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What Foods are Recommended for Cancer?
is a very common question. Personalized Nutrition Plans are foods and supplements which are personalized to a cancer indication, genes, any treatments and lifestyle conditions.

Which Foods are Recommended for Esophageal Neuroendocrine Tumor?

Sep 2, 2022

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Highlights

No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Esophageal Neuroendocrine Tumor when undergoing chemotherapy or when you determine you have a genetic risk for developing Esophageal Neuroendocrine Tumor because of RB1 and FBXW7 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.

There is no one answer to this question for cancers such as Esophageal Neuroendocrine Tumor which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.

In short – the process to answer questions like “Should I Avoid eating fruit Fig” or “Include fruit Graviola in my diet” or “Should I reduce consumption of vegetable Celery” or “Can I take Senna and Buckthorn supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.

RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO ESOPHAGEAL NEUROENDOCRINE TUMOR, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.

The overall objective of personalized nutrition for Esophageal Neuroendocrine Tumor is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.

RECOMMENDATION: UPDATE YOUR NUTRITION FOR ESOPHAGEAL NEUROENDOCRINE TUMOR, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.



About Esophageal Neuroendocrine Tumor

cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.

Following key highlights are derived from clinical data for Esophageal Neuroendocrine Tumor from cBioPortal. 66.7% of males and 33.3% of females were the distribution of gender in these clinical studies. From a patient sample size of 3; the top genes with mutations and other abnormalities for Esophageal Neuroendocrine Tumor include genes TP53, RB1, FBXW7, CHEK2 and CREBBP. The occurrence frequency distribution for these genes respectively is 100.0%, 100.0%, 50.0%, 50.0% and 50.0%. These tumor genetic details of Esophageal Neuroendocrine Tumor are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Esophageal Neuroendocrine Tumor.

Significance of Nutrition for Esophageal Neuroendocrine Tumor

All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Esophageal Neuroendocrine Tumor. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.

For example Fig includes active ingredients Lupeol, Beta-sitosterol, Bergapten, Psoralen, Vitamin C and others. And Graviola contains active ingredients Emodin, Vitamin E, Myricetin, Tangeretin, Quercetin and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.

For cancers like Esophageal Neuroendocrine Tumor, activation or inhibition of selected biochemical pathways like Cell Cycle, DNA Repair, Cell Cycle Checkpoints, Apoptosis plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Esophageal Neuroendocrine Tumor, while eating some other foods and supplements may not be recommended.

One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.

For cancers like Esophageal Neuroendocrine Tumor, activation or inhibition of selected biochemical pathways like Cell Cycle, DNA Repair, Cell Cycle Checkpoints, Apoptosis plays an important role in driving cancer growth.

RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR ESOPHAGEAL NEUROENDOCRINE TUMOR – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.

Foods for Esophageal Neuroendocrine Tumor undergoing chemotherapy treatment

In Esophageal Neuroendocrine Tumor – the genes TP53, RB1, FBXW7, CHEK2 and CREBBP have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Esophageal Neuroendocrine Tumor are Cell Cycle, DNA Repair, Notch Signaling and others. Radiation is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Cell Cycle, DNA Repair, Notch Signaling so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.

RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.

Eat more pulses, Mung Bean or Moth Bean?

Pulses are an important part of many diets. The active ingredients contained in Mung Bean are Quercetin, Stigmasterol, Linolenic Acid, Vitamin C, Oleic Acid among others. While the active ingredients contained in Moth Bean are Beta-sitosterol, Stigmasterol, Linolenic Acid, Oleic Acid, Vitamin A and others.

Quercetin can manipulate biochemical pathways MYC Signaling, DNA Repair and Cell Cycle. Stigmasterol has biological action on biochemical pathways MYC Signaling, DNA Repair and Cell Cycle.

Folic Acid can manipulate biochemical pathways MYC Signaling. And so on.

When treating Esophageal Neuroendocrine Tumor with chemotherapy Radiation – Foods like Mung Bean are recommended compared to Moth Bean. This is because the active ingredients Folic Acid in Moth Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Quercetin and Stigmasterol contained in Mung Bean support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: MUNG BEAN IS RECOMMENDED OVER MOTH BEAN FOR ESOPHAGEAL NEUROENDOCRINE TUMOR ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Eat more vegetables, Arugula or Celery?

Vegetables are an important part of many diets. The active ingredients contained in Arugula are Esculin, Vitamin A, Kaempferol, Vitamin K, Erysolin among others. While the active ingredients contained in Celery are Apigenin, Luteolin, Quercetin, Linolenic Acid, Vitamin C and others.

