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What Foods are Recommended for Cancer?
is a very common question. Personalized Nutrition Plans are foods and supplements which are personalized to a cancer indication, genes, any treatments and lifestyle conditions.

Which Foods are Recommended for Mesenchymal Chondrosarcoma?

Sep 1, 2022

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Highlights

No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Mesenchymal Chondrosarcoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Mesenchymal Chondrosarcoma because of AR and INSR gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.

There is no one answer to this question for cancers such as Mesenchymal Chondrosarcoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.

In short – the process to answer questions like “Should I Avoid eating fruit Pear” or “Include fruit Currant in my diet” or “Should I reduce consumption of vegetable Arrowroot” or “Can I take Myricetin and Agaricus Mushroom supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.

RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO MESENCHYMAL CHONDROSARCOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.

The overall objective of personalized nutrition for Mesenchymal Chondrosarcoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.

RECOMMENDATION: UPDATE YOUR NUTRITION FOR MESENCHYMAL CHONDROSARCOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.



About Mesenchymal Chondrosarcoma

cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.

Following key highlights are derived from clinical data for Mesenchymal Chondrosarcoma from cBioPortal. 57.1% of males and 42.9% of females were the distribution of gender in these clinical studies. From a patient sample size of 4; the top genes with mutations and other abnormalities for Mesenchymal Chondrosarcoma include genes AR and INSR. The occurrence frequency distribution for these genes respectively is 100.0% and 100.0%. These tumor genetic details of Mesenchymal Chondrosarcoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Mesenchymal Chondrosarcoma.

Significance of Nutrition for Mesenchymal Chondrosarcoma

All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Mesenchymal Chondrosarcoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.

For example Pear includes active ingredients Isorhamnetin, Chlorogenic Acid and others. And Currant contains active ingredients Myricetin, Quercetin and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.

For cancers like Mesenchymal Chondrosarcoma, activation or inhibition of selected biochemical pathways like Cytoskeletal Dynamics, Nutrient sensing, cGMP Signaling, Focal Adhesion plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Mesenchymal Chondrosarcoma, while eating some other foods and supplements may not be recommended.

One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.

For cancers like Mesenchymal Chondrosarcoma, activation or inhibition of selected biochemical pathways like Cytoskeletal Dynamics, Nutrient sensing, cGMP Signaling, Focal Adhesion plays an important role in driving cancer growth.

RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR MESENCHYMAL CHONDROSARCOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.

Foods for Mesenchymal Chondrosarcoma undergoing chemotherapy treatment

In Mesenchymal Chondrosarcoma – the genes AR and INSR have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Mesenchymal Chondrosarcoma are Cytoskeletal Dynamics, Nutrient sensing and others. Cisplatin is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Cytoskeletal Dynamics, Nutrient sensing so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.

RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.

Eat more pulses, Lentils?

Pulses are an important part of many diets. The active ingredients contained in Lentils are Ellagic Acid among others.

Ellagic Acid can manipulate biochemical pathways Insulin Signaling.

When treating Mesenchymal Chondrosarcoma with chemotherapy Cisplatin – Foods like Lentils are recommended. While the active ingredients Ellagic Acid contained in Lentils support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: LENTILS IS RECOMMENDED FOR MESENCHYMAL CHONDROSARCOMA ON TREATMENT WITH CHEMOTHERAPY CISPLATIN FOR SOME CONDITIONS.

Eat more vegetables, Carob or Arrowroot?

Vegetables are an important part of many diets. The active ingredients contained in Carob are Myricetin, Palmitic Acid, Quercetin among others. While the active ingredients contained in Arrowroot are Quercetin, Chlorogenic Acid, Vanillic Acid and others.

Palmitic Acid can manipulate biochemical pathways Insulin Signaling. Myricetin has biological action on biochemical pathways Insulin Signaling.

Chlorogenic Acid can manipulate biochemical pathways Insulin Signaling. Vanillic Acid has biological action on biochemical pathways Insulin Signaling. And so on.

