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What Foods are Recommended for Cancer?
is a very common question. Personalized Nutrition Plans are foods and supplements which are personalized to a cancer indication, genes, any treatments and lifestyle conditions.

Foods for Breast Ductal Carcinoma In Situ!

Aug 4, 2023

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Introduction

Foods for Breast Ductal Carcinoma In Situ should be personalized for each individual and also must adapt when cancer treatment or tumor genetic change. The personalization and adaptation must consider all the active ingredients or bioactives contained in different foods with respect to cancer tissue biology, genetics, treatments, lifestyle conditions and diet preferences. Hence while nutrition is one of the very important decisions for a cancer patient and individual at risk of cancer to make – how to choose foods to eat is not an easy task.

Breast ductal carcinoma in situ (DCIS) refers to a non-invasive form of breast cancer that starts in the milk ducts and has not spread to the surrounding tissues. It is also called ductal carcinoma of the breast. Being a type of breast cancer, DCIS requires appropriate treatment and management. Pathology outlines aid in understanding the characteristics and histology of DCIS. It is important to note that while DCIS is considered non-invasive, it has the potential to progress if left untreated. Treatment options for breast ductal carcinoma in situ include surgery, radiation therapy, and sometimes hormone therapy. Prognosis for DCIS is generally excellent, with a high survival rate when treated effectively. Patient information and support from organizations such as the National Institutes of Health (NIH) are valuable resources for individuals with this diagnosis. The grade of DCIS provides information about the aggressiveness of the cancer cells. Routine screening is essential for early detection and intervention of breast ductal carcinoma in situ. Understanding the evolution and progression of DCIS helps in determining appropriate management strategies. Clear coding and identification of DCIS in medical records are facilitated by the ICD-10 classification system. Recognizing symptoms and histological features of breast ductal carcinoma is important in timely diagnosis and initiating appropriate treatment. Cytology plays a role in confirming the presence of cancer cells. While DCIS is non-invasive, it still requires comprehensive management to prevent the potential for invasive breast cancer in the future.



For Breast Ductal Carcinoma In Situ does it matter what vegetables, fruits, nuts, seeds one eats?

A very common nutrition question asked by cancer patients and individuals at-genetic risk of cancer is – for cancers like Breast Ductal Carcinoma In Situ does it matter what foods I eat and which I do not? Or if I follow a plant-based diet is that enough for cancer like Breast Ductal Carcinoma In Situ?

For example does it matter if vegetable Wild Carrot is consumed more compared to Arrowhead? Does it make any difference if fruit Asian Pear is preferred over Red Raspberry? Also if similar choices are made for nuts/seeds like Pistachio over Macadamia Nut and for pulses like Black-eyed Pea over Catjang Pea. And if what I eat matters – then how does one identify foods which are recommended for Breast Ductal Carcinoma In Situ and is it the same answer for everyone with the same diagnosis or genetic risk?

Yes! Foods you eat matters for Breast Ductal Carcinoma In Situ!

Food recommendations may not be the same for everyone and can be different even for the same diagnosis and genetic risk.

All cancers like Breast Ductal Carcinoma In Situ can be characterized by a unique set of biochemical pathways - the signature pathways of Breast Ductal Carcinoma In Situ. Biochemical pathways like Cell Cycle, PI3K-AKT-MTOR Signaling, Focal Adhesion, Cell Cycle Checkpoints are part of the signature definition of Breast Ductal Carcinoma In Situ

All foods (vegetables, fruits, nuts, seeds, pulses, oils etc.) and nutritional supplements are made up of more than one active molecular ingredient or bio-actives in different proportions and quantities. Each active ingredient has a unique mechanism of action – which can be activation or inhibition of different biochemical pathways. Simply stated foods and supplements which are recommended are those which do not cause an increase of molecular drivers of cancer but reduce them. Else those foods should not be recommended. Foods contain multiple active ingredients – hence when evaluating foods and supplements you need to consider the impact of all active ingredients cumulatively rather than individually.