Vitamin A can manipulate biochemical pathways MYC Signaling and Cell Cycle. Kaempferol has biological action on biochemical pathways Cell Cycle.

Luteolin can manipulate biochemical pathways MYC Signaling. Chrysin has biological action on biochemical pathways MYC Signaling. And so on.

When treating Esophageal Neuroendocrine Tumor with chemotherapy Radiation – Foods like Arugula are recommended compared to Celery. This is because the active ingredients Luteolin and Chrysin in Celery interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin A and Kaempferol contained in Arugula support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: ARUGULA IS RECOMMENDED OVER CELERY FOR ESOPHAGEAL NEUROENDOCRINE TUMOR ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Which Foods are Recommended for Esophageal Neuroendocrine Tumor?

Eat more fruits, Graviola or Fig?

Fruits are an important part of many diets. The active ingredients contained in Graviola are Emodin, Vitamin E, Myricetin, Tangeretin, Quercetin among others. While the active ingredients contained in Fig are Lupeol, Beta-sitosterol, Bergapten, Psoralen, Vitamin C and others.

Emodin can manipulate biochemical pathways MYC Signaling, DNA Repair and Cell Cycle. Fisetin has biological action on biochemical pathways Cell Cycle.

Lauric Acid can manipulate biochemical pathways MYC Signaling. Myristic Acid has biological action on biochemical pathways Cell Cycle and MYC Signaling. And so on.

When treating Esophageal Neuroendocrine Tumor with chemotherapy Radiation – Foods like Graviola are recommended compared to Fig. This is because the active ingredients Lauric Acid and Myristic Acid in Fig interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Emodin and Fisetin contained in Graviola support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: GRAVIOLA IS RECOMMENDED OVER FIG FOR ESOPHAGEAL NEUROENDOCRINE TUMOR ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Eat more nuts, Hazelnut or Walnut?

Nuts are an important part of many diets. The active ingredients contained in Hazelnut are Vitamin E, Quercetin, Linolenic Acid, Oleic Acid, Vitamin A among others. While the active ingredients contained in Walnut are Vitamin E, Myricetin, Quercetin, Beta-sitosterol, Ellagic Acid and others.

Vitamin E can manipulate biochemical pathways MYC Signaling, DNA Repair and Cell Cycle. Quercetin has biological action on biochemical pathways MYC Signaling, DNA Repair and Cell Cycle.

Ellagic Acid can manipulate biochemical pathways MYC Signaling. Plumbagin has biological action on biochemical pathways MYC Signaling. And so on.

When treating Esophageal Neuroendocrine Tumor with chemotherapy Radiation – Foods like Hazelnut are recommended compared to Walnut. This is because the active ingredients Ellagic Acid and Plumbagin in Walnut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin E and Quercetin contained in Hazelnut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: HAZELNUT IS RECOMMENDED OVER WALNUT FOR ESOPHAGEAL NEUROENDOCRINE TUMOR ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Foods for Genetic Risk of Esophageal Neuroendocrine Tumor

One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. RB1 and FBXW7 are two genes whose abnormalities are risk factors for Esophageal Neuroendocrine Tumor. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Esophageal Neuroendocrine Tumor can be used as a guide for coming up with a recommended personalized nutrition plan. For Esophageal Neuroendocrine Tumor gene RB1 has causative impact on biological pathways like Cell Cycle Checkpoints, DNA Repair and Cell Cycle. And FBXW7 has a causative impact on biological pathways like Antigen Presentation and Post Translation Modification. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like RB1 and FBXW7 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes RB1 and FBXW7 should be avoided.

Eat more pulses, Hyacinth Bean or Pigeon Pea?

The active ingredients contained in Hyacinth Bean are Vitamin C, Palmitic Acid, Genistein, Myristic Acid, Folic Acid among others. While the active ingredients contained in Pigeon Pea are Oleic Acid, Vitamin C, Linolenic Acid, Linoleic Acid, Genistein and others.

Palmitic Acid can manipulate biochemical pathways Cell Cycle Checkpoints, RAS-RAF Signaling and P53 Signaling. Vitamin C has biological action on biochemical pathways MYC Signaling, PI3K-AKT-MTOR Signaling and Apoptosis.

Folic Acid can manipulate biochemical pathways Cell Cycle Checkpoints, RAS-RAF Signaling and P53 Signaling. And so on.

