Which Foods are Recommended for Oligodendroglioma?

Highlights

No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Oligodendroglioma when undergoing chemotherapy or when you determine you have a genetic risk for developing Oligodendroglioma because of IDH1 and TERT gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.

There is no one answer to this question for cancers such as Oligodendroglioma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.

In short – the process to answer questions like “Should I Avoid eating fruit Gooseberry” or “Include fruit Partridgeberry in my diet” or “Should I reduce consumption of vegetable Beetroot” or “Can I take Thunder God and Birch supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.

RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO OLIGODENDROGLIOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.

The overall objective of personalized nutrition for Oligodendroglioma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.

RECOMMENDATION: UPDATE YOUR NUTRITION FOR OLIGODENDROGLIOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.

About Oligodendroglioma

cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.

Following key highlights are derived from clinical data for Oligodendroglioma from cBioPortal. The patients enrolled in the studies for Oligodendroglioma are in ages between 13 to 71 with an average age of 39. 55.6% of males and 44.4% of females were the distribution of gender in these clinical studies. From a patient sample size of 150; the top genes with mutations and other abnormalities for Oligodendroglioma include genes TERT, IDH1, TP53, ATRX and PIK3CA. The occurrence frequency distribution for these genes respectively is 38.7%, 15.1%, 5.7%, 4.7% and 3.8%. These tumor genetic details of Oligodendroglioma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Oligodendroglioma.

Oligodendroglioma is a primary glial brain tumor classified as low grade (Grade 2) or high grade (Grade 3) tumor. The grade 2 tumors are slow growing and invade the nearby regions, while the grade 3 oligodendrogliomas are malignant (cancerous), fast-growing tumors. They are commonly found in the outer layer of the brain, but could form anywhere in the central nervous system, and these tumors rarely spread outside of the CNS to other organs. Most oligodendrogliomas have co-deletion of arms of chromosome 1p and 19q and a mutation in isocitrate dehydrogenase IDH gene. Oligodendrogliomas occur most often in adults between ages 25-45 years, occur more often in males and rarely occur in children. Symptoms related to oligodendroglioma could vary based on the location of the tumor, but a common sign is a seizure prior to diagnosis. Other symptoms may include headaches, problems with thinking and memory, weakness, numbness, problems with balance and movement. The 5-year survival rate for low grade oligodendroglioma is 74% but the high-grade tumor has a poor prognosis with 5-year survival rates of 30-38%. Treatment options for oligodendroglioma include surgery, radiation, chemotherapy, or clinical trials for access to novel therapies in clinical development. Additionally, the right nutrition (foods and natural supplements) aligned with the cancer stage and treatment context can further enhance patient well-being. (Ref: https://www.cancer.gov/rare-brain-spine-tumor/tumors/oligodendroglioma ; https://www.ncbi.nlm.nih.gov/books/NBK559184/ ; https://emedicine.medscape.com/article/1156699-overview#a4 )

Significance of Nutrition for Oligodendroglioma

All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Oligodendroglioma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.

For example Gooseberry includes active ingredients Beta-sitosterol, Vitamin C, Oleic Acid, Gallic Acid, Linolenic Acid and others. And Partridgeberry contains active ingredients Resveratrol, Beta-sitosterol, Stigmasterol and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.

For cancers like Oligodendroglioma, activation or inhibition of selected biochemical pathways like RAS-RAF Signaling, mRNA Splicing, Apoptosis, Oncogenic Cancer Epigenetics plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Oligodendroglioma, while eating some other foods and supplements may not be recommended.

One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.

RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR OLIGODENDROGLIOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.

Foods for Oligodendroglioma undergoing chemotherapy treatment

In Oligodendroglioma – the genes TERT, IDH1, TP53, ATRX and PIK3CA have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Oligodendroglioma are RAS-RAF Signaling, mRNA Splicing, Cell Cycle and others. Radiation is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers RAS-RAF Signaling, mRNA Splicing, Cell Cycle so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.

RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.

Eat more pulses, Common Pea or Pigeon Pea?

Pulses are an important part of many diets. The active ingredients contained in Common Pea are Daidzein, Lupeol, Genistein, Beta-sitosterol, Vitamin C among others. While the active ingredients contained in Pigeon Pea are Genistein, Vitamin C, Oleic Acid, Linolenic Acid, Vitamin A and others.

