Which Foods are Recommended for High-grade Glioma?

Highlights

No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like High-grade Glioma when undergoing chemotherapy or when you determine you have a genetic risk for developing High-grade Glioma because of PTPN11 and PTEN gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.

There is no one answer to this question for cancers such as High-grade Glioma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.

In short – the process to answer questions like “Should I Avoid eating fruit Peach” or “Include fruit Apple in my diet” or “Should I reduce consumption of vegetable Carrot” or “Can I take Lavender and Curcumin supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.

RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO HIGH-GRADE GLIOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.

The overall objective of personalized nutrition for High-grade Glioma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.

RECOMMENDATION: UPDATE YOUR NUTRITION FOR HIGH-GRADE GLIOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.

About High-grade Glioma

cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.

Following key highlights are derived from clinical data for High-grade Glioma from cBioPortal. The patients enrolled in the studies for High-grade Glioma are in ages between 1 to 30 with an average age of 9. 49.1% of males and 50.9% of females were the distribution of gender in these clinical studies. From a patient sample size of 171; the top genes with mutations and other abnormalities for High-grade Glioma include genes TP53, PIK3CA, IDH1, PTPN11 and PTEN. The occurrence frequency distribution for these genes respectively is 28.0%, 12.0%, 12.0%, 12.0% and 12.0%. These tumor genetic details of High-grade Glioma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of High-grade Glioma.

Significance of Nutrition for High-grade Glioma

All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of High-grade Glioma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.

For example Peach includes active ingredients Modified Citrus Pectin, Vitamin C, Glucaric Acid, Caffeic Acid, Beta-sitosterol and others. And Apple contains active ingredients Modified Citrus Pectin, Glucaric Acid, Caffeic Acid, Phloretin, Fisetin and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.

For cancers like High-grade Glioma, activation or inhibition of selected biochemical pathways like RAS-RAF Signaling, Cell Cycle, PI3K-AKT-MTOR Signaling, Cell Cycle Checkpoints plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of High-grade Glioma, while eating some other foods and supplements may not be recommended.

One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.

RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR HIGH-GRADE GLIOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.

Foods for High-grade Glioma undergoing chemotherapy treatment

In High-grade Glioma – the genes TP53, PIK3CA, IDH1, PTPN11 and PTEN have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for High-grade Glioma are RAS-RAF Signaling, Cell Cycle, Cytoskeletal Dynamics and others. Radiation is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers RAS-RAF Signaling, Cell Cycle, Cytoskeletal Dynamics so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.

RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.

Eat more pulses, Mung Bean or Soy Bean?

Pulses are an important part of many diets. The active ingredients contained in Mung Bean are Quercetin, Vitamin C, Glucaric Acid, Oleic Acid, Linolenic Acid among others. While the active ingredients contained in Soy Bean are Quercetin, Lupeol, Daidzein, Vitamin E, Vitamin C and others.

Quercetin can manipulate biochemical pathways Extracellular Matrix Remodelling, MAPK Signaling and RAS-RAF Signaling. Vitamin C has biological action on biochemical pathways MYC Signaling, Hypoxia and PI3K-AKT-MTOR Signaling.

Genistein can manipulate biochemical pathways Oxidative Stress. Aescin has biological action on biochemical pathways Cell Cycle. And so on.

When treating High-grade Glioma with chemotherapy Radiation – Foods like Mung Bean are recommended compared to Soy Bean. This is because the active ingredients Genistein and Aescin in Soy Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Quercetin and Vitamin C contained in Mung Bean support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: MUNG BEAN IS RECOMMENDED OVER SOY BEAN FOR HIGH-GRADE GLIOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Eat more vegetables, Giant Butterbur or Carrot?

Vegetables are an important part of many diets. The active ingredients contained in Giant Butterbur are Vitamin C, Beta-sitosterol, Melatonin, Vitamin B3, Vitamin A among others. While the active ingredients contained in Carrot are D-limonene, Quercetin, Linalool, Lupeol, Vitamin E and others.

Vitamin C can manipulate biochemical pathways MAPK Signaling, RAS-RAF Signaling and MYC Signaling. Beta-sitosterol has biological action on biochemical pathways Hypoxia, PI3K-AKT-MTOR Signaling and Oxidative Stress.

