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What Foods are Recommended for Cancer?
is a very common question. Personalized Nutrition Plans are foods and supplements which are personalized to a cancer indication, genes, any treatments and lifestyle conditions.

Which Foods are Recommended for Ampullary Carcinoma?

Sep 1, 2022

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Highlights

No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Ampullary Carcinoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Ampullary Carcinoma because of APC and SMAD4 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.

There is no one answer to this question for cancers such as Ampullary Carcinoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.

In short – the process to answer questions like “Should I Avoid eating fruit Lingonberry” or “Include fruit Nance in my diet” or “Should I reduce consumption of vegetable Cauliflower” or “Can I take Birch and Neem Extract supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.

RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO AMPULLARY CARCINOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.

The overall objective of personalized nutrition for Ampullary Carcinoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.

RECOMMENDATION: UPDATE YOUR NUTRITION FOR AMPULLARY CARCINOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.



About Ampullary Carcinoma

cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.

Following key highlights are derived from clinical data for Ampullary Carcinoma from cBioPortal. The patients enrolled in the studies for Ampullary Carcinoma are in ages between 32 to 87 with an average age of 66. 62.3% of males and 37.7% of females were the distribution of gender in these clinical studies. From a patient sample size of 238; the top genes with mutations and other abnormalities for Ampullary Carcinoma include genes TP53, KRAS, APC, SMAD4 and PIK3CA. The occurrence frequency distribution for these genes respectively is 56.2%, 48.9%, 20.5%, 16.5% and 11.9%. These tumor genetic details of Ampullary Carcinoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Ampullary Carcinoma.

Significance of Nutrition for Ampullary Carcinoma

All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Ampullary Carcinoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.

For example Lingonberry includes active ingredients Quercetin, Hyperoside, Resveratrol, Linolenic Acid, Caffeic Acid and others. And Nance contains active ingredients Vitamin C, Betulin, Vitamin A and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.

For cancers like Ampullary Carcinoma, activation or inhibition of selected biochemical pathways like Cell Cycle, Nucleotide Metabolism, PI3K-AKT-MTOR Signaling, MAPK Signaling plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Ampullary Carcinoma, while eating some other foods and supplements may not be recommended.

One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.

For cancers like Ampullary Carcinoma, activation or inhibition of selected biochemical pathways like Cell Cycle, Nucleotide Metabolism, PI3K-AKT-MTOR Signaling, MAPK Signaling plays an important role in driving cancer growth.

RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR AMPULLARY CARCINOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.

Foods for Ampullary Carcinoma undergoing chemotherapy treatment

In Ampullary Carcinoma – the genes TP53, KRAS, APC, SMAD4 and PIK3CA have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Ampullary Carcinoma are Cell Cycle, Nucleotide Metabolism, Apoptosis and others. Cisplatin is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Cell Cycle, Nucleotide Metabolism, Apoptosis so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.

RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.

Eat more pulses, Yellow Wax Bean or Pigeon Pea?

Pulses are an important part of many diets. The active ingredients contained in Yellow Wax Bean are Ferulic Acid, Vitamin C, Cianidanol, Vitamin A, Palmitic Acid among others. While the active ingredients contained in Pigeon Pea are Linolenic Acid, Oleic Acid, Vitamin C, Linoleic Acid, Genistein and others.

Vitamin A can manipulate biochemical pathways WNT Beta Catenin Signaling, Cell Cycle Checkpoints and NFKB Signaling. Palmitic Acid has biological action on biochemical pathways JAK-STAT Signaling, P53 Signaling and MYC Signaling.

Genistein can manipulate biochemical pathways Oxidative Stress, DNA Repair and Nutrient sensing. Linolenic Acid has biological action on biochemical pathways Vitamin D Signaling and Oxidative Stress. And so on.

When treating Ampullary Carcinoma with chemotherapy Cisplatin – Foods like Yellow Wax Bean are recommended compared to Pigeon Pea. This is because the active ingredients Genistein and Linolenic Acid in Pigeon Pea interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin A and Palmitic Acid contained in Yellow Wax Bean support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: YELLOW WAX BEAN IS RECOMMENDED OVER PIGEON PEA FOR AMPULLARY CARCINOMA ON TREATMENT WITH CHEMOTHERAPY CISPLATIN FOR SOME CONDITIONS.

Eat more vegetables, Giant Butterbur or Cauliflower?

Vegetables are an important part of many diets. The active ingredients contained in Giant Butterbur are Beta-sitosterol, Vitamin C, Vitamin A, Melatonin, Vitamin B3 among others. While the active ingredients contained in Cauliflower are Beta-sitosterol, Brassinin, Indole-3-carbinol, Linolenic Acid, Oleic Acid and others.

