Highlights
No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Mucoepidermoid Carcinoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Mucoepidermoid Carcinoma because of HRAS and TGFBR1 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.
There is no one answer to this question for cancers such as Mucoepidermoid Carcinoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.
In short – the process to answer questions like “Should I Avoid eating fruit Peach” or “Include fruit Blackberry in my diet” or “Should I reduce consumption of vegetable Chicory” or “Can I take Turmeric and Stevia supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.
RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO MUCOEPIDERMOID CARCINOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.
The overall objective of personalized nutrition for Mucoepidermoid Carcinoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.
RECOMMENDATION: UPDATE YOUR NUTRITION FOR MUCOEPIDERMOID CARCINOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.
About Mucoepidermoid Carcinoma
cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.
Following key highlights are derived from clinical data for Mucoepidermoid Carcinoma from cBioPortal. The patients enrolled in the studies for Mucoepidermoid Carcinoma are in ages between 38 to 70 with an average age of 54. 20.0% of males and 80.0% of females were the distribution of gender in these clinical studies. From a patient sample size of 5; the top genes with mutations and other abnormalities for Mucoepidermoid Carcinoma include genes HRAS, TGFBR1, BAP1 and SDHA. The occurrence frequency distribution for these genes respectively is 20.0%, 20.0%, 20.0% and 20.0%. These tumor genetic details of Mucoepidermoid Carcinoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Mucoepidermoid Carcinoma.
Significance of Nutrition for Mucoepidermoid Carcinoma
All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Mucoepidermoid Carcinoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.
For example Peach includes active ingredients Vitamin A, Modified Citrus Pectin, Kaempferol, Vitamin C, Glucaric Acid and others. And Blackberry contains active ingredients Quercetin, Ellagic Acid, Myricetin, Salicylic Acid, Kaempferol and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.
For cancers like Mucoepidermoid Carcinoma, activation or inhibition of selected biochemical pathways like RAS-RAF Signaling, TGFB Signaling, Extracellular Matrix Remodelling, Hypoxia plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Mucoepidermoid Carcinoma, while eating some other foods and supplements may not be recommended.
One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.
RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR MUCOEPIDERMOID CARCINOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.
Foods for Mucoepidermoid Carcinoma undergoing chemotherapy treatment
In Mucoepidermoid Carcinoma – the genes HRAS, TGFBR1, BAP1 and SDHA have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Mucoepidermoid Carcinoma are and others. Pembrolizumab is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.
RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.
Eat more pulses, Mung Bean or Moth Bean?
Pulses are an important part of many diets. The active ingredients contained in Mung Bean are Quercetin, Vitamin A, Kaempferol, Vitamin C, Genistein among others. While the active ingredients contained in Moth Bean are Vitamin A, Linoleic Acid, Folic Acid and others.
Quercetin can manipulate biochemical pathways TGFB Signaling and RAS-RAF Signaling. Vitamin A has biological action on biochemical pathways TGFB Signaling.
Linoleic Acid can manipulate biochemical pathways TGFB Signaling. Folic Acid has biological action on biochemical pathways RAS-RAF Signaling. And so on.
When treating Mucoepidermoid Carcinoma with chemotherapy Pembrolizumab – Foods like Mung Bean are recommended compared to Moth Bean. This is because the active ingredients Linoleic Acid and Folic Acid in Moth Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Quercetin and Vitamin A contained in Mung Bean support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: MUNG BEAN IS RECOMMENDED OVER MOTH BEAN FOR MUCOEPIDERMOID CARCINOMA ON TREATMENT WITH CHEMOTHERAPY PEMBROLIZUMAB FOR SOME CONDITIONS.
Eat more vegetables, Cabbage or Chicory?
Vegetables are an important part of many diets. The active ingredients contained in Cabbage are Quercetin, Delphinidin, Kaempferol, Pelargonidin, Vitamin C among others. While the active ingredients contained in Chicory are Quercetin, Protocatechuic Acid, Vitamin A, Salicylic Acid, Luteolin and others.
Vitamin C can manipulate biochemical pathways RAS-RAF Signaling. Glucaric Acid has biological action on biochemical pathways RAS-RAF Signaling.
Caffeic Acid can manipulate biochemical pathways TGFB Signaling. Apigenin has biological action on biochemical pathways TGFB Signaling. And so on.
