Foods for Inflammatory Myofibroblastic Tumor!

Introduction

Foods for Inflammatory Myofibroblastic Tumor should be personalized for each individual and also must adapt when cancer treatment or tumor genetic change. The personalization and adaptation must consider all the active ingredients or bioactives contained in different foods with respect to cancer tissue biology, genetics, treatments, lifestyle conditions and diet preferences. Hence while nutrition is one of the very important decisions for a cancer patient and individual at risk of cancer to make – how to choose foods to eat is not an easy task.

Inflammatory Myofibroblastic Tumor (IMT) is a rare tumor that can be benign or malignant and is characterized by a proliferation of myofibroblastic and inflammatory cells. The pathology outlines of IMT, particularly in cases involving the lung, are vital for accurate diagnosis and often complemented by cytology studies. Radiology plays a key role in detecting and assessing these tumors. The survival rate of IMT is generally favorable, but it can vary based on the tumor’s location, size, and malignant potential. Classified under the ICD-10 system, IMT’s management involves treatment guidelines that typically include surgical resection, with chemotherapy used in some cases. Understanding what an inflammatory myofibroblastic tumor is, along with its causes and potential for recurrence or transformation, is crucial for effective treatment planning. The approach to treating IMT is continually evolving, and the classification of IMT as either benign or malignant influences the therapeutic strategy and prognosis.

For Inflammatory Myofibroblastic Tumor does it matter what vegetables, fruits, nuts, seeds one eats?

A very common nutrition question asked by cancer patients and individuals at-genetic risk of cancer is – for cancers like Inflammatory Myofibroblastic Tumor does it matter what foods I eat and which I do not? Or if I follow a plant-based diet is that enough for cancer like Inflammatory Myofibroblastic Tumor?

For example does it matter if vegetable Brussel Sprouts is consumed more compared to Rocket Salad (ssp.)? Does it make any difference if fruit Pummelo is preferred over Evergreen Blackberry? Also if similar choices are made for nuts/seeds like Pistachio over European Chestnut and for pulses like Chickpea over Common Bean. And if what I eat matters – then how does one identify foods which are recommended for Inflammatory Myofibroblastic Tumor and is it the same answer for everyone with the same diagnosis or genetic risk?

Yes! Foods you eat matters for Inflammatory Myofibroblastic Tumor!

Food recommendations may not be the same for everyone and can be different even for the same diagnosis and genetic risk.

All foods (vegetables, fruits, nuts, seeds, pulses, oils etc.) and nutritional supplements are made up of more than one active molecular ingredient or bio-actives in different proportions and quantities. Each active ingredient has a unique mechanism of action – which can be activation or inhibition of different biochemical pathways. Simply stated foods and supplements which are recommended are those which do not cause an increase of molecular drivers of cancer but reduce them. Else those foods should not be recommended. Foods contain multiple active ingredients – hence when evaluating foods and supplements you need to consider the impact of all active ingredients cumulatively rather than individually.

For example Pummelo contains active ingredients Curcumin, Apigenin, Lycopene, Protocatechuic Acid, Daidzein. And Evergreen Blackberry contains active ingredients Linalool, Ellagic Acid, Eugenol, Alpha Pinene, Beta-ionone and possibly others.

A common mistake made when deciding and choosing foods to eat for Inflammatory Myofibroblastic Tumor – is to evaluate only selected active ingredients contained in foods and ignore the rest. Because different active ingredients contained in foods may have opposing effects on cancer drivers – you cannot cherry pick active ingredients in foods and supplements for making a nutrition decision for Inflammatory Myofibroblastic Tumor.

YES – FOOD CHOICES MATTER FOR CANCER. NUTRITION DECISIONS MUST CONSIDER ALL ACTIVE INGREDIENTS OF FOODS.

Skills Needed for Nutrition Personalization for Inflammatory Myofibroblastic Tumor?

Personalized nutrition for cancers like Inflammatory Myofibroblastic Tumor consists of recommended foods / supplements; not recommended foods / supplements with example recipes which prioritize use of recommended foods. An example of personalized nutrition can be seen at this link.

Deciding which foods are recommended or not is extremely complicated, requiring expertise in Inflammatory Myofibroblastic Tumor biology, food science, genetics, biochemistry along with good understanding of how cancer treatments work and associated vulnerabilities by which the treatments could stop being effective.

MINIMUM KNOWLEDGE EXPERTISE NEEDED FOR NUTRITION PERSONALIZATION FOR CANCER ARE: CANCER BIOLOGY, FOOD SCIENCE, CANCER TREATMENTS AND GENETICS.

Characteristics of cancers like Inflammatory Myofibroblastic Tumor

All cancers like Inflammatory Myofibroblastic Tumor can be characterized by a unique set of biochemical pathways – the signature pathways of Inflammatory Myofibroblastic Tumor. Biochemical pathways like MAPK Signaling, PI3K-AKT-MTOR Signaling, RAS-RAF Signaling, Angiogenesis are part of the signature definition of Inflammatory Myofibroblastic Tumor. Each individual’s cancer genetics can be different and hence their specific cancer signature could be unique.