When treating Mesenchymal Chondrosarcoma with chemotherapy Cisplatin – Foods like Carob are recommended compared to Arrowroot. This is because the active ingredients Chlorogenic Acid and Vanillic Acid in Arrowroot interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Palmitic Acid and Myricetin contained in Carob support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: CAROB IS RECOMMENDED OVER ARROWROOT FOR MESENCHYMAL CHONDROSARCOMA ON TREATMENT WITH CHEMOTHERAPY CISPLATIN FOR SOME CONDITIONS.

Which Foods are Recommended for Mesenchymal Chondrosarcoma?

Eat more fruits, Currant or Pear?

Fruits are an important part of many diets. The active ingredients contained in Currant are Myricetin, Quercetin among others. While the active ingredients contained in Pear are Isorhamnetin, Chlorogenic Acid and others.

Myricetin can manipulate biochemical pathways Insulin Signaling. Quercetin has biological action on biochemical pathways Insulin Signaling.

Chlorogenic Acid can manipulate biochemical pathways Insulin Signaling. And so on.

When treating Mesenchymal Chondrosarcoma with chemotherapy Cisplatin – Foods like Currant are recommended compared to Pear. This is because the active ingredients Chlorogenic Acid in Pear interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Myricetin and Quercetin contained in Currant support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: CURRANT IS RECOMMENDED OVER PEAR FOR MESENCHYMAL CHONDROSARCOMA ON TREATMENT WITH CHEMOTHERAPY CISPLATIN FOR SOME CONDITIONS.

Eat more nuts, Chestnut?

Nuts are an important part of many diets. The active ingredients contained in Chestnut are Ellagic Acid, Quercetin among others.

Ellagic Acid can manipulate biochemical pathways Insulin Signaling. Quercetin has biological action on biochemical pathways Insulin Signaling.

When treating Mesenchymal Chondrosarcoma with chemotherapy Cisplatin – Foods like Chestnut are recommended. While the active ingredients Ellagic Acid and Quercetin contained in Chestnut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: CHESTNUT IS RECOMMENDED FOR MESENCHYMAL CHONDROSARCOMA ON TREATMENT WITH CHEMOTHERAPY CISPLATIN FOR SOME CONDITIONS.

Foods for Genetic Risk of Mesenchymal Chondrosarcoma

One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. AR and INSR are two genes whose abnormalities are risk factors for Mesenchymal Chondrosarcoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Mesenchymal Chondrosarcoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Mesenchymal Chondrosarcoma gene AR has causative impact on biological pathways like Androgen Signaling and Cytoskeletal Dynamics. And INSR has a causative impact on biological pathways like cGMP Signaling and PI3K-AKT-MTOR Signaling. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like AR and INSR should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes AR and INSR should be avoided.

Eat more pulses, Mung Bean or Soy Bean?

The active ingredients contained in Mung Bean are Oleic Acid, Linolenic Acid, Vitamin C, Quercetin, Stigmasterol among others. While the active ingredients contained in Soy Bean are Lupeol, Daidzein, Beta-sitosterol, Vitamin E, Oleic Acid and others.

Vitamin C can manipulate biochemical pathways Cell Cycle Checkpoints, P53 Signaling and Apoptosis. Quercetin has biological action on biochemical pathways Insulin Signaling, MYC Signaling and PI3K-AKT-MTOR Signaling.

Aescin can manipulate biochemical pathways Cell Cycle Checkpoints. Lecithin has biological action on biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. And so on.

For genetic risk of Mesenchymal Chondrosarcoma due to abnormalities in genes AR and INSR – Foods like Mung Bean are recommended compared to Soy Bean. This is because the active ingredients Aescin and Lecithin in Soy Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Quercetin contained in Mung Bean together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: MUNG BEAN IS RECOMMENDED OVER SOY BEAN FOR REDUCING THE GENETIC RISK OF MESENCHYMAL CHONDROSARCOMA DUE TO GENES AR AND INSR

Eat more vegetables, Giant Butterbur or Celery?

