Foods for Solitary Fibrous Tumor!

Introduction

Foods for Solitary Fibrous Tumor should be personalized for each individual and also must adapt when cancer treatment or tumor genetic change. The personalization and adaptation must consider all the active ingredients or bioactives contained in different foods with respect to cancer tissue biology, genetics, treatments, lifestyle conditions and diet preferences. Hence while nutrition is one of the very important decisions for a cancer patient and individual at risk of cancer to make – how to choose foods to eat is not an easy task.

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For Solitary Fibrous Tumor does it matter what vegetables, fruits, nuts, seeds one eats?

A very common nutrition question asked by cancer patients and individuals at-genetic risk of cancer is – for cancers like Solitary Fibrous Tumor does it matter what foods I eat and which I do not? Or if I follow a plant-based diet is that enough for cancer like Solitary Fibrous Tumor?

For example does it matter if vegetable Kohlrabi is consumed more compared to Horned Melon? Does it make any difference if fruit Bayberry is preferred over Evergreen Blackberry? Also if similar choices are made for nuts/seeds like Black Walnut over Pumpkin Seeds and for pulses like White Lupine over Catjang Pea. And if what I eat matters – then how does one identify foods which are recommended for Solitary Fibrous Tumor and is it the same answer for everyone with the same diagnosis or genetic risk?

Yes! Foods you eat matters for Solitary Fibrous Tumor!

Food recommendations may not be the same for everyone and can be different even for the same diagnosis and genetic risk.

All foods (vegetables, fruits, nuts, seeds, pulses, oils etc.) and nutritional supplements are made up of more than one active molecular ingredient or bio-actives in different proportions and quantities. Each active ingredient has a unique mechanism of action – which can be activation or inhibition of different biochemical pathways. Simply stated foods and supplements which are recommended are those which do not cause an increase of molecular drivers of cancer but reduce them. Else those foods should not be recommended. Foods contain multiple active ingredients – hence when evaluating foods and supplements you need to consider the impact of all active ingredients cumulatively rather than individually.

For example Bayberry contains active ingredients Apigenin, Curcumin, Lycopene, Lupeol, Psoralen. And Evergreen Blackberry contains active ingredients Linalool, Alpha Pinene, Eugenol, Beta-ionone, Ellagic Acid and possibly others.

A common mistake made when deciding and choosing foods to eat for Solitary Fibrous Tumor – is to evaluate only selected active ingredients contained in foods and ignore the rest. Because different active ingredients contained in foods may have opposing effects on cancer drivers – you cannot cherry pick active ingredients in foods and supplements for making a nutrition decision for Solitary Fibrous Tumor.

YES – FOOD CHOICES MATTER FOR CANCER. NUTRITION DECISIONS MUST CONSIDER ALL ACTIVE INGREDIENTS OF FOODS.

Skills Needed for Nutrition Personalization for Solitary Fibrous Tumor?

Personalized nutrition for cancers like Solitary Fibrous Tumor consists of recommended foods / supplements; not recommended foods / supplements with example recipes which prioritize use of recommended foods. An example of personalized nutrition can be seen at this link.

Deciding which foods are recommended or not is extremely complicated, requiring expertise in Solitary Fibrous Tumor biology, food science, genetics, biochemistry along with good understanding of how cancer treatments work and associated vulnerabilities by which the treatments could stop being effective.

MINIMUM KNOWLEDGE EXPERTISE NEEDED FOR NUTRITION PERSONALIZATION FOR CANCER ARE: CANCER BIOLOGY, FOOD SCIENCE, CANCER TREATMENTS AND GENETICS.

Characteristics of cancers like Solitary Fibrous Tumor

All cancers like Solitary Fibrous Tumor can be characterized by a unique set of biochemical pathways – the signature pathways of Solitary Fibrous Tumor. Biochemical pathways like DNA Repair, Cell Cycle, Oncogenic Histone Methylation, Cell Cycle Checkpoints are part of the signature definition of Solitary Fibrous Tumor. Each individual’s cancer genetics can be different and hence their specific cancer signature could be unique.

The treatments which are effective for Solitary Fibrous Tumor need to be cognizant of the associated signature biochemical pathways for each cancer patient and individual at genetic risk. Therefore different treatments with different mechanisms of actions are effective for different patients. Similarly and for the same reasons foods and supplements need to be personalized for each individual. Hence some foods and supplements are recommended for Solitary Fibrous Tumor when taking cancer treatment Avastin, and some foods and supplements are not recommended.

Sources like cBioPortal and many others provide population representative patient anonymized data from clinical trials for all cancer indications. This data consists of clinical trial study details like sample size / number of patients, age groups, gender, ethnicity, treatments, tumor site and any genetic mutations.