The treatments which are effective for Inflammatory Myofibroblastic Tumor need to be cognizant of the associated signature biochemical pathways for each cancer patient and individual at genetic risk. Therefore different treatments with different mechanisms of actions are effective for different patients. Similarly and for the same reasons foods and supplements need to be personalized for each individual. Hence some foods and supplements are recommended for Inflammatory Myofibroblastic Tumor when taking cancer treatment Gemcitabine, and some foods and supplements are not recommended.

Sources like cBioPortal and many others provide population representative patient anonymized data from clinical trials for all cancer indications. This data consists of clinical trial study details like sample size / number of patients, age groups, gender, ethnicity, treatments, tumor site and any genetic mutations.

ARID2, FLT4, IGF1R, KRAS and EED are the top ranked reported genes for Inflammatory Myofibroblastic Tumor. ARID2 is reported in 25.0 % of the representative patients across all clinical trials. And FLT4 is reported in 25.0 %. The combined population patient data cover ages from to . 50.0 % of the patient data are identified as men. The Inflammatory Myofibroblastic Tumor biology along with reported genetics together define the population represented signature biochemical pathways for this cancer. If the individual cancer tumor genetics or genes contributing to the risk are also known then that should also be used for nutrition personalization.

NUTRITION CHOICES SHOULD MATCH WITH EACH INDIVIDUAL’S CANCER SIGNATURE.

Food and Supplements for Inflammatory Myofibroblastic Tumor

For Cancer Patients

Cancer patients on treatment or on palliative care need to make decisions on food and supplements – for the needed dietary calories, for managing any treatment side effects and also for improved cancer management. All plant-based foods are not equal and choosing and prioritizing foods which are personalized and customized to ongoing cancer treatment is important and complicated. Here are some examples providing guidelines for making nutrition decisions.

Choose Vegetable BRUSSEL SPROUTS or ROCKET SALAD (SSP.)

Vegetable Brussel Sprouts contains many active ingredients or bioactives such as Curcumin, Protocatechuic Acid, Daidzein, Lupeol, Formononetin. These active ingredients manipulate various biochemical pathways like MAPK Signaling, MYC Signaling and PI3K-AKT-MTOR Signaling and others. Brussel Sprouts is recommended for Inflammatory Myofibroblastic Tumor when ongoing cancer treatment is Gemcitabine. This is because Brussel Sprouts modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Gemcitabine.

Some of the active ingredients or bioactives in vegetable Rocket Salad (ssp.) are Curcumin, Apigenin, Lycopene, Protocatechuic Acid, Daidzein. These active ingredients manipulate various biochemical pathways like MAPK Signaling and PI3K-AKT-MTOR Signaling and others. Rocket Salad (ssp.) is not recommended for Inflammatory Myofibroblastic Tumor when ongoing cancer treatment is Gemcitabine because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

VEGETABLE BRUSSEL SPROUTS IS RECOMMENDED OVER ROCKET SALAD (SSP.) FOR Inflammatory Myofibroblastic Tumor AND TREATMENT Gemcitabine.

Choose Fruit EVERGREEN BLACKBERRY or PUMMELO

Fruit Evergreen Blackberry contains many active ingredients or bioactives such as Linalool, Ellagic Acid, Eugenol, Alpha Pinene, Beta-ionone. These active ingredients manipulate various biochemical pathways like MAPK Signaling, MYC Signaling and PI3K-AKT-MTOR Signaling and others. Evergreen Blackberry is recommended for Inflammatory Myofibroblastic Tumor when ongoing cancer treatment is Gemcitabine. This is because Evergreen Blackberry modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Gemcitabine.

Some of the active ingredients or bioactives in fruit Pummelo are Curcumin, Apigenin, Lycopene, Protocatechuic Acid, Daidzein. These active ingredients manipulate various biochemical pathways like MYC Signaling and PI3K-AKT-MTOR Signaling and others. Pummelo is not recommended for Inflammatory Myofibroblastic Tumor when ongoing cancer treatment is Gemcitabine because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

FRUIT EVERGREEN BLACKBERRY IS RECOMMENDED OVER PUMMELO FOR Inflammatory Myofibroblastic Tumor AND TREATMENT Gemcitabine.

Choose Nut PISTACHIO or EUROPEAN CHESTNUT

Pistachio contains many active ingredients or bioactives such as Curcumin, Protocatechuic Acid, Daidzein, Lupeol, Formononetin. These active ingredients manipulate various biochemical pathways like MAPK Signaling, P53 Signaling, MYC Signaling and PI3K-AKT-MTOR Signaling and others. Pistachio is recommended for Inflammatory Myofibroblastic Tumor when ongoing cancer treatment is Gemcitabine. This is because Pistachio modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Gemcitabine.

Some of the active ingredients or bioactives in European Chestnut are Curcumin, Apigenin, Protocatechuic Acid, Ellagic Acid, Lupeol. These active ingredients manipulate various biochemical pathways like MYC Signaling and PI3K-AKT-MTOR Signaling and others. European Chestnut is not recommended for Inflammatory Myofibroblastic Tumor when ongoing cancer treatment is Gemcitabine because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

PISTACHIO IS RECOMMENDED OVER EUROPEAN CHESTNUT FOR Inflammatory Myofibroblastic Tumor AND TREATMENT Gemcitabine.

