Which Foods are Recommended for Parathyroid Carcinoma?

Highlights

No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Parathyroid Carcinoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Parathyroid Carcinoma because of CDC73 and RAD50 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.

There is no one answer to this question for cancers such as Parathyroid Carcinoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.

In short – the process to answer questions like “Should I Avoid eating fruit Cranberry” or “Include fruit Naranjilla in my diet” or “Should I reduce consumption of vegetable Carob” or “Can I take Psyllium and Spirulina supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.

RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO PARATHYROID CARCINOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.

The overall objective of personalized nutrition for Parathyroid Carcinoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.

RECOMMENDATION: UPDATE YOUR NUTRITION FOR PARATHYROID CARCINOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.

About Parathyroid Carcinoma

cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.

Following key highlights are derived from clinical data for Parathyroid Carcinoma from cBioPortal. The top genes with mutations and other abnormalities for Parathyroid Carcinoma include genes CDC73, TP53, RAD50, AKAP9 and KMT2D. The occurrence frequency distribution for these genes respectively is 13.8%, 13.8%, 13.8%, 10.3% and 6.9%. These tumor genetic details of Parathyroid Carcinoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Parathyroid Carcinoma.

Significance of Nutrition for Parathyroid Carcinoma

All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Parathyroid Carcinoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.

For example Cranberry includes active ingredients Quercetin, Hyperoside, Vitamin C, P-coumaric Acid, Ellagic Acid and others. And Naranjilla contains active ingredients Beta-carotene, Zeaxanthin, Vitamin A and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.

For cancers like Parathyroid Carcinoma, activation or inhibition of selected biochemical pathways like Apoptosis, DNA Repair, Cell Cycle Checkpoints, Oncogenic Histone Methylation plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Parathyroid Carcinoma, while eating some other foods and supplements may not be recommended.

One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.

RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR PARATHYROID CARCINOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.

Foods for Parathyroid Carcinoma undergoing chemotherapy treatment

In Parathyroid Carcinoma – the genes CDC73, TP53, RAD50, AKAP9 and KMT2D have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Parathyroid Carcinoma are Apoptosis, DNA Repair, PI3K-AKT-MTOR Signaling and others. Carboplatin is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Apoptosis, DNA Repair, PI3K-AKT-MTOR Signaling so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.

RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.

Eat more pulses, Common Pea or Common Bean?

Pulses are an important part of many diets. The active ingredients contained in Common Pea are Lupeol, Beta-sitosterol, Daidzein, Linolenic Acid, Vitamin C among others. While the active ingredients contained in Common Bean are Apigenin, Esculin, Ferulic Acid, Linolenic Acid, Vitamin C and others.

Beta-sitosterol can manipulate biochemical pathways Apoptosis, MYC Signaling and WNT Beta Catenin Signaling. Vitamin C has biological action on biochemical pathways P53 Signaling, PI3K-AKT-MTOR Signaling and Apoptosis.

Apigenin can manipulate biochemical pathways DNA Repair. Esculin has biological action on biochemical pathways DNA Repair. And so on.

When treating Parathyroid Carcinoma with chemotherapy Carboplatin – Foods like Common Pea are recommended compared to Common Bean. This is because the active ingredients Apigenin and Esculin in Common Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin C contained in Common Pea support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: COMMON PEA IS RECOMMENDED OVER COMMON BEAN FOR PARATHYROID CARCINOMA ON TREATMENT WITH CHEMOTHERAPY CARBOPLATIN FOR SOME CONDITIONS.

Eat more vegetables, Arrowroot or Carob?

Vegetables are an important part of many diets. The active ingredients contained in Arrowroot are Beta-carotene, Quercetin, Protocatechuic Acid, Vitamin C, Chlorogenic Acid among others. While the active ingredients contained in Carob are Quercetin, Palmitic Acid, Gallic Acid, Phloroglucinol, Myricetin and others.

Beta-carotene can manipulate biochemical pathways Apoptosis, DNA Repair and MYC Signaling. Quercetin has biological action on biochemical pathways WNT Beta Catenin Signaling, P53 Signaling and PI3K-AKT-MTOR Signaling.

Palmitic Acid can manipulate biochemical pathways WNT Beta Catenin Signaling. Folic Acid has biological action on biochemical pathways MYC Signaling, P53 Signaling and Apoptosis. And so on.

When treating Parathyroid Carcinoma with chemotherapy Carboplatin – Foods like Arrowroot are recommended compared to Carob. This is because the active ingredients Palmitic Acid and Folic Acid in Carob interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-carotene and Quercetin contained in Arrowroot support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: ARROWROOT IS RECOMMENDED OVER CAROB FOR PARATHYROID CARCINOMA ON TREATMENT WITH CHEMOTHERAPY CARBOPLATIN FOR SOME CONDITIONS.

Eat more fruits, Naranjilla or Cranberry?

