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What Foods are Recommended for Cancer?
is a very common question. Personalized Nutrition Plans are foods and supplements which are personalized to a cancer indication, genes, any treatments and lifestyle conditions.

Which Foods are Recommended for Anaplastic Thyroid Cancer?

Sep 1, 2022

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Highlights

No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Anaplastic Thyroid Cancer when undergoing chemotherapy or when you determine you have a genetic risk for developing Anaplastic Thyroid Cancer because of BRAF and NRAS gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.

There is no one answer to this question for cancers such as Anaplastic Thyroid Cancer which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.

In short – the process to answer questions like “Should I Avoid eating fruit Bael” or “Include fruit Saskatoon Berry in my diet” or “Should I reduce consumption of vegetable Carrot” or “Can I take D-limonene and Modified Citrus Pectin supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.

RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO ANAPLASTIC THYROID CANCER, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.

The overall objective of personalized nutrition for Anaplastic Thyroid Cancer is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.

RECOMMENDATION: UPDATE YOUR NUTRITION FOR ANAPLASTIC THYROID CANCER, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.



About Anaplastic Thyroid Cancer

cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.

Following key highlights are derived from clinical data for Anaplastic Thyroid Cancer from cBioPortal. The patients enrolled in the studies for Anaplastic Thyroid Cancer are in ages between 34 to 82 with an average age of 66. 54.2% of males and 45.8% of females were the distribution of gender in these clinical studies. From a patient sample size of 66; the top genes with mutations and other abnormalities for Anaplastic Thyroid Cancer include genes TERT, TP53, BRAF, NRAS and CREBBP. The occurrence frequency distribution for these genes respectively is 39.2%, 39.2%, 23.5%, 11.8% and 9.8%. These tumor genetic details of Anaplastic Thyroid Cancer are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Anaplastic Thyroid Cancer.

Significance of Nutrition for Anaplastic Thyroid Cancer

All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Anaplastic Thyroid Cancer. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.

For example Bael includes active ingredients Linolenic Acid, Chlorogenic Acid, Oleic Acid, Vitamin C, Auraptene and others. And Saskatoon Berry contains active ingredients Quercetin, Delphinidin and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.

For cancers like Anaplastic Thyroid Cancer, activation or inhibition of selected biochemical pathways like RAS-RAF Signaling, Inositol Phosphate Signaling, PI3K-AKT-MTOR Signaling, Apoptosis plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Anaplastic Thyroid Cancer, while eating some other foods and supplements may not be recommended.

One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.

For cancers like Anaplastic Thyroid Cancer, activation or inhibition of selected biochemical pathways like RAS-RAF Signaling, Inositol Phosphate Signaling, PI3K-AKT-MTOR Signaling, Apoptosis plays an important role in driving cancer growth.

RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR ANAPLASTIC THYROID CANCER – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.

Foods for Anaplastic Thyroid Cancer undergoing chemotherapy treatment

In Anaplastic Thyroid Cancer – the genes TERT, TP53, BRAF, NRAS and CREBBP have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Anaplastic Thyroid Cancer are RAS-RAF Signaling, Inositol Phosphate Signaling, MAPK Signaling and others. Dabrafenib is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers RAS-RAF Signaling, Inositol Phosphate Signaling, MAPK Signaling so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.

RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.

Eat more pulses, Mung Bean or Chickpea?

Pulses are an important part of many diets. The active ingredients contained in Mung Bean are Quercetin, Kaempferol, Linolenic Acid, Oleic Acid, Vitamin C among others. While the active ingredients contained in Chickpea are Linolenic Acid, Oleic Acid, Genistein, Vitamin A, Folic Acid and others.

Quercetin can manipulate biochemical pathways WNT Beta Catenin Signaling, MAPK Signaling and Angiogenesis. Kaempferol has biological action on biochemical pathways RAS-RAF Signaling, JAK-STAT Signaling and PI3K-AKT-MTOR Signaling.

Genistein can manipulate biochemical pathways DNA Repair. Vitamin A has biological action on biochemical pathways Oxidative Stress and PI3K-AKT-MTOR Signaling. And so on.

When treating Anaplastic Thyroid Cancer with chemotherapy Dabrafenib – Foods like Mung Bean are recommended compared to Chickpea. This is because the active ingredients Genistein and Vitamin A in Chickpea interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Quercetin and Kaempferol contained in Mung Bean support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: MUNG BEAN IS RECOMMENDED OVER CHICKPEA FOR ANAPLASTIC THYROID CANCER ON TREATMENT WITH CHEMOTHERAPY DABRAFENIB FOR SOME CONDITIONS.

Eat more vegetables, Cassava or Carrot?

Vegetables are an important part of many diets. The active ingredients contained in Cassava are Linolenic Acid, Oleic Acid, Vitamin C, Beta-sitosterol, Linoleic Acid among others. While the active ingredients contained in Carrot are D-limonene, Quercetin, Lycopene, Caffeic Acid, Linalool and others.

