Which Foods are Recommended for Anaplastic Ependymoma?

Highlights

No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Anaplastic Ependymoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Anaplastic Ependymoma because of BRAF and CDC73 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.

There is no one answer to this question for cancers such as Anaplastic Ependymoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.

In short – the process to answer questions like “Should I Avoid eating fruit Cherry” or “Include fruit Kiwi in my diet” or “Can I take Fisetin and Apigenin supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.

RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO ANAPLASTIC EPENDYMOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.

The overall objective of personalized nutrition for Anaplastic Ependymoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.

RECOMMENDATION: UPDATE YOUR NUTRITION FOR ANAPLASTIC EPENDYMOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.

About Anaplastic Ependymoma

cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.

Following key highlights are derived from clinical data for Anaplastic Ependymoma from cBioPortal. 40.0% of males and 60.0% of females were the distribution of gender in these clinical studies. From a patient sample size of 5; the top genes with mutations and other abnormalities for Anaplastic Ependymoma include genes BRAF, CDC73, CDKN2A, FBXW7 and FH. The occurrence frequency distribution for these genes respectively is 25.0%, 25.0%, 25.0%, 25.0% and 25.0%. These tumor genetic details of Anaplastic Ependymoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Anaplastic Ependymoma.

Significance of Nutrition for Anaplastic Ependymoma

All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Anaplastic Ependymoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.

For example Cherry includes active ingredients Chrysin, Quercetin, Salicylic Acid, Beta-sitosterol, Isorhamnetin and others. And Kiwi contains active ingredients Fisetin, Quercetin, Vitamin A, Vitamin C and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.

For cancers like Anaplastic Ependymoma, activation or inhibition of selected biochemical pathways like Cell Cycle, Cell Cycle Checkpoints, RAS-RAF Signaling, Hypoxia plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Anaplastic Ependymoma, while eating some other foods and supplements may not be recommended.

One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.

RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR ANAPLASTIC EPENDYMOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.

Foods for Anaplastic Ependymoma undergoing chemotherapy treatment

In Anaplastic Ependymoma – the genes BRAF, CDC73, CDKN2A, FBXW7 and FH have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Anaplastic Ependymoma are Cell Cycle and others. Radiation is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Cell Cycle so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.

RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.

Eat more pulses, Moth Bean or Soy Bean?

Pulses are an important part of many diets. The active ingredients contained in Moth Bean are Beta-sitosterol, Vitamin A, Linolenic Acid, Linoleic Acid, Oleic Acid among others. While the active ingredients contained in Soy Bean are Fisetin, Lupeol, Vitamin E, Quercetin, Daidzein and others.

Beta-sitosterol can manipulate biochemical pathways Cell Cycle. Vitamin A has biological action on biochemical pathways Cell Cycle.

Aescin can manipulate biochemical pathways Cell Cycle. And so on.

When treating Anaplastic Ependymoma with chemotherapy Radiation – Foods like Moth Bean are recommended compared to Soy Bean. This is because the active ingredients Aescin in Soy Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin A contained in Moth Bean support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: MOTH BEAN IS RECOMMENDED OVER SOY BEAN FOR ANAPLASTIC EPENDYMOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Eat more vegetables, Lotus?

Vegetables are an important part of many diets. The active ingredients contained in Lotus are Fisetin, Quercetin, Beta-sitosterol, Linolenic Acid, Vitamin C among others.

Fisetin can manipulate biochemical pathways Cell Cycle. Quercetin has biological action on biochemical pathways Cell Cycle.

When treating Anaplastic Ependymoma with chemotherapy Radiation – Foods like Lotus are recommended. This is because the active ingredients Fisetin and Quercetin contained in Lotus support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: LOTUS IS RECOMMENDED FOR ANAPLASTIC EPENDYMOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Eat more fruits, Kiwi or Cherry?

Fruits are an important part of many diets. The active ingredients contained in Kiwi are Fisetin, Quercetin, Vitamin A, Vitamin C among others. While the active ingredients contained in Cherry are Chrysin, Quercetin, Salicylic Acid, Beta-sitosterol, Isorhamnetin and others.

Vitamin C can manipulate biochemical pathways Cell Cycle. Fisetin has biological action on biochemical pathways Cell Cycle.

Shikimic Acid can manipulate biochemical pathways Cell Cycle. Pelargonidin has biological action on biochemical pathways Cell Cycle. And so on.

When treating Anaplastic Ependymoma with chemotherapy Radiation – Foods like Kiwi are recommended compared to Cherry. This is because the active ingredients Shikimic Acid and Pelargonidin in Cherry interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Fisetin contained in Kiwi support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: KIWI IS RECOMMENDED OVER CHERRY FOR ANAPLASTIC EPENDYMOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Eat more nuts, Chestnut or Cashew Nut?

Nuts are an important part of many diets. The active ingredients contained in Chestnut are Ellagic Acid, Quercetin, Gallic Acid, Vitamin A, Betulin among others. While the active ingredients contained in Cashew Nut are Beta-sitosterol, Gallic Acid, Vitamin C, Butyric Acid, Lauric Acid and others.

Ellagic Acid can manipulate biochemical pathways Cell Cycle. Gallic Acid has biological action on biochemical pathways Cell Cycle.

Myristic Acid can manipulate biochemical pathways Cell Cycle. And so on.

