Highlights
No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Solitary Fibrous Tumor when undergoing chemotherapy or when you determine you have a genetic risk for developing Solitary Fibrous Tumor because of BRD4 and PIK3R1 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.
There is no one answer to this question for cancers such as Solitary Fibrous Tumor which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.
In short – the process to answer questions like “Should I Avoid eating fruit Fig” or “Include fruit Persimmon in my diet” or “Should I reduce consumption of vegetable Chicory” or “Can I take Horse Chestnut and Lycopene supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.
RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO SOLITARY FIBROUS TUMOR, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.
The overall objective of personalized nutrition for Solitary Fibrous Tumor is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.
RECOMMENDATION: UPDATE YOUR NUTRITION FOR SOLITARY FIBROUS TUMOR, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.
About Solitary Fibrous Tumor
cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.
Following key highlights are derived from clinical data for Solitary Fibrous Tumor from cBioPortal. 40.0% of males and 60.0% of females were the distribution of gender in these clinical studies. From a patient sample size of 11; the top genes with mutations and other abnormalities for Solitary Fibrous Tumor include genes BRD4, KMT2C, PIK3R1, TP53 and FBXW7. The occurrence frequency distribution for these genes respectively is 20.0%, 20.0%, 20.0%, 20.0% and 20.0%. These tumor genetic details of Solitary Fibrous Tumor are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Solitary Fibrous Tumor.
Solitary fibrous tumors (SFT) are rare, slow growing, mostly benign (noncancerous) tumors of the soft tissue cells that can form anywhere in the body. Solitary fibrous tumors most often occur in the lining around the outside of the lungs (pleural solitary fibrous tumors). The solitary fibrous tumor growths have also been found in the head and neck, breast, kidney, prostate, spinal cord, and other sites. These tumors may not cause any symptoms until they have become very large. Most SFTs occur in adults with a median age of 45-50 years. In most cases, surgery is the main treatment for these tumors, however, if the entire tumor cannot be removed, radiation therapy is used. Chemotherapy and targeted therapy with drugs that disrupt the blood supply to the tumor are also treatment options for more advanced solitary fibrous tumors. For patients with a solitary fibrous tumor who has undergone a complete resection, their 5-year survival rate is 89-100%. For patients with SFTs of an extremity, the local recurrence rate is 0-6%, and the distant metastasis rate is 0-19%. Besides careful long-term follow-up, supportive care with the right nutrition (foods and natural supplements) can help improve patients’ well-being. (Ref: Davanzo B et al, Transl Gastroenterol Hepatol., 2018; https://www.mayoclinic.org/diseases-conditions/solitary-fibrous-tumors/cdc-20395823; https://emedicine.medscape.com/article/1255879-overview/)
Significance of Nutrition for Solitary Fibrous Tumor
All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Solitary Fibrous Tumor. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.
For example Fig includes active ingredients Lupeol, Psoralen, Vitamin C, Beta-sitosterol, Bergapten and others. And Persimmon contains active ingredients Lupeol, Lycopene, Betulinic Acid, Vitamin C, Quercetin and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.
For cancers like Solitary Fibrous Tumor, activation or inhibition of selected biochemical pathways like DNA Repair, Cell Cycle, Oncogenic Histone Methylation, Cell Cycle Checkpoints plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Solitary Fibrous Tumor, while eating some other foods and supplements may not be recommended.
One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.
RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR SOLITARY FIBROUS TUMOR – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.
Foods for Solitary Fibrous Tumor undergoing chemotherapy treatment
In Solitary Fibrous Tumor – the genes BRD4, KMT2C, PIK3R1, TP53 and FBXW7 have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Solitary Fibrous Tumor are and others. Pazopanib is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.
RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.
Eat more pulses, Mung Bean or Fava Bean?
Pulses are an important part of many diets. The active ingredients contained in Mung Bean are Vitamin C, Linolenic Acid, Oleic Acid, Stigmasterol, Vitexin among others. While the active ingredients contained in Fava Bean are Vitamin C, Daidzein, Ferulic Acid, Stigmasterol, P-coumaric Acid and others.
