Which Foods are Recommended for Angiocentric Glioma?

Highlights

No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Angiocentric Glioma when undergoing chemotherapy or when you determine you have a genetic risk for developing Angiocentric Glioma because of NOTCH4 and YES1 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.

There is no one answer to this question for cancers such as Angiocentric Glioma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.

In short – the process to answer questions like “Should I Avoid eating fruit Currant” or “Include fruit Papaya in my diet” or “Should I reduce consumption of vegetable Spinach” or “Can I take Stevia and D-limonene supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.

RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO ANGIOCENTRIC GLIOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.

The overall objective of personalized nutrition for Angiocentric Glioma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.

RECOMMENDATION: UPDATE YOUR NUTRITION FOR ANGIOCENTRIC GLIOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.

About Angiocentric Glioma

cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.

Following key highlights are derived from clinical data for Angiocentric Glioma from cBioPortal. The patients enrolled in the studies for Angiocentric Glioma are in ages between 9 to 78 with an average age of 45. 47.1% of males and 52.9% of females were the distribution of gender in these clinical studies. From a patient sample size of 17; the top genes with mutations and other abnormalities for Angiocentric Glioma include genes KMT2D, KRAS, NOTCH4, TET2 and YES1. The occurrence frequency distribution for these genes respectively is 25.0%, 25.0%, 25.0%, 25.0% and 25.0%. These tumor genetic details of Angiocentric Glioma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Angiocentric Glioma.

Significance of Nutrition for Angiocentric Glioma

All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Angiocentric Glioma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.

For example Currant includes active ingredients Myricetin, Oleic Acid, Quercetin, Linolenic Acid, Caffeic Acid and others. And Papaya contains active ingredients Linalool, Lycopene, Benzyl Isothiocyanate, Oleic Acid, Linolenic Acid and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.

For cancers like Angiocentric Glioma, activation or inhibition of selected biochemical pathways like Oncogenic Cancer Epigenetics, PI3K-AKT-MTOR Signaling, Oncogenic Histone Methylation, MAPK Signaling plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Angiocentric Glioma, while eating some other foods and supplements may not be recommended.

One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.

RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR ANGIOCENTRIC GLIOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.

Foods for Angiocentric Glioma undergoing chemotherapy treatment

In Angiocentric Glioma – the genes KMT2D, KRAS, NOTCH4, TET2 and YES1 have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Angiocentric Glioma are Oncogenic Cancer Epigenetics, PI3K-AKT-MTOR Signaling, MAPK Signaling and others. Lomustine is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Oncogenic Cancer Epigenetics, PI3K-AKT-MTOR Signaling, MAPK Signaling so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.

RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.

Eat more pulses, Mung Bean or Common Bean?

Pulses are an important part of many diets. The active ingredients contained in Mung Bean are Glucaric Acid, Oleic Acid, Quercetin, Linolenic Acid, Vitexin among others. While the active ingredients contained in Common Bean are Apigenin, Oleic Acid, Linolenic Acid, Delphinidin, Ferulic Acid and others.

Glucaric Acid can manipulate biochemical pathways MAPK Signaling, MYC Signaling and PI3K-AKT-MTOR Signaling. Quercetin has biological action on biochemical pathways MAPK Signaling, MYC Signaling and PI3K-AKT-MTOR Signaling.

Genistein can manipulate biochemical pathways Oncogenic Cancer Epigenetics. Vitamin C has biological action on biochemical pathways Oncogenic Cancer Epigenetics. And so on.

When treating Angiocentric Glioma with chemotherapy Lomustine – Foods like Mung Bean are recommended compared to Common Bean. This is because the active ingredients Genistein and Vitamin C in Common Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Glucaric Acid and Quercetin contained in Mung Bean support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: MUNG BEAN IS RECOMMENDED OVER COMMON BEAN FOR ANGIOCENTRIC GLIOMA ON TREATMENT WITH CHEMOTHERAPY LOMUSTINE FOR SOME CONDITIONS.

Eat more vegetables, Green Bean or Spinach?

Vegetables are an important part of many diets. The active ingredients contained in Green Bean are Oleic Acid, Linolenic Acid, Beta-sitosterol, Ferulic Acid, Linoleic Acid among others. While the active ingredients contained in Spinach are Glucaric Acid, Apigenin, Oleic Acid, Quercetin, Linolenic Acid and others.

Vitamin A can manipulate biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. Ferulic Acid has biological action on biochemical pathways MAPK Signaling, MYC Signaling and PI3K-AKT-MTOR Signaling.

