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Foods for Hairy Cell Leukemia!

Aug 4, 2023

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Introduction

Foods for Hairy Cell Leukemia should be personalized for each individual and also must adapt when cancer treatment or tumor genetic change. The personalization and adaptation must consider all the active ingredients or bioactives contained in different foods with respect to cancer tissue biology, genetics, treatments, lifestyle conditions and diet preferences. Hence while nutrition is one of the very important decisions for a cancer patient and individual at risk of cancer to make – how to choose foods to eat is not an easy task.

Hairy cell leukemia is a rare form of cancer affecting the blood and bone marrow. Accurate diagnosis is important, and pathology outlines provide valuable information about the distinctive features of hairy cell leukemia cells. Cladribine is a commonly used chemotherapy drug for treating hairy cell leukemia. Treatment for hairy cell leukemia may also involve targeted therapies and immunotherapies tailored to the individual patient. Understanding the symptoms of hairy cell leukemia is crucial for early detection and prompt intervention. Proper medical coding utilizing the ICD-10 code ensures accurate documentation. Prognosis and survival rates for hairy cell leukemia vary depending on various factors, including the stage and response to treatment. The Hairy Cell Leukemia Foundation provides support and resources for individuals affected by the disease. Ongoing clinical trials offer opportunities for innovative treatments and advancements in hairy cell leukemia management. By staying informed and seeking appropriate medical care, individuals with hairy cell leukemia can improve their chances of successful treatment and long-term survival. Maintaining a healthy diet and lifestyle can also support overall well-being during hairy cell leukemia treatment.



For Hairy Cell Leukemia does it matter what vegetables, fruits, nuts, seeds one eats?

A very common nutrition question asked by cancer patients and individuals at-genetic risk of cancer is – for cancers like Hairy Cell Leukemia does it matter what foods I eat and which I do not? Or if I follow a plant-based diet is that enough for cancer like Hairy Cell Leukemia?

For example does it matter if vegetable Cabbage is consumed more compared to Cardoon? Does it make any difference if fruit Pummelo is preferred over Red Raspberry? Also if similar choices are made for nuts/seeds like Black Walnut over European Chestnut and for pulses like Black-eyed Pea over Common Bean. And if what I eat matters – then how does one identify foods which are recommended for Hairy Cell Leukemia and is it the same answer for everyone with the same diagnosis or genetic risk?

Yes! Foods you eat matters for Hairy Cell Leukemia!

Food recommendations may not be the same for everyone and can be different even for the same diagnosis and genetic risk.

All cancers like Hairy Cell Leukemia can be characterized by a unique set of biochemical pathways - the signature pathways of Hairy Cell Leukemia. Biochemical pathways like Cell Cycle Checkpoints, Apoptosis, RAS-RAF Signaling, MAPK Signaling are part of the signature definition of Hairy Cell Leukemia.

All foods (vegetables, fruits, nuts, seeds, pulses, oils etc.) and nutritional supplements are made up of more than one active molecular ingredient or bio-actives in different proportions and quantities. Each active ingredient has a unique mechanism of action – which can be activation or inhibition of different biochemical pathways. Simply stated foods and supplements which are recommended are those which do not cause an increase of molecular drivers of cancer but reduce them. Else those foods should not be recommended. Foods contain multiple active ingredients – hence when evaluating foods and supplements you need to consider the impact of all active ingredients cumulatively rather than individually.

For example Pummelo contains active ingredients Apigenin, Curcumin, Lycopene, Lupeol, Daidzein. And Red Raspberry contains active ingredients Curcumin, Ellagic Acid, Lupeol, Daidzein, Beta-sitosterol and possibly others.

A common mistake made when deciding and choosing foods to eat for Hairy Cell Leukemia – is to evaluate only selected active ingredients contained in foods and ignore the rest. Because different active ingredients contained in foods may have opposing effects on cancer drivers – you cannot cherry pick active ingredients in foods and supplements for making a nutrition decision for Hairy Cell Leukemia.

YES – FOOD CHOICES MATTER FOR CANCER. NUTRITION DECISIONS MUST CONSIDER ALL ACTIVE INGREDIENTS OF FOODS.

Skills Needed for Nutrition Personalization for Hairy Cell Leukemia?

Personalized nutrition for cancers like Hairy Cell Leukemia consists of recommended foods / supplements; not recommended foods / supplements with example recipes which prioritize use of recommended foods. An example of personalized nutrition can be seen at this link.

Deciding which foods are recommended or not is extremely complicated, requiring expertise in Hairy Cell Leukemia biology, food science, genetics, biochemistry along with good understanding of how cancer treatments work and associated vulnerabilities by which the treatments could stop being effective.

MINIMUM KNOWLEDGE EXPERTISE NEEDED FOR NUTRITION PERSONALIZATION FOR CANCER ARE: CANCER BIOLOGY, FOOD SCIENCE, CANCER TREATMENTS AND GENETICS.

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.

