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What Foods are Recommended for Cancer?
is a very common question. Personalized Nutrition Plans are foods and supplements which are personalized to a cancer indication, genes, any treatments and lifestyle conditions.

Foods for Anaplastic Thyroid Cancer!

Aug 4, 2023

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Introduction

Foods for Anaplastic Thyroid Cancer should be personalized for each individual and also must adapt when cancer treatment or tumor genetic change. The personalization and adaptation must consider all the active ingredients or bioactives contained in different foods with respect to cancer tissue biology, genetics, treatments, lifestyle conditions and diet preferences. Hence while nutrition is one of the very important decisions for a cancer patient and individual at risk of cancer to make – how to choose foods to eat is not an easy task.



For Anaplastic Thyroid Cancer does it matter what vegetables, fruits, nuts, seeds one eats?

A very common nutrition question asked by cancer patients and individuals at-genetic risk of cancer is – for cancers like Anaplastic Thyroid Cancer does it matter what foods I eat and which I do not? Or if I follow a plant-based diet is that enough for cancer like Anaplastic Thyroid Cancer?

For example does it matter if vegetable Cauliflower is consumed more compared to Arrowhead? Does it make any difference if fruit Pummelo is preferred over Sour Cherry? Also if similar choices are made for nuts/seeds like Butternut over Flaxseed and for pulses like Black-eyed Pea over Lima Bean. And if what I eat matters – then how does one identify foods which are recommended for Anaplastic Thyroid Cancer and is it the same answer for everyone with the same diagnosis or genetic risk?

Yes! Foods you eat matters for Anaplastic Thyroid Cancer!

Food recommendations may not be the same for everyone and can be different even for the same diagnosis and genetic risk.

All cancers like Anaplastic Thyroid Cancer can be characterized by a unique set of biochemical pathways - the signature pathways of Anaplastic Thyroid Cancer. Biochemical pathways like RAS-RAF Signaling, Inositol Phosphate Signaling, PI3K-AKT-MTOR Signaling, Apoptosis are part of the signature definition of Anaplastic Thyroid Cancer.

All foods (vegetables, fruits, nuts, seeds, pulses, oils etc.) and nutritional supplements are made up of more than one active molecular ingredient or bio-actives in different proportions and quantities. Each active ingredient has a unique mechanism of action – which can be activation or inhibition of different biochemical pathways. Simply stated foods and supplements which are recommended are those which do not cause an increase of molecular drivers of cancer but reduce them. Else those foods should not be recommended. Foods contain multiple active ingredients – hence when evaluating foods and supplements you need to consider the impact of all active ingredients cumulatively rather than individually.

For example Pummelo contains active ingredients Quercetin, Curcumin, Isoliquiritigenin, Caffeine, Formononetin. And Sour Cherry contains active ingredients Quercetin, Curcumin, Isoliquiritigenin, Formononetin, Linalool and possibly others.

A common mistake made when deciding and choosing foods to eat for Anaplastic Thyroid Cancer – is to evaluate only selected active ingredients contained in foods and ignore the rest. Because different active ingredients contained in foods may have opposing effects on cancer drivers – you cannot cherry pick active ingredients in foods and supplements for making a nutrition decision for Anaplastic Thyroid Cancer.

YES – FOOD CHOICES MATTER FOR CANCER. NUTRITION DECISIONS MUST CONSIDER ALL ACTIVE INGREDIENTS OF FOODS.

Skills Needed for Nutrition Personalization for Anaplastic Thyroid Cancer?

Personalized nutrition for cancers like Anaplastic Thyroid Cancer consists of recommended foods / supplements; not recommended foods / supplements with example recipes which prioritize use of recommended foods. An example of personalized nutrition can be seen at this link.

Deciding which foods are recommended or not is extremely complicated, requiring expertise in Anaplastic Thyroid Cancer biology, food science, genetics, biochemistry along with good understanding of how cancer treatments work and associated vulnerabilities by which the treatments could stop being effective.

MINIMUM KNOWLEDGE EXPERTISE NEEDED FOR NUTRITION PERSONALIZATION FOR CANCER ARE: CANCER BIOLOGY, FOOD SCIENCE, CANCER TREATMENTS AND GENETICS.

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.

Characteristics of cancers like Anaplastic Thyroid Cancer

All cancers like Anaplastic Thyroid Cancer can be characterized by a unique set of biochemical pathways – the signature pathways of Anaplastic Thyroid Cancer. Biochemical pathways like RAS-RAF Signaling, Inositol Phosphate Signaling, PI3K-AKT-MTOR Signaling, Apoptosis are part of the signature definition of Anaplastic Thyroid Cancer. Each individual’s cancer genetics can be different and hence their specific cancer signature could be unique.

The treatments which are effective for Anaplastic Thyroid Cancer need to be cognizant of the associated signature biochemical pathways for each cancer patient and individual at genetic risk. Therefore different treatments with different mechanisms of actions are effective for different patients. Similarly and for the same reasons foods and supplements need to be personalized for each individual. Hence some foods and supplements are recommended for Anaplastic Thyroid Cancer when taking cancer treatment Trametinib, and some foods and supplements are not recommended.