Vitamin C can manipulate biochemical pathways MYC Signaling. Stigmasterol has biological action on biochemical pathways MYC Signaling.
Folic Acid can manipulate biochemical pathways MYC Signaling. And so on.
When treating Solitary Fibrous Tumor with chemotherapy Pazopanib – Foods like Mung Bean are recommended compared to Fava Bean. This is because the active ingredients Folic Acid in Fava Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Stigmasterol contained in Mung Bean support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: MUNG BEAN IS RECOMMENDED OVER FAVA BEAN FOR SOLITARY FIBROUS TUMOR ON TREATMENT WITH CHEMOTHERAPY PAZOPANIB FOR SOME CONDITIONS.
Eat more vegetables, Arugula or Chicory?
Vegetables are an important part of many diets. The active ingredients contained in Arugula are Esculin, Vitamin A, Vitamin K, Erysolin among others. While the active ingredients contained in Chicory are Apigenin, Esculin, Protocatechuic Acid, Lupeol, Betulinic Acid and others.
Vitamin A can manipulate biochemical pathways MYC Signaling. Vitamin K has biological action on biochemical pathways MYC Signaling.
Luteolin can manipulate biochemical pathways MYC Signaling. Folic Acid has biological action on biochemical pathways MYC Signaling. And so on.
When treating Solitary Fibrous Tumor with chemotherapy Pazopanib – Foods like Arugula are recommended compared to Chicory. This is because the active ingredients Luteolin and Folic Acid in Chicory interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin A and Vitamin K contained in Arugula support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: ARUGULA IS RECOMMENDED OVER CHICORY FOR SOLITARY FIBROUS TUMOR ON TREATMENT WITH CHEMOTHERAPY PAZOPANIB FOR SOME CONDITIONS.
Eat more fruits, Persimmon or Fig?
Fruits are an important part of many diets. The active ingredients contained in Persimmon are Lupeol, Lycopene, Betulinic Acid, Vitamin C, Quercetin among others. While the active ingredients contained in Fig are Lupeol, Psoralen, Vitamin C, Beta-sitosterol, Bergapten and others.
Lycopene can manipulate biochemical pathways MYC Signaling. Vitamin C has biological action on biochemical pathways MYC Signaling.
Lauric Acid can manipulate biochemical pathways MYC Signaling. Myristic Acid has biological action on biochemical pathways MYC Signaling. And so on.
When treating Solitary Fibrous Tumor with chemotherapy Pazopanib – Foods like Persimmon are recommended compared to Fig. This is because the active ingredients Lauric Acid and Myristic Acid in Fig interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Lycopene and Vitamin C contained in Persimmon support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: PERSIMMON IS RECOMMENDED OVER FIG FOR SOLITARY FIBROUS TUMOR ON TREATMENT WITH CHEMOTHERAPY PAZOPANIB FOR SOME CONDITIONS.
Eat more nuts, Almond or Macadamia Nut?
Nuts are an important part of many diets. The active ingredients contained in Almond are Vitamin E, Beta-sitosterol, Linolenic Acid, Oleic Acid, Stigmasterol among others. While the active ingredients contained in Macadamia Nut are Beta-sitosterol, Palmitic Acid, Lauric Acid, Myristic Acid, Folic Acid and others.
Beta-sitosterol can manipulate biochemical pathways MYC Signaling. Vitamin E has biological action on biochemical pathways MYC Signaling.
Lauric Acid can manipulate biochemical pathways MYC Signaling. Myristic Acid has biological action on biochemical pathways MYC Signaling. And so on.
When treating Solitary Fibrous Tumor with chemotherapy Pazopanib – Foods like Almond are recommended compared to Macadamia Nut. This is because the active ingredients Lauric Acid and Myristic Acid in Macadamia Nut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin E contained in Almond support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: ALMOND IS RECOMMENDED OVER MACADAMIA NUT FOR SOLITARY FIBROUS TUMOR ON TREATMENT WITH CHEMOTHERAPY PAZOPANIB FOR SOME CONDITIONS.
