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What Foods are Recommended for Cancer?
is a very common question. Personalized Nutrition Plans are foods and supplements which are personalized to a cancer indication, genes, any treatments and lifestyle conditions.

Which Foods are Recommended for Extramammary Paget Disease?

Sep 2, 2022

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Highlights

No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Extramammary Paget Disease when undergoing chemotherapy or when you determine you have a genetic risk for developing Extramammary Paget Disease because of ERBB2 and PPP2R1A gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.

There is no one answer to this question for cancers such as Extramammary Paget Disease which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.

In short – the process to answer questions like “Should I Avoid eating fruit Cherry” or “Include fruit Partridgeberry in my diet” or “Should I reduce consumption of vegetable Radish” or “Can I take Resveratrol and Gotu Kola supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.

RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO EXTRAMAMMARY PAGET DISEASE, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.

The overall objective of personalized nutrition for Extramammary Paget Disease is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.

RECOMMENDATION: UPDATE YOUR NUTRITION FOR EXTRAMAMMARY PAGET DISEASE, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.



About Extramammary Paget Disease

cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.

Following key highlights are derived from clinical data for Extramammary Paget Disease from cBioPortal. 50.0% of males and 50.0% of females were the distribution of gender in these clinical studies. From a patient sample size of 3; the top genes with mutations and other abnormalities for Extramammary Paget Disease include genes ERBB2, PPP2R1A and SMARCA4. The occurrence frequency distribution for these genes respectively is 33.3%, 33.3% and 33.3%. These tumor genetic details of Extramammary Paget Disease are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Extramammary Paget Disease.

Significance of Nutrition for Extramammary Paget Disease

All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Extramammary Paget Disease. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.

For example Cherry includes active ingredients Oleic Acid, Linolenic Acid, Quercetin, Beta-sitosterol, Genistein and others. And Partridgeberry contains active ingredients Resveratrol, Beta-sitosterol, Stigmasterol and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.

For cancers like Extramammary Paget Disease, activation or inhibition of selected biochemical pathways like PI3K-AKT-MTOR Signaling, Growth Factor Signaling, Chromatin Remodeling, MAPK Signaling plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Extramammary Paget Disease, while eating some other foods and supplements may not be recommended.

One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.

For cancers like Extramammary Paget Disease, activation or inhibition of selected biochemical pathways like PI3K-AKT-MTOR Signaling, Growth Factor Signaling, Chromatin Remodeling, MAPK Signaling plays an important role in driving cancer growth.

RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR EXTRAMAMMARY PAGET DISEASE – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.

Foods for Extramammary Paget Disease undergoing chemotherapy treatment

In Extramammary Paget Disease – the genes ERBB2, PPP2R1A and SMARCA4 have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Extramammary Paget Disease are PI3K-AKT-MTOR Signaling and others. Radiation is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers PI3K-AKT-MTOR Signaling so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.

RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.

Eat more pulses, Winged Bean?

Pulses are an important part of many diets. The active ingredients contained in Winged Bean are Oleic Acid, Linolenic Acid, Betulinic Acid, Vitamin C, Linoleic Acid among others.

Betulinic Acid can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Vitamin C has biological action on biochemical pathways PI3K-AKT-MTOR Signaling.

When treating Extramammary Paget Disease with chemotherapy Radiation – Foods like Winged Bean are recommended. This is because the active ingredients Betulinic Acid and Vitamin C contained in Winged Bean support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: WINGED BEAN IS RECOMMENDED FOR EXTRAMAMMARY PAGET DISEASE ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Eat more vegetables, Artichoke or Radish?

Vegetables are an important part of many diets. The active ingredients contained in Artichoke are Naringenin, Apigenin, Chlorogenic Acid, Cynaroside, Vitamin C among others. While the active ingredients contained in Radish are Oleic Acid, Linolenic Acid, Quercetin, Beta-sitosterol, Kaempferol and others.

Vitamin K can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Naringenin has biological action on biochemical pathways PI3K-AKT-MTOR Signaling.

Pelargonidin can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways PI3K-AKT-MTOR Signaling. And so on.

