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Taxol.

Some of the active ingredients or bioactives in fruit Mammee Apple are Apigenin, Curcumin, Lupeol, Lycopene, Phloretin. These active ingredients manipulate various biochemical pathways like MYC Signaling and others. Mammee Apple is not recommended for Salivary Adenocarcinoma when ongoing cancer treatment is Taxol because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

FRUIT SOURSOP IS RECOMMENDED OVER MAMMEE APPLE FOR Salivary Adenocarcinoma AND TREATMENT Taxol.

Choose Nut WALNUT or FLAXSEED?

Walnut contains many active ingredients or bioactives such as Apigenin, Curcumin, Juglone, Hyperoside, Lupeol. These active ingredients manipulate various biochemical pathways like Apoptosis and MYC Signaling and others. Walnut is recommended for Salivary Adenocarcinoma when ongoing cancer treatment is Taxol. This is because Walnut modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Taxol.

Some of the active ingredients or bioactives in Flaxseed are Apigenin, Curcumin, Lupeol, Phloretin, Daidzein. These active ingredients manipulate various biochemical pathways like MYC Signaling and others. Flaxseed is not recommended for Salivary Adenocarcinoma when ongoing cancer treatment is Taxol because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

WALNUT IS RECOMMENDED OVER FLAXSEED FOR Salivary Adenocarcinoma AND TREATMENT Taxol.

For Individuals with Genetic Risk of Cancer

The question asked by individuals who have genetic risk of Salivary Adenocarcinoma or familial history is “What Should I Eat Differently from Before?” and how they should choose foods and supplements to manage risks of the disease. Since for cancer risk there is nothing actionable in terms of treatment – decisions of foods and supplements become important and one of the very few actionable things which can be done. All plant-based foods are not equal and based on identified genetics and pathway signature – the choices of food and supplements should be personalized.

Choose Vegetable CAULIFLOWER or MALABAR SPINACH?

Vegetable Cauliflower contains many active ingredients or bioactives such as Curcumin, Lupeol, Beta-sitosterol, Phloretin, Formononetin. These active ingredients manipulate various biochemical pathways like Cell Cycle, P53 Signaling, MAPK Signaling and MYC Signaling and others. Cauliflower is recommended for risk of Salivary Adenocarcinoma when associated genetic risk is ARID1A. This is because Cauliflower increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in vegetable Malabar Spinach are Apigenin, Curcumin, Quercetin, Lupeol, Beta-sitosterol. These active ingredients manipulate various biochemical pathways like DNA Repair, Epithelial to Mesenchymal Transition, WNT Beta Catenin Signaling and MAPK Signaling and others. Malabar Spinach is not recommended when risk of Salivary Adenocarcinoma when associated genetic risk is ARID1A because it increases the signature pathways of it.

VEGETABLE CAULIFLOWER IS RECOMMENDED OVER MALABAR SPINACH FOR ARID1A GENETIC RISK OF CANCER.

Choose Fruit JAVA PLUM or PUMMELO?

Fruit Java Plum contains many active ingredients or bioactives such as Apigenin, Curcumin, Lupeol, Beta-sitosterol, Phloretin. These active ingredients manipulate various biochemical pathways like Cell Cycle, P53 Signaling, DNA Repair and MAPK Signaling and others. Java Plum is recommended for risk of Salivary Adenocarcinoma when associated genetic risk is ARID1A. This is because Java Plum increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in fruit Pummelo are Apigenin, Curcumin, Quercetin, Lupeol, Naringin. These active ingredients manipulate various biochemical pathways like DNA Repair, Epithelial to Mesenchymal Transition and WNT Beta Catenin Signaling and others. Pummelo is not recommended when risk of Salivary Adenocarcinoma when associated genetic risk is ARID1A because it increases the signature pathways of it.

FRUIT JAVA PLUM IS RECOMMENDED OVER PUMMELO FOR ARID1A GENETIC RISK OF CANCER.

Choose Nut BUTTERNUT or CHESTNUT?

Butternut contains many active ingredients or bioactives such as Apigenin, Curcumin, Lupeol, Beta-sitosterol, Phloretin. These active ingredients manipulate various biochemical pathways like DNA Repair, Cell Cycle, MAPK Signaling and Epithelial to Mesenchymal Transition and others. Butternut is recommended for risk of Salivary Adenocarcinoma when associated genetic risk is ARID1A. This is because Butternut increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in Chestnut are Apigenin, Curcumin, Lupeol, Beta-sitosterol, Phloretin. These active ingredients manipulate various biochemical pathways like DNA Repair, Epithelial to Mesenchymal Transition and WNT Beta Catenin Signaling and others. Chestnut is not recommended when risk of Salivary Adenocarcinoma when associated genetic risk is ARID1A because it increases the signature pathways of it.

BUTTERNUT IS RECOMMENDED OVER CHESTNUT FOR ARID1A GENETIC RISK OF CANCER.


In Conclusion

Foods and Supplements chosen are important decisions for cancers like Salivary Adenocarcinoma. Salivary Adenocarcinoma patients and individuals with genetic-risk always have this question: “What foods and nutritional supplements are recommended for me and which are not?” There is a common belief which is a misconception that all plant-based foods could be beneficial or not but would not be harmful. Certain foods and supplements can interfere with cancer treatments or promote molecular pathway drivers of cancer.

There are different types of cancer indications like Salivary Adenocarcinoma, each with different tumor genetics with further genomic variations across each individual. Further every cancer treatment and chemotherapy has a unique mechanism of action. Each food like Celery Stalks contains various bioactives in different quantities, which have an impact on different and distinct sets of biochemical pathways. The definition of personalized nutrition is individualized food recommendations for the cancer indication, treatments, genetics, lifestyle and other factors. Nutrition personalization decisions for cancer require knowledge of cancer biology, food science and an understanding of different chemotherapy treatments. Finally when there are treatment changes or new genomics is identified – the nutrition personalization needs re-evaluation.

The addon nutrition personalization solution makes the decision making easy and removes all the guesswork in answering the question, “What foods should I choose or not choose for Salivary Adenocarcinoma?”. The addon multi-disciplinary team includes cancer physicians, clinical scientists, software engineers and data scientists.


Personalized Nutrition for Cancer!

Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.

References

Scientifically Reviewed by: Dr. Cogle

Christopher R. Cogle, M.D. is a tenured professor at the University of Florida, Chief Medical Officer of Florida Medicaid, and Director of the Florida Health Policy Leadership Academy at the Bob Graham Center for Public Service.

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