Highlights
No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Breast Ductal Carcinoma In Situ when undergoing chemotherapy or when you determine you have a genetic risk for developing Breast Ductal Carcinoma In Situ because of AFF1 and BRCA2 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.
There is no one answer to this question for cancers such as Breast Ductal Carcinoma In Situ which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.
In short – the process to answer questions like “Should I Avoid eating fruit Sapota” or “Include fruit Cloudberry in my diet” or “Should I reduce consumption of vegetable Radish” or “Can I take Ellagic Acid and Chamomile supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.
RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO BREAST DUCTAL CARCINOMA IN SITU, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.
The overall objective of personalized nutrition for Breast Ductal Carcinoma In Situ is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.
RECOMMENDATION: UPDATE YOUR NUTRITION FOR BREAST DUCTAL CARCINOMA IN SITU, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.
About Breast Ductal Carcinoma In Situ
cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.
Following key highlights are derived from clinical data for Breast Ductal Carcinoma In Situ from cBioPortal. The patients enrolled in the studies for Breast Ductal Carcinoma In Situ are in ages between 38 to 69 with an average age of 43.From a patient sample size of 10; the top genes with mutations and other abnormalities for Breast Ductal Carcinoma In Situ include genes TP53, PIK3CA, AFF1, BRCA2 and BIRC8. The occurrence frequency distribution for these genes respectively is 30.0%, 10.0%, 10.0%, 10.0% and 10.0%. These tumor genetic details of Breast Ductal Carcinoma In Situ are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Breast Ductal Carcinoma In Situ.
Significance of Nutrition for Breast Ductal Carcinoma In Situ
All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Breast Ductal Carcinoma In Situ. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.
For example Sapota includes active ingredients Lycopene, Beta-sitosterol, Vitamin C, Oleic Acid, Gallic Acid and others. And Cloudberry contains active ingredients Ellagic Acid, Vitamin C, Vitamin A, Urolithin B and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.
For cancers like Breast Ductal Carcinoma In Situ, activation or inhibition of selected biochemical pathways like Cell Cycle, PI3K-AKT-MTOR Signaling, Focal Adhesion, Cell Cycle Checkpoints plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Breast Ductal Carcinoma In Situ, while eating some other foods and supplements may not be recommended.
One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.
RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR BREAST DUCTAL CARCINOMA IN SITU – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.
Foods for Breast Ductal Carcinoma In Situ undergoing chemotherapy treatment
In Breast Ductal Carcinoma In Situ – the genes TP53, PIK3CA, AFF1, BRCA2 and BIRC8 have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Breast Ductal Carcinoma In Situ are Cell Cycle, PI3K-AKT-MTOR Signaling, RAS-RAF Signaling and others. Tamoxifen is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Cell Cycle, PI3K-AKT-MTOR Signaling, RAS-RAF Signaling so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.
RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.
Eat more pulses, Mung Bean or Soy Bean?
Pulses are an important part of many diets. The active ingredients contained in Mung Bean are Quercetin, Genistein, Kaempferol, Glucaric Acid, Vitamin C among others. While the active ingredients contained in Soy Bean are Fisetin, Quercetin, Lupeol, Daidzein, Vitamin E and others.
Quercetin can manipulate biochemical pathways Cell Cycle, RAS-RAF Signaling and PI3K-AKT-MTOR Signaling. Genistein has biological action on biochemical pathways Cell Cycle, RAS-RAF Signaling and PI3K-AKT-MTOR Signaling.
Aescin can manipulate biochemical pathways Cell Cycle. Lecithin has biological action on biochemical pathways PI3K-AKT-MTOR Signaling. And so on.
When treating Breast Ductal Carcinoma In Situ with chemotherapy Tamoxifen – Foods like Mung Bean are recommended compared to Soy Bean. This is because the active ingredients Aescin and Lecithin in Soy Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Quercetin and Genistein contained in Mung Bean support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: MUNG BEAN IS RECOMMENDED OVER SOY BEAN FOR BREAST DUCTAL CARCINOMA IN SITU ON TREATMENT WITH CHEMOTHERAPY TAMOXIFEN FOR SOME CONDITIONS.