Foods for Genetic Risk of Solitary Fibrous Tumor
One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. BRD4 and PIK3R1 are two genes whose abnormalities are risk factors for Solitary Fibrous Tumor. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Solitary Fibrous Tumor can be used as a guide for coming up with a recommended personalized nutrition plan. For Solitary Fibrous Tumor gene BRD4 has causative impact on biological pathways like Chromatin Remodeling, DNA Repair and Epithelial to Mesenchymal Transition. And PIK3R1 has a causative impact on biological pathways like Hematopoiesis and Cytokine Signaling. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like BRD4 and PIK3R1 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes BRD4 and PIK3R1 should be avoided.
Eat more pulses, Yellow Wax Bean or Chickpea?
The active ingredients contained in Yellow Wax Bean are Vitamin C, Cianidanol, Ferulic Acid, Palmitic Acid, Butyric Acid among others. While the active ingredients contained in Chickpea are Oleic Acid, Linolenic Acid, Genistein, Vitamin A, Folic Acid and others.
Palmitic Acid can manipulate biochemical pathways P53 Signaling, MYC Signaling and Apoptosis. Vitamin A has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and Cell Cycle.
Folic Acid can manipulate biochemical pathways Cell Cycle Checkpoints, P53 Signaling and MYC Signaling. And so on.
For genetic risk of Solitary Fibrous Tumor due to abnormalities in genes BRD4 and PIK3R1 – Foods like Yellow Wax Bean are recommended compared to Chickpea. This is because the active ingredients Folic Acid in Chickpea further promote the effects of genes on the biochemical pathways. While the active ingredients Palmitic Acid and Vitamin A contained in Yellow Wax Bean together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: YELLOW WAX BEAN IS RECOMMENDED OVER CHICKPEA FOR REDUCING THE GENETIC RISK OF SOLITARY FIBROUS TUMOR DUE TO GENES BRD4 AND PIK3R1
Eat more vegetables, Giant Butterbur or Radish?
The active ingredients contained in Giant Butterbur are Beta-sitosterol, Vitamin C, Vitamin B3, Melatonin, Vitamin A among others. While the active ingredients contained in Radish are Beta-sitosterol, Quercetin, Vitamin C, P-coumaric Acid, Oleic Acid and others.
Vitamin C can manipulate biochemical pathways Cell Cycle Checkpoints, P53 Signaling and MYC Signaling. Beta-sitosterol has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, Apoptosis and Cell Cycle.
Pelargonidin can manipulate biochemical pathways MYC Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling. Salicylic Acid has biological action on biochemical pathways DNA Repair. And so on.
For genetic risk of Solitary Fibrous Tumor due to abnormalities in genes BRD4 and PIK3R1 – Foods like Giant Butterbur are recommended compared to Radish. This is because the active ingredients Pelargonidin and Salicylic Acid in Radish further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Giant Butterbur together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: GIANT BUTTERBUR IS RECOMMENDED OVER RADISH FOR REDUCING THE GENETIC RISK OF SOLITARY FIBROUS TUMOR DUE TO GENES BRD4 AND PIK3R1
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
Eat more fruits, Orange or Cranberry?
The active ingredients contained in Orange are D-limonene, Linalool, Vitamin C, Oleic Acid, Linolenic Acid among others. While the active ingredients contained in Cranberry are Ellagic Acid, Resveratrol, Hyperoside, Quercetin, Vitamin C and others.
D-limonene can manipulate biochemical pathways Cell Cycle Checkpoints, P53 Signaling and MYC Signaling. Vitamin C has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, Apoptosis and Cell Cycle.
Ellagic Acid can manipulate biochemical pathways MYC Signaling and Cell Cycle Checkpoints. Resveratrol has biological action on biochemical pathways P53 Signaling. And so on.