Vitamin C can manipulate biochemical pathways Oncogenic Cancer Epigenetics. Beta-sitosterol has biological action on biochemical pathways Oncogenic Cancer Epigenetics. And so on.

When treating Angiocentric Glioma with chemotherapy Lomustine – Foods like Green Bean are recommended compared to Spinach. This is because the active ingredients Vitamin C and Beta-sitosterol in Spinach interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin A and Ferulic Acid contained in Green Bean support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: GREEN BEAN IS RECOMMENDED OVER SPINACH FOR ANGIOCENTRIC GLIOMA ON TREATMENT WITH CHEMOTHERAPY LOMUSTINE FOR SOME CONDITIONS.

Eat more fruits, Papaya or Currant?

Fruits are an important part of many diets. The active ingredients contained in Papaya are Linalool, Lycopene, Benzyl Isothiocyanate, Oleic Acid, Linolenic Acid among others. While the active ingredients contained in Currant are Myricetin, Oleic Acid, Quercetin, Linolenic Acid, Caffeic Acid and others.

Lycopene can manipulate biochemical pathways MAPK Signaling, MYC Signaling and PI3K-AKT-MTOR Signaling. Zeaxanthin has biological action on biochemical pathways MAPK Signaling, MYC Signaling and PI3K-AKT-MTOR Signaling.

Vitamin C can manipulate biochemical pathways Oncogenic Cancer Epigenetics. Beta-sitosterol has biological action on biochemical pathways Oncogenic Cancer Epigenetics. And so on.

When treating Angiocentric Glioma with chemotherapy Lomustine – Foods like Papaya are recommended compared to Currant. This is because the active ingredients Vitamin C and Beta-sitosterol in Currant interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Lycopene and Zeaxanthin contained in Papaya support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: PAPAYA IS RECOMMENDED OVER CURRANT FOR ANGIOCENTRIC GLIOMA ON TREATMENT WITH CHEMOTHERAPY LOMUSTINE FOR SOME CONDITIONS.

Eat more nuts, Hazelnut or Chestnut?

Nuts are an important part of many diets. The active ingredients contained in Hazelnut are Vitamin E, Oleic Acid, Quercetin, Linolenic Acid, Linoleic Acid among others. While the active ingredients contained in Chestnut are Ellagic Acid, Oleic Acid, Quercetin, Linolenic Acid, Betulin and others.

Vitamin E can manipulate biochemical pathways MAPK Signaling, MYC Signaling and PI3K-AKT-MTOR Signaling. Quercetin has biological action on biochemical pathways MAPK Signaling, MYC Signaling and PI3K-AKT-MTOR Signaling.

Ellagic Acid can manipulate biochemical pathways MYC Signaling and Oncogenic Cancer Epigenetics. Vitamin C has biological action on biochemical pathways Oncogenic Cancer Epigenetics. And so on.

When treating Angiocentric Glioma with chemotherapy Lomustine – Foods like Hazelnut are recommended compared to Chestnut. This is because the active ingredients Ellagic Acid and Vitamin C in Chestnut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin E and Quercetin contained in Hazelnut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: HAZELNUT IS RECOMMENDED OVER CHESTNUT FOR ANGIOCENTRIC GLIOMA ON TREATMENT WITH CHEMOTHERAPY LOMUSTINE FOR SOME CONDITIONS.

Foods for Genetic Risk of Angiocentric Glioma

One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. NOTCH4 and YES1 are two genes whose abnormalities are risk factors for Angiocentric Glioma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Angiocentric Glioma can be used as a guide for coming up with a recommended personalized nutrition plan. For Angiocentric Glioma gene NOTCH4 has causative impact on biological pathways like Notch Signaling, Thyroid Hormone Signaling and Angiogenesis. And YES1 has a causative impact on biological pathways like CBL Signaling, Cytoskeletal Dynamics and Immune Checkpoints. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like NOTCH4 and YES1 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes NOTCH4 and YES1 should be avoided.

Eat more pulses, Lentils or Pigeon Pea?

The active ingredients contained in Lentils are Esculin, Ellagic Acid, Vitamin C, Daidzein, Beta-sitosterol among others. While the active ingredients contained in Pigeon Pea are Vitamin C, Linolenic Acid, Oleic Acid, Linoleic Acid, Genistein and others.

Esculin can manipulate biochemical pathways MAPK Signaling, Cell Cycle Checkpoints and MYC Signaling. Daidzein has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, Apoptosis and MAPK Signaling.

Folic Acid can manipulate biochemical pathways MAPK Signaling, Cell Cycle Checkpoints and RAS-RAF Signaling. And so on.