Vitamin C can manipulate biochemical pathways WNT Beta Catenin Signaling, MAPK Signaling and Angiogenesis. Beta-sitosterol has biological action on biochemical pathways MYC Signaling, Cell Survival and Inositol Phosphate Signaling.

Eugenol can manipulate biochemical pathways Oxidative Stress. Beta-caryophyllene has biological action on biochemical pathways Oxidative Stress. And so on.

When treating Anaplastic Thyroid Cancer with chemotherapy Dabrafenib – Foods like Cassava are recommended compared to Carrot. This is because the active ingredients Eugenol and Beta-caryophyllene in Carrot interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Beta-sitosterol contained in Cassava support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: CASSAVA IS RECOMMENDED OVER CARROT FOR ANAPLASTIC THYROID CANCER ON TREATMENT WITH CHEMOTHERAPY DABRAFENIB FOR SOME CONDITIONS.

Which Foods are Recommended for Anaplastic Thyroid Cancer?

Eat more fruits, Saskatoon Berry or Bael?

Fruits are an important part of many diets. The active ingredients contained in Saskatoon Berry are Quercetin, Delphinidin among others. While the active ingredients contained in Bael are Linolenic Acid, Chlorogenic Acid, Oleic Acid, Vitamin C, Auraptene and others.

Delphinidin can manipulate biochemical pathways MAPK Signaling, Angiogenesis and RAS-RAF Signaling. Quercetin has biological action on biochemical pathways WNT Beta Catenin Signaling, Insulin Signaling and JAK-STAT Signaling.

Auraptene can manipulate biochemical pathways Oxidative Stress. Chlorogenic Acid has biological action on biochemical pathways Cell Junctions and Insulin Signaling. And so on.

When treating Anaplastic Thyroid Cancer with chemotherapy Dabrafenib – Foods like Saskatoon Berry are recommended compared to Bael. This is because the active ingredients Auraptene and Chlorogenic Acid in Bael interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Delphinidin and Quercetin contained in Saskatoon Berry support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: SASKATOON BERRY IS RECOMMENDED OVER BAEL FOR ANAPLASTIC THYROID CANCER ON TREATMENT WITH CHEMOTHERAPY DABRAFENIB FOR SOME CONDITIONS.

Eat more nuts, Almond or Brazil Nut?

Nuts are an important part of many diets. The active ingredients contained in Almond are Quercetin, Vitamin E, Linolenic Acid, Oleic Acid, Salicylic Acid among others. While the active ingredients contained in Brazil Nut are Vitamin E, Linolenic Acid, Oleic Acid, Lecithin, Folic Acid and others.

Beta-sitosterol can manipulate biochemical pathways WNT Beta Catenin Signaling, Angiogenesis and MYC Signaling. Quercetin has biological action on biochemical pathways MAPK Signaling, Insulin Signaling and RAS-RAF Signaling.

Lecithin can manipulate biochemical pathways MAPK Signaling, RAS-RAF Signaling and Cytoskeletal Dynamics. Oleic Acid has biological action on biochemical pathways Oxidative Stress, Cell Junctions and Cytoskeletal Dynamics. And so on.

When treating Anaplastic Thyroid Cancer with chemotherapy Dabrafenib – Foods like Almond are recommended compared to Brazil Nut. This is because the active ingredients Lecithin and Oleic Acid in Brazil Nut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Quercetin contained in Almond support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: ALMOND IS RECOMMENDED OVER BRAZIL NUT FOR ANAPLASTIC THYROID CANCER ON TREATMENT WITH CHEMOTHERAPY DABRAFENIB FOR SOME CONDITIONS.

Foods for Genetic Risk of Anaplastic Thyroid Cancer

One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. BRAF and NRAS are two genes whose abnormalities are risk factors for Anaplastic Thyroid Cancer. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Anaplastic Thyroid Cancer can be used as a guide for coming up with a recommended personalized nutrition plan. For Anaplastic Thyroid Cancer gene BRAF has causative impact on biological pathways like RAS-RAF Signaling, MAPK Signaling and Antigen Presentation. And NRAS has a causative impact on biological pathways like G-protein-coupled Receptor Signaling, Growth Factor Signaling and RAS-RAF Signaling. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like BRAF and NRAS should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes BRAF and NRAS should be avoided.

Eat more pulses, Winged Bean or Adzuki Bean?

The active ingredients contained in Winged Bean are Betulinic Acid, Oleic Acid, Linolenic Acid, Vitamin C, Linoleic Acid among others. While the active ingredients contained in Adzuki Bean are Isoliquiritigenin, Glucaric Acid, Genistein, Folic Acid and others.

Betulinic Acid can manipulate biochemical pathways MAPK Signaling, Cell Cycle Checkpoints and P53 Signaling. Vitamin C has biological action on biochemical pathways RAS-RAF Signaling, MYC Signaling and PI3K-AKT-MTOR Signaling.

