Highlights
No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Inflammatory Myofibroblastic Tumor when undergoing chemotherapy or when you determine you have a genetic risk for developing Inflammatory Myofibroblastic Tumor because of ARID2 and FLT4 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.
There is no one answer to this question for cancers such as Inflammatory Myofibroblastic Tumor which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.
In short – the process to answer questions like “Should I Avoid eating fruit Cranberry” or “Include fruit Orange in my diet” or “Should I reduce consumption of vegetable Radish” or “Can I take D-limonene and Sesamin supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.
RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO INFLAMMATORY MYOFIBROBLASTIC TUMOR, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.
The overall objective of personalized nutrition for Inflammatory Myofibroblastic Tumor is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.
RECOMMENDATION: UPDATE YOUR NUTRITION FOR INFLAMMATORY MYOFIBROBLASTIC TUMOR, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.
About Inflammatory Myofibroblastic Tumor
cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.
Following key highlights are derived from clinical data for Inflammatory Myofibroblastic Tumor from cBioPortal. 50.0% of males and 50.0% of females were the distribution of gender in these clinical studies. From a patient sample size of 13; the top genes with mutations and other abnormalities for Inflammatory Myofibroblastic Tumor include genes ARID2, FLT4, IGF1R, KRAS and EED. The occurrence frequency distribution for these genes respectively is 25.0%, 25.0%, 25.0%, 25.0% and 25.0%. These tumor genetic details of Inflammatory Myofibroblastic Tumor are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Inflammatory Myofibroblastic Tumor.
Significance of Nutrition for Inflammatory Myofibroblastic Tumor
All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Inflammatory Myofibroblastic Tumor. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.
For example Cranberry includes active ingredients Ellagic Acid, Quercetin, Hyperoside, Vitamin C, P-coumaric Acid and others. And Orange contains active ingredients D-limonene, Modified Citrus Pectin, Linalool, Vitamin C, Linolenic Acid and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.
For cancers like Inflammatory Myofibroblastic Tumor, activation or inhibition of selected biochemical pathways like PI3K-AKT-MTOR Signaling, RAS-RAF Signaling, Angiogenesis, Growth Factor Signaling plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Inflammatory Myofibroblastic Tumor, while eating some other foods and supplements may not be recommended.
One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.
RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR INFLAMMATORY MYOFIBROBLASTIC TUMOR – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.
Foods for Inflammatory Myofibroblastic Tumor undergoing chemotherapy treatment
In Inflammatory Myofibroblastic Tumor – the genes ARID2, FLT4, IGF1R, KRAS and EED have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Inflammatory Myofibroblastic Tumor are PI3K-AKT-MTOR Signaling, RAS-RAF Signaling and others. Fluorouracil is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers PI3K-AKT-MTOR Signaling, RAS-RAF Signaling so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.
RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.
Eat more pulses, Mung Bean or Moth Bean?
Pulses are an important part of many diets. The active ingredients contained in Mung Bean are Quercetin, Vitamin C, Linolenic Acid, Vitexin, Stigmasterol among others. While the active ingredients contained in Moth Bean are Beta-sitosterol, Linolenic Acid, Stigmasterol, Oleic Acid, Linoleic Acid and others.
Quercetin can manipulate biochemical pathways Cell Cycle Checkpoints, RAS-RAF Signaling and Apoptosis. Vitamin C has biological action on biochemical pathways MAPK Signaling, PI3K-AKT-MTOR Signaling and MYC Signaling.
Folic Acid can manipulate biochemical pathways Cell Cycle Checkpoints, RAS-RAF Signaling and Apoptosis. And so on.
When treating Inflammatory Myofibroblastic Tumor with chemotherapy Fluorouracil – Foods like Mung Bean are recommended compared to Moth Bean. This is because the active ingredients Folic Acid in Moth Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Quercetin and Vitamin C contained in Mung Bean support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: MUNG BEAN IS RECOMMENDED OVER MOTH BEAN FOR INFLAMMATORY MYOFIBROBLASTIC TUMOR ON TREATMENT WITH CHEMOTHERAPY FLUOROURACIL FOR SOME CONDITIONS.