Eat more vegetables, Artichoke or Radish?
Vegetables are an important part of many diets. The active ingredients contained in Artichoke are Apigenin, Luteolin, Cynaroside, Vitamin C, Naringenin among others. While the active ingredients contained in Radish are Quercetin, Isorhamnetin, Salicylic Acid, Beta-sitosterol, Kaempferol and others.
Vitamin K can manipulate biochemical pathways Cell Cycle and PI3K-AKT-MTOR Signaling. Apigenin has biological action on biochemical pathways RAS-RAF Signaling, Cell Cycle and PI3K-AKT-MTOR Signaling.
Pelargonidin can manipulate biochemical pathways Cell Cycle and PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways RAS-RAF Signaling and PI3K-AKT-MTOR Signaling. And so on.
When treating Breast Ductal Carcinoma In Situ with chemotherapy Tamoxifen – Foods like Artichoke are recommended compared to Radish. This is because the active ingredients Pelargonidin and Folic Acid in Radish interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin K and Apigenin contained in Artichoke support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: ARTICHOKE IS RECOMMENDED OVER RADISH FOR BREAST DUCTAL CARCINOMA IN SITU ON TREATMENT WITH CHEMOTHERAPY TAMOXIFEN FOR SOME CONDITIONS.
Eat more fruits, Cloudberry or Sapota?
Fruits are an important part of many diets. The active ingredients contained in Cloudberry are Ellagic Acid, Vitamin C, Vitamin A, Urolithin B among others. While the active ingredients contained in Sapota are Lycopene, Beta-sitosterol, Vitamin C, Oleic Acid, Gallic Acid and others.
Vitamin C can manipulate biochemical pathways Cell Cycle, RAS-RAF Signaling and PI3K-AKT-MTOR Signaling. Vitamin A has biological action on biochemical pathways Cell Cycle and PI3K-AKT-MTOR Signaling.
Aescin can manipulate biochemical pathways Cell Cycle. Folic Acid has biological action on biochemical pathways RAS-RAF Signaling and PI3K-AKT-MTOR Signaling. And so on.
When treating Breast Ductal Carcinoma In Situ with chemotherapy Tamoxifen – Foods like Cloudberry are recommended compared to Sapota. This is because the active ingredients Aescin and Folic Acid in Sapota interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Vitamin A contained in Cloudberry support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: CLOUDBERRY IS RECOMMENDED OVER SAPOTA FOR BREAST DUCTAL CARCINOMA IN SITU ON TREATMENT WITH CHEMOTHERAPY TAMOXIFEN FOR SOME CONDITIONS.
Eat more nuts, Almond or Brazil Nut?
Nuts are an important part of many diets. The active ingredients contained in Almond are Quercetin, Salicylic Acid, Vitamin E, Beta-sitosterol, Oleic Acid among others. While the active ingredients contained in Brazil Nut are Vitamin E, Oleic Acid, Linolenic Acid, Lecithin, Folic Acid and others.
Beta-sitosterol can manipulate biochemical pathways Cell Cycle and PI3K-AKT-MTOR Signaling. Quercetin has biological action on biochemical pathways RAS-RAF Signaling, Cell Cycle and PI3K-AKT-MTOR Signaling.
Lecithin can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways RAS-RAF Signaling and PI3K-AKT-MTOR Signaling. And so on.
When treating Breast Ductal Carcinoma In Situ with chemotherapy Tamoxifen – Foods like Almond are recommended compared to Brazil Nut. This is because the active ingredients Lecithin and Folic Acid in Brazil Nut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Quercetin contained in Almond support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: ALMOND IS RECOMMENDED OVER BRAZIL NUT FOR BREAST DUCTAL CARCINOMA IN SITU ON TREATMENT WITH CHEMOTHERAPY TAMOXIFEN FOR SOME CONDITIONS.