For example Asian Pear contains active ingredients Apigenin, Curcumin, Luteolin, Lupeol, Daidzein. And Red Raspberry contains active ingredients Curcumin, Quercetin, Ellagic Acid, Lupeol, Daidzein and possibly others.

A common mistake made when deciding and choosing foods to eat for Breast Ductal Carcinoma In Situ – is to evaluate only selected active ingredients contained in foods and ignore the rest. Because different active ingredients contained in foods may have opposing effects on cancer drivers – you cannot cherry pick active ingredients in foods and supplements for making a nutrition decision for Breast Ductal Carcinoma In Situ.

YES – FOOD CHOICES MATTER FOR CANCER. NUTRITION DECISIONS MUST CONSIDER ALL ACTIVE INGREDIENTS OF FOODS.

Skills Needed for Nutrition Personalization for Breast Ductal Carcinoma In Situ?

Personalized nutrition for cancers like Breast Ductal Carcinoma In Situ consists of recommended foods / supplements; not recommended foods / supplements with example recipes which prioritize use of recommended foods. An example of personalized nutrition can be seen at this link.

Deciding which foods are recommended or not is extremely complicated, requiring expertise in Breast Ductal Carcinoma In Situ biology, food science, genetics, biochemistry along with good understanding of how cancer treatments work and associated vulnerabilities by which the treatments could stop being effective.

MINIMUM KNOWLEDGE EXPERTISE NEEDED FOR NUTRITION PERSONALIZATION FOR CANCER ARE: CANCER BIOLOGY, FOOD SCIENCE, CANCER TREATMENTS AND GENETICS.

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.

Characteristics of cancers like Breast Ductal Carcinoma In Situ

All cancers like Breast Ductal Carcinoma In Situ can be characterized by a unique set of biochemical pathways – the signature pathways of Breast Ductal Carcinoma In Situ. Biochemical pathways like Cell Cycle, PI3K-AKT-MTOR Signaling, Focal Adhesion, Cell Cycle Checkpoints are part of the signature definition of Breast Ductal Carcinoma In Situ. Each individual’s cancer genetics can be different and hence their specific cancer signature could be unique.

The treatments which are effective for Breast Ductal Carcinoma In Situ need to be cognizant of the associated signature biochemical pathways for each cancer patient and individual at genetic risk. Therefore different treatments with different mechanisms of actions are effective for different patients. Similarly and for the same reasons foods and supplements need to be personalized for each individual. Hence some foods and supplements are recommended for Breast Ductal Carcinoma In Situ when taking cancer treatment Tamoxifen, and some foods and supplements are not recommended.

Sources like cBioPortal and many others provide population representative patient anonymized data from clinical trials for all cancer indications. This data consists of clinical trial study details like sample size / number of patients, age groups, gender, ethnicity, treatments, tumor site and any genetic mutations.

TP53, PIK3CA, AFF1, BRCA2 and BIRC8 are the top ranked reported genes for Breast Ductal Carcinoma In Situ. TP53 is reported in 30.0 % of the representative patients across all clinical trials. And PIK3CA is reported in 10.0 %. The combined population patient data cover ages from 38 to 69. 0.0 % of the patient data are identified as men. The Breast Ductal Carcinoma In Situ biology along with reported genetics together define the population represented signature biochemical pathways for this cancer. If the individual cancer tumor genetics or genes contributing to the risk are also known then that should also be used for nutrition personalization.

NUTRITION CHOICES SHOULD MATCH WITH EACH INDIVIDUAL’S CANCER SIGNATURE.

Foods for Breast Ductal Carcinoma In Situ!

Food and Supplements for Breast Ductal Carcinoma In Situ

For Cancer Patients

Cancer patients on treatment or on palliative care need to make decisions on food and supplements – for the needed dietary calories, for managing any treatment side effects and also for improved cancer management. All plant-based foods are not equal and choosing and prioritizing foods which are personalized and customized to ongoing cancer treatment is important and complicated. Here are some examples providing guidelines for making nutrition decisions.

Choose Vegetable WILD CARROT or ARROWHEAD?