Sources like cBioPortal and many others provide population representative patient anonymized data from clinical trials for all cancer indications. This data consists of clinical trial study details like sample size / number of patients, age groups, gender, ethnicity, treatments, tumor site and any genetic mutations.

TERT, TP53, BRAF, NRAS and CREBBP are the top ranked reported genes for Anaplastic Thyroid Cancer. TERT is reported in 39.2 % of the representative patients across all clinical trials. And TP53 is reported in 39.2 %. The combined population patient data cover ages from 34 to 82. 54.2 % of the patient data are identified as men. The Anaplastic Thyroid Cancer biology along with reported genetics together define the population represented signature biochemical pathways for this cancer. If the individual cancer tumor genetics or genes contributing to the risk are also known then that should also be used for nutrition personalization.

NUTRITION CHOICES SHOULD MATCH WITH EACH INDIVIDUAL’S CANCER SIGNATURE.

Foods for Anaplastic Thyroid Cancer!

Food and Supplements for Anaplastic Thyroid Cancer

For Cancer Patients

Cancer patients on treatment or on palliative care need to make decisions on food and supplements – for the needed dietary calories, for managing any treatment side effects and also for improved cancer management. All plant-based foods are not equal and choosing and prioritizing foods which are personalized and customized to ongoing cancer treatment is important and complicated. Here are some examples providing guidelines for making nutrition decisions.

Choose Vegetable CAULIFLOWER or ARROWHEAD?

Vegetable Cauliflower contains many active ingredients or bioactives such as Curcumin, Isoliquiritigenin, Formononetin, Catechol, Delphinidin. These active ingredients manipulate various biochemical pathways like Angiogenesis, Inositol Phosphate Signaling, RAS-RAF Signaling and JAK-STAT Signaling and others. Cauliflower is recommended for Anaplastic Thyroid Cancer when ongoing cancer treatment is Trametinib. This is because Cauliflower modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Trametinib.

Some of the active ingredients or bioactives in vegetable Arrowhead are Curcumin, Myricetin, Isoliquiritigenin, Caffeine, Formononetin. These active ingredients manipulate various biochemical pathways like PI3K-AKT-MTOR Signaling and DNA Repair and others. Arrowhead is not recommended for Anaplastic Thyroid Cancer when ongoing cancer treatment is Trametinib because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

VEGETABLE CAULIFLOWER IS RECOMMENDED OVER ARROWHEAD FOR Anaplastic Thyroid Cancer AND TREATMENT Trametinib.

Choose Fruit SOUR CHERRY or PUMMELO?

Fruit Sour Cherry contains many active ingredients or bioactives such as Quercetin, Curcumin, Isoliquiritigenin, Formononetin, Linalool. These active ingredients manipulate various biochemical pathways like Angiogenesis, PI3K-AKT-MTOR Signaling and MAPK Signaling and others. Sour Cherry is recommended for Anaplastic Thyroid Cancer when ongoing cancer treatment is Trametinib. This is because Sour Cherry modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Trametinib.

Some of the active ingredients or bioactives in fruit Pummelo are Quercetin, Curcumin, Isoliquiritigenin, Caffeine, Formononetin. These active ingredients manipulate various biochemical pathways like WNT Beta Catenin Signaling and DNA Repair and others. Pummelo is not recommended for Anaplastic Thyroid Cancer when ongoing cancer treatment is Trametinib because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

FRUIT SOUR CHERRY IS RECOMMENDED OVER PUMMELO FOR Anaplastic Thyroid Cancer AND TREATMENT Trametinib.

Choose Nut BUTTERNUT or FLAXSEED?

Butternut contains many active ingredients or bioactives such as Curcumin, Myricetin, Isoliquiritigenin, Caffeine, Formononetin. These active ingredients manipulate various biochemical pathways like PI3K-AKT-MTOR Signaling, JAK-STAT Signaling and Insulin Signaling and others. Butternut is recommended for Anaplastic Thyroid Cancer when ongoing cancer treatment is Trametinib. This is because Butternut modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Trametinib.

Some of the active ingredients or bioactives in Flaxseed are Curcumin, Myricetin, Isoliquiritigenin, Formononetin, Catechol. These active ingredients manipulate various biochemical pathways like JAK-STAT Signaling, PI3K-AKT-MTOR Signaling and DNA Repair and others. Flaxseed is not recommended for Anaplastic Thyroid Cancer when ongoing cancer treatment is Trametinib because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

BUTTERNUT IS RECOMMENDED OVER FLAXSEED FOR Anaplastic Thyroid Cancer AND TREATMENT Trametinib.

For Individuals with Genetic Risk of Cancer

The question asked by individuals who have genetic risk of Anaplastic Thyroid Cancer or familial history is “What Should I Eat Differently from Before?” and how they should choose foods and supplements to manage risks of the disease. Since for cancer risk there is nothing actionable in terms of treatment – decisions of foods and supplements become important and one of the very few actionable things which can be done. All plant-based foods are not equal and based on identified genetics and pathway signature – the choices of food and supplements should be personalized.