Fruits are an important part of many diets. The active ingredients contained in Naranjilla are Beta-carotene, Zeaxanthin, Vitamin A among others. While the active ingredients contained in Cranberry are Quercetin, Hyperoside, Vitamin C, P-coumaric Acid, Ellagic Acid and others.

Beta-carotene can manipulate biochemical pathways Apoptosis, DNA Repair and MYC Signaling. Vitamin A has biological action on biochemical pathways WNT Beta Catenin Signaling, PI3K-AKT-MTOR Signaling and MYC Signaling.

Ellagic Acid can manipulate biochemical pathways MYC Signaling and WNT Beta Catenin Signaling. Resveratrol has biological action on biochemical pathways P53 Signaling and DNA Repair. And so on.

When treating Parathyroid Carcinoma with chemotherapy Carboplatin – Foods like Naranjilla are recommended compared to Cranberry. This is because the active ingredients Ellagic Acid and Resveratrol in Cranberry interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-carotene and Vitamin A contained in Naranjilla support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: NARANJILLA IS RECOMMENDED OVER CRANBERRY FOR PARATHYROID CARCINOMA ON TREATMENT WITH CHEMOTHERAPY CARBOPLATIN FOR SOME CONDITIONS.

Eat more nuts, Almond or Peanut?

Nuts are an important part of many diets. The active ingredients contained in Almond are Beta-sitosterol, Vitamin E, Quercetin, Linolenic Acid, Stigmasterol among others. While the active ingredients contained in Peanut are Beta-sitosterol, Vitamin E, Ferulic Acid, Quercetin, Linolenic Acid and others.

Beta-sitosterol can manipulate biochemical pathways Apoptosis, MYC Signaling and WNT Beta Catenin Signaling. Vitamin E has biological action on biochemical pathways DNA Repair, P53 Signaling and PI3K-AKT-MTOR Signaling.

Lecithin can manipulate biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways P53 Signaling, Apoptosis and MYC Signaling. And so on.

When treating Parathyroid Carcinoma with chemotherapy Carboplatin – Foods like Almond are recommended compared to Peanut. This is because the active ingredients Lecithin and Folic Acid in Peanut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin E contained in Almond support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: ALMOND IS RECOMMENDED OVER PEANUT FOR PARATHYROID CARCINOMA ON TREATMENT WITH CHEMOTHERAPY CARBOPLATIN FOR SOME CONDITIONS.

Foods for Genetic Risk of Parathyroid Carcinoma

One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. CDC73 and RAD50 are two genes whose abnormalities are risk factors for Parathyroid Carcinoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Parathyroid Carcinoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Parathyroid Carcinoma gene CDC73 has causative impact on biological pathways like Cell Cycle Checkpoints. And RAD50 has a causative impact on biological pathways like DNA Repair and Cell Cycle Checkpoints. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like CDC73 and RAD50 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes CDC73 and RAD50 should be avoided.

Eat more pulses, Scarlet Bean or Soy Bean?

The active ingredients contained in Scarlet Bean are Vitamin C, Beta-sitosterol, Linolenic Acid, Genistein, Oleic Acid among others. While the active ingredients contained in Soy Bean are Lupeol, Vitamin C, Beta-sitosterol, Quercetin, Daidzein and others.

Vitamin C can manipulate biochemical pathways Adherens junction, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling. Beta-sitosterol has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and Adherens junction.

Aescin can manipulate biochemical pathways Cell Cycle Checkpoints. Lecithin has biological action on biochemical pathways RAS-RAF Signaling and PI3K-AKT-MTOR Signaling. And so on.

For genetic risk of Parathyroid Carcinoma due to abnormalities in genes CDC73 and RAD50 – Foods like Scarlet Bean are recommended compared to Soy Bean. This is because the active ingredients Aescin and Lecithin in Soy Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Scarlet Bean together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: SCARLET BEAN IS RECOMMENDED OVER SOY BEAN FOR REDUCING THE GENETIC RISK OF PARATHYROID CARCINOMA DUE TO GENES CDC73 AND RAD50

Eat more vegetables, Jicama or Chicory?

The active ingredients contained in Jicama are Vitamin C, Beta-carotene, Vitamin B3, Vitamin A, Folic Acid among others. While the active ingredients contained in Chicory are Apigenin, Lupeol, Betulinic Acid, Esculin, Vitamin C and others.

Vitamin C can manipulate biochemical pathways Adherens junction, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling. Beta-carotene has biological action on biochemical pathways Hypoxia, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling.

Gallic Acid can manipulate biochemical pathways DNA Repair. Esculetin has biological action on biochemical pathways Hypoxia. And so on.

