Which Foods are Recommended for Infantile Sarcoma?

Highlights

No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Infantile Sarcoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Infantile Sarcoma because of ACVR1 and CDKN2A gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.

There is no one answer to this question for cancers such as Infantile Sarcoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.

In short – the process to answer questions like “Should I Avoid eating fruit Cherry” or “Include fruit Graviola in my diet” or “Can I take Graviola and Apple supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.

RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO INFANTILE SARCOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.

The overall objective of personalized nutrition for Infantile Sarcoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.

RECOMMENDATION: UPDATE YOUR NUTRITION FOR INFANTILE SARCOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.

About Infantile Sarcoma

cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.

Following key highlights are derived from clinical data for Infantile Sarcoma from cBioPortal. 50.0% of males and 50.0% of females were the distribution of gender in these clinical studies. From a patient sample size of 2; the top genes with mutations and other abnormalities for Infantile Sarcoma include genes ACVR1, CDKN2A, MAP3K13 and NTRK3. The occurrence frequency distribution for these genes respectively is 100.0%, 100.0%, 100.0% and 100.0%. These tumor genetic details of Infantile Sarcoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Infantile Sarcoma.

Significance of Nutrition for Infantile Sarcoma

All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Infantile Sarcoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.

For example Cherry includes active ingredients Chrysin, Quercetin, Salicylic Acid, Beta-sitosterol, Isorhamnetin and others. And Graviola contains active ingredients Fisetin, Vitamin E, Quercetin, Daidzein, Tangeretin and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.

For cancers like Infantile Sarcoma, activation or inhibition of selected biochemical pathways like Cell Cycle, TGFB Signaling, Cell Cycle Checkpoints, MAPK Signaling plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Infantile Sarcoma, while eating some other foods and supplements may not be recommended.

One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.

RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR INFANTILE SARCOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.

Foods for Infantile Sarcoma undergoing chemotherapy treatment

In Infantile Sarcoma – the genes ACVR1, CDKN2A, MAP3K13 and NTRK3 have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Infantile Sarcoma are Cell Cycle and others. Radiation is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Cell Cycle so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.

RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.

Eat more pulses, Fava Bean or Soy Bean?

Pulses are an important part of many diets. The active ingredients contained in Fava Bean are Quercetin, Daidzein, Butein, Ferulic Acid, Beta-sitosterol among others. While the active ingredients contained in Soy Bean are Fisetin, Lupeol, Vitamin E, Quercetin, Daidzein and others.

Quercetin can manipulate biochemical pathways Cell Cycle. Daidzein has biological action on biochemical pathways Cell Cycle.

Aescin can manipulate biochemical pathways Cell Cycle. And so on.

When treating Infantile Sarcoma with chemotherapy Radiation – Foods like Fava Bean are recommended compared to Soy Bean. This is because the active ingredients Aescin in Soy Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Quercetin and Daidzein contained in Fava Bean support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: FAVA BEAN IS RECOMMENDED OVER SOY BEAN FOR INFANTILE SARCOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Eat more vegetables, Cucumber?

Vegetables are an important part of many diets. The active ingredients contained in Cucumber are Fisetin, Lupeol, Salicylic Acid, Beta-sitosterol, Cucurbitacin E among others.

Fisetin can manipulate biochemical pathways Cell Cycle. Lupeol has biological action on biochemical pathways Cell Cycle.

When treating Infantile Sarcoma with chemotherapy Radiation – Foods like Cucumber are recommended. This is because the active ingredients Fisetin and Lupeol contained in Cucumber support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: CUCUMBER IS RECOMMENDED FOR INFANTILE SARCOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Eat more fruits, Graviola or Cherry?

Fruits are an important part of many diets. The active ingredients contained in Graviola are Fisetin, Vitamin E, Quercetin, Daidzein, Tangeretin among others. While the active ingredients contained in Cherry are Chrysin, Quercetin, Salicylic Acid, Beta-sitosterol, Isorhamnetin and others.

Fisetin can manipulate biochemical pathways Cell Cycle. Emodin has biological action on biochemical pathways Cell Cycle.

Shikimic Acid can manipulate biochemical pathways Cell Cycle. Pelargonidin has biological action on biochemical pathways Cell Cycle. And so on.

When treating Infantile Sarcoma with chemotherapy Radiation – Foods like Graviola are recommended compared to Cherry. This is because the active ingredients Shikimic Acid and Pelargonidin in Cherry interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Fisetin and Emodin contained in Graviola support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: GRAVIOLA IS RECOMMENDED OVER CHERRY FOR INFANTILE SARCOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Eat more nuts, Hazelnut or Macadamia Nut?

Nuts are an important part of many diets. The active ingredients contained in Hazelnut are Vitamin E, Quercetin, Vitamin A, Linolenic Acid, Linoleic Acid among others. While the active ingredients contained in Macadamia Nut are Beta-sitosterol, Lauric Acid, Myristic Acid and others.

Vitamin E can manipulate biochemical pathways Cell Cycle. Quercetin has biological action on biochemical pathways Cell Cycle.

Myristic Acid can manipulate biochemical pathways Cell Cycle. And so on.

When treating Infantile Sarcoma with chemotherapy Radiation – Foods like Hazelnut are recommended compared to Macadamia Nut. This is because the active ingredients Myristic Acid in Macadamia Nut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin E and Quercetin contained in Hazelnut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: HAZELNUT IS RECOMMENDED OVER MACADAMIA NUT FOR INFANTILE SARCOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Foods for Genetic Risk of Infantile Sarcoma

One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. ACVR1 and CDKN2A are two genes whose abnormalities are risk factors for Infantile Sarcoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Infantile Sarcoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Infantile Sarcoma gene ACVR1 has causative impact on biological pathways like TGFB Signaling and Hematopoiesis. And CDKN2A has a causative impact on biological pathways like Cell Cycle Checkpoints and Cell Cycle. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like ACVR1 and CDKN2A should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes ACVR1 and CDKN2A should be avoided.