Beta-sitosterol can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and Glucocorticoid Signaling. Vitamin C has biological action on biochemical pathways Cell Cycle, MYC Signaling and MAPK Signaling.

Genistein can manipulate biochemical pathways DNA Repair and Oxidative Stress. Vitamin A has biological action on biochemical pathways Focal Adhesion. And so on.

When treating Oligodendroglioma with chemotherapy Radiation – Foods like Common Pea are recommended compared to Pigeon Pea. This is because the active ingredients Genistein and Vitamin A in Pigeon Pea interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin C contained in Common Pea support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: COMMON PEA IS RECOMMENDED OVER PIGEON PEA FOR OLIGODENDROGLIOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Eat more vegetables, Kohlrabi or Beetroot?

Vegetables are an important part of many diets. The active ingredients contained in Kohlrabi are Beta-sitosterol, Vitamin C, Brassinin, Sulforaphane, Oleic Acid among others. While the active ingredients contained in Beetroot are Beta-sitosterol, Vitamin E, Vitamin C, Oleic Acid, Linolenic Acid and others.

Vitamin C can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Cell Cycle and MYC Signaling. Brassinin has biological action on biochemical pathways NFKB Signaling, JAK-STAT Signaling and Cell Survival.

Vitamin E can manipulate biochemical pathways Oxidative Stress. Vitamin A has biological action on biochemical pathways Focal Adhesion. And so on.

When treating Oligodendroglioma with chemotherapy Radiation – Foods like Kohlrabi are recommended compared to Beetroot. This is because the active ingredients Vitamin E and Vitamin A in Beetroot interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Brassinin contained in Kohlrabi support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: KOHLRABI IS RECOMMENDED OVER BEETROOT FOR OLIGODENDROGLIOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Eat more fruits, Partridgeberry or Gooseberry?

Fruits are an important part of many diets. The active ingredients contained in Partridgeberry are Resveratrol, Beta-sitosterol, Stigmasterol among others. While the active ingredients contained in Gooseberry are Beta-sitosterol, Vitamin C, Oleic Acid, Gallic Acid, Linolenic Acid and others.

Resveratrol can manipulate biochemical pathways NFKB Signaling, Microtubule Dynamics and JAK-STAT Signaling. Beta-sitosterol has biological action on biochemical pathways Epithelial to Mesenchymal Transition, Glucocorticoid Signaling and Cell Cycle.

Gallic Acid can manipulate biochemical pathways Oxidative Stress. Citric Acid has biological action on biochemical pathways Oxidative Stress. And so on.

When treating Oligodendroglioma with chemotherapy Radiation – Foods like Partridgeberry are recommended compared to Gooseberry. This is because the active ingredients Gallic Acid and Citric Acid in Gooseberry interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Resveratrol and Beta-sitosterol contained in Partridgeberry support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: PARTRIDGEBERRY IS RECOMMENDED OVER GOOSEBERRY FOR OLIGODENDROGLIOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Eat more nuts, Walnut or Acorn?

Nuts are an important part of many diets. The active ingredients contained in Walnut are Ellagic Acid, Quercetin, Betulinic Acid, Juglone, Genistein among others. While the active ingredients contained in Acorn are Quercetin, Beta-sitosterol, Vitamin C, Gallic Acid, Beta-carotene and others.

Ellagic Acid can manipulate biochemical pathways NFKB Signaling, Glucocorticoid Signaling and Microtubule Dynamics. Juglone has biological action on biochemical pathways Epithelial to Mesenchymal Transition, TGFB Signaling and Cell Cycle.

Quercetin can manipulate biochemical pathways Oxidative Stress. Gallic Acid has biological action on biochemical pathways Oxidative Stress. And so on.

When treating Oligodendroglioma with chemotherapy Radiation – Foods like Walnut are recommended compared to Acorn. This is because the active ingredients Quercetin and Gallic Acid in Acorn interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Ellagic Acid and Juglone contained in Walnut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: WALNUT IS RECOMMENDED OVER ACORN FOR OLIGODENDROGLIOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Foods for Genetic Risk of Oligodendroglioma

One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. IDH1 and TERT are two genes whose abnormalities are risk factors for Oligodendroglioma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Oligodendroglioma can be used as a guide for coming up with a recommended personalized nutrition plan. For Oligodendroglioma gene IDH1 has causative impact on biological pathways like Oncogenic Cancer Epigenetics, Glutathione Metabolism and Hypoxia. And TERT has a causative impact on biological pathways like Cell Cycle Checkpoints, Apoptosis and DNA Repair. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like IDH1 and TERT should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes IDH1 and TERT should be avoided.