Folic Acid can manipulate biochemical pathways MAPK Signaling, Cell Cycle Checkpoints and RAS-RAF Signaling. And so on.

For genetic risk of Anaplastic Thyroid Cancer due to abnormalities in genes BRAF and NRAS – Foods like Winged Bean are recommended compared to Adzuki Bean. This is because the active ingredients Folic Acid in Adzuki Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Betulinic Acid and Vitamin C contained in Winged Bean together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: WINGED BEAN IS RECOMMENDED OVER ADZUKI BEAN FOR REDUCING THE GENETIC RISK OF ANAPLASTIC THYROID CANCER DUE TO GENES BRAF AND NRAS

Eat more vegetables, Giant Butterbur or Celery?

The active ingredients contained in Giant Butterbur are Beta-sitosterol, Vitamin C, Vitamin B3, Kaempferol, Melatonin among others. While the active ingredients contained in Celery are Apigenin, Quercetin, Oleic Acid, Linolenic Acid, Vitamin C and others.

Vitamin C can manipulate biochemical pathways MAPK Signaling, Cell Cycle Checkpoints and RAS-RAF Signaling. Beta-sitosterol has biological action on biochemical pathways P53 Signaling, MYC Signaling and PI3K-AKT-MTOR Signaling.

Luteolin can manipulate biochemical pathways MYC Signaling. Chrysin has biological action on biochemical pathways MYC Signaling. And so on.

For genetic risk of Anaplastic Thyroid Cancer due to abnormalities in genes BRAF and NRAS – Foods like Giant Butterbur are recommended compared to Celery. This is because the active ingredients Luteolin and Chrysin in Celery further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Giant Butterbur together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: GIANT BUTTERBUR IS RECOMMENDED OVER CELERY FOR REDUCING THE GENETIC RISK OF ANAPLASTIC THYROID CANCER DUE TO GENES BRAF AND NRAS

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.

Eat more fruits, Orange or Cranberry?

The active ingredients contained in Orange are D-limonene, Linalool, Modified Citrus Pectin, Oleic Acid, Linolenic Acid among others. While the active ingredients contained in Cranberry are Ellagic Acid, Myricetin, Quercetin, Resveratrol, Hyperoside and others.

D-limonene can manipulate biochemical pathways MAPK Signaling, Cell Cycle Checkpoints and RAS-RAF Signaling. Vitamin C has biological action on biochemical pathways P53 Signaling, MYC Signaling and PI3K-AKT-MTOR Signaling.

Ellagic Acid can manipulate biochemical pathways MYC Signaling. Resveratrol has biological action on biochemical pathways P53 Signaling. And so on.

For genetic risk of Anaplastic Thyroid Cancer due to abnormalities in genes BRAF and NRAS – Foods like Orange are recommended compared to Cranberry. This is because the active ingredients Ellagic Acid and Resveratrol in Cranberry further promote the effects of genes on the biochemical pathways. While the active ingredients D-limonene and Vitamin C contained in Orange together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: ORANGE IS RECOMMENDED OVER CRANBERRY FOR REDUCING THE GENETIC RISK OF ANAPLASTIC THYROID CANCER DUE TO GENES BRAF AND NRAS

Eat more nuts, Pistachio or Macadamia Nut?

The active ingredients contained in Pistachio are Vitamin E, Resveratrol, Beta-sitosterol, Oleic Acid, Linolenic Acid among others. While the active ingredients contained in Macadamia Nut are Palmitic Acid, Beta-sitosterol, Lauric Acid, Myristic Acid, Folic Acid and others.

Beta-sitosterol can manipulate biochemical pathways Cell Cycle Checkpoints, P53 Signaling and MYC Signaling. Vitamin E has biological action on biochemical pathways MAPK Signaling, RAS-RAF Signaling and PI3K-AKT-MTOR Signaling.

Palmitic Acid can manipulate biochemical pathways MAPK Signaling. Lauric Acid has biological action on biochemical pathways MYC Signaling, PI3K-AKT-MTOR Signaling and MAPK Signaling. And so on.

For genetic risk of Anaplastic Thyroid Cancer due to abnormalities in genes BRAF and NRAS – Foods like Pistachio are recommended compared to Macadamia Nut. This is because the active ingredients Palmitic Acid and Lauric Acid in Macadamia Nut further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin E contained in Pistachio together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: PISTACHIO IS RECOMMENDED OVER MACADAMIA NUT FOR REDUCING THE GENETIC RISK OF ANAPLASTIC THYROID CANCER DUE TO GENES BRAF AND NRAS


In Summary

An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.

“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.

The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.

You can get started NOW and design a personalized nutrition plan for Anaplastic Thyroid Cancer by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

sample-report


References

Personalized Nutrition for Cancer!

Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.


Scientifically Reviewed by: Dr. Cogle

Christopher R. Cogle, M.D. is a tenured professor at the University of Florida, Chief Medical Officer of Florida Medicaid, and Director of the Florida Health Policy Leadership Academy at the Bob Graham Center for Public Service.

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