Which Foods are Recommended for Lung Carcinoid?

Highlights

No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Lung Carcinoid when undergoing chemotherapy or when you determine you have a genetic risk for developing Lung Carcinoid because of EIF1AX and MEN1 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.

There is no one answer to this question for cancers such as Lung Carcinoid which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.

In short – the process to answer questions like “Should I Avoid eating fruit Plum” or “Include fruit Pear in my diet” or “Should I reduce consumption of vegetable Japanese Pumpkin” or “Can I take Rutaecarpine and Carvacrol supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.

RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO LUNG CARCINOID, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.

The overall objective of personalized nutrition for Lung Carcinoid is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.

RECOMMENDATION: UPDATE YOUR NUTRITION FOR LUNG CARCINOID, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.

About Lung Carcinoid

cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.

Following key highlights are derived from clinical data for Lung Carcinoid from cBioPortal. 33.3% of males and 66.7% of females were the distribution of gender in these clinical studies. From a patient sample size of 9; the top genes with mutations and other abnormalities for Lung Carcinoid include genes ARID1A, EIF1AX, MEN1 and NOTCH1. The occurrence frequency distribution for these genes respectively is 33.3%, 16.7%, 16.7% and 16.7%. These tumor genetic details of Lung Carcinoid are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Lung Carcinoid.

Significance of Nutrition for Lung Carcinoid

All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Lung Carcinoid. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.

For example Plum includes active ingredients Chlorogenic Acid, Beta-sitosterol, Betulinic Acid, Cianidanol, Melatonin and others. And Pear contains active ingredients Chlorogenic Acid, Linolenic Acid, Beta-sitosterol, Isoliquiritigenin, P-coumaric Acid and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.

For cancers like Lung Carcinoid, activation or inhibition of selected biochemical pathways like Chromatin Remodeling, Oncogenic Histone Methylation, Notch Signaling, RUNX Signaling plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Lung Carcinoid, while eating some other foods and supplements may not be recommended.

One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.

RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR LUNG CARCINOID – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.

Foods for Lung Carcinoid undergoing chemotherapy treatment

In Lung Carcinoid – the genes ARID1A, EIF1AX, MEN1 and NOTCH1 have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Lung Carcinoid are Chromatin Remodeling, Oncogenic Histone Methylation and others. Radiation is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Chromatin Remodeling, Oncogenic Histone Methylation so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.

RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.

Eat more pulses, Fava Bean or Hyacinth Bean?

Pulses are an important part of many diets. The active ingredients contained in Fava Bean are Butein, Linolenic Acid, Beta-sitosterol, Cianidanol, Genistein among others. While the active ingredients contained in Hyacinth Bean are Genistein, Myristic Acid, Palmitic Acid and others.

Butein can manipulate biochemical pathways Notch Signaling and RUNX Signaling. Beta-sitosterol has biological action on biochemical pathways RUNX Signaling.

Palmitic Acid can manipulate biochemical pathways Chromatin Remodeling. Myristic Acid has biological action on biochemical pathways RUNX Signaling. And so on.

When treating Lung Carcinoid with chemotherapy Radiation – Foods like Fava Bean are recommended compared to Hyacinth Bean. This is because the active ingredients Palmitic Acid and Myristic Acid in Hyacinth Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Butein and Beta-sitosterol contained in Fava Bean support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: FAVA BEAN IS RECOMMENDED OVER HYACINTH BEAN FOR LUNG CARCINOID ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Eat more vegetables, Celery or Japanese Pumpkin?

Vegetables are an important part of many diets. The active ingredients contained in Celery are Luteolin, Linolenic Acid, Chrysin among others. While the active ingredients contained in Japanese Pumpkin are Vitamin E, Beta-sitosterol, Myristic Acid, Palmitic Acid and others.

Luteolin can manipulate biochemical pathways Notch Signaling and RUNX Signaling. Chrysin has biological action on biochemical pathways Chromatin Remodeling.

Palmitic Acid can manipulate biochemical pathways Chromatin Remodeling. Myristic Acid has biological action on biochemical pathways RUNX Signaling. And so on.