Vitamin C can manipulate biochemical pathways WNT Beta Catenin Signaling, MAPK Signaling and Nutrient sensing. Beta-sitosterol has biological action on biochemical pathways Cell Cycle Checkpoints, NFKB Signaling and Amino Acid Metabolism.

Brassinin can manipulate biochemical pathways Oxidative Stress. Citric Acid has biological action on biochemical pathways Oxidative Stress. And so on.

When treating Ampullary Carcinoma with chemotherapy Cisplatin – Foods like Giant Butterbur are recommended compared to Cauliflower. This is because the active ingredients Brassinin and Citric Acid in Cauliflower interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Beta-sitosterol contained in Giant Butterbur support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: GIANT BUTTERBUR IS RECOMMENDED OVER CAULIFLOWER FOR AMPULLARY CARCINOMA ON TREATMENT WITH CHEMOTHERAPY CISPLATIN FOR SOME CONDITIONS.

Which Foods are Recommended for Ampullary Carcinoma?

Eat more fruits, Nance or Lingonberry?

Fruits are an important part of many diets. The active ingredients contained in Nance are Vitamin C, Betulin, Vitamin A among others. While the active ingredients contained in Lingonberry are Quercetin, Hyperoside, Resveratrol, Linolenic Acid, Caffeic Acid and others.

Vitamin C can manipulate biochemical pathways WNT Beta Catenin Signaling, MAPK Signaling and Nutrient sensing. Betulin has biological action on biochemical pathways MYC Signaling, Hypoxia and Epithelial to Mesenchymal Transition.

Quercetin can manipulate biochemical pathways Oxidative Stress. Hyperoside has biological action on biochemical pathways Oxidative Stress. And so on.

When treating Ampullary Carcinoma with chemotherapy Cisplatin – Foods like Nance are recommended compared to Lingonberry. This is because the active ingredients Quercetin and Hyperoside in Lingonberry interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Betulin contained in Nance support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: NANCE IS RECOMMENDED OVER LINGONBERRY FOR AMPULLARY CARCINOMA ON TREATMENT WITH CHEMOTHERAPY CISPLATIN FOR SOME CONDITIONS.

Eat more nuts, Walnut or Macadamia Nut?

Nuts are an important part of many diets. The active ingredients contained in Walnut are Quercetin, Ellagic Acid, Betulinic Acid, Vitamin E, D-limonene among others. While the active ingredients contained in Macadamia Nut are Beta-sitosterol, Palmitic Acid, Lauric Acid, Myristic Acid, Folic Acid and others.

Ellagic Acid can manipulate biochemical pathways MAPK Signaling, Cell Cycle Checkpoints and NFKB Signaling. D-limonene has biological action on biochemical pathways Nutrient sensing, Amino Acid Metabolism and P53 Signaling.

Lauric Acid can manipulate biochemical pathways MAPK Signaling, MYC Signaling and NFKB Signaling. Myristic Acid has biological action on biochemical pathways Cell Cycle Checkpoints, P53 Signaling and RUNX Signaling. And so on.

When treating Ampullary Carcinoma with chemotherapy Cisplatin – Foods like Walnut are recommended compared to Macadamia Nut. This is because the active ingredients Lauric Acid and Myristic Acid in Macadamia Nut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Ellagic Acid and D-limonene contained in Walnut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: WALNUT IS RECOMMENDED OVER MACADAMIA NUT FOR AMPULLARY CARCINOMA ON TREATMENT WITH CHEMOTHERAPY CISPLATIN FOR SOME CONDITIONS.

Foods for Genetic Risk of Ampullary Carcinoma

One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. APC and SMAD4 are two genes whose abnormalities are risk factors for Ampullary Carcinoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Ampullary Carcinoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Ampullary Carcinoma gene APC has causative impact on biological pathways like Angiogenesis and Growth Factor Signaling. And SMAD4 has a causative impact on biological pathways like TGFB Signaling, Inflammation and Cell Cycle. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like APC and SMAD4 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes APC and SMAD4 should be avoided.

Eat more pulses, Mung Bean or Chickpea?

The active ingredients contained in Mung Bean are Vitamin C, Oleic Acid, Linolenic Acid, Stigmasterol, Vitexin among others. While the active ingredients contained in Chickpea are Oleic Acid, Linolenic Acid, Genistein, Vitamin A, Folic Acid and others.

Vitamin C can manipulate biochemical pathways MAPK Signaling, Cell Cycle Checkpoints and RAS-RAF Signaling. Stigmasterol has biological action on biochemical pathways P53 Signaling, MYC Signaling and PI3K-AKT-MTOR Signaling.

Folic Acid can manipulate biochemical pathways MAPK Signaling, Cell Cycle Checkpoints and RAS-RAF Signaling. And so on.