For genetic risk of Parathyroid Carcinoma due to abnormalities in genes CDC73 and RAD50 – Foods like Jicama are recommended compared to Chicory. This is because the active ingredients Gallic Acid and Esculetin in Chicory further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-carotene contained in Jicama together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: JICAMA IS RECOMMENDED OVER CHICORY FOR REDUCING THE GENETIC RISK OF PARATHYROID CARCINOMA DUE TO GENES CDC73 AND RAD50

Eat more fruits, Grape or Coconut?

The active ingredients contained in Grape are Resveratrol, Lupeol, Vitamin C, Beta-sitosterol, Pterostilbene among others. While the active ingredients contained in Coconut are Beta-sitosterol, Palmitic Acid, Vitamin E, Capric Acid, Lauric Acid and others.

Vitamin C can manipulate biochemical pathways Adherens junction, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling. Geraniin has biological action on biochemical pathways PI3K-AKT-MTOR Signaling.

Palmitic Acid can manipulate biochemical pathways DNA Repair and Energy Metabolism. Capric Acid has biological action on biochemical pathways Energy Metabolism. And so on.

For genetic risk of Parathyroid Carcinoma due to abnormalities in genes CDC73 and RAD50 – Foods like Grape are recommended compared to Coconut. This is because the active ingredients Palmitic Acid and Capric Acid in Coconut further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Geraniin contained in Grape together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: GRAPE IS RECOMMENDED OVER COCONUT FOR REDUCING THE GENETIC RISK OF PARATHYROID CARCINOMA DUE TO GENES CDC73 AND RAD50

Eat more nuts, Hazelnut or Cashew Nut?

The active ingredients contained in Hazelnut are Quercetin, Vitamin E, Linolenic Acid, Oleic Acid, Vitamin A among others. While the active ingredients contained in Cashew Nut are Vitamin C, Beta-sitosterol, Palmitic Acid, Butyric Acid, Vitamin K and others.

Quercetin can manipulate biochemical pathways Cell Cycle Checkpoints, Hypoxia and PI3K-AKT-MTOR Signaling. Vitamin E has biological action on biochemical pathways RAS-RAF Signaling, Cell Cycle Checkpoints and Hypoxia.

Palmitic Acid can manipulate biochemical pathways DNA Repair and Energy Metabolism. Lauric Acid has biological action on biochemical pathways PI3K-AKT-MTOR Signaling. And so on.

For genetic risk of Parathyroid Carcinoma due to abnormalities in genes CDC73 and RAD50 – Foods like Hazelnut are recommended compared to Cashew Nut. This is because the active ingredients Palmitic Acid and Lauric Acid in Cashew Nut further promote the effects of genes on the biochemical pathways. While the active ingredients Quercetin and Vitamin E contained in Hazelnut together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: HAZELNUT IS RECOMMENDED OVER CASHEW NUT FOR REDUCING THE GENETIC RISK OF PARATHYROID CARCINOMA DUE TO GENES CDC73 AND RAD50

In Summary

An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.

“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.

The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.

You can get started NOW and design a personalized nutrition plan for Parathyroid Carcinoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

References

• β-Sitosterol and Gemcitabine Exhibit Synergistic Anti-pancreatic Cancer Activity by Modulating Apoptosis and Inhibiting Epithelial-Mesenchymal Transition by Deactivating Akt/GSK-3β Signaling.
• Vitamin C enhances epigenetic modifications induced by 5-azacytidine and cell cycle arrest in the hepatocellular carcinoma cell lines HLE and Huh7.
• β-carotene Inhibits Expression of c-Myc and Cyclin E in Helicobacter pylori-infected Gastric Epithelial Cells.
• Retinol decreases beta-catenin protein levels in retinoic acid-resistant colon cancer cell lines.
• Identification of ellagic acid as potent inhibitor of protein kinase CK2: a successful example of a virtual screening application.
• Resveratrol, a remarkable inhibitor of ribonucleotide reductase.
• Protein kinase and HDAC inhibitors from the endophytic fungus Epicoccum nigrum.
• Functional lipidomics: Palmitic acid impairs hepatocellular carcinoma development by modulating membrane fluidity and glucose metabolism.
• Effects of folate deficiency on gene expression in the apoptosis and cancer pathways in colon cancer cells.
• Gamma- and delta-tocotrienols exert a more potent anticancer effect than alpha-tocopheryl succinate on breast cancer cell lines irrespective of HER-2/neu expression.
• New concepts in phospholipase D signaling in inflammation and cancer.
• Suppression of lipopolysaccharide-induced nuclear factor-kappaB activity by theaflavin-3,3′-digallate from black tea and other polyphenols through down-regulation of IkappaB kinase activity in macrophages.
• Decanoic Acid and Not Octanoic Acid Stimulates Fatty Acid Synthesis in U87MG Glioblastoma Cells: A Metabolomics Study.
• Gallic acid provokes DNA damage and suppresses DNA repair gene expression in human prostate cancer PC-3 cells.
• HyperFoods: Machine intelligent mapping of cancer-beating molecules in foods.