When treating Lung Carcinoid with chemotherapy Radiation – Foods like Celery are recommended compared to Japanese Pumpkin. This is because the active ingredients Palmitic Acid and Myristic Acid in Japanese Pumpkin interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Luteolin and Chrysin contained in Celery support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: CELERY IS RECOMMENDED OVER JAPANESE PUMPKIN FOR LUNG CARCINOID ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Eat more fruits, Pear or Plum?

Fruits are an important part of many diets. The active ingredients contained in Pear are Chlorogenic Acid, Linolenic Acid, Beta-sitosterol, Isoliquiritigenin, P-coumaric Acid among others. While the active ingredients contained in Plum are Chlorogenic Acid, Beta-sitosterol, Betulinic Acid, Cianidanol, Melatonin and others.

Chlorogenic Acid can manipulate biochemical pathways Notch Signaling and RUNX Signaling. Beta-sitosterol has biological action on biochemical pathways RUNX Signaling.

Myristic Acid can manipulate biochemical pathways RUNX Signaling. Palmitic Acid has biological action on biochemical pathways Chromatin Remodeling. And so on.

When treating Lung Carcinoid with chemotherapy Radiation – Foods like Pear are recommended compared to Plum. This is because the active ingredients Myristic Acid and Palmitic Acid in Plum interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Chlorogenic Acid and Beta-sitosterol contained in Pear support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: PEAR IS RECOMMENDED OVER PLUM FOR LUNG CARCINOID ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Eat more nuts, Walnut or Cashew Nut?

Nuts are an important part of many diets. The active ingredients contained in Walnut are Carvacrol, Chlorogenic Acid, Vitamin E, Juglone, Linolenic Acid among others. While the active ingredients contained in Cashew Nut are Beta-sitosterol, Myristic Acid, Palmitic Acid and others.

Carvacrol can manipulate biochemical pathways Notch Signaling and RUNX Signaling. Juglone has biological action on biochemical pathways Notch Signaling.

Myristic Acid can manipulate biochemical pathways RUNX Signaling. Palmitic Acid has biological action on biochemical pathways Chromatin Remodeling. And so on.

When treating Lung Carcinoid with chemotherapy Radiation – Foods like Walnut are recommended compared to Cashew Nut. This is because the active ingredients Myristic Acid and Palmitic Acid in Cashew Nut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Carvacrol and Juglone contained in Walnut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: WALNUT IS RECOMMENDED OVER CASHEW NUT FOR LUNG CARCINOID ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Foods for Genetic Risk of Lung Carcinoid

One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. EIF1AX and MEN1 are two genes whose abnormalities are risk factors for Lung Carcinoid. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Lung Carcinoid can be used as a guide for coming up with a recommended personalized nutrition plan. For Lung Carcinoid gene EIF1AX has causative impact on biological pathways like PI3K-AKT-MTOR Signaling. And MEN1 has a causative impact on biological pathways like Oncogenic Cancer Epigenetics and DNA Repair. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like EIF1AX and MEN1 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes EIF1AX and MEN1 should be avoided.

Eat more pulses, Mung Bean or Soy Bean?

The active ingredients contained in Mung Bean are Vitamin C, Linolenic Acid, Quercetin, Oleic Acid, Stigmasterol among others. While the active ingredients contained in Soy Bean are Lupeol, Daidzein, Beta-sitosterol, Vitamin E, Vitamin C and others.

Vitamin C can manipulate biochemical pathways Cell Cycle Checkpoints, RAS-RAF Signaling and Apoptosis. Quercetin has biological action on biochemical pathways MAPK Signaling, WNT Beta Catenin Signaling and PI3K-AKT-MTOR Signaling.

Aescin can manipulate biochemical pathways Cell Cycle Checkpoints. Lecithin has biological action on biochemical pathways MAPK Signaling, PI3K-AKT-MTOR Signaling and MYC Signaling. And so on.

For genetic risk of Lung Carcinoid due to abnormalities in genes EIF1AX and MEN1 – Foods like Mung Bean are recommended compared to Soy Bean. This is because the active ingredients Aescin and Lecithin in Soy Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Quercetin contained in Mung Bean together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: MUNG BEAN IS RECOMMENDED OVER SOY BEAN FOR REDUCING THE GENETIC RISK OF LUNG CARCINOID DUE TO GENES EIF1AX AND MEN1

Eat more vegetables, Arugula or Bell Pepper?