For genetic risk of Esophageal Neuroendocrine Tumor due to abnormalities in genes RB1 and FBXW7 – Foods like Hyacinth Bean are recommended compared to Pigeon Pea. This is because the active ingredients Folic Acid in Pigeon Pea further promote the effects of genes on the biochemical pathways. While the active ingredients Palmitic Acid and Vitamin C contained in Hyacinth Bean together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: HYACINTH BEAN IS RECOMMENDED OVER PIGEON PEA FOR REDUCING THE GENETIC RISK OF ESOPHAGEAL NEUROENDOCRINE TUMOR DUE TO GENES RB1 AND FBXW7

Eat more vegetables, Cassava or Broccoli?

The active ingredients contained in Cassava are Beta-sitosterol, Oleic Acid, Vitamin C, Linolenic Acid, Linoleic Acid among others. While the active ingredients contained in Broccoli are Oleic Acid, Vitamin C, Linolenic Acid, Ferulic Acid, Brassinin and others.

Vitamin C can manipulate biochemical pathways Cell Cycle Checkpoints, RAS-RAF Signaling and P53 Signaling. Beta-sitosterol has biological action on biochemical pathways MYC Signaling, PI3K-AKT-MTOR Signaling and Apoptosis.

Folic Acid can manipulate biochemical pathways Cell Cycle Checkpoints, RAS-RAF Signaling and P53 Signaling. And so on.

For genetic risk of Esophageal Neuroendocrine Tumor due to abnormalities in genes RB1 and FBXW7 – Foods like Cassava are recommended compared to Broccoli. This is because the active ingredients Folic Acid in Broccoli further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Cassava together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: CASSAVA IS RECOMMENDED OVER BROCCOLI FOR REDUCING THE GENETIC RISK OF ESOPHAGEAL NEUROENDOCRINE TUMOR DUE TO GENES RB1 AND FBXW7

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.

Eat more fruits, Star Fruit or Naranjilla?

The active ingredients contained in Star Fruit are Beta-sitosterol, Oleic Acid, Vitamin C, Linolenic Acid, Epigallocatechin Gallate among others. While the active ingredients contained in Naranjilla are Zeaxanthin, Beta-carotene, Vitamin A and others.

Vitamin C can manipulate biochemical pathways Cell Cycle Checkpoints, RAS-RAF Signaling and P53 Signaling. Beta-sitosterol has biological action on biochemical pathways MYC Signaling, PI3K-AKT-MTOR Signaling and Apoptosis.

Beta-carotene can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. And so on.

For genetic risk of Esophageal Neuroendocrine Tumor due to abnormalities in genes RB1 and FBXW7 – Foods like Star Fruit are recommended compared to Naranjilla. This is because the active ingredients Beta-carotene in Naranjilla further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Star Fruit together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: STAR FRUIT IS RECOMMENDED OVER NARANJILLA FOR REDUCING THE GENETIC RISK OF ESOPHAGEAL NEUROENDOCRINE TUMOR DUE TO GENES RB1 AND FBXW7

Eat more nuts, Almond or Chestnut?

The active ingredients contained in Almond are Quercetin, Vitamin E, Beta-sitosterol, Oleic Acid, Linolenic Acid among others. While the active ingredients contained in Chestnut are Quercetin, Ellagic Acid, Oleic Acid, Vitamin C, Linolenic Acid and others.

Beta-sitosterol can manipulate biochemical pathways Cell Cycle Checkpoints, P53 Signaling and MYC Signaling. Quercetin has biological action on biochemical pathways RAS-RAF Signaling, PI3K-AKT-MTOR Signaling and Apoptosis.

Ellagic Acid can manipulate biochemical pathways MYC Signaling and Cell Cycle Checkpoints. Folic Acid has biological action on biochemical pathways RAS-RAF Signaling, P53 Signaling and PI3K-AKT-MTOR Signaling. And so on.

For genetic risk of Esophageal Neuroendocrine Tumor due to abnormalities in genes RB1 and FBXW7 – Foods like Almond are recommended compared to Chestnut. This is because the active ingredients Ellagic Acid and Folic Acid in Chestnut further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Quercetin contained in Almond together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: ALMOND IS RECOMMENDED OVER CHESTNUT FOR REDUCING THE GENETIC RISK OF ESOPHAGEAL NEUROENDOCRINE TUMOR DUE TO GENES RB1 AND FBXW7


In Summary

An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.

“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.

The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.

You can get started NOW and design a personalized nutrition plan for Esophageal Neuroendocrine Tumor by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

sample-report


References

Personalized Nutrition for Cancer!

Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.


Scientifically Reviewed by: Dr. Cogle

Christopher R. Cogle, M.D. is a tenured professor at the University of Florida, Chief Medical Officer of Florida Medicaid, and Director of the Florida Health Policy Leadership Academy at the Bob Graham Center for Public Service.

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