addonfinal2
What Foods are Recommended for Cancer?
is a very common question. Personalized Nutrition Plans are foods and supplements which are personalized to a cancer indication, genes, any treatments and lifestyle conditions.

Which Foods are Recommended for Hairy Cell Leukemia?

Sep 2, 2022

4.3
(23)
Estimated reading time: 15 minutes
Home » Blogs » Which Foods are Recommended for Hairy Cell Leukemia?

Highlights

No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Hairy Cell Leukemia when undergoing chemotherapy or when you determine you have a genetic risk for developing Hairy Cell Leukemia because of BRAF and CDKN1B gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.

There is no one answer to this question for cancers such as Hairy Cell Leukemia which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.

In short – the process to answer questions like “Should I Avoid eating fruit Strawberry” or “Include fruit Orange in my diet” or “Should I reduce consumption of vegetable Celery” or “Can I take Guggul and Cardamom supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.

RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO HAIRY CELL LEUKEMIA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.

The overall objective of personalized nutrition for Hairy Cell Leukemia is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.

RECOMMENDATION: UPDATE YOUR NUTRITION FOR HAIRY CELL LEUKEMIA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.



About Hairy Cell Leukemia

cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.

Following key highlights are derived from clinical data for Hairy Cell Leukemia from cBioPortal. The top genes with mutations and other abnormalities for Hairy Cell Leukemia include genes BRAF, KMT2C, CDKN1B, CEBPA and CREBBP. The occurrence frequency distribution for these genes respectively is 86.89%, 16.39%, 9.84%, 6.56% and 6.56%. These tumor genetic details of Hairy Cell Leukemia are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Hairy Cell Leukemia.

Significance of Nutrition for Hairy Cell Leukemia

All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Hairy Cell Leukemia. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.

For example Strawberry includes active ingredients Ellagic Acid, Lupeol, Fisetin, Beta-sitosterol, Linolenic Acid and others. And Orange contains active ingredients D-limonene, Linalool, Modified Citrus Pectin, Linolenic Acid, Rhamnetin and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.

For cancers like Hairy Cell Leukemia, activation or inhibition of selected biochemical pathways like Cell Cycle Checkpoints, Apoptosis, RAS-RAF Signaling, MAPK Signaling plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Hairy Cell Leukemia, while eating some other foods and supplements may not be recommended.

One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.

For cancers like Hairy Cell Leukemia, activation or inhibition of selected biochemical pathways like Cell Cycle Checkpoints, Apoptosis, RAS-RAF Signaling, MAPK Signaling plays an important role in driving cancer growth.

RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR HAIRY CELL LEUKEMIA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.

Foods for Hairy Cell Leukemia undergoing chemotherapy treatment

In Hairy Cell Leukemia – the genes BRAF, KMT2C, CDKN1B, CEBPA and CREBBP have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Hairy Cell Leukemia are Cell Cycle Checkpoints, Apoptosis, DNA Repair and others. Cladribine is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Cell Cycle Checkpoints, Apoptosis, DNA Repair so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.

RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.

Eat more pulses, Mung Bean or Soy Bean?

Pulses are an important part of many diets. The active ingredients contained in Mung Bean are Quercetin, Linolenic Acid, Vitamin C, Stigmasterol, Oleic Acid among others. While the active ingredients contained in Soy Bean are Vitamin E, Lupeol, Daidzein, Fisetin, Beta-sitosterol and others.

Quercetin can manipulate biochemical pathways MAPK Signaling, Cell Cycle Checkpoints and P53 Signaling. Vitamin C has biological action on biochemical pathways RAS-RAF Signaling, MYC Signaling and Oncogenic Cancer Epigenetics.

Aescin can manipulate biochemical pathways Cell Cycle Checkpoints and Cell Cycle. Lecithin has biological action on biochemical pathways MAPK Signaling, MYC Signaling and RAS-RAF Signaling. And so on.

When treating Hairy Cell Leukemia with chemotherapy Cladribine – Foods like Mung Bean are recommended compared to Soy Bean. This is because the active ingredients Aescin and Lecithin in Soy Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Quercetin and Vitamin C contained in Mung Bean support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: MUNG BEAN IS RECOMMENDED OVER SOY BEAN FOR HAIRY CELL LEUKEMIA ON TREATMENT WITH CHEMOTHERAPY CLADRIBINE FOR SOME CONDITIONS.

Eat more vegetables, Tomato or Celery?

Vegetables are an important part of many diets. The active ingredients contained in Tomato are Lycopene, Lupeol, Linolenic Acid, Vitamin C, Oleic Acid among others. While the active ingredients contained in Celery are Apigenin, Quercetin, Luteolin, Linolenic Acid, Vitamin C and others.

Lycopene can manipulate biochemical pathways MAPK Signaling, Cell Cycle Checkpoints and RAS-RAF Signaling. Glucaric Acid has biological action on biochemical pathways MYC Signaling, PI3K-AKT-MTOR Signaling and Apoptosis.