Osthole can manipulate biochemical pathways Oxidative Stress. Gamma-linolenic Acid has biological action on biochemical pathways Oxidative Stress. And so on.

When treating High-grade Glioma with chemotherapy Radiation – Foods like Giant Butterbur are recommended compared to Carrot. This is because the active ingredients Osthole and Gamma-linolenic Acid in Carrot interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Beta-sitosterol contained in Giant Butterbur support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: GIANT BUTTERBUR IS RECOMMENDED OVER CARROT FOR HIGH-GRADE GLIOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Eat more fruits, Apple or Peach?

Fruits are an important part of many diets. The active ingredients contained in Apple are Modified Citrus Pectin, Glucaric Acid, Caffeic Acid, Phloretin, Fisetin among others. While the active ingredients contained in Peach are Modified Citrus Pectin, Vitamin C, Glucaric Acid, Caffeic Acid, Beta-sitosterol and others.

Glucaric Acid can manipulate biochemical pathways MAPK Signaling, RAS-RAF Signaling and MYC Signaling. Modified Citrus Pectin has biological action on biochemical pathways TGFB Signaling, PI3K-AKT-MTOR Signaling and Growth Factor Signaling.

Citric Acid can manipulate biochemical pathways Oxidative Stress. Caffeic Acid has biological action on biochemical pathways TGFB Signaling. And so on.

When treating High-grade Glioma with chemotherapy Radiation – Foods like Apple are recommended compared to Peach. This is because the active ingredients Citric Acid and Caffeic Acid in Peach interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Glucaric Acid and Modified Citrus Pectin contained in Apple support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: APPLE IS RECOMMENDED OVER PEACH FOR HIGH-GRADE GLIOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Eat more nuts, Almond or Macadamia Nut?

Nuts are an important part of many diets. The active ingredients contained in Almond are Quercetin, Vitamin E, Salicylic Acid, Beta-sitosterol, Oleic Acid among others. While the active ingredients contained in Macadamia Nut are Beta-sitosterol, Palmitic Acid, Lauric Acid, Myristic Acid, Folic Acid and others.

Beta-sitosterol can manipulate biochemical pathways MYC Signaling, Hypoxia and PI3K-AKT-MTOR Signaling. Quercetin has biological action on biochemical pathways Extracellular Matrix Remodelling, MAPK Signaling and RAS-RAF Signaling.

Palmitic Acid can manipulate biochemical pathways Extracellular Matrix Remodelling, MAPK Signaling and Growth Factor Signaling. Lauric Acid has biological action on biochemical pathways MYC Signaling, PI3K-AKT-MTOR Signaling and MAPK Signaling. And so on.

When treating High-grade Glioma with chemotherapy Radiation – Foods like Almond are recommended compared to Macadamia Nut. This is because the active ingredients Palmitic Acid and Lauric Acid in Macadamia Nut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Quercetin contained in Almond support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: ALMOND IS RECOMMENDED OVER MACADAMIA NUT FOR HIGH-GRADE GLIOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Foods for Genetic Risk of High-grade Glioma

One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. PTPN11 and PTEN are two genes whose abnormalities are risk factors for High-grade Glioma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of High-grade Glioma can be used as a guide for coming up with a recommended personalized nutrition plan. For High-grade Glioma gene PTPN11 has causative impact on biological pathways like Angiogenesis and C-type Lectin Receptor Signaling. And PTEN has a causative impact on biological pathways like Autophagy and Focal Adhesion. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like PTPN11 and PTEN should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes PTPN11 and PTEN should be avoided.

Eat more pulses, Yellow Wax Bean or Chickpea?

The active ingredients contained in Yellow Wax Bean are Cianidanol, Palmitic Acid, Vitamin C, Ferulic Acid, Butyric Acid among others. While the active ingredients contained in Chickpea are Oleic Acid, Linolenic Acid, Genistein, Vitamin A, Folic Acid and others.

Vitamin A can manipulate biochemical pathways MYC Signaling, Apoptosis and Cell Cycle Checkpoints. Cianidanol has biological action on biochemical pathways P53 Signaling, PI3K-AKT-MTOR Signaling and Cell Cycle Checkpoints.

Folic Acid can manipulate biochemical pathways Cell Cycle Checkpoints, RAS-RAF Signaling and P53 Signaling. And so on.