When treating Anaplastic Ependymoma with chemotherapy Radiation – Foods like Chestnut are recommended compared to Cashew Nut. This is because the active ingredients Myristic Acid in Cashew Nut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Ellagic Acid and Gallic Acid contained in Chestnut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: CHESTNUT IS RECOMMENDED OVER CASHEW NUT FOR ANAPLASTIC EPENDYMOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Foods for Genetic Risk of Anaplastic Ependymoma

One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. BRAF and CDC73 are two genes whose abnormalities are risk factors for Anaplastic Ependymoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Anaplastic Ependymoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Anaplastic Ependymoma gene BRAF has causative impact on biological pathways like RAS-RAF Signaling, MAPK Signaling and Antigen Presentation. And CDC73 has a causative impact on biological pathways like Cell Cycle Checkpoints. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like BRAF and CDC73 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes BRAF and CDC73 should be avoided.

Eat more pulses, Mung Bean or Pigeon Pea?

The active ingredients contained in Mung Bean are Vitamin C, Oleic Acid, Linolenic Acid, Stigmasterol, Quercetin among others. While the active ingredients contained in Pigeon Pea are Vitamin C, Oleic Acid, Linolenic Acid, Linoleic Acid, Genistein and others.

Vitamin C can manipulate biochemical pathways Cell Cycle Checkpoints, RAS-RAF Signaling and P53 Signaling. Stigmasterol has biological action on biochemical pathways MYC Signaling, PI3K-AKT-MTOR Signaling and Apoptosis.

Folic Acid can manipulate biochemical pathways Cell Cycle Checkpoints, P53 Signaling and MYC Signaling. And so on.

For genetic risk of Anaplastic Ependymoma due to abnormalities in genes BRAF and CDC73 – Foods like Mung Bean are recommended compared to Pigeon Pea. This is because the active ingredients Folic Acid in Pigeon Pea further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Stigmasterol contained in Mung Bean together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: MUNG BEAN IS RECOMMENDED OVER PIGEON PEA FOR REDUCING THE GENETIC RISK OF ANAPLASTIC EPENDYMOMA DUE TO GENES BRAF AND CDC73

Eat more vegetables, Giant Butterbur or Celery?

The active ingredients contained in Giant Butterbur are Beta-sitosterol, Vitamin C, Vitamin B3, Melatonin, Vitamin A among others. While the active ingredients contained in Celery are Apigenin, Vitamin C, Oleic Acid, Linolenic Acid, Quercetin and others.

Vitamin C can manipulate biochemical pathways Cell Cycle Checkpoints, RAS-RAF Signaling and P53 Signaling. Beta-sitosterol has biological action on biochemical pathways MYC Signaling, Oncogenic Cancer Epigenetics and PI3K-AKT-MTOR Signaling.

Cynaroside can manipulate biochemical pathways Oncogenic Cancer Epigenetics. Luteolin has biological action on biochemical pathways MYC Signaling. And so on.

For genetic risk of Anaplastic Ependymoma due to abnormalities in genes BRAF and CDC73 – Foods like Giant Butterbur are recommended compared to Celery. This is because the active ingredients Cynaroside and Luteolin in Celery further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Giant Butterbur together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: GIANT BUTTERBUR IS RECOMMENDED OVER CELERY FOR REDUCING THE GENETIC RISK OF ANAPLASTIC EPENDYMOMA DUE TO GENES BRAF AND CDC73

Eat more fruits, Orange or Strawberry?

The active ingredients contained in Orange are D-limonene, Linalool, Vitamin C, Modified Citrus Pectin, Oleic Acid among others. While the active ingredients contained in Strawberry are Ellagic Acid, Lupeol, Beta-sitosterol, Vitamin C, Oleic Acid and others.

D-limonene can manipulate biochemical pathways Cell Cycle Checkpoints, RAS-RAF Signaling and P53 Signaling. Vitamin C has biological action on biochemical pathways MYC Signaling, Oncogenic Cancer Epigenetics and PI3K-AKT-MTOR Signaling.

Pelargonidin can manipulate biochemical pathways MYC Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling. And so on.

For genetic risk of Anaplastic Ependymoma due to abnormalities in genes BRAF and CDC73 – Foods like Orange are recommended compared to Strawberry. This is because the active ingredients Pelargonidin in Strawberry further promote the effects of genes on the biochemical pathways. While the active ingredients D-limonene and Vitamin C contained in Orange together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: ORANGE IS RECOMMENDED OVER STRAWBERRY FOR REDUCING THE GENETIC RISK OF ANAPLASTIC EPENDYMOMA DUE TO GENES BRAF AND CDC73

Eat more nuts, Almond or Macadamia Nut?

The active ingredients contained in Almond are Vitamin E, Beta-sitosterol, Oleic Acid, Linolenic Acid, Stigmasterol among others. While the active ingredients contained in Macadamia Nut are Beta-sitosterol, Palmitic Acid, Lauric Acid, Myristic Acid, Folic Acid and others.

Beta-sitosterol can manipulate biochemical pathways Cell Cycle Checkpoints, P53 Signaling and MYC Signaling. Vitamin E has biological action on biochemical pathways RAS-RAF Signaling, PI3K-AKT-MTOR Signaling and Apoptosis.

Palmitic Acid can manipulate biochemical pathways Oncogenic Cancer Epigenetics. Lauric Acid has biological action on biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. And so on.

For genetic risk of Anaplastic Ependymoma due to abnormalities in genes BRAF and CDC73 – Foods like Almond are recommended compared to Macadamia Nut. This is because the active ingredients Palmitic Acid and Lauric Acid in Macadamia Nut further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin E contained in Almond together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: ALMOND IS RECOMMENDED OVER MACADAMIA NUT FOR REDUCING THE GENETIC RISK OF ANAPLASTIC EPENDYMOMA DUE TO GENES BRAF AND CDC73

In Summary

An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.

“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.

The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.

You can get started NOW and design a personalized nutrition plan for Anaplastic Ependymoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

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