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What Foods are Recommended for Cancer?
is a very common question. Personalized Nutrition Plans are foods and supplements which are personalized to a cancer indication, genes, any treatments and lifestyle conditions.

Which Foods are Recommended for Salivary Adenocarcinoma?

Sep 3, 2022

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Highlights

No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Salivary Adenocarcinoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Salivary Adenocarcinoma because of PIK3R1 and KDM6A gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.

There is no one answer to this question for cancers such as Salivary Adenocarcinoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.

In short – the process to answer questions like “Should I Avoid eating fruit Grape” or “Include fruit Sapota in my diet” or “Should I reduce consumption of vegetable Chicory” or “Can I take Senna and Buckthorn supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.

RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO SALIVARY ADENOCARCINOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.

The overall objective of personalized nutrition for Salivary Adenocarcinoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.

RECOMMENDATION: UPDATE YOUR NUTRITION FOR SALIVARY ADENOCARCINOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.



About Salivary Adenocarcinoma

cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.

Following key highlights are derived from clinical data for Salivary Adenocarcinoma from cBioPortal. The patients enrolled in the studies for Salivary Adenocarcinoma are in ages between 54 to 89 with an average age of 73. 25.0% of males and 75.0% of females were the distribution of gender in these clinical studies. From a patient sample size of 6; the top genes with mutations and other abnormalities for Salivary Adenocarcinoma include genes ARID1A, TP53, PIK3R1 and KDM6A. The occurrence frequency distribution for these genes respectively is 50.0%, 50.0%, 50.0% and 50.0%. These tumor genetic details of Salivary Adenocarcinoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Salivary Adenocarcinoma.

Significance of Nutrition for Salivary Adenocarcinoma

All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Salivary Adenocarcinoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.

For example Grape includes active ingredients Lupeol, Vitamin E, Beta-sitosterol, Linolenic Acid, Vitamin C and others. And Sapota contains active ingredients Lycopene, Beta-sitosterol, Linolenic Acid, Vitamin C, Linoleic Acid and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.

For cancers like Salivary Adenocarcinoma, activation or inhibition of selected biochemical pathways like Apoptosis, Chromatin Remodeling, Cell Cycle Checkpoints, Epithelial to Mesenchymal Transition plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Salivary Adenocarcinoma, while eating some other foods and supplements may not be recommended.

One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.

For cancers like Salivary Adenocarcinoma, activation or inhibition of selected biochemical pathways like Apoptosis, Chromatin Remodeling, Cell Cycle Checkpoints, Epithelial to Mesenchymal Transition plays an important role in driving cancer growth.

RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR SALIVARY ADENOCARCINOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.

Foods for Salivary Adenocarcinoma undergoing chemotherapy treatment

In Salivary Adenocarcinoma – the genes ARID1A, TP53, PIK3R1 and KDM6A have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Salivary Adenocarcinoma are Apoptosis and others. Carboplatin is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Apoptosis so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.

RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.

Eat more pulses, Winged Bean?

Pulses are an important part of many diets. The active ingredients contained in Winged Bean are Betulinic Acid, Linolenic Acid, Vitamin C, Linoleic Acid, Oleic Acid among others.

Betulinic Acid can manipulate biochemical pathways P53 Signaling, MYC Signaling and Apoptosis. Vitamin C has biological action on biochemical pathways P53 Signaling, MYC Signaling and Apoptosis.

When treating Salivary Adenocarcinoma with chemotherapy Carboplatin – Foods like Winged Bean are recommended. This is because the active ingredients Betulinic Acid and Vitamin C contained in Winged Bean support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: WINGED BEAN IS RECOMMENDED FOR SALIVARY ADENOCARCINOMA ON TREATMENT WITH CHEMOTHERAPY CARBOPLATIN FOR SOME CONDITIONS.

Eat more vegetables, Arugula or Chicory?

Vegetables are an important part of many diets. The active ingredients contained in Arugula are Esculin, Vitamin A, Vitamin K, Erysolin among others. While the active ingredients contained in Chicory are Apigenin, Esculin, Betulinic Acid, Lupeol, Protocatechuic Acid and others.

Vitamin A can manipulate biochemical pathways MYC Signaling and Apoptosis. Vitamin K has biological action on biochemical pathways MYC Signaling.

Luteolin can manipulate biochemical pathways MYC Signaling. Folic Acid has biological action on biochemical pathways P53 Signaling, Apoptosis and MYC Signaling. And so on.