For genetic risk of High-grade Glioma due to abnormalities in genes PTPN11 and PTEN – Foods like Yellow Wax Bean are recommended compared to Chickpea. This is because the active ingredients Folic Acid in Chickpea further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin A and Cianidanol contained in Yellow Wax Bean together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: YELLOW WAX BEAN IS RECOMMENDED OVER CHICKPEA FOR REDUCING THE GENETIC RISK OF HIGH-GRADE GLIOMA DUE TO GENES PTPN11 AND PTEN

Eat more vegetables, Cassava or Celery?

The active ingredients contained in Cassava are Beta-sitosterol, Oleic Acid, Linolenic Acid, Vitamin C, Linoleic Acid among others. While the active ingredients contained in Celery are Apigenin, Quercetin, Oleic Acid, Linolenic Acid, Vitamin C and others.

Vitamin C can manipulate biochemical pathways Cell Cycle Checkpoints, RAS-RAF Signaling and P53 Signaling. Beta-sitosterol has biological action on biochemical pathways MYC Signaling, Inositol Phosphate Signaling and PI3K-AKT-MTOR Signaling.

Luteolin can manipulate biochemical pathways MYC Signaling. Chrysin has biological action on biochemical pathways MYC Signaling. And so on.

For genetic risk of High-grade Glioma due to abnormalities in genes PTPN11 and PTEN – Foods like Cassava are recommended compared to Celery. This is because the active ingredients Luteolin and Chrysin in Celery further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Cassava together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: CASSAVA IS RECOMMENDED OVER CELERY FOR REDUCING THE GENETIC RISK OF HIGH-GRADE GLIOMA DUE TO GENES PTPN11 AND PTEN

Eat more fruits, Orange or Huckleberry?

The active ingredients contained in Orange are D-limonene, Linalool, Modified Citrus Pectin, Oleic Acid, Hesperidin among others. While the active ingredients contained in Huckleberry are Quercetin, Resveratrol, Caffeic Acid, Vitamin C, Ferulic Acid and others.

D-limonene can manipulate biochemical pathways Cell Cycle Checkpoints, RAS-RAF Signaling and P53 Signaling. Vitamin C has biological action on biochemical pathways MYC Signaling, PI3K-AKT-MTOR Signaling and Apoptosis.

Resveratrol can manipulate biochemical pathways P53 Signaling. Pelargonidin has biological action on biochemical pathways MYC Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling. And so on.

For genetic risk of High-grade Glioma due to abnormalities in genes PTPN11 and PTEN – Foods like Orange are recommended compared to Huckleberry. This is because the active ingredients Resveratrol and Pelargonidin in Huckleberry further promote the effects of genes on the biochemical pathways. While the active ingredients D-limonene and Vitamin C contained in Orange together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: ORANGE IS RECOMMENDED OVER HUCKLEBERRY FOR REDUCING THE GENETIC RISK OF HIGH-GRADE GLIOMA DUE TO GENES PTPN11 AND PTEN

Eat more nuts, Walnut or Brazil Nut?

The active ingredients contained in Walnut are D-limonene, Ellagic Acid, Quercetin, Protocatechuic Acid, Beta-sitosterol among others. While the active ingredients contained in Brazil Nut are Vitamin E, Oleic Acid, Linolenic Acid, Lecithin, Folic Acid and others.

D-limonene can manipulate biochemical pathways Cell Cycle Checkpoints, RAS-RAF Signaling and P53 Signaling. Ellagic Acid has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, Apoptosis and Cell Cycle Checkpoints.

Lecithin can manipulate biochemical pathways MYC Signaling, RAS-RAF Signaling and PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways Cell Cycle Checkpoints, P53 Signaling and Apoptosis. And so on.

For genetic risk of High-grade Glioma due to abnormalities in genes PTPN11 and PTEN – Foods like Walnut are recommended compared to Brazil Nut. This is because the active ingredients Lecithin and Folic Acid in Brazil Nut further promote the effects of genes on the biochemical pathways. While the active ingredients D-limonene and Ellagic Acid contained in Walnut together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: WALNUT IS RECOMMENDED OVER BRAZIL NUT FOR REDUCING THE GENETIC RISK OF HIGH-GRADE GLIOMA DUE TO GENES PTPN11 AND PTEN

In Summary

An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.

“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.

The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.

You can get started NOW and design a personalized nutrition plan for High-grade Glioma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

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