Characteristics of cancers like Hairy Cell Leukemia

All cancers like Hairy Cell Leukemia can be characterized by a unique set of biochemical pathways – the signature pathways of Hairy Cell Leukemia. Biochemical pathways like Cell Cycle Checkpoints, Apoptosis, RAS-RAF Signaling, MAPK Signaling are part of the signature definition of Hairy Cell Leukemia. Each individual’s cancer genetics can be different and hence their specific cancer signature could be unique.

The treatments which are effective for Hairy Cell Leukemia need to be cognizant of the associated signature biochemical pathways for each cancer patient and individual at genetic risk. Therefore different treatments with different mechanisms of actions are effective for different patients. Similarly and for the same reasons foods and supplements need to be personalized for each individual. Hence some foods and supplements are recommended for Hairy Cell Leukemia when taking cancer treatment Cladribine, and some foods and supplements are not recommended.

Sources like cBioPortal and many others provide population representative patient anonymized data from clinical trials for all cancer indications. This data consists of clinical trial study details like sample size / number of patients, age groups, gender, ethnicity, treatments, tumor site and any genetic mutations.

BRAF, KMT2C, CDKN1B, CEBPA and CREBBP are the top ranked reported genes for Hairy Cell Leukemia. BRAF is reported in 86.89 % of the representative patients across all clinical trials. And KMT2C is reported in 16.39 %. The combined population patient data cover ages from to . % of the patient data are identified as men. The Hairy Cell Leukemia biology along with reported genetics together define the population represented signature biochemical pathways for this cancer. If the individual cancer tumor genetics or genes contributing to the risk are also known then that should also be used for nutrition personalization.

NUTRITION CHOICES SHOULD MATCH WITH EACH INDIVIDUAL’S CANCER SIGNATURE.

Foods for Hairy Cell Leukemia!

Food and Supplements for Hairy Cell Leukemia

For Cancer Patients

Cancer patients on treatment or on palliative care need to make decisions on food and supplements – for the needed dietary calories, for managing any treatment side effects and also for improved cancer management. All plant-based foods are not equal and choosing and prioritizing foods which are personalized and customized to ongoing cancer treatment is important and complicated. Here are some examples providing guidelines for making nutrition decisions.

Choose Vegetable CABBAGE or CARDOON?

Vegetable Cabbage contains many active ingredients or bioactives such as Apigenin, Curcumin, Lycopene, Lupeol, Daidzein. These active ingredients manipulate various biochemical pathways like MAPK Signaling, MYC Signaling, Apoptosis and PI3K-AKT-MTOR Signaling and others. Cabbage is recommended for Hairy Cell Leukemia when ongoing cancer treatment is Cladribine. This is because Cabbage modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Cladribine.

Some of the active ingredients or bioactives in vegetable Cardoon are Apigenin, Curcumin, Lycopene, Lupeol, Daidzein. These active ingredients manipulate various biochemical pathways like DNA Repair and others. Cardoon is not recommended for Hairy Cell Leukemia when ongoing cancer treatment is Cladribine because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

VEGETABLE CABBAGE IS RECOMMENDED OVER CARDOON FOR Hairy Cell Leukemia AND TREATMENT Cladribine.

Choose Fruit RED RASPBERRY or PUMMELO?

Fruit Red Raspberry contains many active ingredients or bioactives such as Curcumin, Ellagic Acid, Lupeol, Daidzein, Beta-sitosterol. These active ingredients manipulate various biochemical pathways like MAPK Signaling, Cell Cycle Checkpoints, MYC Signaling and PI3K-AKT-MTOR Signaling and others. Red Raspberry is recommended for Hairy Cell Leukemia when ongoing cancer treatment is Cladribine. This is because Red Raspberry modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Cladribine.

Some of the active ingredients or bioactives in fruit Pummelo are Apigenin, Curcumin, Lycopene, Lupeol, Daidzein. These active ingredients manipulate various biochemical pathways like DNA Repair and others. Pummelo is not recommended for Hairy Cell Leukemia when ongoing cancer treatment is Cladribine because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

FRUIT RED RASPBERRY IS RECOMMENDED OVER PUMMELO FOR Hairy Cell Leukemia AND TREATMENT Cladribine.

Choose Nut BLACK WALNUT or EUROPEAN CHESTNUT?

Black Walnut contains many active ingredients or bioactives such as Apigenin, Curcumin, Ellagic Acid, Lupeol, Daidzein. These active ingredients manipulate various biochemical pathways like MAPK Signaling, MYC Signaling, Apoptosis and PI3K-AKT-MTOR Signaling and others. Black Walnut is recommended for Hairy Cell Leukemia when ongoing cancer treatment is Cladribine. This is because Black Walnut modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Cladribine.

Some of the active ingredients or bioactives in European Chestnut are Apigenin, Curcumin, Ellagic Acid, Lupeol, Daidzein. These active ingredients manipulate various biochemical pathways like DNA Repair and others. European Chestnut is not recommended for Hairy Cell Leukemia when ongoing cancer treatment is Cladribine because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

BLACK WALNUT IS RECOMMENDED OVER EUROPEAN CHESTNUT FOR Hairy Cell Leukemia AND TREATMENT Cladribine.