When treating Extramammary Paget Disease with chemotherapy Radiation – Foods like Artichoke are recommended compared to Radish. This is because the active ingredients Pelargonidin and Folic Acid in Radish interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin K and Naringenin contained in Artichoke support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: ARTICHOKE IS RECOMMENDED OVER RADISH FOR EXTRAMAMMARY PAGET DISEASE ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Which Foods are Recommended for Extramammary Paget Disease?

Eat more fruits, Partridgeberry or Cherry?

Fruits are an important part of many diets. The active ingredients contained in Partridgeberry are Resveratrol, Beta-sitosterol, Stigmasterol among others. While the active ingredients contained in Cherry are Oleic Acid, Linolenic Acid, Quercetin, Beta-sitosterol, Genistein and others.

Resveratrol can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Beta-sitosterol has biological action on biochemical pathways PI3K-AKT-MTOR Signaling.

Shikimic Acid can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Pelargonidin has biological action on biochemical pathways PI3K-AKT-MTOR Signaling. And so on.

When treating Extramammary Paget Disease with chemotherapy Radiation – Foods like Partridgeberry are recommended compared to Cherry. This is because the active ingredients Shikimic Acid and Pelargonidin in Cherry interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Resveratrol and Beta-sitosterol contained in Partridgeberry support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: PARTRIDGEBERRY IS RECOMMENDED OVER CHERRY FOR EXTRAMAMMARY PAGET DISEASE ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Eat more nuts, Chestnut or Brazil Nut?

Nuts are an important part of many diets. The active ingredients contained in Chestnut are Ellagic Acid, Oleic Acid, Linolenic Acid, Quercetin, Betulin among others. While the active ingredients contained in Brazil Nut are Oleic Acid, Vitamin E, Linolenic Acid, Folic Acid, Lecithin and others.

Ellagic Acid can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Betulin has biological action on biochemical pathways PI3K-AKT-MTOR Signaling.

Lecithin can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways PI3K-AKT-MTOR Signaling. And so on.

When treating Extramammary Paget Disease with chemotherapy Radiation – Foods like Chestnut are recommended compared to Brazil Nut. This is because the active ingredients Lecithin and Folic Acid in Brazil Nut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Ellagic Acid and Betulin contained in Chestnut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: CHESTNUT IS RECOMMENDED OVER BRAZIL NUT FOR EXTRAMAMMARY PAGET DISEASE ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Foods for Genetic Risk of Extramammary Paget Disease

One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. ERBB2 and PPP2R1A are two genes whose abnormalities are risk factors for Extramammary Paget Disease. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Extramammary Paget Disease can be used as a guide for coming up with a recommended personalized nutrition plan. For Extramammary Paget Disease gene ERBB2 has causative impact on biological pathways like Growth Factor Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling. And PPP2R1A has a causative impact on biological pathways like Nutrient sensing, PI3K-AKT-MTOR Signaling and DNA Repair. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like ERBB2 and PPP2R1A should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes ERBB2 and PPP2R1A should be avoided.

Eat more pulses, Mung Bean or Moth Bean?

The active ingredients contained in Mung Bean are Oleic Acid, Linolenic Acid, Quercetin, Vitamin C, Stigmasterol among others. While the active ingredients contained in Moth Bean are Oleic Acid, Linolenic Acid, Beta-sitosterol, Stigmasterol, Linoleic Acid and others.

Quercetin can manipulate biochemical pathways Cell Cycle Checkpoints, P53 Signaling and MYC Signaling. Vitamin C has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, Growth Factor Signaling and Apoptosis.

Vitamin A can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Linoleic Acid has biological action on biochemical pathways Growth Factor Signaling. And so on.

For genetic risk of Extramammary Paget Disease due to abnormalities in genes ERBB2 and PPP2R1A – Foods like Mung Bean are recommended compared to Moth Bean. This is because the active ingredients Vitamin A and Linoleic Acid in Moth Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Quercetin and Vitamin C contained in Mung Bean together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: MUNG BEAN IS RECOMMENDED OVER MOTH BEAN FOR REDUCING THE GENETIC RISK OF EXTRAMAMMARY PAGET DISEASE DUE TO GENES ERBB2 AND PPP2R1A

Eat more vegetables, Giant Butterbur or Yardlong Bean?

