Highlights
No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Desmoplastic Small Round Cell Tumor when undergoing chemotherapy or when you determine you have a genetic risk for developing Desmoplastic Small Round Cell Tumor because of ARID1A and NTRK2 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.
There is no one answer to this question for cancers such as Desmoplastic Small Round Cell Tumor which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.
In short – the process to answer questions like “Should I Avoid eating fruit Fig” or “Include fruit Blackberry in my diet” or “Should I reduce consumption of vegetable Spinach” or “Can I take Boneset and St. John’s Wort supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.
RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO DESMOPLASTIC SMALL ROUND CELL TUMOR, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.
The overall objective of personalized nutrition for Desmoplastic Small Round Cell Tumor is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.
RECOMMENDATION: UPDATE YOUR NUTRITION FOR DESMOPLASTIC SMALL ROUND CELL TUMOR, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.
About Desmoplastic Small Round Cell Tumor
cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.
Following key highlights are derived from clinical data for Desmoplastic Small Round Cell Tumor from cBioPortal. The patients enrolled in the studies for Desmoplastic Small Round Cell Tumor are in ages between 8 to 24 with an average age of 21. 89.4% of males and 10.6% of females were the distribution of gender in these clinical studies. From a patient sample size of 102; the top genes with mutations and other abnormalities for Desmoplastic Small Round Cell Tumor include genes ARID1A, KMT2C, NTRK2, KDM5A and EPHA3. The occurrence frequency distribution for these genes respectively is 9.5%, 4.8%, 4.8%, 4.8% and 4.8%. These tumor genetic details of Desmoplastic Small Round Cell Tumor are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Desmoplastic Small Round Cell Tumor.
Significance of Nutrition for Desmoplastic Small Round Cell Tumor
All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Desmoplastic Small Round Cell Tumor. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.
For example Fig includes active ingredients Angelicin, Lupeol, Bergapten, Vitamin C, Beta-sitosterol and others. And Blackberry contains active ingredients Quercetin, Ellagic Acid, Myricetin, Gallic Acid, Kaempferol and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.
For cancers like Desmoplastic Small Round Cell Tumor, activation or inhibition of selected biochemical pathways like RAS-RAF Signaling, Angiogenesis, Chromatin Remodeling, Oncogenic Histone Methylation plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Desmoplastic Small Round Cell Tumor, while eating some other foods and supplements may not be recommended.
One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.
RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR DESMOPLASTIC SMALL ROUND CELL TUMOR – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.
Foods for Desmoplastic Small Round Cell Tumor undergoing chemotherapy treatment
In Desmoplastic Small Round Cell Tumor – the genes ARID1A, KMT2C, NTRK2, KDM5A and EPHA3 have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Desmoplastic Small Round Cell Tumor are RAS-RAF Signaling, Angiogenesis, DNA Repair and others. Radiation is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers RAS-RAF Signaling, Angiogenesis, DNA Repair so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.
RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.
Eat more pulses, Mung Bean or Soy Bean?
Pulses are an important part of many diets. The active ingredients contained in Mung Bean are Quercetin, Kaempferol, Stigmasterol, Vitamin C, Oleic Acid among others. While the active ingredients contained in Soy Bean are Quercetin, Lupeol, Vitamin E, Stigmasterol, 7-8-dihydroxyflavone and others.
Quercetin can manipulate biochemical pathways Angiogenesis, RAS-RAF Signaling and JAK-STAT Signaling. Kaempferol has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, JAK-STAT Signaling and RAS-RAF Signaling.
Genistein can manipulate biochemical pathways DNA Repair. Lecithin has biological action on biochemical pathways JAK-STAT Signaling and PI3K-AKT-MTOR Signaling. And so on.
When treating Desmoplastic Small Round Cell Tumor with chemotherapy Radiation – Foods like Mung Bean are recommended compared to Soy Bean. This is because the active ingredients Genistein and Lecithin in Soy Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Quercetin and Kaempferol contained in Mung Bean support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: MUNG BEAN IS RECOMMENDED OVER SOY BEAN FOR DESMOPLASTIC SMALL ROUND CELL TUMOR ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Eat more vegetables, Arrowroot or Spinach?
Vegetables are an important part of many diets. The active ingredients contained in Arrowroot are Quercetin, Beta-carotene, Protocatechuic Acid, Vitamin C, Chlorogenic Acid among others. While the active ingredients contained in Spinach are Quercetin, Apigenin, Kaempferol, Beta-sitosterol, Vitamin C and others.