Luteolin can manipulate biochemical pathways MYC Signaling. Chrysin has biological action on biochemical pathways MYC Signaling. And so on.

When treating Hairy Cell Leukemia with chemotherapy Cladribine – Foods like Tomato are recommended compared to Celery. This is because the active ingredients Luteolin and Chrysin in Celery interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Lycopene and Glucaric Acid contained in Tomato support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: TOMATO IS RECOMMENDED OVER CELERY FOR HAIRY CELL LEUKEMIA ON TREATMENT WITH CHEMOTHERAPY CLADRIBINE FOR SOME CONDITIONS.

Which Foods are Recommended for Hairy Cell Leukemia?

Eat more fruits, Orange or Strawberry?

Fruits are an important part of many diets. The active ingredients contained in Orange are D-limonene, Linalool, Modified Citrus Pectin, Linolenic Acid, Rhamnetin among others. While the active ingredients contained in Strawberry are Ellagic Acid, Lupeol, Fisetin, Beta-sitosterol, Linolenic Acid and others.

D-limonene can manipulate biochemical pathways MAPK Signaling, Cell Cycle Checkpoints and RAS-RAF Signaling. Vitamin C has biological action on biochemical pathways P53 Signaling, MYC Signaling and Oncogenic Cancer Epigenetics.

Fisetin can manipulate biochemical pathways MYC Signaling. Ellagic Acid has biological action on biochemical pathways MYC Signaling. And so on.

When treating Hairy Cell Leukemia with chemotherapy Cladribine – Foods like Orange are recommended compared to Strawberry. This is because the active ingredients Fisetin and Ellagic Acid in Strawberry interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients D-limonene and Vitamin C contained in Orange support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: ORANGE IS RECOMMENDED OVER STRAWBERRY FOR HAIRY CELL LEUKEMIA ON TREATMENT WITH CHEMOTHERAPY CLADRIBINE FOR SOME CONDITIONS.

Eat more nuts, Walnut or Cashew Nut?

Nuts are an important part of many diets. The active ingredients contained in Walnut are D-limonene, Ellagic Acid, Vitamin E, Betulinic Acid, Hyperoside among others. While the active ingredients contained in Cashew Nut are Beta-sitosterol, Vitamin C, Gallic Acid, Palmitic Acid, Butyric Acid and others.

D-limonene can manipulate biochemical pathways MAPK Signaling, Cell Cycle Checkpoints and RAS-RAF Signaling. Hyperoside has biological action on biochemical pathways P53 Signaling, MYC Signaling and PI3K-AKT-MTOR Signaling.

Palmitic Acid can manipulate biochemical pathways MAPK Signaling, Cell Cycle and Oncogenic Cancer Epigenetics. Lauric Acid has biological action on biochemical pathways MYC Signaling, PI3K-AKT-MTOR Signaling and MAPK Signaling. And so on.

When treating Hairy Cell Leukemia with chemotherapy Cladribine – Foods like Walnut are recommended compared to Cashew Nut. This is because the active ingredients Palmitic Acid and Lauric Acid in Cashew Nut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients D-limonene and Hyperoside contained in Walnut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: WALNUT IS RECOMMENDED OVER CASHEW NUT FOR HAIRY CELL LEUKEMIA ON TREATMENT WITH CHEMOTHERAPY CLADRIBINE FOR SOME CONDITIONS.

Foods for Genetic Risk of Hairy Cell Leukemia

One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. BRAF and CDKN1B are two genes whose abnormalities are risk factors for Hairy Cell Leukemia. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Hairy Cell Leukemia can be used as a guide for coming up with a recommended personalized nutrition plan. For Hairy Cell Leukemia gene BRAF has causative impact on biological pathways like RAS-RAF Signaling, MAPK Signaling and Antigen Presentation. And CDKN1B has a causative impact on biological pathways like Cell Cycle Checkpoints and Cell Cycle. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like BRAF and CDKN1B should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes BRAF and CDKN1B should be avoided.

Eat more pulses, Yellow Wax Bean or Pigeon Pea?

The active ingredients contained in Yellow Wax Bean are Ferulic Acid, Vitamin C, Palmitic Acid, Cianidanol, Vitamin A among others. While the active ingredients contained in Pigeon Pea are Linolenic Acid, Vitamin C, Oleic Acid, Linoleic Acid, Genistein and others.

Vitamin A can manipulate biochemical pathways MYC Signaling, Apoptosis and Cell Cycle Checkpoints. Ferulic Acid has biological action on biochemical pathways P53 Signaling, Cell Cycle and Cell Cycle Checkpoints.

Folic Acid can manipulate biochemical pathways Cell Cycle Checkpoints, RAS-RAF Signaling and P53 Signaling. And so on.