The active ingredients contained in Arugula are Esculin, Vitamin A, Kaempferol, Vitamin K, Erysolin among others. While the active ingredients contained in Bell Pepper are Vitamin E, Vitamin C, Linolenic Acid, P-coumaric Acid, Capsaicin and others.

Vitamin A can manipulate biochemical pathways Cell Cycle Checkpoints, Apoptosis and WNT Beta Catenin Signaling. Kaempferol has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, RAS-RAF Signaling and Cell Cycle Checkpoints.

Capsaicin can manipulate biochemical pathways MAPK Signaling. Folic Acid has biological action on biochemical pathways Cell Cycle Checkpoints, RAS-RAF Signaling and Apoptosis. And so on.

For genetic risk of Lung Carcinoid due to abnormalities in genes EIF1AX and MEN1 – Foods like Arugula are recommended compared to Bell Pepper. This is because the active ingredients Capsaicin and Folic Acid in Bell Pepper further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin A and Kaempferol contained in Arugula together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: ARUGULA IS RECOMMENDED OVER BELL PEPPER FOR REDUCING THE GENETIC RISK OF LUNG CARCINOID DUE TO GENES EIF1AX AND MEN1

Eat more fruits, Kiwi or Cranberry?

The active ingredients contained in Kiwi are Vitamin C, Quercetin, Vitamin A, Chlorogenic Acid, Fisetin among others. While the active ingredients contained in Cranberry are Vitamin C, Hyperoside, Resveratrol, Ellagic Acid, P-coumaric Acid and others.

Vitamin C can manipulate biochemical pathways Cell Cycle Checkpoints, RAS-RAF Signaling and Apoptosis. Quercetin has biological action on biochemical pathways MAPK Signaling, WNT Beta Catenin Signaling and PI3K-AKT-MTOR Signaling.

Resveratrol can manipulate biochemical pathways P53 Signaling. Ellagic Acid has biological action on biochemical pathways MYC Signaling and WNT Beta Catenin Signaling. And so on.

For genetic risk of Lung Carcinoid due to abnormalities in genes EIF1AX and MEN1 – Foods like Kiwi are recommended compared to Cranberry. This is because the active ingredients Resveratrol and Ellagic Acid in Cranberry further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Quercetin contained in Kiwi together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: KIWI IS RECOMMENDED OVER CRANBERRY FOR REDUCING THE GENETIC RISK OF LUNG CARCINOID DUE TO GENES EIF1AX AND MEN1

Eat more nuts, Almond or Brazil Nut?

The active ingredients contained in Almond are Beta-sitosterol, Vitamin E, Linolenic Acid, Quercetin, Oleic Acid among others. While the active ingredients contained in Brazil Nut are Vitamin E, Linolenic Acid, Oleic Acid, Lecithin, Folic Acid and others.

Beta-sitosterol can manipulate biochemical pathways Cell Cycle Checkpoints, Apoptosis and WNT Beta Catenin Signaling. Vitamin E has biological action on biochemical pathways MAPK Signaling, PI3K-AKT-MTOR Signaling and MYC Signaling.

Lecithin can manipulate biochemical pathways MAPK Signaling, PI3K-AKT-MTOR Signaling and MYC Signaling. Folic Acid has biological action on biochemical pathways Cell Cycle Checkpoints, RAS-RAF Signaling and Apoptosis. And so on.

For genetic risk of Lung Carcinoid due to abnormalities in genes EIF1AX and MEN1 – Foods like Almond are recommended compared to Brazil Nut. This is because the active ingredients Lecithin and Folic Acid in Brazil Nut further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin E contained in Almond together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: ALMOND IS RECOMMENDED OVER BRAZIL NUT FOR REDUCING THE GENETIC RISK OF LUNG CARCINOID DUE TO GENES EIF1AX AND MEN1

In Summary

An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.

“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.

The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.

You can get started NOW and design a personalized nutrition plan for Lung Carcinoid by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

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