When treating Mucoepidermoid Carcinoma with chemotherapy Pembrolizumab – Foods like Cabbage are recommended compared to Chicory. This is because the active ingredients Caffeic Acid and Apigenin in Chicory interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Glucaric Acid contained in Cabbage support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: CABBAGE IS RECOMMENDED OVER CHICORY FOR MUCOEPIDERMOID CARCINOMA ON TREATMENT WITH CHEMOTHERAPY PEMBROLIZUMAB FOR SOME CONDITIONS.
Eat more fruits, Blackberry or Peach?
Fruits are an important part of many diets. The active ingredients contained in Blackberry are Quercetin, Ellagic Acid, Myricetin, Salicylic Acid, Kaempferol among others. While the active ingredients contained in Peach are Vitamin A, Modified Citrus Pectin, Kaempferol, Vitamin C, Glucaric Acid and others.
Quercetin can manipulate biochemical pathways TGFB Signaling and RAS-RAF Signaling. Ellagic Acid has biological action on biochemical pathways TGFB Signaling and RAS-RAF Signaling.
Caffeic Acid can manipulate biochemical pathways TGFB Signaling. Linoleic Acid has biological action on biochemical pathways TGFB Signaling. And so on.
When treating Mucoepidermoid Carcinoma with chemotherapy Pembrolizumab – Foods like Blackberry are recommended compared to Peach. This is because the active ingredients Caffeic Acid and Linoleic Acid in Peach interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Quercetin and Ellagic Acid contained in Blackberry support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: BLACKBERRY IS RECOMMENDED OVER PEACH FOR MUCOEPIDERMOID CARCINOMA ON TREATMENT WITH CHEMOTHERAPY PEMBROLIZUMAB FOR SOME CONDITIONS.
Eat more nuts, Almond or Macadamia Nut?
Nuts are an important part of many diets. The active ingredients contained in Almond are Quercetin, Salicylic Acid, Linoleic Acid among others. While the active ingredients contained in Macadamia Nut are Palmitic Acid, Folic Acid, Myristic Acid and others.
Quercetin can manipulate biochemical pathways TGFB Signaling and RAS-RAF Signaling. Salicylic Acid has biological action on biochemical pathways TGFB Signaling and RAS-RAF Signaling.
Palmitic Acid can manipulate biochemical pathways TGFB Signaling. Myristic Acid has biological action on biochemical pathways RAS-RAF Signaling. And so on.
When treating Mucoepidermoid Carcinoma with chemotherapy Pembrolizumab – Foods like Almond are recommended compared to Macadamia Nut. This is because the active ingredients Palmitic Acid and Myristic Acid in Macadamia Nut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Quercetin and Salicylic Acid contained in Almond support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: ALMOND IS RECOMMENDED OVER MACADAMIA NUT FOR MUCOEPIDERMOID CARCINOMA ON TREATMENT WITH CHEMOTHERAPY PEMBROLIZUMAB FOR SOME CONDITIONS.
Foods for Genetic Risk of Mucoepidermoid Carcinoma
One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. HRAS and TGFBR1 are two genes whose abnormalities are risk factors for Mucoepidermoid Carcinoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Mucoepidermoid Carcinoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Mucoepidermoid Carcinoma gene HRAS has causative impact on biological pathways like Growth Factor Signaling and G-protein-coupled Receptor Signaling. And TGFBR1 has a causative impact on biological pathways like G-protein-coupled Receptor Signaling, TGFB Signaling and Extracellular Matrix Remodelling. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like HRAS and TGFBR1 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes HRAS and TGFBR1 should be avoided.
Eat more pulses, Fava Bean or Chickpea?
The active ingredients contained in Fava Bean are Quercetin, Daidzein, Butein, Betulin, Oleic Acid among others. While the active ingredients contained in Chickpea are Oleic Acid, Linolenic Acid, Vitamin A, Genistein, Folic Acid and others.
Quercetin can manipulate biochemical pathways Small Molecule Transport, Apoptosis and PI3K-AKT-MTOR Signaling. Daidzein has biological action on biochemical pathways Growth Factor Signaling, PI3K-AKT-MTOR Signaling and Apoptosis.
Folic Acid can manipulate biochemical pathways PI3K-AKT-MTOR Signaling, Apoptosis and RAS-RAF Signaling. And so on.
For genetic risk of Mucoepidermoid Carcinoma due to abnormalities in genes HRAS and TGFBR1 – Foods like Fava Bean are recommended compared to Chickpea. This is because the active ingredients Folic Acid in Chickpea further promote the effects of genes on the biochemical pathways. While the active ingredients Quercetin and Daidzein contained in Fava Bean together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: FAVA BEAN IS RECOMMENDED OVER CHICKPEA FOR REDUCING THE GENETIC RISK OF MUCOEPIDERMOID CARCINOMA DUE TO GENES HRAS AND TGFBR1
Eat more vegetables, Asparagus or Rhubarb?