For genetic risk of Angiocentric Glioma due to abnormalities in genes NOTCH4 and YES1 – Foods like Lentils are recommended compared to Pigeon Pea. This is because the active ingredients Folic Acid in Pigeon Pea further promote the effects of genes on the biochemical pathways. While the active ingredients Esculin and Daidzein contained in Lentils together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: LENTILS IS RECOMMENDED OVER PIGEON PEA FOR REDUCING THE GENETIC RISK OF ANGIOCENTRIC GLIOMA DUE TO GENES NOTCH4 AND YES1

Eat more vegetables, Cassava or Jute?

The active ingredients contained in Cassava are Vitamin C, Beta-sitosterol, Linolenic Acid, Oleic Acid, Linoleic Acid among others. While the active ingredients contained in Jute are Vitamin C, Quercetin, Linolenic Acid, Oleic Acid, Vitamin B3 and others.

Vitamin A can manipulate biochemical pathways MYC Signaling, Apoptosis and Cell Cycle Checkpoints.

Folic Acid can manipulate biochemical pathways MAPK Signaling, Cell Cycle Checkpoints and RAS-RAF Signaling. And so on.

For genetic risk of Angiocentric Glioma due to abnormalities in genes NOTCH4 and YES1 – Foods like Cassava are recommended compared to Jute. This is because the active ingredients Folic Acid in Jute further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin A contained in Cassava together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: CASSAVA IS RECOMMENDED OVER JUTE FOR REDUCING THE GENETIC RISK OF ANGIOCENTRIC GLIOMA DUE TO GENES NOTCH4 AND YES1

Eat more fruits, Kiwi or Cranberry?

The active ingredients contained in Kiwi are Vitamin C, Quercetin, Chlorogenic Acid, Fisetin, Vitamin A among others. While the active ingredients contained in Cranberry are Ellagic Acid, Vitamin C, Quercetin, Hyperoside, Resveratrol and others.

Quercetin can manipulate biochemical pathways MAPK Signaling, Cell Cycle Checkpoints and RAS-RAF Signaling. Chlorogenic Acid has biological action on biochemical pathways MYC Signaling, Oncogenic Cancer Epigenetics and PI3K-AKT-MTOR Signaling.

Ellagic Acid can manipulate biochemical pathways MYC Signaling. Myricetin has biological action on biochemical pathways Oncogenic Cancer Epigenetics. And so on.

For genetic risk of Angiocentric Glioma due to abnormalities in genes NOTCH4 and YES1 – Foods like Kiwi are recommended compared to Cranberry. This is because the active ingredients Ellagic Acid and Myricetin in Cranberry further promote the effects of genes on the biochemical pathways. While the active ingredients Quercetin and Chlorogenic Acid contained in Kiwi together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: KIWI IS RECOMMENDED OVER CRANBERRY FOR REDUCING THE GENETIC RISK OF ANGIOCENTRIC GLIOMA DUE TO GENES NOTCH4 AND YES1

Eat more nuts, Pistachio or Macadamia Nut?

The active ingredients contained in Pistachio are Vitamin E, Beta-sitosterol, Linolenic Acid, Resveratrol, Stigmasterol among others. While the active ingredients contained in Macadamia Nut are Beta-sitosterol, Palmitic Acid, Lauric Acid, Myristic Acid, Folic Acid and others.

Vitamin E can manipulate biochemical pathways MAPK Signaling, Cell Cycle Checkpoints and MYC Signaling. Resveratrol has biological action on biochemical pathways RAS-RAF Signaling, PI3K-AKT-MTOR Signaling and Apoptosis.

Palmitic Acid can manipulate biochemical pathways MAPK Signaling and Oncogenic Cancer Epigenetics. Lauric Acid has biological action on biochemical pathways MYC Signaling, PI3K-AKT-MTOR Signaling and MAPK Signaling. And so on.

For genetic risk of Angiocentric Glioma due to abnormalities in genes NOTCH4 and YES1 – Foods like Pistachio are recommended compared to Macadamia Nut. This is because the active ingredients Palmitic Acid and Lauric Acid in Macadamia Nut further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin E and Resveratrol contained in Pistachio together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: PISTACHIO IS RECOMMENDED OVER MACADAMIA NUT FOR REDUCING THE GENETIC RISK OF ANGIOCENTRIC GLIOMA DUE TO GENES NOTCH4 AND YES1

In Summary

An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.

“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.

The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.

You can get started NOW and design a personalized nutrition plan for Angiocentric Glioma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

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