When treating Salivary Adenocarcinoma with chemotherapy Carboplatin – Foods like Arugula are recommended compared to Chicory. This is because the active ingredients Luteolin and Folic Acid in Chicory interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin A and Vitamin K contained in Arugula support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: ARUGULA IS RECOMMENDED OVER CHICORY FOR SALIVARY ADENOCARCINOMA ON TREATMENT WITH CHEMOTHERAPY CARBOPLATIN FOR SOME CONDITIONS.

Which Foods are Recommended for Salivary Adenocarcinoma?

Eat more fruits, Sapota or Grape?

Fruits are an important part of many diets. The active ingredients contained in Sapota are Lycopene, Beta-sitosterol, Linolenic Acid, Vitamin C, Linoleic Acid among others. While the active ingredients contained in Grape are Lupeol, Vitamin E, Beta-sitosterol, Linolenic Acid, Vitamin C and others.

Lycopene can manipulate biochemical pathways P53 Signaling, MYC Signaling and Apoptosis. Beta-sitosterol has biological action on biochemical pathways P53 Signaling, MYC Signaling and Apoptosis.

Resveratrol can manipulate biochemical pathways P53 Signaling. Pelargonidin has biological action on biochemical pathways MYC Signaling. And so on.

When treating Salivary Adenocarcinoma with chemotherapy Carboplatin – Foods like Sapota are recommended compared to Grape. This is because the active ingredients Resveratrol and Pelargonidin in Grape interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Lycopene and Beta-sitosterol contained in Sapota support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: SAPOTA IS RECOMMENDED OVER GRAPE FOR SALIVARY ADENOCARCINOMA ON TREATMENT WITH CHEMOTHERAPY CARBOPLATIN FOR SOME CONDITIONS.

Eat more nuts, Almond or Macadamia Nut?

Nuts are an important part of many diets. The active ingredients contained in Almond are Vitamin E, Stigmasterol, Beta-sitosterol, Linolenic Acid, Vitamin B3 among others. While the active ingredients contained in Macadamia Nut are Beta-sitosterol, Palmitic Acid, Lauric Acid, Folic Acid, Myristic Acid and others.

Beta-sitosterol can manipulate biochemical pathways P53 Signaling, MYC Signaling and Apoptosis. Stigmasterol has biological action on biochemical pathways P53 Signaling, MYC Signaling and Apoptosis.

Lauric Acid can manipulate biochemical pathways MYC Signaling. Myristic Acid has biological action on biochemical pathways P53 Signaling, Apoptosis and MYC Signaling. And so on.

When treating Salivary Adenocarcinoma with chemotherapy Carboplatin – Foods like Almond are recommended compared to Macadamia Nut. This is because the active ingredients Lauric Acid and Myristic Acid in Macadamia Nut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Stigmasterol contained in Almond support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: ALMOND IS RECOMMENDED OVER MACADAMIA NUT FOR SALIVARY ADENOCARCINOMA ON TREATMENT WITH CHEMOTHERAPY CARBOPLATIN FOR SOME CONDITIONS.

Foods for Genetic Risk of Salivary Adenocarcinoma

One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. PIK3R1 and KDM6A are two genes whose abnormalities are risk factors for Salivary Adenocarcinoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Salivary Adenocarcinoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Salivary Adenocarcinoma gene PIK3R1 has causative impact on biological pathways like Hematopoiesis and Cytokine Signaling. And KDM6A has a causative impact on biological pathways like Suppressive Histone Methylation. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like PIK3R1 and KDM6A should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes PIK3R1 and KDM6A should be avoided.

Eat more pulses, Mung Bean or Soy Bean?

The active ingredients contained in Mung Bean are Quercetin, Vitamin C, Linolenic Acid, Oleic Acid, Stigmasterol among others. While the active ingredients contained in Soy Bean are Lupeol, Daidzein, Vitamin E, Quercetin, Beta-sitosterol and others.

Quercetin can manipulate biochemical pathways Cell Cycle Checkpoints, RAS-RAF Signaling and P53 Signaling. Vitamin C has biological action on biochemical pathways MYC Signaling, PI3K-AKT-MTOR Signaling and Apoptosis.

Aescin can manipulate biochemical pathways Cell Cycle Checkpoints. Lecithin has biological action on biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. And so on.

For genetic risk of Salivary Adenocarcinoma due to abnormalities in genes PIK3R1 and KDM6A – Foods like Mung Bean are recommended compared to Soy Bean. This is because the active ingredients Aescin and Lecithin in Soy Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Quercetin and Vitamin C contained in Mung Bean together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: MUNG BEAN IS RECOMMENDED OVER SOY BEAN FOR REDUCING THE GENETIC RISK OF SALIVARY ADENOCARCINOMA DUE TO GENES PIK3R1 AND KDM6A

Eat more vegetables, Cassava or Carob?