Eat more vegetables, Giant Butterbur or Radish?
Vegetables are an important part of many diets. The active ingredients contained in Giant Butterbur are Beta-sitosterol, Vitamin C, Vitamin B3, Melatonin, Kaempferol among others. While the active ingredients contained in Radish are Quercetin, Beta-sitosterol, Vitamin C, Linolenic Acid, P-coumaric Acid and others.
Vitamin C can manipulate biochemical pathways Cell Cycle Checkpoints, RAS-RAF Signaling and Apoptosis. Beta-sitosterol has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, MYC Signaling and Angiogenesis.
Pelargonidin can manipulate biochemical pathways MYC Signaling, PI3K-AKT-MTOR Signaling and Cell Cycle Checkpoints. Folic Acid has biological action on biochemical pathways RAS-RAF Signaling, Apoptosis and MAPK Signaling. And so on.
When treating Inflammatory Myofibroblastic Tumor with chemotherapy Fluorouracil – Foods like Giant Butterbur are recommended compared to Radish. This is because the active ingredients Pelargonidin and Folic Acid in Radish interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Beta-sitosterol contained in Giant Butterbur support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: GIANT BUTTERBUR IS RECOMMENDED OVER RADISH FOR INFLAMMATORY MYOFIBROBLASTIC TUMOR ON TREATMENT WITH CHEMOTHERAPY FLUOROURACIL FOR SOME CONDITIONS.
Eat more fruits, Orange or Cranberry?
Fruits are an important part of many diets. The active ingredients contained in Orange are D-limonene, Modified Citrus Pectin, Linalool, Vitamin C, Linolenic Acid among others. While the active ingredients contained in Cranberry are Ellagic Acid, Quercetin, Hyperoside, Vitamin C, P-coumaric Acid and others.
D-limonene can manipulate biochemical pathways Cell Cycle Checkpoints, RAS-RAF Signaling and Apoptosis. Vitamin C has biological action on biochemical pathways MAPK Signaling, PI3K-AKT-MTOR Signaling and MYC Signaling.
Ellagic Acid can manipulate biochemical pathways MYC Signaling. Resveratrol has biological action on biochemical pathways P53 Signaling. And so on.
When treating Inflammatory Myofibroblastic Tumor with chemotherapy Fluorouracil – Foods like Orange are recommended compared to Cranberry. This is because the active ingredients Ellagic Acid and Resveratrol in Cranberry interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients D-limonene and Vitamin C contained in Orange support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: ORANGE IS RECOMMENDED OVER CRANBERRY FOR INFLAMMATORY MYOFIBROBLASTIC TUMOR ON TREATMENT WITH CHEMOTHERAPY FLUOROURACIL FOR SOME CONDITIONS.
Eat more nuts, Almond or Macadamia Nut?
Nuts are an important part of many diets. The active ingredients contained in Almond are Quercetin, Vitamin E, Beta-sitosterol, Linolenic Acid, Stigmasterol among others. While the active ingredients contained in Macadamia Nut are Beta-sitosterol, Palmitic Acid, Lauric Acid, Myristic Acid, Folic Acid and others.
Beta-sitosterol can manipulate biochemical pathways Cell Cycle Checkpoints, Apoptosis and PI3K-AKT-MTOR Signaling. Quercetin has biological action on biochemical pathways RAS-RAF Signaling, MAPK Signaling and MYC Signaling.
Palmitic Acid can manipulate biochemical pathways MAPK Signaling. Lauric Acid has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, MYC Signaling and MAPK Signaling. And so on.
