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What Foods are Recommended for Cancer?
is a very common question. Personalized Nutrition Plans are foods and supplements which are personalized to a cancer indication, genes, any treatments and lifestyle conditions.

Foods for Esophageal Neuroendocrine Tumor!

Aug 4, 2023

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Introduction

Foods for Esophageal Neuroendocrine Tumor should be personalized for each individual and also must adapt when cancer treatment or tumor genetic change. The personalization and adaptation must consider all the active ingredients or bioactives contained in different foods with respect to cancer tissue biology, genetics, treatments, lifestyle conditions and diet preferences. Hence while nutrition is one of the very important decisions for a cancer patient and individual at risk of cancer to make – how to choose foods to eat is not an easy task.



For Esophageal Neuroendocrine Tumor does it matter what vegetables, fruits, nuts, seeds one eats?

A very common nutrition question asked by cancer patients and individuals at-genetic risk of cancer is – for cancers like Esophageal Neuroendocrine Tumor does it matter what foods I eat and which I do not? Or if I follow a plant-based diet is that enough for cancer like Esophageal Neuroendocrine Tumor?

For example does it matter if vegetable Spinach is consumed more compared to Mountain Yam? Does it make any difference if fruit Grapefruit is preferred over Blackberry? Also if similar choices are made for nuts/seeds like Walnut over Hickory Nut and for pulses like Black-eyed Pea over Catjang Pea. And if what I eat matters – then how does one identify foods which are recommended for Esophageal Neuroendocrine Tumor and is it the same answer for everyone with the same diagnosis or genetic risk?

Yes! Foods you eat matters for Esophageal Neuroendocrine Tumor!

Food recommendations may not be the same for everyone and can be different even for the same diagnosis and genetic risk.

All cancers like Esophageal Neuroendocrine Tumor can be characterized by a unique set of biochemical pathways - the signature pathways of Esophageal Neuroendocrine Tumor. Biochemical pathways like Cell Cycle, DNA Repair, Cell Cycle Checkpoints, Apoptosis are part of the signature definition of Esophageal Neuroendocrine Tumor.

All foods (vegetables, fruits, nuts, seeds, pulses, oils etc.) and nutritional supplements are made up of more than one active molecular ingredient or bio-actives in different proportions and quantities. Each active ingredient has a unique mechanism of action – which can be activation or inhibition of different biochemical pathways. Simply stated foods and supplements which are recommended are those which do not cause an increase of molecular drivers of cancer but reduce them. Else those foods should not be recommended. Foods contain multiple active ingredients – hence when evaluating foods and supplements you need to consider the impact of all active ingredients cumulatively rather than individually.

For example Grapefruit contains active ingredients Curcumin, Luteolin, Lupeol, Phloretin, Eugenol. And Blackberry contains active ingredients Myricetin, Ellagic Acid, Eugenol, Quercetin, Linalool and possibly others.

A common mistake made when deciding and choosing foods to eat for Esophageal Neuroendocrine Tumor – is to evaluate only selected active ingredients contained in foods and ignore the rest. Because different active ingredients contained in foods may have opposing effects on cancer drivers – you cannot cherry pick active ingredients in foods and supplements for making a nutrition decision for Esophageal Neuroendocrine Tumor.

YES – FOOD CHOICES MATTER FOR CANCER. NUTRITION DECISIONS MUST CONSIDER ALL ACTIVE INGREDIENTS OF FOODS.

Skills Needed for Nutrition Personalization for Esophageal Neuroendocrine Tumor?

Personalized nutrition for cancers like Esophageal Neuroendocrine Tumor consists of recommended foods / supplements; not recommended foods / supplements with example recipes which prioritize use of recommended foods. An example of personalized nutrition can be seen at this link.

Deciding which foods are recommended or not is extremely complicated, requiring expertise in Esophageal Neuroendocrine Tumor biology, food science, genetics, biochemistry along with good understanding of how cancer treatments work and associated vulnerabilities by which the treatments could stop being effective.

MINIMUM KNOWLEDGE EXPERTISE NEEDED FOR NUTRITION PERSONALIZATION FOR CANCER ARE: CANCER BIOLOGY, FOOD SCIENCE, CANCER TREATMENTS AND GENETICS.

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.

Characteristics of cancers like Esophageal Neuroendocrine Tumor

All cancers like Esophageal Neuroendocrine Tumor can be characterized by a unique set of biochemical pathways – the signature pathways of Esophageal Neuroendocrine Tumor. Biochemical pathways like Cell Cycle, DNA Repair, Cell Cycle Checkpoints, Apoptosis are part of the signature definition of Esophageal Neuroendocrine Tumor. Each individual’s cancer genetics can be different and hence their specific cancer signature could be unique.