For Individuals with Genetic Risk of Cancer

The question asked by individuals who have genetic risk of Inflammatory Myofibroblastic Tumor or familial history is “What Should I Eat Differently from Before?” and how they should choose foods and supplements to manage risks of the disease. Since for cancer risk there is nothing actionable in terms of treatment – decisions of foods and supplements become important and one of the very few actionable things which can be done. All plant-based foods are not equal and based on identified genetics and pathway signature – the choices of food and supplements should be personalized.

Choose Vegetable GIANT BUTTERBUR or BLACK CABBAGE

Vegetable Giant Butterbur contains many active ingredients or bioactives such as Curcumin, Delphinidin, Apigenin, Formononetin, Myricetin. These active ingredients manipulate various biochemical pathways like MAPK Signaling, PI3K-AKT-MTOR Signaling, RAS-RAF Signaling and Oxidative Stress and others. Giant Butterbur is recommended for risk of Inflammatory Myofibroblastic Tumor when associated genetic risk is ARID2. This is because Giant Butterbur increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in vegetable Black Cabbage are Curcumin, Delphinidin, Apigenin, Formononetin, Myricetin. These active ingredients manipulate various biochemical pathways like Oxidative Stress and others. Black Cabbage is not recommended when risk of Inflammatory Myofibroblastic Tumor when associated genetic risk is ARID2 because it increases the signature pathways of it.

VEGETABLE GIANT BUTTERBUR IS RECOMMENDED OVER BLACK CABBAGE FOR ARID2 GENETIC RISK OF CANCER.

Choose Fruit NANCE or BLACKCURRANT

Fruit Nance contains many active ingredients or bioactives such as Curcumin, Delphinidin, Apigenin, Formononetin, Myricetin. These active ingredients manipulate various biochemical pathways like MAPK Signaling, PI3K-AKT-MTOR Signaling, RAS-RAF Signaling and Oxidative Stress and others. Nance is recommended for risk of Inflammatory Myofibroblastic Tumor when associated genetic risk is ARID2. This is because Nance increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in fruit Blackcurrant are Quercetin, Curcumin, Delphinidin, Formononetin, Linalool. These active ingredients manipulate various biochemical pathways like Oxidative Stress and others. Blackcurrant is not recommended when risk of Inflammatory Myofibroblastic Tumor when associated genetic risk is ARID2 because it increases the signature pathways of it.

FRUIT NANCE IS RECOMMENDED OVER BLACKCURRANT FOR ARID2 GENETIC RISK OF CANCER.

Choose Nut COMMON HAZELNUT or CASHEW NUT

Common Hazelnut contains many active ingredients or bioactives such as Quercetin, Curcumin, Delphinidin, Formononetin, Myricetin. These active ingredients manipulate various biochemical pathways like MAPK Signaling, Oxidative Stress, RAS-RAF Signaling and PI3K-AKT-MTOR Signaling and others. Common Hazelnut is recommended for risk of Inflammatory Myofibroblastic Tumor when associated genetic risk is ARID2. This is because Common Hazelnut increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in Cashew Nut are Quercetin, Curcumin, Delphinidin, Formononetin, Myricetin. These active ingredients manipulate various biochemical pathways like MAPK Signaling, Oxidative Stress and PI3K-AKT-MTOR Signaling and others. Cashew Nut is not recommended when risk of Inflammatory Myofibroblastic Tumor when associated genetic risk is ARID2 because it increases the signature pathways of it.

COMMON HAZELNUT IS RECOMMENDED OVER CASHEW NUT FOR ARID2 GENETIC RISK OF CANCER.

In Conclusion

Foods and Supplements chosen are important decisions for cancers like Inflammatory Myofibroblastic Tumor. Inflammatory Myofibroblastic Tumor patients and individuals with genetic-risk always have this question: “What foods and nutritional supplements are recommended for me and which are not?” There is a common belief which is a misconception that all plant-based foods could be beneficial or not but would not be harmful. Certain foods and supplements can interfere with cancer treatments or promote molecular pathway drivers of cancer.

There are different types of cancer indications like Inflammatory Myofibroblastic Tumor, each with different tumor genetics with further genomic variations across each individual. Further every cancer treatment and chemotherapy has a unique mechanism of action. Each food like Brussel Sprouts contains various bioactives in different quantities, which have an impact on different and distinct sets of biochemical pathways. The definition of personalized nutrition is individualized food recommendations for the cancer indication, treatments, genetics, lifestyle and other factors. Nutrition personalization decisions for cancer require knowledge of cancer biology, food science and an understanding of different chemotherapy treatments. Finally when there are treatment changes or new genomics is identified – the nutrition personalization needs re-evaluation.

The addon nutrition personalization solution makes the decision making easy and removes all the guesswork in answering the question, “What foods should I choose or not choose for Inflammatory Myofibroblastic Tumor?”. The addon multi-disciplinary team includes cancer physicians, clinical scientists, software engineers and data scientists.

References

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