For Individuals with Genetic Risk of Cancer

The question asked by individuals who have genetic risk of Hairy Cell Leukemia or familial history is “What Should I Eat Differently from Before?” and how they should choose foods and supplements to manage risks of the disease. Since for cancer risk there is nothing actionable in terms of treatment – decisions of foods and supplements become important and one of the very few actionable things which can be done. All plant-based foods are not equal and based on identified genetics and pathway signature – the choices of food and supplements should be personalized.

Choose Vegetable GIANT BUTTERBUR or SPINACH?

Vegetable Giant Butterbur contains many active ingredients or bioactives such as Curcumin, Apigenin, Lupeol, Lycopene, Daidzein. These active ingredients manipulate various biochemical pathways like MAPK Signaling, MYC Signaling, Apoptosis and PI3K-AKT-MTOR Signaling and others. Giant Butterbur is recommended for risk of Hairy Cell Leukemia when associated genetic risk is BRAF. This is because Giant Butterbur increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in vegetable Spinach are Curcumin, Apigenin, Lupeol, Daidzein, Alpha Lipoic Acid. These active ingredients manipulate various biochemical pathways like Oncogenic Cancer Epigenetics and PI3K-AKT-MTOR Signaling and others. Spinach is not recommended when risk of Hairy Cell Leukemia when associated genetic risk is BRAF because it increases the signature pathways of it.

VEGETABLE GIANT BUTTERBUR IS RECOMMENDED OVER SPINACH FOR BRAF GENETIC RISK OF CANCER.

Choose Fruit LEMON or FIG?

Fruit Lemon contains many active ingredients or bioactives such as Curcumin, D-limonene, Lupeol, Nobiletin, Daidzein. These active ingredients manipulate various biochemical pathways like MAPK Signaling, Cell Cycle Checkpoints, MYC Signaling and PI3K-AKT-MTOR Signaling and others. Lemon is recommended for risk of Hairy Cell Leukemia when associated genetic risk is BRAF. This is because Lemon increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in fruit Fig are Curcumin, Lupeol, Lycopene, Daidzein, Linalool. These active ingredients manipulate various biochemical pathways like MAPK Signaling and PI3K-AKT-MTOR Signaling and others. Fig is not recommended when risk of Hairy Cell Leukemia when associated genetic risk is BRAF because it increases the signature pathways of it.

FRUIT LEMON IS RECOMMENDED OVER FIG FOR BRAF GENETIC RISK OF CANCER.

Choose Nut COMMON HAZELNUT or BRAZIL NUT?

Common Hazelnut contains many active ingredients or bioactives such as Curcumin, Lupeol, Lycopene, Daidzein, Beta-sitosterol. These active ingredients manipulate various biochemical pathways like MAPK Signaling, RAS-RAF Signaling, MYC Signaling and PI3K-AKT-MTOR Signaling and others. Common Hazelnut is recommended for risk of Hairy Cell Leukemia when associated genetic risk is BRAF. This is because Common Hazelnut increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in Brazil Nut are Curcumin, Ellagic Acid, Lupeol, Daidzein, Beta-sitosterol. These active ingredients manipulate various biochemical pathways like MAPK Signaling and PI3K-AKT-MTOR Signaling and others. Brazil Nut is not recommended when risk of Hairy Cell Leukemia when associated genetic risk is BRAF because it increases the signature pathways of it.

COMMON HAZELNUT IS RECOMMENDED OVER BRAZIL NUT FOR BRAF GENETIC RISK OF CANCER.


In Conclusion

Foods and Supplements chosen are important decisions for cancers like Hairy Cell Leukemia. Hairy Cell Leukemia patients and individuals with genetic-risk always have this question: “What foods and nutritional supplements are recommended for me and which are not?” There is a common belief which is a misconception that all plant-based foods could be beneficial or not but would not be harmful. Certain foods and supplements can interfere with cancer treatments or promote molecular pathway drivers of cancer.

There are different types of cancer indications like Hairy Cell Leukemia, each with different tumor genetics with further genomic variations across each individual. Further every cancer treatment and chemotherapy has a unique mechanism of action. Each food like Cabbage contains various bioactives in different quantities, which have an impact on different and distinct sets of biochemical pathways. The definition of personalized nutrition is individualized food recommendations for the cancer indication, treatments, genetics, lifestyle and other factors. Nutrition personalization decisions for cancer require knowledge of cancer biology, food science and an understanding of different chemotherapy treatments. Finally when there are treatment changes or new genomics is identified – the nutrition personalization needs re-evaluation.

The addon nutrition personalization solution makes the decision making easy and removes all the guesswork in answering the question, “What foods should I choose or not choose for Hairy Cell Leukemia?”. The addon multi-disciplinary team includes cancer physicians, clinical scientists, software engineers and data scientists.


Personalized Nutrition for Cancer!

Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.

References

Scientifically Reviewed by: Dr. Cogle

Christopher R. Cogle, M.D. is a tenured professor at the University of Florida, Chief Medical Officer of Florida Medicaid, and Director of the Florida Health Policy Leadership Academy at the Bob Graham Center for Public Service.

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