For genetic risk of Ampullary Carcinoma due to abnormalities in genes APC and SMAD4 – Foods like Mung Bean are recommended compared to Chickpea. This is because the active ingredients Folic Acid in Chickpea further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Stigmasterol contained in Mung Bean together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: MUNG BEAN IS RECOMMENDED OVER CHICKPEA FOR REDUCING THE GENETIC RISK OF AMPULLARY CARCINOMA DUE TO GENES APC AND SMAD4

Eat more vegetables, Arugula or Celery?

The active ingredients contained in Arugula are Esculin, Kaempferol, Vitamin A, Vitamin K, Erysolin among others. While the active ingredients contained in Celery are Apigenin, Vitamin C, Oleic Acid, Linolenic Acid, Cynaroside and others.

Kaempferol can manipulate biochemical pathways Cell Cycle Checkpoints, RAS-RAF Signaling and PI3K-AKT-MTOR Signaling. Vitamin A has biological action on biochemical pathways MYC Signaling, Apoptosis and Cell Cycle Checkpoints.

Luteolin can manipulate biochemical pathways MYC Signaling. Chrysin has biological action on biochemical pathways MYC Signaling. And so on.

For genetic risk of Ampullary Carcinoma due to abnormalities in genes APC and SMAD4 – Foods like Arugula are recommended compared to Celery. This is because the active ingredients Luteolin and Chrysin in Celery further promote the effects of genes on the biochemical pathways. While the active ingredients Kaempferol and Vitamin A contained in Arugula together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: ARUGULA IS RECOMMENDED OVER CELERY FOR REDUCING THE GENETIC RISK OF AMPULLARY CARCINOMA DUE TO GENES APC AND SMAD4

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.

Eat more fruits, Kiwi or Grape?

The active ingredients contained in Kiwi are Vitamin C, Quercetin, Fisetin, Chlorogenic Acid, Vitamin A among others. While the active ingredients contained in Grape are Lupeol, Resveratrol, Vitamin E, Beta-sitosterol, Vitamin C and others.

Vitamin C can manipulate biochemical pathways MAPK Signaling, Cell Cycle Checkpoints and RAS-RAF Signaling. Fisetin has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, MAPK Signaling and Cell Cycle Checkpoints.

Resveratrol can manipulate biochemical pathways P53 Signaling. Pelargonidin has biological action on biochemical pathways MYC Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling. And so on.

For genetic risk of Ampullary Carcinoma due to abnormalities in genes APC and SMAD4 – Foods like Kiwi are recommended compared to Grape. This is because the active ingredients Resveratrol and Pelargonidin in Grape further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Fisetin contained in Kiwi together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: KIWI IS RECOMMENDED OVER GRAPE FOR REDUCING THE GENETIC RISK OF AMPULLARY CARCINOMA DUE TO GENES APC AND SMAD4

Eat more nuts, Almond or Cashew Nut?

The active ingredients contained in Almond are Vitamin E, Beta-sitosterol, Oleic Acid, Linolenic Acid, Stigmasterol among others. While the active ingredients contained in Cashew Nut are Beta-sitosterol, Vitamin C, Gallic Acid, Palmitic Acid, Butyric Acid and others.

Beta-sitosterol can manipulate biochemical pathways Cell Cycle Checkpoints, P53 Signaling and MYC Signaling. Vitamin E has biological action on biochemical pathways MAPK Signaling, PI3K-AKT-MTOR Signaling and Apoptosis.

Lauric Acid can manipulate biochemical pathways MAPK Signaling, MYC Signaling and PI3K-AKT-MTOR Signaling. Myristic Acid has biological action on biochemical pathways Cell Cycle Checkpoints, RAS-RAF Signaling and P53 Signaling. And so on.

For genetic risk of Ampullary Carcinoma due to abnormalities in genes APC and SMAD4 – Foods like Almond are recommended compared to Cashew Nut. This is because the active ingredients Lauric Acid and Myristic Acid in Cashew Nut further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin E contained in Almond together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: ALMOND IS RECOMMENDED OVER CASHEW NUT FOR REDUCING THE GENETIC RISK OF AMPULLARY CARCINOMA DUE TO GENES APC AND SMAD4


In Summary

An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.

“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.

The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.

You can get started NOW and design a personalized nutrition plan for Ampullary Carcinoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

sample-report


References

Personalized Nutrition for Cancer!

Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.


Scientifically Reviewed by: Dr. Cogle

Christopher R. Cogle, M.D. is a tenured professor at the University of Florida, Chief Medical Officer of Florida Medicaid, and Director of the Florida Health Policy Leadership Academy at the Bob Graham Center for Public Service.

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