The treatments which are effective for Esophageal Neuroendocrine Tumor need to be cognizant of the associated signature biochemical pathways for each cancer patient and individual at genetic risk. Therefore different treatments with different mechanisms of actions are effective for different patients. Similarly and for the same reasons foods and supplements need to be personalized for each individual. Hence some foods and supplements are recommended for Esophageal Neuroendocrine Tumor when taking cancer treatment Radiation, and some foods and supplements are not recommended.

Sources like cBioPortal and many others provide population representative patient anonymized data from clinical trials for all cancer indications. This data consists of clinical trial study details like sample size / number of patients, age groups, gender, ethnicity, treatments, tumor site and any genetic mutations.

TP53, RB1, FBXW7, CHEK2 and CREBBP are the top ranked reported genes for Esophageal Neuroendocrine Tumor. TP53 is reported in 100.0 % of the representative patients across all clinical trials. And RB1 is reported in 100.0 %. The combined population patient data cover ages from to . 66.7 % of the patient data are identified as men. The Esophageal Neuroendocrine Tumor biology along with reported genetics together define the population represented signature biochemical pathways for this cancer. If the individual cancer tumor genetics or genes contributing to the risk are also known then that should also be used for nutrition personalization.

NUTRITION CHOICES SHOULD MATCH WITH EACH INDIVIDUAL’S CANCER SIGNATURE.

Foods for Esophageal Neuroendocrine Tumor!

Food and Supplements for Esophageal Neuroendocrine Tumor

For Cancer Patients

Cancer patients on treatment or on palliative care need to make decisions on food and supplements – for the needed dietary calories, for managing any treatment side effects and also for improved cancer management. All plant-based foods are not equal and choosing and prioritizing foods which are personalized and customized to ongoing cancer treatment is important and complicated. Here are some examples providing guidelines for making nutrition decisions.

Choose Vegetable SPINACH or MOUNTAIN YAM?

Vegetable Spinach contains many active ingredients or bioactives such as Apigenin, Curcumin, Myricetin, Luteolin, Lupeol. These active ingredients manipulate various biochemical pathways like Cell Cycle and MYC Signaling and others. Spinach is recommended for Esophageal Neuroendocrine Tumor when ongoing cancer treatment is Radiation. This is because Spinach modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Radiation.

Some of the active ingredients or bioactives in vegetable Mountain Yam are Apigenin, Curcumin, Myricetin, Luteolin, Lupeol. These active ingredients manipulate various biochemical pathways like Notch Signaling and Cell Cycle and others. Mountain Yam is not recommended for Esophageal Neuroendocrine Tumor when ongoing cancer treatment is Radiation because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

VEGETABLE SPINACH IS RECOMMENDED OVER MOUNTAIN YAM FOR Esophageal Neuroendocrine Tumor AND TREATMENT Radiation.

Choose Fruit BLACKBERRY or GRAPEFRUIT?

Fruit Blackberry contains many active ingredients or bioactives such as Myricetin, Ellagic Acid, Eugenol, Quercetin, Linalool. These active ingredients manipulate various biochemical pathways like DNA Repair, Cell Cycle and MYC Signaling and others. Blackberry is recommended for Esophageal Neuroendocrine Tumor when ongoing cancer treatment is Radiation. This is because Blackberry modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Radiation.

Some of the active ingredients or bioactives in fruit Grapefruit are Curcumin, Luteolin, Lupeol, Phloretin, Eugenol. These active ingredients manipulate various biochemical pathways like Notch Signaling and DNA Repair and others. Grapefruit is not recommended for Esophageal Neuroendocrine Tumor when ongoing cancer treatment is Radiation because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

FRUIT BLACKBERRY IS RECOMMENDED OVER GRAPEFRUIT FOR Esophageal Neuroendocrine Tumor AND TREATMENT Radiation.

Choose Nut WALNUT or HICKORY NUT?

Walnut contains many active ingredients or bioactives such as Apigenin, Curcumin, Myricetin, Luteolin, Lupeol. These active ingredients manipulate various biochemical pathways like DNA Repair and Cell Cycle and others. Walnut is recommended for Esophageal Neuroendocrine Tumor when ongoing cancer treatment is Radiation. This is because Walnut modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Radiation.

Some of the active ingredients or bioactives in Hickory Nut are Apigenin, Curcumin, Myricetin, Luteolin, Lupeol. These active ingredients manipulate various biochemical pathways like Cell Cycle and MYC Signaling and others. Hickory Nut is not recommended for Esophageal Neuroendocrine Tumor when ongoing cancer treatment is Radiation because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

WALNUT IS RECOMMENDED OVER HICKORY NUT FOR Esophageal Neuroendocrine Tumor AND TREATMENT Radiation.

For Individuals with Genetic Risk of Cancer

The question asked by individuals who have genetic risk of Esophageal Neuroendocrine Tumor or familial history is “What Should I Eat Differently from Before?” and how they should choose foods and supplements to manage risks of the disease. Since for cancer risk there is nothing actionable in terms of treatment – decisions of foods and supplements become important and one of the very few actionable things which can be done. All plant-based foods are not equal and based on identified genetics and pathway signature – the choices of food and supplements should be personalized.