Eat more pulses, Mung Bean or Chickpea?

The active ingredients contained in Mung Bean are Quercetin, Vitamin C, Linolenic Acid, Oleic Acid, Stigmasterol among others. While the active ingredients contained in Chickpea are Linolenic Acid, Oleic Acid, Genistein, Vitamin A, Folic Acid and others.

Quercetin can manipulate biochemical pathways Cell Cycle Checkpoints, P53 Signaling and MYC Signaling. Vitamin C has biological action on biochemical pathways Oncogenic Cancer Epigenetics, PI3K-AKT-MTOR Signaling and Apoptosis.

Folic Acid can manipulate biochemical pathways Cell Cycle Checkpoints, P53 Signaling and MYC Signaling. And so on.

For genetic risk of Infantile Sarcoma due to abnormalities in genes ACVR1 and CDKN2A – Foods like Mung Bean are recommended compared to Chickpea. This is because the active ingredients Folic Acid in Chickpea further promote the effects of genes on the biochemical pathways. While the active ingredients Quercetin and Vitamin C contained in Mung Bean together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: MUNG BEAN IS RECOMMENDED OVER CHICKPEA FOR REDUCING THE GENETIC RISK OF INFANTILE SARCOMA DUE TO GENES ACVR1 AND CDKN2A

Eat more vegetables, Cassava or Celery?

The active ingredients contained in Cassava are Beta-sitosterol, Vitamin C, Linolenic Acid, Oleic Acid, Linoleic Acid among others. While the active ingredients contained in Celery are Apigenin, Quercetin, Vitamin C, Linolenic Acid, Oleic Acid and others.

Vitamin C can manipulate biochemical pathways Cell Cycle Checkpoints, P53 Signaling and MYC Signaling. Beta-sitosterol has biological action on biochemical pathways Oncogenic Cancer Epigenetics, PI3K-AKT-MTOR Signaling and Apoptosis.

Cynaroside can manipulate biochemical pathways Oncogenic Cancer Epigenetics. Luteolin has biological action on biochemical pathways MYC Signaling. And so on.

For genetic risk of Infantile Sarcoma due to abnormalities in genes ACVR1 and CDKN2A – Foods like Cassava are recommended compared to Celery. This is because the active ingredients Cynaroside and Luteolin in Celery further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Cassava together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: CASSAVA IS RECOMMENDED OVER CELERY FOR REDUCING THE GENETIC RISK OF INFANTILE SARCOMA DUE TO GENES ACVR1 AND CDKN2A

Eat more fruits, Date or Cranberry?

The active ingredients contained in Date are Apigenin, Lupeol, Beta-sitosterol, Quercetin, Vitamin C among others. While the active ingredients contained in Cranberry are Ellagic Acid, Hyperoside, Quercetin, P-coumaric Acid, Vitamin C and others.

Apigenin can manipulate biochemical pathways Cell Cycle Checkpoints, P53 Signaling and MYC Signaling. Lupeol has biological action on biochemical pathways Oncogenic Cancer Epigenetics, PI3K-AKT-MTOR Signaling and Apoptosis.

Ellagic Acid can manipulate biochemical pathways MYC Signaling. Resveratrol has biological action on biochemical pathways P53 Signaling. And so on.

For genetic risk of Infantile Sarcoma due to abnormalities in genes ACVR1 and CDKN2A – Foods like Date are recommended compared to Cranberry. This is because the active ingredients Ellagic Acid and Resveratrol in Cranberry further promote the effects of genes on the biochemical pathways. While the active ingredients Apigenin and Lupeol contained in Date together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: DATE IS RECOMMENDED OVER CRANBERRY FOR REDUCING THE GENETIC RISK OF INFANTILE SARCOMA DUE TO GENES ACVR1 AND CDKN2A

Eat more nuts, Almond or Chestnut?

The active ingredients contained in Almond are Vitamin E, Beta-sitosterol, Quercetin, Linolenic Acid, Oleic Acid among others. While the active ingredients contained in Chestnut are Ellagic Acid, Quercetin, Vitamin C, Linolenic Acid, Oleic Acid and others.

Beta-sitosterol can manipulate biochemical pathways Cell Cycle Checkpoints, P53 Signaling and MYC Signaling. Vitamin E has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, Apoptosis and Cell Cycle.

Ellagic Acid can manipulate biochemical pathways MYC Signaling. Folic Acid has biological action on biochemical pathways Cell Cycle Checkpoints, P53 Signaling and PI3K-AKT-MTOR Signaling. And so on.

For genetic risk of Infantile Sarcoma due to abnormalities in genes ACVR1 and CDKN2A – Foods like Almond are recommended compared to Chestnut. This is because the active ingredients Ellagic Acid and Folic Acid in Chestnut further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin E contained in Almond together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: ALMOND IS RECOMMENDED OVER CHESTNUT FOR REDUCING THE GENETIC RISK OF INFANTILE SARCOMA DUE TO GENES ACVR1 AND CDKN2A

In Summary

An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.

“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.

The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.

You can get started NOW and design a personalized nutrition plan for Infantile Sarcoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

References

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• HyperFoods/food_compound_original.csv at master • warcraft12321/HyperFoods • GitHub