The active ingredients contained in Asparagus are Quercetin, Isorhamnetin, Oleic Acid, Vitamin C, Linolenic Acid among others. While the active ingredients contained in Rhubarb are Quercetin, Vitamin C, Chrysophanol, Vitamin E, Rhein and others.
Quercetin can manipulate biochemical pathways Small Molecule Transport, Apoptosis and PI3K-AKT-MTOR Signaling. Isorhamnetin has biological action on biochemical pathways Extracellular Matrix Remodelling, RAS-RAF Signaling and PI3K-AKT-MTOR Signaling.
Rhein can manipulate biochemical pathways TGFB Signaling. Emodin has biological action on biochemical pathways TGFB Signaling. And so on.
For genetic risk of Mucoepidermoid Carcinoma due to abnormalities in genes HRAS and TGFBR1 – Foods like Asparagus are recommended compared to Rhubarb. This is because the active ingredients Rhein and Emodin in Rhubarb further promote the effects of genes on the biochemical pathways. While the active ingredients Quercetin and Isorhamnetin contained in Asparagus together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: ASPARAGUS IS RECOMMENDED OVER RHUBARB FOR REDUCING THE GENETIC RISK OF MUCOEPIDERMOID CARCINOMA DUE TO GENES HRAS AND TGFBR1
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
Eat more fruits, Raspberry or Roselle?
The active ingredients contained in Raspberry are Ellagic Acid, Resveratrol, Quercetin, Vitamin C, Gallic Acid among others. While the active ingredients contained in Roselle are Oleic Acid, Beta-sitosterol, Vitamin C, Vitamin E, Stigmasterol and others.
Ellagic Acid can manipulate biochemical pathways Apoptosis, PI3K-AKT-MTOR Signaling and Growth Factor Signaling. Vitamin C has biological action on biochemical pathways RAS-RAF Signaling, PI3K-AKT-MTOR Signaling and Apoptosis.
Linoleic Acid can manipulate biochemical pathways Extracellular Matrix Remodelling and TGFB Signaling. And so on.
For genetic risk of Mucoepidermoid Carcinoma due to abnormalities in genes HRAS and TGFBR1 – Foods like Raspberry are recommended compared to Roselle. This is because the active ingredients Linoleic Acid in Roselle further promote the effects of genes on the biochemical pathways. While the active ingredients Ellagic Acid and Vitamin C contained in Raspberry together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: RASPBERRY IS RECOMMENDED OVER ROSELLE FOR REDUCING THE GENETIC RISK OF MUCOEPIDERMOID CARCINOMA DUE TO GENES HRAS AND TGFBR1
Eat more nuts, Chestnut or Pumpkin Seeds?
The active ingredients contained in Chestnut are Ellagic Acid, Quercetin, Betulin, Oleic Acid, Vitamin C among others. While the active ingredients contained in Pumpkin Seeds are Oleic Acid, Beta-sitosterol, Cucurbitacin I, Stigmasterol, Linolenic Acid and others.
Ellagic Acid can manipulate biochemical pathways Apoptosis, PI3K-AKT-MTOR Signaling and Growth Factor Signaling. Betulin has biological action on biochemical pathways TGFB Signaling, PI3K-AKT-MTOR Signaling and Apoptosis.
Lecithin can manipulate biochemical pathways PI3K-AKT-MTOR Signaling and RAS-RAF Signaling. Vitamin B3 has biological action on biochemical pathways PI3K-AKT-MTOR Signaling. And so on.
For genetic risk of Mucoepidermoid Carcinoma due to abnormalities in genes HRAS and TGFBR1 – Foods like Chestnut are recommended compared to Pumpkin Seeds. This is because the active ingredients Lecithin and Vitamin B3 in Pumpkin Seeds further promote the effects of genes on the biochemical pathways. While the active ingredients Ellagic Acid and Betulin contained in Chestnut together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: CHESTNUT IS RECOMMENDED OVER PUMPKIN SEEDS FOR REDUCING THE GENETIC RISK OF MUCOEPIDERMOID CARCINOMA DUE TO GENES HRAS AND TGFBR1
In Summary
An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.
“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.
The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.
You can get started NOW and design a personalized nutrition plan for Mucoepidermoid Carcinoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
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Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.