Choose Vegetable BITTER GOURD or ROCKET SALAD (SSP.)?

Vegetable Bitter Gourd contains many active ingredients or bioactives such as Curcumin, Apigenin, Myricetin, Formononetin, Lupeol. These active ingredients manipulate various biochemical pathways like RAS-RAF Signaling, JAK-STAT Signaling, PI3K-AKT-MTOR Signaling and Growth Factor Signaling and others. Bitter Gourd is recommended for risk of Anaplastic Thyroid Cancer when associated genetic risk is BRAF. This is because Bitter Gourd increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in vegetable Rocket Salad (ssp.) are Curcumin, Quercetin, Apigenin, Myricetin, Lycopene. These active ingredients manipulate various biochemical pathways like TGFB Signaling and Oncogenic Cancer Epigenetics and others. Rocket Salad (ssp.) is not recommended when risk of Anaplastic Thyroid Cancer when associated genetic risk is BRAF because it increases the signature pathways of it.

VEGETABLE BITTER GOURD IS RECOMMENDED OVER ROCKET SALAD (SSP.) FOR BRAF GENETIC RISK OF CANCER.

Choose Fruit RED RASPBERRY or FIG?

Fruit Red Raspberry contains many active ingredients or bioactives such as Ellagic Acid, Curcumin, Quercetin, Formononetin, Lupeol. These active ingredients manipulate various biochemical pathways like Angiogenesis, RAS-RAF Signaling, JAK-STAT Signaling and PI3K-AKT-MTOR Signaling and others. Red Raspberry is recommended for risk of Anaplastic Thyroid Cancer when associated genetic risk is BRAF. This is because Red Raspberry increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in fruit Fig are Curcumin, Quercetin, Linalool, Lycopene, Formononetin. These active ingredients manipulate various biochemical pathways like TGFB Signaling, PI3K-AKT-MTOR Signaling and Growth Factor Signaling and others. Fig is not recommended when risk of Anaplastic Thyroid Cancer when associated genetic risk is BRAF because it increases the signature pathways of it.

FRUIT RED RASPBERRY IS RECOMMENDED OVER FIG FOR BRAF GENETIC RISK OF CANCER.

Choose Nut COMMON HAZELNUT or EUROPEAN CHESTNUT?

Common Hazelnut contains many active ingredients or bioactives such as Curcumin, Quercetin, Myricetin, Lycopene, Formononetin. These active ingredients manipulate various biochemical pathways like Angiogenesis, RAS-RAF Signaling, JAK-STAT Signaling and PI3K-AKT-MTOR Signaling and others. Common Hazelnut is recommended for risk of Anaplastic Thyroid Cancer when associated genetic risk is BRAF. This is because Common Hazelnut increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in European Chestnut are Ellagic Acid, Curcumin, Quercetin, Apigenin, Myricetin. These active ingredients manipulate various biochemical pathways like TGFB Signaling and Oncogenic Cancer Epigenetics and others. European Chestnut is not recommended when risk of Anaplastic Thyroid Cancer when associated genetic risk is BRAF because it increases the signature pathways of it.

COMMON HAZELNUT IS RECOMMENDED OVER EUROPEAN CHESTNUT FOR BRAF GENETIC RISK OF CANCER.


In Conclusion

Foods and Supplements chosen are important decisions for cancers like Anaplastic Thyroid Cancer. Anaplastic Thyroid Cancer patients and individuals with genetic-risk always have this question: “What foods and nutritional supplements are recommended for me and which are not?” There is a common belief which is a misconception that all plant-based foods could be beneficial or not but would not be harmful. Certain foods and supplements can interfere with cancer treatments or promote molecular pathway drivers of cancer.

There are different types of cancer indications like Anaplastic Thyroid Cancer, each with different tumor genetics with further genomic variations across each individual. Further every cancer treatment and chemotherapy has a unique mechanism of action. Each food like Cauliflower contains various bioactives in different quantities, which have an impact on different and distinct sets of biochemical pathways. The definition of personalized nutrition is individualized food recommendations for the cancer indication, treatments, genetics, lifestyle and other factors. Nutrition personalization decisions for cancer require knowledge of cancer biology, food science and an understanding of different chemotherapy treatments. Finally when there are treatment changes or new genomics is identified – the nutrition personalization needs re-evaluation.

The addon nutrition personalization solution makes the decision making easy and removes all the guesswork in answering the question, “What foods should I choose or not choose for Anaplastic Thyroid Cancer?”. The addon multi-disciplinary team includes cancer physicians, clinical scientists, software engineers and data scientists.


Personalized Nutrition for Cancer!

Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.

References

Scientifically Reviewed by: Dr. Cogle

Christopher R. Cogle, M.D. is a tenured professor at the University of Florida, Chief Medical Officer of Florida Medicaid, and Director of the Florida Health Policy Leadership Academy at the Bob Graham Center for Public Service.

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