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What Foods are Recommended for Cancer?
is a very common question. Personalized Nutrition Plans are foods and supplements which are personalized to a cancer indication, genes, any treatments and lifestyle conditions.

Which Foods are Recommended for Therapy-related Myelodysplastic Syndrome?

Sep 1, 2022

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Home » Blogs » Which Foods are Recommended for Therapy-related Myelodysplastic Syndrome?

Highlights

No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Therapy-related Myelodysplastic Syndrome when undergoing chemotherapy or when you determine you have a genetic risk for developing Therapy-related Myelodysplastic Syndrome because of EZH2 and ZRSR2 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.

There is no one answer to this question for cancers such as Therapy-related Myelodysplastic Syndrome which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.

In short – the process to answer questions like “Should I Avoid eating fruit Bilberry” or “Include fruit Graviola in my diet” or “Should I reduce consumption of vegetable Bell Pepper” or “Can I take D-limonene and Apigenin supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.

RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO THERAPY-RELATED MYELODYSPLASTIC SYNDROME, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.

The overall objective of personalized nutrition for Therapy-related Myelodysplastic Syndrome is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.

RECOMMENDATION: UPDATE YOUR NUTRITION FOR THERAPY-RELATED MYELODYSPLASTIC SYNDROME, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.



About Therapy-related Myelodysplastic Syndrome

cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.

Following key highlights are derived from clinical data for Therapy-related Myelodysplastic Syndrome from cBioPortal. From a patient sample size of 11; the top genes with mutations and other abnormalities for Therapy-related Myelodysplastic Syndrome include genes TP53, TET2, ASXL1, EZH2 and ZRSR2. The occurrence frequency distribution for these genes respectively is 63.6%, 27.3%, 18.2%, 18.2% and 18.2%. These tumor genetic details of Therapy-related Myelodysplastic Syndrome are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Therapy-related Myelodysplastic Syndrome.

Significance of Nutrition for Therapy-related Myelodysplastic Syndrome

All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Therapy-related Myelodysplastic Syndrome. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.

For example Bilberry includes active ingredients P-coumaric Acid, Resveratrol, Quercetin, Arbutin, Gallic Acid and others. And Graviola contains active ingredients Emodin, Lycopene, Daidzein, Vitamin E, Beta-sitosterol and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.

For cancers like Therapy-related Myelodysplastic Syndrome, activation or inhibition of selected biochemical pathways like PI3K-AKT-MTOR Signaling, mRNA Splicing, Oncogenic Cancer Epigenetics, Cell Cycle Checkpoints plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Therapy-related Myelodysplastic Syndrome, while eating some other foods and supplements may not be recommended.

One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.

For cancers like Therapy-related Myelodysplastic Syndrome, activation or inhibition of selected biochemical pathways like PI3K-AKT-MTOR Signaling, mRNA Splicing, Oncogenic Cancer Epigenetics, Cell Cycle Checkpoints plays an important role in driving cancer growth.

RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR THERAPY-RELATED MYELODYSPLASTIC SYNDROME – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.

Foods for Therapy-related Myelodysplastic Syndrome undergoing chemotherapy treatment

In Therapy-related Myelodysplastic Syndrome – the genes TP53, TET2, ASXL1, EZH2 and ZRSR2 have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Therapy-related Myelodysplastic Syndrome are PI3K-AKT-MTOR Signaling, mRNA Splicing, Cell Cycle Checkpoints and others. Fludarabine is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers PI3K-AKT-MTOR Signaling, mRNA Splicing, Cell Cycle Checkpoints so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.

RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.

Eat more pulses, Mung Bean or Soy Bean?

Pulses are an important part of many diets. The active ingredients contained in Mung Bean are Linolenic Acid, Vitamin C, Stigmasterol, Vitexin, Oleic Acid among others. While the active ingredients contained in Soy Bean are Lupeol, Daidzein, Vitamin E, Beta-sitosterol, Linolenic Acid and others.