For genetic risk of Solitary Fibrous Tumor due to abnormalities in genes BRD4 and PIK3R1 – Foods like Orange are recommended compared to Cranberry. This is because the active ingredients Ellagic Acid and Resveratrol in Cranberry further promote the effects of genes on the biochemical pathways. While the active ingredients D-limonene and Vitamin C contained in Orange together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: ORANGE IS RECOMMENDED OVER CRANBERRY FOR REDUCING THE GENETIC RISK OF SOLITARY FIBROUS TUMOR DUE TO GENES BRD4 AND PIK3R1
Eat more nuts, Brazil Nut or Cashew Nut?
The active ingredients contained in Brazil Nut are Vitamin E, Oleic Acid, Linolenic Acid, Lecithin, Folic Acid among others. While the active ingredients contained in Cashew Nut are Beta-sitosterol, Vitamin C, Palmitic Acid, Butyric Acid, Gallic Acid and others.
Vitamin E can manipulate biochemical pathways Cell Cycle Checkpoints, P53 Signaling and MYC Signaling. Oleic Acid has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, Apoptosis and Cell Cycle.
Lauric Acid can manipulate biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. Myristic Acid has biological action on biochemical pathways Cell Cycle Checkpoints, P53 Signaling and DNA Repair. And so on.
For genetic risk of Solitary Fibrous Tumor due to abnormalities in genes BRD4 and PIK3R1 – Foods like Brazil Nut are recommended compared to Cashew Nut. This is because the active ingredients Lauric Acid and Myristic Acid in Cashew Nut further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin E and Oleic Acid contained in Brazil Nut together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: BRAZIL NUT IS RECOMMENDED OVER CASHEW NUT FOR REDUCING THE GENETIC RISK OF SOLITARY FIBROUS TUMOR DUE TO GENES BRD4 AND PIK3R1
In Summary
An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.
“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.
The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.
You can get started NOW and design a personalized nutrition plan for Solitary Fibrous Tumor by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
References
- Pan Origimed 2020
- Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients.
- Vitamin C enhances epigenetic modifications induced by 5-azacytidine and cell cycle arrest in the hepatocellular carcinoma cell lines HLE and Huh7.
- Stigmasterol Causes Ovarian Cancer Cell Apoptosis by Inducing Endoplasmic Reticulum and Mitochondrial Dysfunction.
- Effects of folate deficiency on gene expression in the apoptosis and cancer pathways in colon cancer cells.
- Lycopene induces apoptosis by inhibiting nuclear translocation of β-catenin in gastric cancer cells.
- Clinical pharmacodynamics of antihistamines.
- Saturated fatty acids modulate cell response to DNA damage: implication for their role in tumorigenesis.
- Transcriptional activation of the cyclin-dependent kinase inhibitor p21 by PML/RARalpha.
- Research progress on the anticancer effects of vitamin K2.
- Crystal structure of a human cyclin-dependent kinase 6 complex with a flavonol inhibitor, fisetin.
- β-Sitosterol targets Trx/Trx1 reductase to induce apoptosis in A549 cells via ROS mediated mitochondrial dysregulation and p53 activation.
- Gamma- and delta-tocotrienols exert a more potent anticancer effect than alpha-tocopheryl succinate on breast cancer cell lines irrespective of HER-2/neu expression.
- A redox-resistant sirtuin-1 mutant protects against hepatic metabolic and oxidant stress.
- D-Limonene modulates inflammation, oxidative stress and Ras-ERK pathway to inhibit murine skin tumorigenesis.
- Indeno[1,2-b]indole derivatives as a novel class of potent human protein kinase CK2 inhibitors.
- Resveratrol, a remarkable inhibitor of ribonucleotide reductase.
- Pelargonidin suppresses adipogenesis in 3T3-L1 cells through inhibition of PPAR-γ signaling pathway.
- Cyclin A2 and CDK2 as Novel Targets of Aspirin and Salicylic Acid: A Potential Role in Cancer Prevention.
- Oleic acid induces apoptosis and autophagy in the treatment of Tongue Squamous cell carcinomas.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.