Vegetable Wild Carrot contains many active ingredients or bioactives such as Apigenin, Curcumin, Quercetin, Luteolin, Vitamin D3. These active ingredients manipulate various biochemical pathways like RAS-RAF Signaling and Cell Cycle and others. Wild Carrot is recommended for Breast Ductal Carcinoma In Situ when ongoing cancer treatment is Tamoxifen. This is because Wild Carrot modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Tamoxifen.

Some of the active ingredients or bioactives in vegetable Arrowhead are Apigenin, Curcumin, Luteolin, Lupeol, Daidzein. These active ingredients manipulate various biochemical pathways like Cell Cycle and PI3K-AKT-MTOR Signaling and others. Arrowhead is not recommended for Breast Ductal Carcinoma In Situ when ongoing cancer treatment is Tamoxifen because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

VEGETABLE WILD CARROT IS RECOMMENDED OVER ARROWHEAD FOR Breast Ductal Carcinoma In Situ AND TREATMENT Tamoxifen.

Choose Fruit RED RASPBERRY or ASIAN PEAR?

Fruit Red Raspberry contains many active ingredients or bioactives such as Curcumin, Quercetin, Ellagic Acid, Lupeol, Daidzein. These active ingredients manipulate various biochemical pathways like RAS-RAF Signaling and Cell Cycle and others. Red Raspberry is recommended for Breast Ductal Carcinoma In Situ when ongoing cancer treatment is Tamoxifen. This is because Red Raspberry modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Tamoxifen.

Some of the active ingredients or bioactives in fruit Asian Pear are Apigenin, Curcumin, Luteolin, Lupeol, Daidzein. These active ingredients manipulate various biochemical pathways like Cell Cycle and PI3K-AKT-MTOR Signaling and others. Asian Pear is not recommended for Breast Ductal Carcinoma In Situ when ongoing cancer treatment is Tamoxifen because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

FRUIT RED RASPBERRY IS RECOMMENDED OVER ASIAN PEAR FOR Breast Ductal Carcinoma In Situ AND TREATMENT Tamoxifen.

Choose Nut PISTACHIO or MACADAMIA NUT?

Pistachio contains many active ingredients or bioactives such as Curcumin, Quercetin, Lupeol, Daidzein, Geraniol. These active ingredients manipulate various biochemical pathways like RAS-RAF Signaling, Cell Cycle and PI3K-AKT-MTOR Signaling and others. Pistachio is recommended for Breast Ductal Carcinoma In Situ when ongoing cancer treatment is Tamoxifen. This is because Pistachio modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Tamoxifen.

Some of the active ingredients or bioactives in Macadamia Nut are Apigenin, Curcumin, Luteolin, Lupeol, Daidzein. These active ingredients manipulate various biochemical pathways like PI3K-AKT-MTOR Signaling and others. Macadamia Nut is not recommended for Breast Ductal Carcinoma In Situ when ongoing cancer treatment is Tamoxifen because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

PISTACHIO IS RECOMMENDED OVER MACADAMIA NUT FOR Breast Ductal Carcinoma In Situ AND TREATMENT Tamoxifen.

For Individuals with Genetic Risk of Cancer

The question asked by individuals who have genetic risk of Breast Ductal Carcinoma In Situ or familial history is “What Should I Eat Differently from Before?” and how they should choose foods and supplements to manage risks of the disease. Since for cancer risk there is nothing actionable in terms of treatment – decisions of foods and supplements become important and one of the very few actionable things which can be done. All plant-based foods are not equal and based on identified genetics and pathway signature – the choices of food and supplements should be personalized.

Choose Vegetable GIANT BUTTERBUR or CHICORY?

Vegetable Giant Butterbur contains many active ingredients or bioactives such as Apigenin, Curcumin, Myricetin, Catechol, Formononetin. These active ingredients manipulate various biochemical pathways like Angiogenesis, JAK-STAT Signaling, PI3K-AKT-MTOR Signaling and P53 Signaling and others. Giant Butterbur is recommended for risk of Breast Ductal Carcinoma In Situ when associated genetic risk is AFF1. This is because Giant Butterbur increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in vegetable Chicory are Quercetin, Curcumin, Myricetin, Catechol, Formononetin. These active ingredients manipulate various biochemical pathways like Stem Cell Signaling, Insulin Signaling and DNA Repair and others. Chicory is not recommended when risk of Breast Ductal Carcinoma In Situ when associated genetic risk is AFF1 because it increases the signature pathways of it.