Foods for Genetic Risk of Breast Ductal Carcinoma In Situ
One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. AFF1 and BRCA2 are two genes whose abnormalities are risk factors for Breast Ductal Carcinoma In Situ. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Breast Ductal Carcinoma In Situ can be used as a guide for coming up with a recommended personalized nutrition plan. For Breast Ductal Carcinoma In Situ gene AFF1 has causative impact on biological pathways like Oncogenic Histone Methylation. And BRCA2 has a causative impact on biological pathways like DNA Repair and DNA Repair. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like AFF1 and BRCA2 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes AFF1 and BRCA2 should be avoided.
Eat more pulses, Common Bean or Moth Bean?
The active ingredients contained in Common Bean are Apigenin, Esculin, Linolenic Acid, Oleic Acid, Vitamin C among others. While the active ingredients contained in Moth Bean are Linolenic Acid, Oleic Acid, Stigmasterol, Beta-sitosterol, Linoleic Acid and others.
Vitamin A can manipulate biochemical pathways MYC Signaling, Apoptosis and Cell Cycle Checkpoints. Apigenin has biological action on biochemical pathways MAPK Signaling, P53 Signaling and Hypoxia.
Folic Acid can manipulate biochemical pathways MAPK Signaling, Cell Cycle Checkpoints and P53 Signaling. And so on.
For genetic risk of Breast Ductal Carcinoma In Situ due to abnormalities in genes AFF1 and BRCA2 – Foods like Common Bean are recommended compared to Moth Bean. This is because the active ingredients Folic Acid in Moth Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin A and Apigenin contained in Common Bean together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: COMMON BEAN IS RECOMMENDED OVER MOTH BEAN FOR REDUCING THE GENETIC RISK OF BREAST DUCTAL CARCINOMA IN SITU DUE TO GENES AFF1 AND BRCA2
Eat more vegetables, Cassava or Celery?
The active ingredients contained in Cassava are Linolenic Acid, Oleic Acid, Vitamin C, Beta-sitosterol, Linoleic Acid among others. While the active ingredients contained in Celery are Apigenin, Quercetin, Linolenic Acid, Oleic Acid, Vitamin C and others.
Vitamin C can manipulate biochemical pathways MAPK Signaling, Cell Cycle Checkpoints and P53 Signaling. Beta-sitosterol has biological action on biochemical pathways MYC Signaling, PI3K-AKT-MTOR Signaling and Apoptosis.
Cynaroside can manipulate biochemical pathways MAPK Signaling. Luteolin has biological action on biochemical pathways MYC Signaling. And so on.
For genetic risk of Breast Ductal Carcinoma In Situ due to abnormalities in genes AFF1 and BRCA2 – Foods like Cassava are recommended compared to Celery. This is because the active ingredients Cynaroside and Luteolin in Celery further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Cassava together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: CASSAVA IS RECOMMENDED OVER CELERY FOR REDUCING THE GENETIC RISK OF BREAST DUCTAL CARCINOMA IN SITU DUE TO GENES AFF1 AND BRCA2
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
Eat more fruits, Tamarind or Cranberry?
The active ingredients contained in Tamarind are Linolenic Acid, Oleic Acid, Vitamin C, Beta-sitosterol, Epicatechin among others. While the active ingredients contained in Cranberry are Quercetin, Resveratrol, Ellagic Acid, Vitamin C, Hyperoside and others.
Vitamin C can manipulate biochemical pathways MAPK Signaling, Cell Cycle Checkpoints and P53 Signaling. Beta-sitosterol has biological action on biochemical pathways MYC Signaling, PI3K-AKT-MTOR Signaling and Apoptosis.
Resveratrol can manipulate biochemical pathways P53 Signaling. Ellagic Acid has biological action on biochemical pathways MYC Signaling. And so on.