When treating Inflammatory Myofibroblastic Tumor with chemotherapy Fluorouracil – Foods like Almond are recommended compared to Macadamia Nut. This is because the active ingredients Palmitic Acid and Lauric Acid in Macadamia Nut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Quercetin contained in Almond support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: ALMOND IS RECOMMENDED OVER MACADAMIA NUT FOR INFLAMMATORY MYOFIBROBLASTIC TUMOR ON TREATMENT WITH CHEMOTHERAPY FLUOROURACIL FOR SOME CONDITIONS.
Foods for Genetic Risk of Inflammatory Myofibroblastic Tumor
One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. ARID2 and FLT4 are two genes whose abnormalities are risk factors for Inflammatory Myofibroblastic Tumor. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Inflammatory Myofibroblastic Tumor can be used as a guide for coming up with a recommended personalized nutrition plan. For Inflammatory Myofibroblastic Tumor gene ARID2 has causative impact on biological pathways like Chromatin Remodeling. And FLT4 has a causative impact on biological pathways like Angiogenesis, Hematopoiesis and Focal Adhesion. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like ARID2 and FLT4 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes ARID2 and FLT4 should be avoided.
Eat more pulses, Winged Bean or Fava Bean?
The active ingredients contained in Winged Bean are Oleic Acid, Betulinic Acid, Vitamin C, Linolenic Acid, Linoleic Acid among others. While the active ingredients contained in Fava Bean are Quercetin, Daidzein, Oleic Acid, Genistein, Beta-sitosterol and others.
Betulinic Acid can manipulate biochemical pathways Cell Cycle Checkpoints, Apoptosis and PI3K-AKT-MTOR Signaling. Vitamin C has biological action on biochemical pathways RAS-RAF Signaling, MYC Signaling and Angiogenesis.
Ferulic Acid can manipulate biochemical pathways DNA Repair. Vitamin A has biological action on biochemical pathways PI3K-AKT-MTOR Signaling. And so on.
For genetic risk of Inflammatory Myofibroblastic Tumor due to abnormalities in genes ARID2 and FLT4 – Foods like Winged Bean are recommended compared to Fava Bean. This is because the active ingredients Ferulic Acid and Vitamin A in Fava Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Betulinic Acid and Vitamin C contained in Winged Bean together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: WINGED BEAN IS RECOMMENDED OVER FAVA BEAN FOR REDUCING THE GENETIC RISK OF INFLAMMATORY MYOFIBROBLASTIC TUMOR DUE TO GENES ARID2 AND FLT4
Eat more vegetables, Cassava or Endive?
The active ingredients contained in Cassava are Oleic Acid, Beta-sitosterol, Vitamin C, Linolenic Acid, Linoleic Acid among others. While the active ingredients contained in Endive are Quercetin, Oleic Acid, Vitamin C, Linolenic Acid, Kaempferol and others.
Vitamin C can manipulate biochemical pathways Cell Cycle Checkpoints, RAS-RAF Signaling and Apoptosis. Beta-sitosterol has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, MYC Signaling and Angiogenesis.
Vitamin A can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways Cell Cycle Checkpoints, RAS-RAF Signaling and Apoptosis. And so on.
For genetic risk of Inflammatory Myofibroblastic Tumor due to abnormalities in genes ARID2 and FLT4 – Foods like Cassava are recommended compared to Endive. This is because the active ingredients Vitamin A and Folic Acid in Endive further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Cassava together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: CASSAVA IS RECOMMENDED OVER ENDIVE FOR REDUCING THE GENETIC RISK OF INFLAMMATORY MYOFIBROBLASTIC TUMOR DUE TO GENES ARID2 AND FLT4
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
Eat more fruits, Kiwi or Huckleberry?
The active ingredients contained in Kiwi are Quercetin, Vitamin C, Chlorogenic Acid, Fisetin, Vitamin A among others. While the active ingredients contained in Huckleberry are Quercetin, Resveratrol, Vitamin C, Delphinidin, P-coumaric Acid and others.
Vitamin C can manipulate biochemical pathways Cell Cycle Checkpoints, RAS-RAF Signaling and Apoptosis. Quercetin has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, MYC Signaling and Angiogenesis.