Vitamin C can manipulate biochemical pathways MAPK Signaling, Cell Cycle Checkpoints and P53 Signaling. Stigmasterol has biological action on biochemical pathways MYC Signaling, PI3K-AKT-MTOR Signaling and Apoptosis.

Aescin can manipulate biochemical pathways Cell Cycle Checkpoints. Lecithin has biological action on biochemical pathways MAPK Signaling, MYC Signaling and PI3K-AKT-MTOR Signaling. And so on.

When treating Therapy-related Myelodysplastic Syndrome with chemotherapy Fludarabine – Foods like Mung Bean are recommended compared to Soy Bean. This is because the active ingredients Aescin and Lecithin in Soy Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Stigmasterol contained in Mung Bean support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: MUNG BEAN IS RECOMMENDED OVER SOY BEAN FOR THERAPY-RELATED MYELODYSPLASTIC SYNDROME ON TREATMENT WITH CHEMOTHERAPY FLUDARABINE FOR SOME CONDITIONS.

Eat more vegetables, Arugula or Bell Pepper?

Vegetables are an important part of many diets. The active ingredients contained in Arugula are Esculin, Vitamin A, Kaempferol, Vitamin K, Erysolin among others. While the active ingredients contained in Bell Pepper are Vitamin E, Linolenic Acid, Vitamin C, P-coumaric Acid, Capsaicin and others.

Vitamin A can manipulate biochemical pathways MYC Signaling, Apoptosis and Cell Cycle Checkpoints. Kaempferol has biological action on biochemical pathways PI3K-AKT-MTOR Signaling and Cell Cycle Checkpoints.

Capsaicin can manipulate biochemical pathways MAPK Signaling. Folic Acid has biological action on biochemical pathways Cell Cycle Checkpoints, P53 Signaling and MYC Signaling. And so on.

When treating Therapy-related Myelodysplastic Syndrome with chemotherapy Fludarabine – Foods like Arugula are recommended compared to Bell Pepper. This is because the active ingredients Capsaicin and Folic Acid in Bell Pepper interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin A and Kaempferol contained in Arugula support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: ARUGULA IS RECOMMENDED OVER BELL PEPPER FOR THERAPY-RELATED MYELODYSPLASTIC SYNDROME ON TREATMENT WITH CHEMOTHERAPY FLUDARABINE FOR SOME CONDITIONS.

Which Foods are Recommended for Therapy related Myelodysplastic Syndrome?

Eat more fruits, Graviola or Bilberry?

Fruits are an important part of many diets. The active ingredients contained in Graviola are Emodin, Lycopene, Daidzein, Vitamin E, Beta-sitosterol among others. While the active ingredients contained in Bilberry are P-coumaric Acid, Resveratrol, Quercetin, Arbutin, Gallic Acid and others.

Emodin can manipulate biochemical pathways Cell Cycle Checkpoints, P53 Signaling and MYC Signaling. Cinnamic Acid has biological action on biochemical pathways MAPK Signaling, PI3K-AKT-MTOR Signaling and Apoptosis.

Arbutin can manipulate biochemical pathways mRNA Splicing. Resveratrol has biological action on biochemical pathways P53 Signaling. And so on.

When treating Therapy-related Myelodysplastic Syndrome with chemotherapy Fludarabine – Foods like Graviola are recommended compared to Bilberry. This is because the active ingredients Arbutin and Resveratrol in Bilberry interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Emodin and Cinnamic Acid contained in Graviola support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: GRAVIOLA IS RECOMMENDED OVER BILBERRY FOR THERAPY-RELATED MYELODYSPLASTIC SYNDROME ON TREATMENT WITH CHEMOTHERAPY FLUDARABINE FOR SOME CONDITIONS.

Eat more nuts, Hazelnut or Brazil Nut?