For genetic risk of Hairy Cell Leukemia due to abnormalities in genes BRAF and CDKN1B – Foods like Yellow Wax Bean are recommended compared to Pigeon Pea. This is because the active ingredients Folic Acid in Pigeon Pea further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin A and Ferulic Acid contained in Yellow Wax Bean together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: YELLOW WAX BEAN IS RECOMMENDED OVER PIGEON PEA FOR REDUCING THE GENETIC RISK OF HAIRY CELL LEUKEMIA DUE TO GENES BRAF AND CDKN1B

Eat more vegetables, Giant Butterbur or Carob?

The active ingredients contained in Giant Butterbur are Beta-sitosterol, Vitamin C, Vitamin B3, Melatonin, Vitamin A among others. While the active ingredients contained in Carob are Quercetin, Palmitic Acid, Myricetin, Phloroglucinol, Gallic Acid and others.

Vitamin C can manipulate biochemical pathways Cell Cycle Checkpoints, RAS-RAF Signaling and P53 Signaling. Beta-sitosterol has biological action on biochemical pathways MYC Signaling, Apoptosis and Cell Cycle.

Palmitic Acid can manipulate biochemical pathways Cell Cycle. Folic Acid has biological action on biochemical pathways Cell Cycle Checkpoints, RAS-RAF Signaling and P53 Signaling. And so on.

For genetic risk of Hairy Cell Leukemia due to abnormalities in genes BRAF and CDKN1B – Foods like Giant Butterbur are recommended compared to Carob. This is because the active ingredients Palmitic Acid and Folic Acid in Carob further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Giant Butterbur together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: GIANT BUTTERBUR IS RECOMMENDED OVER CAROB FOR REDUCING THE GENETIC RISK OF HAIRY CELL LEUKEMIA DUE TO GENES BRAF AND CDKN1B

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.

Eat more fruits, Lemon or Cranberry?

The active ingredients contained in Lemon are D-limonene, Modified Citrus Pectin, P-coumaric Acid, Obacunone, Vitamin C among others. While the active ingredients contained in Cranberry are Ellagic Acid, Hyperoside, Quercetin, P-coumaric Acid, Vitamin C and others.

D-limonene can manipulate biochemical pathways Cell Cycle Checkpoints, RAS-RAF Signaling and P53 Signaling. Vitamin C has biological action on biochemical pathways MYC Signaling, Apoptosis and Cell Cycle.

Ellagic Acid can manipulate biochemical pathways MYC Signaling. Resveratrol has biological action on biochemical pathways P53 Signaling. And so on.

For genetic risk of Hairy Cell Leukemia due to abnormalities in genes BRAF and CDKN1B – Foods like Lemon are recommended compared to Cranberry. This is because the active ingredients Ellagic Acid and Resveratrol in Cranberry further promote the effects of genes on the biochemical pathways. While the active ingredients D-limonene and Vitamin C contained in Lemon together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: LEMON IS RECOMMENDED OVER CRANBERRY FOR REDUCING THE GENETIC RISK OF HAIRY CELL LEUKEMIA DUE TO GENES BRAF AND CDKN1B

Eat more nuts, Almond or Macadamia Nut?

The active ingredients contained in Almond are Vitamin E, Quercetin, Beta-sitosterol, Linolenic Acid, Stigmasterol among others. While the active ingredients contained in Macadamia Nut are Beta-sitosterol, Palmitic Acid, Lauric Acid, Folic Acid, Myristic Acid and others.

Beta-sitosterol can manipulate biochemical pathways Cell Cycle Checkpoints, P53 Signaling and MYC Signaling. Vitamin E has biological action on biochemical pathways RAS-RAF Signaling, Apoptosis and Cell Cycle.

Palmitic Acid can manipulate biochemical pathways Cell Cycle. Lauric Acid has biological action on biochemical pathways MYC Signaling. And so on.

For genetic risk of Hairy Cell Leukemia due to abnormalities in genes BRAF and CDKN1B – Foods like Almond are recommended compared to Macadamia Nut. This is because the active ingredients Palmitic Acid and Lauric Acid in Macadamia Nut further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin E contained in Almond together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: ALMOND IS RECOMMENDED OVER MACADAMIA NUT FOR REDUCING THE GENETIC RISK OF HAIRY CELL LEUKEMIA DUE TO GENES BRAF AND CDKN1B


In Summary

An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.

“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.

The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.

You can get started NOW and design a personalized nutrition plan for Hairy Cell Leukemia by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

sample-report


References

Personalized Nutrition for Cancer!

Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.


Scientifically Reviewed by: Dr. Cogle

Christopher R. Cogle, M.D. is a tenured professor at the University of Florida, Chief Medical Officer of Florida Medicaid, and Director of the Florida Health Policy Leadership Academy at the Bob Graham Center for Public Service.

You can also read this in

How useful was this post?

Click on a star to rate it!

Average rating 4.3 / 5. Vote count: 23

No votes so far! Be the first to rate this post.

As you found this post useful...

Follow us on social media!

We are sorry that this post was not useful for you!

Let us improve this post!

Tell us how we can improve this post?