Quercetin can manipulate biochemical pathways Angiogenesis, RAS-RAF Signaling and JAK-STAT Signaling. Beta-carotene has biological action on biochemical pathways DNA Repair, PI3K-AKT-MTOR Signaling and Angiogenesis.
Apigenin can manipulate biochemical pathways DNA Repair. Folic Acid has biological action on biochemical pathways JAK-STAT Signaling, RAS-RAF Signaling and PI3K-AKT-MTOR Signaling. And so on.
When treating Desmoplastic Small Round Cell Tumor with chemotherapy Radiation – Foods like Arrowroot are recommended compared to Spinach. This is because the active ingredients Apigenin and Folic Acid in Spinach interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Quercetin and Beta-carotene contained in Arrowroot support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: ARROWROOT IS RECOMMENDED OVER SPINACH FOR DESMOPLASTIC SMALL ROUND CELL TUMOR ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Eat more fruits, Blackberry or Fig?
Fruits are an important part of many diets. The active ingredients contained in Blackberry are Quercetin, Ellagic Acid, Myricetin, Gallic Acid, Kaempferol among others. While the active ingredients contained in Fig are Angelicin, Lupeol, Bergapten, Vitamin C, Beta-sitosterol and others.
Cianidanol can manipulate biochemical pathways Angiogenesis and PI3K-AKT-MTOR Signaling. Scopoletin has biological action on biochemical pathways Angiogenesis and PI3K-AKT-MTOR Signaling.
Myristic Acid can manipulate biochemical pathways RAS-RAF Signaling. Lauric Acid has biological action on biochemical pathways PI3K-AKT-MTOR Signaling. And so on.
When treating Desmoplastic Small Round Cell Tumor with chemotherapy Radiation – Foods like Blackberry are recommended compared to Fig. This is because the active ingredients Myristic Acid and Lauric Acid in Fig interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Cianidanol and Scopoletin contained in Blackberry support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: BLACKBERRY IS RECOMMENDED OVER FIG FOR DESMOPLASTIC SMALL ROUND CELL TUMOR ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Eat more nuts, Almond or Brazil Nut?
Nuts are an important part of many diets. The active ingredients contained in Almond are Quercetin, Vitamin E, Stigmasterol, Salicylic Acid, Beta-sitosterol among others. While the active ingredients contained in Brazil Nut are Vitamin E, Oleic Acid, Linolenic Acid, Lecithin, Folic Acid and others.
Beta-sitosterol can manipulate biochemical pathways Angiogenesis and PI3K-AKT-MTOR Signaling. Quercetin has biological action on biochemical pathways RAS-RAF Signaling, JAK-STAT Signaling and DNA Repair.
Lecithin can manipulate biochemical pathways JAK-STAT Signaling and PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways RAS-RAF Signaling, JAK-STAT Signaling and PI3K-AKT-MTOR Signaling. And so on.
When treating Desmoplastic Small Round Cell Tumor with chemotherapy Radiation – Foods like Almond are recommended compared to Brazil Nut. This is because the active ingredients Lecithin and Folic Acid in Brazil Nut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Quercetin contained in Almond support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: ALMOND IS RECOMMENDED OVER BRAZIL NUT FOR DESMOPLASTIC SMALL ROUND CELL TUMOR ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Foods for Genetic Risk of Desmoplastic Small Round Cell Tumor
One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. ARID1A and NTRK2 are two genes whose abnormalities are risk factors for Desmoplastic Small Round Cell Tumor. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Desmoplastic Small Round Cell Tumor can be used as a guide for coming up with a recommended personalized nutrition plan. For Desmoplastic Small Round Cell Tumor gene ARID1A has causative impact on biological pathways like Androgen Signaling and Chromatin Remodeling. And NTRK2 has a causative impact on biological pathways like Growth Factor Signaling, Adherens junction and MAPK Signaling. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like ARID1A and NTRK2 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes ARID1A and NTRK2 should be avoided.
Eat more pulses, Yellow Wax Bean or Moth Bean?
The active ingredients contained in Yellow Wax Bean are Vitamin C, Cianidanol, Palmitic Acid, Ferulic Acid, Butyric Acid among others. While the active ingredients contained in Moth Bean are Beta-sitosterol, Linolenic Acid, Oleic Acid, Stigmasterol, Linoleic Acid and others.
Palmitic Acid can manipulate biochemical pathways Cell Cycle Checkpoints, P53 Signaling and MYC Signaling. Vitamin A has biological action on biochemical pathways Apoptosis, PI3K-AKT-MTOR Signaling and MYC Signaling.