The active ingredients contained in Giant Butterbur are Beta-sitosterol, Vitamin C, Vitamin B3, Melatonin, Vitamin A among others. While the active ingredients contained in Celery are Apigenin, Oleic Acid, Linolenic Acid, Vitamin C, Cynaroside and others.

Vitamin C can manipulate biochemical pathways Cell Cycle Checkpoints, P53 Signaling and Apoptosis. Beta-sitosterol has biological action on biochemical pathways MYC Signaling, PI3K-AKT-MTOR Signaling and Cell Cycle Checkpoints.

Luteolin can manipulate biochemical pathways MYC Signaling and Insulin Signaling. Chrysin has biological action on biochemical pathways MYC Signaling and Insulin Signaling. And so on.

For genetic risk of Mesenchymal Chondrosarcoma due to abnormalities in genes AR and INSR – Foods like Giant Butterbur are recommended compared to Celery. This is because the active ingredients Luteolin and Chrysin in Celery further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Giant Butterbur together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: GIANT BUTTERBUR IS RECOMMENDED OVER CELERY FOR REDUCING THE GENETIC RISK OF MESENCHYMAL CHONDROSARCOMA DUE TO GENES AR AND INSR

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.

Eat more fruits, Kiwi or Cranberry?

The active ingredients contained in Kiwi are Vitamin C, Quercetin, Fisetin, Chlorogenic Acid, Vitamin A among others. While the active ingredients contained in Cranberry are Ellagic Acid, Resveratrol, Myricetin, Hyperoside, Vitamin C and others.

Vitamin C can manipulate biochemical pathways Cell Cycle Checkpoints, P53 Signaling and Apoptosis. Quercetin has biological action on biochemical pathways Insulin Signaling, MYC Signaling and PI3K-AKT-MTOR Signaling.

Resveratrol can manipulate biochemical pathways P53 Signaling. Chlorogenic Acid has biological action on biochemical pathways Insulin Signaling. And so on.

For genetic risk of Mesenchymal Chondrosarcoma due to abnormalities in genes AR and INSR – Foods like Kiwi are recommended compared to Cranberry. This is because the active ingredients Resveratrol and Chlorogenic Acid in Cranberry further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Quercetin contained in Kiwi together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: KIWI IS RECOMMENDED OVER CRANBERRY FOR REDUCING THE GENETIC RISK OF MESENCHYMAL CHONDROSARCOMA DUE TO GENES AR AND INSR

Eat more nuts, Almond or Brazil Nut?

The active ingredients contained in Almond are Beta-sitosterol, Vitamin E, Oleic Acid, Linolenic Acid, Quercetin among others. While the active ingredients contained in Brazil Nut are Vitamin E, Oleic Acid, Linolenic Acid, Lecithin, Folic Acid and others.

Beta-sitosterol can manipulate biochemical pathways Cell Cycle Checkpoints, P53 Signaling and Apoptosis. Vitamin E has biological action on biochemical pathways MYC Signaling, PI3K-AKT-MTOR Signaling and Cell Cycle Checkpoints.

Lecithin can manipulate biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways Cell Cycle Checkpoints, P53 Signaling and Apoptosis. And so on.

For genetic risk of Mesenchymal Chondrosarcoma due to abnormalities in genes AR and INSR – Foods like Almond are recommended compared to Brazil Nut. This is because the active ingredients Lecithin and Folic Acid in Brazil Nut further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin E contained in Almond together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: ALMOND IS RECOMMENDED OVER BRAZIL NUT FOR REDUCING THE GENETIC RISK OF MESENCHYMAL CHONDROSARCOMA DUE TO GENES AR AND INSR


In Summary

An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.

“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.

The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.

You can get started NOW and design a personalized nutrition plan for Mesenchymal Chondrosarcoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

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References

Personalized Nutrition for Cancer!

Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.


Scientifically Reviewed by: Dr. Cogle

Christopher R. Cogle, M.D. is a tenured professor at the University of Florida, Chief Medical Officer of Florida Medicaid, and Director of the Florida Health Policy Leadership Academy at the Bob Graham Center for Public Service.

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