Nuts are an important part of many diets. The active ingredients contained in Hazelnut are Vitamin E, Linolenic Acid, Oleic Acid, Quercetin, Linoleic Acid among others. While the active ingredients contained in Brazil Nut are Vitamin E, Linolenic Acid, Oleic Acid, Lecithin, Folic Acid and others.

Vitamin E can manipulate biochemical pathways MAPK Signaling, Cell Cycle Checkpoints and P53 Signaling. Quercetin has biological action on biochemical pathways MYC Signaling, PI3K-AKT-MTOR Signaling and Apoptosis.

Lecithin can manipulate biochemical pathways MAPK Signaling, MYC Signaling and PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways Cell Cycle Checkpoints, P53 Signaling and Apoptosis. And so on.

When treating Therapy-related Myelodysplastic Syndrome with chemotherapy Fludarabine – Foods like Hazelnut are recommended compared to Brazil Nut. This is because the active ingredients Lecithin and Folic Acid in Brazil Nut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin E and Quercetin contained in Hazelnut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: HAZELNUT IS RECOMMENDED OVER BRAZIL NUT FOR THERAPY-RELATED MYELODYSPLASTIC SYNDROME ON TREATMENT WITH CHEMOTHERAPY FLUDARABINE FOR SOME CONDITIONS.

Foods for Genetic Risk of Therapy-related Myelodysplastic Syndrome

One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. EZH2 and ZRSR2 are two genes whose abnormalities are risk factors for Therapy-related Myelodysplastic Syndrome. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Therapy-related Myelodysplastic Syndrome can be used as a guide for coming up with a recommended personalized nutrition plan. For Therapy-related Myelodysplastic Syndrome gene EZH2 has causative impact on biological pathways like Oncogenic Cancer Epigenetics, Suppressive Histone Methylation and Amino Acid Metabolism. And ZRSR2 has a causative impact on biological pathways like mRNA Splicing. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like EZH2 and ZRSR2 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes EZH2 and ZRSR2 should be avoided.

Eat more pulses, Yellow Wax Bean or Pigeon Pea?

The active ingredients contained in Yellow Wax Bean are Vitamin C, Ferulic Acid, Palmitic Acid, Cianidanol, Butyric Acid among others. While the active ingredients contained in Pigeon Pea are Vitamin C, Linolenic Acid, Oleic Acid, Linoleic Acid, Genistein and others.

Palmitic Acid can manipulate biochemical pathways P53 Signaling, MYC Signaling and Apoptosis. Vitamin A has biological action on biochemical pathways Cell Cycle Checkpoints, MYC Signaling and Apoptosis.

Folic Acid can manipulate biochemical pathways P53 Signaling, MYC Signaling and Apoptosis. And so on.

For genetic risk of Therapy-related Myelodysplastic Syndrome due to abnormalities in genes EZH2 and ZRSR2 – Foods like Yellow Wax Bean are recommended compared to Pigeon Pea. This is because the active ingredients Folic Acid in Pigeon Pea further promote the effects of genes on the biochemical pathways. While the active ingredients Palmitic Acid and Vitamin A contained in Yellow Wax Bean together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: YELLOW WAX BEAN IS RECOMMENDED OVER PIGEON PEA FOR REDUCING THE GENETIC RISK OF THERAPY-RELATED MYELODYSPLASTIC SYNDROME DUE TO GENES EZH2 AND ZRSR2

Eat more vegetables, Cassava or Celery?

The active ingredients contained in Cassava are Vitamin C, Beta-sitosterol, Linolenic Acid, Oleic Acid, Linoleic Acid among others. While the active ingredients contained in Celery are Apigenin, Vitamin C, Quercetin, Linolenic Acid, Cynaroside and others.

Vitamin C can manipulate biochemical pathways Cell Cycle Checkpoints, P53 Signaling and MYC Signaling. Beta-sitosterol has biological action on biochemical pathways Oncogenic Cancer Epigenetics, Apoptosis and Cell Cycle Checkpoints.