For genetic risk of Breast Ductal Carcinoma In Situ due to abnormalities in genes AFF1 and BRCA2 – Foods like Tamarind are recommended compared to Cranberry. This is because the active ingredients Resveratrol and Ellagic Acid in Cranberry further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Tamarind together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: TAMARIND IS RECOMMENDED OVER CRANBERRY FOR REDUCING THE GENETIC RISK OF BREAST DUCTAL CARCINOMA IN SITU DUE TO GENES AFF1 AND BRCA2
Eat more nuts, Hazelnut or Macadamia Nut?
The active ingredients contained in Hazelnut are Quercetin, Vitamin E, Linolenic Acid, Oleic Acid, Linoleic Acid among others. While the active ingredients contained in Macadamia Nut are Beta-sitosterol, Palmitic Acid, Lauric Acid, Folic Acid, Myristic Acid and others.
Quercetin can manipulate biochemical pathways MAPK Signaling, Cell Cycle Checkpoints and P53 Signaling. Vitamin E has biological action on biochemical pathways MYC Signaling, Hypoxia and PI3K-AKT-MTOR Signaling.
Palmitic Acid can manipulate biochemical pathways MAPK Signaling, Chromatin Remodeling and DNA Repair. Lauric Acid has biological action on biochemical pathways MYC Signaling, PI3K-AKT-MTOR Signaling and MAPK Signaling. And so on.
For genetic risk of Breast Ductal Carcinoma In Situ due to abnormalities in genes AFF1 and BRCA2 – Foods like Hazelnut are recommended compared to Macadamia Nut. This is because the active ingredients Palmitic Acid and Lauric Acid in Macadamia Nut further promote the effects of genes on the biochemical pathways. While the active ingredients Quercetin and Vitamin E contained in Hazelnut together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: HAZELNUT IS RECOMMENDED OVER MACADAMIA NUT FOR REDUCING THE GENETIC RISK OF BREAST DUCTAL CARCINOMA IN SITU DUE TO GENES AFF1 AND BRCA2
In Summary
An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.
“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.
The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.
You can get started NOW and design a personalized nutrition plan for Breast Ductal Carcinoma In Situ by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
References
- Msk Impact 2017
- Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients.
- Crystal structure of a human cyclin-dependent kinase 6 complex with a flavonol inhibitor, fisetin.
- Sensitivity of TP53-Mutated Cancer Cells to the Phytoestrogen Genistein Is Associated With Direct Inhibition of Plk1 Activity.
- New concepts in phospholipase D signaling in inflammation and cancer.
- Vitamin C enhances epigenetic modifications induced by 5-azacytidine and cell cycle arrest in the hepatocellular carcinoma cell lines HLE and Huh7.
- Transcriptional activation of the cyclin-dependent kinase inhibitor p21 by PML/RARalpha.
- Effects of folate deficiency on gene expression in the apoptosis and cancer pathways in colon cancer cells.
- Research progress on the anticancer effects of vitamin K2.
- Pelargonidin induces antitumor effects in human osteosarcoma cells via autophagy induction, loss of mitochondrial membrane potential, G2/M cell cycle arrest and downregulation of PI3K/AKT signalling pathway.
- β-Sitosterol targets Trx/Trx1 reductase to induce apoptosis in A549 cells via ROS mediated mitochondrial dysregulation and p53 activation.
- Resveratrol, a remarkable inhibitor of ribonucleotide reductase.
- Identification of ellagic acid as potent inhibitor of protein kinase CK2: a successful example of a virtual screening application.
- Luteoloside Inhibits Proliferation and Promotes Intrinsic and Extrinsic Pathway-Mediated Apoptosis Involving MAPK and mTOR Signaling Pathways in Human Cervical Cancer Cells.
- Gamma- and delta-tocotrienols exert a more potent anticancer effect than alpha-tocopheryl succinate on breast cancer cell lines irrespective of HER-2/neu expression.
- Functional lipidomics: Palmitic acid impairs hepatocellular carcinoma development by modulating membrane fluidity and glucose metabolism.
- Clinical pharmacodynamics of antihistamines.
- HyperFoods: Machine intelligent mapping of cancer-beating molecules in foods.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.