The active ingredients contained in Cassava are Beta-sitosterol, Vitamin C, Linolenic Acid, Oleic Acid, Linoleic Acid among others. While the active ingredients contained in Carob are Quercetin, Palmitic Acid, Myricetin, Phloroglucinol, Gallic Acid and others.

Vitamin C can manipulate biochemical pathways Cell Cycle Checkpoints, RAS-RAF Signaling and P53 Signaling. Beta-sitosterol has biological action on biochemical pathways MYC Signaling, PI3K-AKT-MTOR Signaling and Apoptosis.

Palmitic Acid can manipulate biochemical pathways Chromatin Remodeling and PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways Cell Cycle Checkpoints, RAS-RAF Signaling and P53 Signaling. And so on.

For genetic risk of Salivary Adenocarcinoma due to abnormalities in genes PIK3R1 and KDM6A – Foods like Cassava are recommended compared to Carob. This is because the active ingredients Palmitic Acid and Folic Acid in Carob further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Cassava together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: CASSAVA IS RECOMMENDED OVER CAROB FOR REDUCING THE GENETIC RISK OF SALIVARY ADENOCARCINOMA DUE TO GENES PIK3R1 AND KDM6A

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.

Eat more fruits, Orange or Raspberry?

The active ingredients contained in Orange are D-limonene, Linalool, Vitamin C, Modified Citrus Pectin, Linolenic Acid among others. While the active ingredients contained in Raspberry are Ellagic Acid, Quercetin, Resveratrol, Vitamin C, Gallic Acid and others.

D-limonene can manipulate biochemical pathways Cell Cycle Checkpoints, RAS-RAF Signaling and P53 Signaling. Vitamin C has biological action on biochemical pathways MYC Signaling, PI3K-AKT-MTOR Signaling and Apoptosis.

Ellagic Acid can manipulate biochemical pathways MYC Signaling and Cell Cycle Checkpoints. Resveratrol has biological action on biochemical pathways P53 Signaling. And so on.

For genetic risk of Salivary Adenocarcinoma due to abnormalities in genes PIK3R1 and KDM6A – Foods like Orange are recommended compared to Raspberry. This is because the active ingredients Ellagic Acid and Resveratrol in Raspberry further promote the effects of genes on the biochemical pathways. While the active ingredients D-limonene and Vitamin C contained in Orange together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: ORANGE IS RECOMMENDED OVER RASPBERRY FOR REDUCING THE GENETIC RISK OF SALIVARY ADENOCARCINOMA DUE TO GENES PIK3R1 AND KDM6A

Eat more nuts, Walnut or Cashew Nut?

The active ingredients contained in Walnut are D-limonene, Ellagic Acid, Vitamin E, Betulinic Acid, Protocatechuic Acid among others. While the active ingredients contained in Cashew Nut are Beta-sitosterol, Vitamin C, Palmitic Acid, Butyric Acid, Gallic Acid and others.

D-limonene can manipulate biochemical pathways Cell Cycle Checkpoints, RAS-RAF Signaling and P53 Signaling. Beta-sitosterol has biological action on biochemical pathways MYC Signaling, PI3K-AKT-MTOR Signaling and Apoptosis.

Palmitic Acid can manipulate biochemical pathways Chromatin Remodeling and PI3K-AKT-MTOR Signaling. Lauric Acid has biological action on biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. And so on.

For genetic risk of Salivary Adenocarcinoma due to abnormalities in genes PIK3R1 and KDM6A – Foods like Walnut are recommended compared to Cashew Nut. This is because the active ingredients Palmitic Acid and Lauric Acid in Cashew Nut further promote the effects of genes on the biochemical pathways. While the active ingredients D-limonene and Beta-sitosterol contained in Walnut together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: WALNUT IS RECOMMENDED OVER CASHEW NUT FOR REDUCING THE GENETIC RISK OF SALIVARY ADENOCARCINOMA DUE TO GENES PIK3R1 AND KDM6A


In Summary

An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.

“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.

The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.

You can get started NOW and design a personalized nutrition plan for Salivary Adenocarcinoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

sample-report


References

Personalized Nutrition for Cancer!

Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.


Scientifically Reviewed by: Dr. Cogle

Christopher R. Cogle, M.D. is a tenured professor at the University of Florida, Chief Medical Officer of Florida Medicaid, and Director of the Florida Health Policy Leadership Academy at the Bob Graham Center for Public Service.

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