The active ingredients contained in Giant Butterbur are Beta-sitosterol, Vitamin C, Melatonin, Vitamin B3, Kaempferol among others. While the active ingredients contained in Yardlong Bean are Oleic Acid, Linolenic Acid, Vitamin C, Linoleic Acid, Vitamin A and others.

Vitamin C can manipulate biochemical pathways Cell Cycle Checkpoints, P53 Signaling and MYC Signaling. Beta-sitosterol has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, Apoptosis and Cell Cycle Checkpoints.

Vitamin A can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Linoleic Acid has biological action on biochemical pathways Growth Factor Signaling. And so on.

For genetic risk of Extramammary Paget Disease due to abnormalities in genes ERBB2 and PPP2R1A – Foods like Giant Butterbur are recommended compared to Yardlong Bean. This is because the active ingredients Vitamin A and Linoleic Acid in Yardlong Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Giant Butterbur together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: GIANT BUTTERBUR IS RECOMMENDED OVER YARDLONG BEAN FOR REDUCING THE GENETIC RISK OF EXTRAMAMMARY PAGET DISEASE DUE TO GENES ERBB2 AND PPP2R1A

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.

Eat more fruits, Currant or Peach?

The active ingredients contained in Currant are Cianidanol, Delphinidin, Oleic Acid, Gamma-linolenic Acid, Linolenic Acid among others. While the active ingredients contained in Peach are Oleic Acid, Linolenic Acid, Beta-sitosterol, Vitamin C, Modified Citrus Pectin and others.

Cianidanol can manipulate biochemical pathways Cell Cycle Checkpoints, P53 Signaling and MYC Signaling. Delphinidin has biological action on biochemical pathways Growth Factor Signaling, PI3K-AKT-MTOR Signaling and MYC Signaling.

Fisetin can manipulate biochemical pathways MYC Signaling. Vitamin A has biological action on biochemical pathways PI3K-AKT-MTOR Signaling. And so on.

For genetic risk of Extramammary Paget Disease due to abnormalities in genes ERBB2 and PPP2R1A – Foods like Currant are recommended compared to Peach. This is because the active ingredients Fisetin and Vitamin A in Peach further promote the effects of genes on the biochemical pathways. While the active ingredients Cianidanol and Delphinidin contained in Currant together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: CURRANT IS RECOMMENDED OVER PEACH FOR REDUCING THE GENETIC RISK OF EXTRAMAMMARY PAGET DISEASE DUE TO GENES ERBB2 AND PPP2R1A

Eat more nuts, Hazelnut or Macadamia Nut?

The active ingredients contained in Hazelnut are Vitamin E, Oleic Acid, Linolenic Acid, Quercetin, Linoleic Acid among others. While the active ingredients contained in Macadamia Nut are Beta-sitosterol, Palmitic Acid, Lauric Acid, Myristic Acid, Folic Acid and others.

Vitamin E can manipulate biochemical pathways Cell Cycle Checkpoints, P53 Signaling and MYC Signaling. Quercetin has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, Growth Factor Signaling and Apoptosis.

Palmitic Acid can manipulate biochemical pathways Growth Factor Signaling. Lauric Acid has biological action on biochemical pathways MYC Signaling, PI3K-AKT-MTOR Signaling and Growth Factor Signaling. And so on.

For genetic risk of Extramammary Paget Disease due to abnormalities in genes ERBB2 and PPP2R1A – Foods like Hazelnut are recommended compared to Macadamia Nut. This is because the active ingredients Palmitic Acid and Lauric Acid in Macadamia Nut further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin E and Quercetin contained in Hazelnut together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: HAZELNUT IS RECOMMENDED OVER MACADAMIA NUT FOR REDUCING THE GENETIC RISK OF EXTRAMAMMARY PAGET DISEASE DUE TO GENES ERBB2 AND PPP2R1A


In Summary

An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.

“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.

The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.

You can get started NOW and design a personalized nutrition plan for Extramammary Paget Disease by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

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References

Personalized Nutrition for Cancer!

Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.


Scientifically Reviewed by: Dr. Cogle

Christopher R. Cogle, M.D. is a tenured professor at the University of Florida, Chief Medical Officer of Florida Medicaid, and Director of the Florida Health Policy Leadership Academy at the Bob Graham Center for Public Service.

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