Ferulic Acid can manipulate biochemical pathways DNA Repair. Pelargonidin has biological action on biochemical pathways MYC Signaling, PI3K-AKT-MTOR Signaling and Cell Cycle Checkpoints. And so on.
For genetic risk of Inflammatory Myofibroblastic Tumor due to abnormalities in genes ARID2 and FLT4 – Foods like Kiwi are recommended compared to Huckleberry. This is because the active ingredients Ferulic Acid and Pelargonidin in Huckleberry further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Quercetin contained in Kiwi together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: KIWI IS RECOMMENDED OVER HUCKLEBERRY FOR REDUCING THE GENETIC RISK OF INFLAMMATORY MYOFIBROBLASTIC TUMOR DUE TO GENES ARID2 AND FLT4
Eat more nuts, Hazelnut or Cashew Nut?
The active ingredients contained in Hazelnut are Quercetin, Vitamin E, Oleic Acid, Linolenic Acid, Linoleic Acid among others. While the active ingredients contained in Cashew Nut are Beta-sitosterol, Vitamin C, Palmitic Acid, Butyric Acid, Gallic Acid and others.
Quercetin can manipulate biochemical pathways Cell Cycle Checkpoints, RAS-RAF Signaling and Apoptosis. Vitamin E has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, MYC Signaling and Angiogenesis.
Palmitic Acid can manipulate biochemical pathways DNA Repair and Oncogenic Cancer Epigenetics. Lauric Acid has biological action on biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. And so on.
For genetic risk of Inflammatory Myofibroblastic Tumor due to abnormalities in genes ARID2 and FLT4 – Foods like Hazelnut are recommended compared to Cashew Nut. This is because the active ingredients Palmitic Acid and Lauric Acid in Cashew Nut further promote the effects of genes on the biochemical pathways. While the active ingredients Quercetin and Vitamin E contained in Hazelnut together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: HAZELNUT IS RECOMMENDED OVER CASHEW NUT FOR REDUCING THE GENETIC RISK OF INFLAMMATORY MYOFIBROBLASTIC TUMOR DUE TO GENES ARID2 AND FLT4
In Summary
An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.
“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.
The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.
You can get started NOW and design a personalized nutrition plan for Inflammatory Myofibroblastic Tumor by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
References
- Msk Impact 2017
- Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients.
- Crystal structure of a human cyclin-dependent kinase 6 complex with a flavonol inhibitor, fisetin.
- The synergy of Vitamin C with decitabine activates TET2 in leukemic cells and significantly improves overall survival in elderly patients with acute myeloid leukemia.
- Effects of folate deficiency on gene expression in the apoptosis and cancer pathways in colon cancer cells.
- D-Limonene modulates inflammation, oxidative stress and Ras-ERK pathway to inhibit murine skin tumorigenesis.
- Identification of ellagic acid as potent inhibitor of protein kinase CK2: a successful example of a virtual screening application.
- Resveratrol, a remarkable inhibitor of ribonucleotide reductase.
- Paederia foetida induces anticancer activity by modulating chromatin modification enzymes and altering pro-inflammatory cytokine gene expression in human prostate cancer cells.
- Pelargonidin suppresses adipogenesis in 3T3-L1 cells through inhibition of PPAR-γ signaling pathway.
- Clinical pharmacodynamics of antihistamines.
- Betulinic acid induces DNA damage and apoptosis in SiHa cells.
- Legionella pneumophila serogroup 12 pneumonia in a renal transplant recipient: case report and environmental observations.
- Vitamin A regulates Akt signaling through the phospholipid fatty acid composition.
- Gamma- and delta-tocotrienols exert a more potent anticancer effect than alpha-tocopheryl succinate on breast cancer cell lines irrespective of HER-2/neu expression.
- Functional lipidomics: Palmitic acid impairs hepatocellular carcinoma development by modulating membrane fluidity and glucose metabolism.
- HyperFoods: Machine intelligent mapping of cancer-beating molecules in foods.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.