Cynaroside can manipulate biochemical pathways Oncogenic Cancer Epigenetics. Luteolin has biological action on biochemical pathways MYC Signaling. And so on.

For genetic risk of Therapy-related Myelodysplastic Syndrome due to abnormalities in genes EZH2 and ZRSR2 – Foods like Cassava are recommended compared to Celery. This is because the active ingredients Cynaroside and Luteolin in Celery further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Cassava together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: CASSAVA IS RECOMMENDED OVER CELERY FOR REDUCING THE GENETIC RISK OF THERAPY-RELATED MYELODYSPLASTIC SYNDROME DUE TO GENES EZH2 AND ZRSR2

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.

Eat more fruits, Date or Cranberry?

The active ingredients contained in Date are Apigenin, Vitamin C, Lupeol, Quercetin, Beta-sitosterol among others. While the active ingredients contained in Cranberry are Vitamin C, Quercetin, Hyperoside, P-coumaric Acid, Quercitrin and others.

Apigenin can manipulate biochemical pathways P53 Signaling, MYC Signaling and Apoptosis. Vitamin C has biological action on biochemical pathways Cell Cycle Checkpoints, Suppressive Histone Methylation and Oncogenic Cancer Epigenetics.

Resveratrol can manipulate biochemical pathways P53 Signaling. Ellagic Acid has biological action on biochemical pathways MYC Signaling. And so on.

For genetic risk of Therapy-related Myelodysplastic Syndrome due to abnormalities in genes EZH2 and ZRSR2 – Foods like Date are recommended compared to Cranberry. This is because the active ingredients Resveratrol and Ellagic Acid in Cranberry further promote the effects of genes on the biochemical pathways. While the active ingredients Apigenin and Vitamin C contained in Date together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: DATE IS RECOMMENDED OVER CRANBERRY FOR REDUCING THE GENETIC RISK OF THERAPY-RELATED MYELODYSPLASTIC SYNDROME DUE TO GENES EZH2 AND ZRSR2

Eat more nuts, Almond or Macadamia Nut?

The active ingredients contained in Almond are Quercetin, Vitamin E, Beta-sitosterol, Linolenic Acid, Stigmasterol among others. While the active ingredients contained in Macadamia Nut are Beta-sitosterol, Palmitic Acid, Lauric Acid, Folic Acid, Myristic Acid and others.

Beta-sitosterol can manipulate biochemical pathways Cell Cycle Checkpoints, P53 Signaling and MYC Signaling. Quercetin has biological action on biochemical pathways Noncoding RNA Signaling, Suppressive Histone Methylation and Oncogenic Cancer Epigenetics.

Lauric Acid can manipulate biochemical pathways MYC Signaling. Myristic Acid has biological action on biochemical pathways P53 Signaling, Apoptosis and Cell Cycle Checkpoints. And so on.

For genetic risk of Therapy-related Myelodysplastic Syndrome due to abnormalities in genes EZH2 and ZRSR2 – Foods like Almond are recommended compared to Macadamia Nut. This is because the active ingredients Lauric Acid and Myristic Acid in Macadamia Nut further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Quercetin contained in Almond together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: ALMOND IS RECOMMENDED OVER MACADAMIA NUT FOR REDUCING THE GENETIC RISK OF THERAPY-RELATED MYELODYSPLASTIC SYNDROME DUE TO GENES EZH2 AND ZRSR2


In Summary

An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.

“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.

The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.

You can get started NOW and design a personalized nutrition plan for Therapy-related Myelodysplastic Syndrome by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

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References

Personalized Nutrition for Cancer!

Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.


Scientifically Reviewed by: Dr. Cogle

Christopher R. Cogle, M.D. is a tenured professor at the University of Florida, Chief Medical Officer of Florida Medicaid, and Director of the Florida Health Policy Leadership Academy at the Bob Graham Center for Public Service.

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