VEGETABLE GIANT BUTTERBUR IS RECOMMENDED OVER CHICORY FOR AFF1 GENETIC RISK OF CANCER.

Choose Fruit NANCE or PUMMELO?

Fruit Nance contains many active ingredients or bioactives such as Apigenin, Curcumin, Myricetin, Catechol, Formononetin. These active ingredients manipulate various biochemical pathways like PI3K-AKT-MTOR Signaling, Hypoxia and P53 Signaling and others. Nance is recommended for risk of Breast Ductal Carcinoma In Situ when associated genetic risk is AFF1. This is because Nance increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in fruit Pummelo are Apigenin, Quercetin, Curcumin, Catechol, Formononetin. These active ingredients manipulate various biochemical pathways like Cell Cycle Checkpoints and DNA Repair and others. Pummelo is not recommended when risk of Breast Ductal Carcinoma In Situ when associated genetic risk is AFF1 because it increases the signature pathways of it.

FRUIT NANCE IS RECOMMENDED OVER PUMMELO FOR AFF1 GENETIC RISK OF CANCER.

Choose Nut BUTTERNUT or EUROPEAN CHESTNUT?

Butternut contains many active ingredients or bioactives such as Apigenin, Curcumin, Myricetin, Catechol, Formononetin. These active ingredients manipulate various biochemical pathways like PI3K-AKT-MTOR Signaling, JAK-STAT Signaling and Insulin Signaling and others. Butternut is recommended for risk of Breast Ductal Carcinoma In Situ when associated genetic risk is AFF1. This is because Butternut increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in European Chestnut are Apigenin, Quercetin, Curcumin, Ellagic Acid, Myricetin. These active ingredients manipulate various biochemical pathways like Insulin Signaling and DNA Repair and others. European Chestnut is not recommended when risk of Breast Ductal Carcinoma In Situ when associated genetic risk is AFF1 because it increases the signature pathways of it.

BUTTERNUT IS RECOMMENDED OVER EUROPEAN CHESTNUT FOR AFF1 GENETIC RISK OF CANCER.


In Conclusion

Foods and Supplements chosen are important decisions for cancers like Breast Ductal Carcinoma In Situ. Breast Ductal Carcinoma In Situ patients and individuals with genetic-risk always have this question: “What foods and nutritional supplements are recommended for me and which are not?” There is a common belief which is a misconception that all plant-based foods could be beneficial or not but would not be harmful. Certain foods and supplements can interfere with cancer treatments or promote molecular pathway drivers of cancer.

There are different types of cancer indications like Breast Ductal Carcinoma In Situ, each with different tumor genetics with further genomic variations across each individual. Further every cancer treatment and chemotherapy has a unique mechanism of action. Each food like Wild Carrot contains various bioactives in different quantities, which have an impact on different and distinct sets of biochemical pathways. The definition of personalized nutrition is individualized food recommendations for the cancer indication, treatments, genetics, lifestyle and other factors. Nutrition personalization decisions for cancer require knowledge of cancer biology, food science and an understanding of different chemotherapy treatments. Finally when there are treatment changes or new genomics is identified – the nutrition personalization needs re-evaluation.

The addon nutrition personalization solution makes the decision making easy and removes all the guesswork in answering the question, “What foods should I choose or not choose for Breast Ductal Carcinoma In Situ?”. The addon multi-disciplinary team includes cancer physicians, clinical scientists, software engineers and data scientists.


Personalized Nutrition for Cancer!

Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.

References

Scientifically Reviewed by: Dr. Cogle

Christopher R. Cogle, M.D. is a tenured professor at the University of Florida, Chief Medical Officer of Florida Medicaid, and Director of the Florida Health Policy Leadership Academy at the Bob Graham Center for Public Service.

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