Choose Vegetable WILD CARROT or ARROWROOT?

Vegetable Wild Carrot contains many active ingredients or bioactives such as Curcumin, Apigenin, Quercetin, Lupeol, Daidzein. These active ingredients manipulate various biochemical pathways like Cell Cycle Checkpoints, Cell Cycle, Angiogenesis and PI3K-AKT-MTOR Signaling and others. Wild Carrot is recommended for risk of Esophageal Neuroendocrine Tumor when associated genetic risk is CHEK2. This is because Wild Carrot increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in vegetable Arrowroot are Curcumin, Apigenin, Quercetin, Lupeol, Daidzein. These active ingredients manipulate various biochemical pathways like Cell Cycle Checkpoints and DNA Repair and others. Arrowroot is not recommended when risk of Esophageal Neuroendocrine Tumor when associated genetic risk is CHEK2 because it increases the signature pathways of it.

VEGETABLE WILD CARROT IS RECOMMENDED OVER ARROWROOT FOR CHEK2 GENETIC RISK OF CANCER.

Choose Fruit NANCE or SQUASHBERRY?

Fruit Nance contains many active ingredients or bioactives such as Curcumin, Apigenin, Lupeol, Daidzein, Formononetin. These active ingredients manipulate various biochemical pathways like Cell Cycle Checkpoints, DNA Repair, TGFB Signaling and PI3K-AKT-MTOR Signaling and others. Nance is recommended for risk of Esophageal Neuroendocrine Tumor when associated genetic risk is CHEK2. This is because Nance increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in fruit Squashberry are Curcumin, Apigenin, Lupeol, Daidzein, Formononetin. These active ingredients manipulate various biochemical pathways like Cell Cycle Checkpoints, DNA Repair and PI3K-AKT-MTOR Signaling and others. Squashberry is not recommended when risk of Esophageal Neuroendocrine Tumor when associated genetic risk is CHEK2 because it increases the signature pathways of it.

FRUIT NANCE IS RECOMMENDED OVER SQUASHBERRY FOR CHEK2 GENETIC RISK OF CANCER.

Choose Nut COMMON HAZELNUT or CHESTNUT?

Common Hazelnut contains many active ingredients or bioactives such as Curcumin, Quercetin, Lupeol, Daidzein, Formononetin. These active ingredients manipulate various biochemical pathways like Cell Cycle Checkpoints, DNA Repair, TGFB Signaling and MYC Signaling and others. Common Hazelnut is recommended for risk of Esophageal Neuroendocrine Tumor when associated genetic risk is CHEK2. This is because Common Hazelnut increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in Chestnut are Curcumin, Apigenin, Lupeol, Ellagic Acid, Daidzein. These active ingredients manipulate various biochemical pathways like DNA Repair and PI3K-AKT-MTOR Signaling and others. Chestnut is not recommended when risk of Esophageal Neuroendocrine Tumor when associated genetic risk is CHEK2 because it increases the signature pathways of it.

COMMON HAZELNUT IS RECOMMENDED OVER CHESTNUT FOR CHEK2 GENETIC RISK OF CANCER.


In Conclusion

Foods and Supplements chosen are important decisions for cancers like Esophageal Neuroendocrine Tumor. Esophageal Neuroendocrine Tumor patients and individuals with genetic-risk always have this question: “What foods and nutritional supplements are recommended for me and which are not?” There is a common belief which is a misconception that all plant-based foods could be beneficial or not but would not be harmful. Certain foods and supplements can interfere with cancer treatments or promote molecular pathway drivers of cancer.

There are different types of cancer indications like Esophageal Neuroendocrine Tumor, each with different tumor genetics with further genomic variations across each individual. Further every cancer treatment and chemotherapy has a unique mechanism of action. Each food like Spinach contains various bioactives in different quantities, which have an impact on different and distinct sets of biochemical pathways. The definition of personalized nutrition is individualized food recommendations for the cancer indication, treatments, genetics, lifestyle and other factors. Nutrition personalization decisions for cancer require knowledge of cancer biology, food science and an understanding of different chemotherapy treatments. Finally when there are treatment changes or new genomics is identified – the nutrition personalization needs re-evaluation.

The addon nutrition personalization solution makes the decision making easy and removes all the guesswork in answering the question, “What foods should I choose or not choose for Esophageal Neuroendocrine Tumor?”. The addon multi-disciplinary team includes cancer physicians, clinical scientists, software engineers and data scientists.


Personalized Nutrition for Cancer!

Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.

References

Scientifically Reviewed by: Dr. Cogle

Christopher R. Cogle, M.D. is a tenured professor at the University of Florida, Chief Medical Officer of Florida Medicaid, and Director of the Florida Health Policy Leadership Academy at the Bob Graham Center for Public Service.

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