Eat more pulses, Scarlet Bean or Common Bean?

The active ingredients contained in Scarlet Bean are Vitamin C, Beta-sitosterol, Oleic Acid, Linolenic Acid, Stigmasterol among others. While the active ingredients contained in Common Bean are Apigenin, Esculin, Vitamin C, Oleic Acid, Linolenic Acid and others.

Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Beta-sitosterol has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and Oncogenic Cancer Epigenetics.

Pelargonidin can manipulate biochemical pathways MYC Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways Apoptosis, P53 Signaling and MYC Signaling. And so on.

For genetic risk of Oligodendroglioma due to abnormalities in genes IDH1 and TERT – Foods like Scarlet Bean are recommended compared to Common Bean. This is because the active ingredients Pelargonidin and Folic Acid in Common Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Scarlet Bean together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: SCARLET BEAN IS RECOMMENDED OVER COMMON BEAN FOR REDUCING THE GENETIC RISK OF OLIGODENDROGLIOMA DUE TO GENES IDH1 AND TERT

Eat more vegetables, Mexican Groundcherry or Chicory?

The active ingredients contained in Mexican Groundcherry are Vitamin C, Vitamin B3 among others. While the active ingredients contained in Chicory are Apigenin, Esculin, Lupeol, Betulinic Acid, Vitamin C and others.

Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Vitamin B3 has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and Hypoxia.

Luteolin can manipulate biochemical pathways MYC Signaling. Esculetin has biological action on biochemical pathways Hypoxia. And so on.

For genetic risk of Oligodendroglioma due to abnormalities in genes IDH1 and TERT – Foods like Mexican Groundcherry are recommended compared to Chicory. This is because the active ingredients Luteolin and Esculetin in Chicory further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Vitamin B3 contained in Mexican Groundcherry together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: MEXICAN GROUNDCHERRY IS RECOMMENDED OVER CHICORY FOR REDUCING THE GENETIC RISK OF OLIGODENDROGLIOMA DUE TO GENES IDH1 AND TERT

Eat more fruits, Feijoa or Strawberry?

The active ingredients contained in Feijoa are Vitamin C, Lycopene, Casuarinin, Folic Acid among others. While the active ingredients contained in Strawberry are Lupeol, Ellagic Acid, Vitamin C, Beta-sitosterol, Oleic Acid and others.

Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Lycopene has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and Hypoxia.

Fisetin can manipulate biochemical pathways MYC Signaling. Pelargonidin has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and MYC Signaling. And so on.

For genetic risk of Oligodendroglioma due to abnormalities in genes IDH1 and TERT – Foods like Feijoa are recommended compared to Strawberry. This is because the active ingredients Fisetin and Pelargonidin in Strawberry further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Lycopene contained in Feijoa together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: FEIJOA IS RECOMMENDED OVER STRAWBERRY FOR REDUCING THE GENETIC RISK OF OLIGODENDROGLIOMA DUE TO GENES IDH1 AND TERT

Eat more nuts, Pine Nut or Peanut?

The active ingredients contained in Pine Nut are Beta-sitosterol, Vitamin E, Oleic Acid, Linolenic Acid, Linoleic Acid among others. While the active ingredients contained in Peanut are Vitamin C, Beta-sitosterol, Vitamin E, Quercetin, Oleic Acid and others.

Beta-sitosterol can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Vitamin K has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and MYC Signaling.

Lecithin can manipulate biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways Apoptosis, P53 Signaling and Cell Cycle Checkpoints. And so on.

For genetic risk of Oligodendroglioma due to abnormalities in genes IDH1 and TERT – Foods like Pine Nut are recommended compared to Peanut. This is because the active ingredients Lecithin and Folic Acid in Peanut further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin K contained in Pine Nut together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: PINE NUT IS RECOMMENDED OVER PEANUT FOR REDUCING THE GENETIC RISK OF OLIGODENDROGLIOMA DUE TO GENES IDH1 AND TERT

In Summary

An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.

“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.

The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.

You can get started NOW and design a personalized nutrition plan for Oligodendroglioma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

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