Folic Acid can manipulate biochemical pathways Cell Cycle Checkpoints, P53 Signaling and MYC Signaling. And so on.
For genetic risk of Desmoplastic Small Round Cell Tumor due to abnormalities in genes ARID1A and NTRK2 – Foods like Yellow Wax Bean are recommended compared to Moth Bean. This is because the active ingredients Folic Acid in Moth Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Palmitic Acid and Vitamin A contained in Yellow Wax Bean together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: YELLOW WAX BEAN IS RECOMMENDED OVER MOTH BEAN FOR REDUCING THE GENETIC RISK OF DESMOPLASTIC SMALL ROUND CELL TUMOR DUE TO GENES ARID1A AND NTRK2
Eat more vegetables, Arugula or Chicory?
The active ingredients contained in Arugula are Esculin, Vitamin A, Vitamin K, Kaempferol, Erysolin among others. While the active ingredients contained in Chicory are Apigenin, Esculin, Lupeol, Betulinic Acid, Vitamin C and others.
Vitamin A can manipulate biochemical pathways MYC Signaling, Apoptosis and Cell Cycle Checkpoints. Vitamin K has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, MYC Signaling and Cell Cycle Checkpoints.
Luteolin can manipulate biochemical pathways MYC Signaling. Folic Acid has biological action on biochemical pathways Cell Cycle Checkpoints, P53 Signaling and PI3K-AKT-MTOR Signaling. And so on.
For genetic risk of Desmoplastic Small Round Cell Tumor due to abnormalities in genes ARID1A and NTRK2 – Foods like Arugula are recommended compared to Chicory. This is because the active ingredients Luteolin and Folic Acid in Chicory further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin A and Vitamin K contained in Arugula together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: ARUGULA IS RECOMMENDED OVER CHICORY FOR REDUCING THE GENETIC RISK OF DESMOPLASTIC SMALL ROUND CELL TUMOR DUE TO GENES ARID1A AND NTRK2
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
Eat more fruits, Kiwi or Raspberry?
The active ingredients contained in Kiwi are Vitamin C, Quercetin, Vitamin A, Chlorogenic Acid, Fisetin among others. While the active ingredients contained in Raspberry are Resveratrol, Vitamin C, Ellagic Acid, Quercetin, Gallic Acid and others.
Vitamin C can manipulate biochemical pathways Cell Cycle Checkpoints, P53 Signaling and MYC Signaling. Quercetin has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, Apoptosis and Cell Cycle Checkpoints.
Ellagic Acid can manipulate biochemical pathways MYC Signaling. Resveratrol has biological action on biochemical pathways P53 Signaling. And so on.
For genetic risk of Desmoplastic Small Round Cell Tumor due to abnormalities in genes ARID1A and NTRK2 – Foods like Kiwi are recommended compared to Raspberry. This is because the active ingredients Ellagic Acid and Resveratrol in Raspberry further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Quercetin contained in Kiwi together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: KIWI IS RECOMMENDED OVER RASPBERRY FOR REDUCING THE GENETIC RISK OF DESMOPLASTIC SMALL ROUND CELL TUMOR DUE TO GENES ARID1A AND NTRK2
Eat more nuts, Hazelnut or Chestnut?
The active ingredients contained in Hazelnut are Vitamin E, Linolenic Acid, Oleic Acid, Quercetin, Linoleic Acid among others. While the active ingredients contained in Chestnut are Vitamin C, Linolenic Acid, Oleic Acid, Ellagic Acid, Quercetin and others.
Vitamin E can manipulate biochemical pathways Cell Cycle Checkpoints, P53 Signaling and MYC Signaling. Quercetin has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, Apoptosis and Cell Cycle Checkpoints.
Ellagic Acid can manipulate biochemical pathways MYC Signaling. Folic Acid has biological action on biochemical pathways Cell Cycle Checkpoints, P53 Signaling and PI3K-AKT-MTOR Signaling. And so on.
For genetic risk of Desmoplastic Small Round Cell Tumor due to abnormalities in genes ARID1A and NTRK2 – Foods like Hazelnut are recommended compared to Chestnut. This is because the active ingredients Ellagic Acid and Folic Acid in Chestnut further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin E and Quercetin contained in Hazelnut together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: HAZELNUT IS RECOMMENDED OVER CHESTNUT FOR REDUCING THE GENETIC RISK OF DESMOPLASTIC SMALL ROUND CELL TUMOR DUE TO GENES ARID1A AND NTRK2
In Summary
An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.
“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.
The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.
You can get started NOW and design a personalized nutrition plan for Desmoplastic Small Round Cell Tumor by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
References
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Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.