BRD4, KMT2C, PIK3R1, TP53 and FBXW7 are the top ranked reported genes for Solitary Fibrous Tumor. BRD4 is reported in 20.0 % of the representative patients across all clinical trials. And KMT2C is reported in 20.0 %. The combined population patient data cover ages from to . 40.0 % of the patient data are identified as men. The Solitary Fibrous Tumor biology along with reported genetics together define the population represented signature biochemical pathways for this cancer. If the individual cancer tumor genetics or genes contributing to the risk are also known then that should also be used for nutrition personalization.

NUTRITION CHOICES SHOULD MATCH WITH EACH INDIVIDUAL’S CANCER SIGNATURE.

Food and Supplements for Solitary Fibrous Tumor

For Cancer Patients

Cancer patients on treatment or on palliative care need to make decisions on food and supplements – for the needed dietary calories, for managing any treatment side effects and also for improved cancer management. All plant-based foods are not equal and choosing and prioritizing foods which are personalized and customized to ongoing cancer treatment is important and complicated. Here are some examples providing guidelines for making nutrition decisions.

Choose Vegetable KOHLRABI or HORNED MELON?

Vegetable Kohlrabi contains many active ingredients or bioactives such as Curcumin, Lupeol, Brassinin, Psoralen, Daidzein. These active ingredients manipulate various biochemical pathways like MYC Signaling and others. Kohlrabi is recommended for Solitary Fibrous Tumor when ongoing cancer treatment is Avastin. This is because Kohlrabi modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Avastin.

Some of the active ingredients or bioactives in vegetable Horned Melon are Apigenin, Curcumin, Lycopene, Lupeol, Psoralen. These active ingredients manipulate various biochemical pathways like MYC Signaling and others. Horned Melon is not recommended for Solitary Fibrous Tumor when ongoing cancer treatment is Avastin because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

VEGETABLE KOHLRABI IS RECOMMENDED OVER HORNED MELON FOR Solitary Fibrous Tumor AND TREATMENT Avastin.

Choose Fruit EVERGREEN BLACKBERRY or BAYBERRY?

Fruit Evergreen Blackberry contains many active ingredients or bioactives such as Linalool, Alpha Pinene, Eugenol, Beta-ionone, Ellagic Acid. These active ingredients manipulate various biochemical pathways like MYC Signaling and others. Evergreen Blackberry is recommended for Solitary Fibrous Tumor when ongoing cancer treatment is Avastin. This is because Evergreen Blackberry modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Avastin.

Some of the active ingredients or bioactives in fruit Bayberry are Apigenin, Curcumin, Lycopene, Lupeol, Psoralen. These active ingredients manipulate various biochemical pathways like MYC Signaling and others. Bayberry is not recommended for Solitary Fibrous Tumor when ongoing cancer treatment is Avastin because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

FRUIT EVERGREEN BLACKBERRY IS RECOMMENDED OVER BAYBERRY FOR Solitary Fibrous Tumor AND TREATMENT Avastin.

Choose Nut BLACK WALNUT or PUMPKIN SEEDS?

Black Walnut contains many active ingredients or bioactives such as Apigenin, Curcumin, Lupeol, Psoralen, Phloretin. These active ingredients manipulate various biochemical pathways like MYC Signaling and others. Black Walnut is recommended for Solitary Fibrous Tumor when ongoing cancer treatment is Avastin. This is because Black Walnut modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Avastin.

Some of the active ingredients or bioactives in Pumpkin Seeds are Beta-sitosterol, Stigmasterol, Linolenic Acid, Oleic Acid, Vitamin B3. These active ingredients manipulate various biochemical pathways like MYC Signaling and others. Pumpkin Seeds is not recommended for Solitary Fibrous Tumor when ongoing cancer treatment is Avastin because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

BLACK WALNUT IS RECOMMENDED OVER PUMPKIN SEEDS FOR Solitary Fibrous Tumor AND TREATMENT Avastin.

For Individuals with Genetic Risk of Cancer

The question asked by individuals who have genetic risk of Solitary Fibrous Tumor or familial history is “What Should I Eat Differently from Before?” and how they should choose foods and supplements to manage risks of the disease. Since for cancer risk there is nothing actionable in terms of treatment – decisions of foods and supplements become important and one of the very few actionable things which can be done. All plant-based foods are not equal and based on identified genetics and pathway signature – the choices of food and supplements should be personalized.

Choose Vegetable PEPPER or ARROWHEAD?

Vegetable Pepper contains many active ingredients or bioactives such as Apigenin, Curcumin, Lupeol, Quercetin, Piperine. These active ingredients manipulate various biochemical pathways like DNA Repair, Cell Cycle, Cell Cycle Checkpoints and MYC Signaling and others. Pepper is recommended for risk of Solitary Fibrous Tumor when associated genetic risk is BRD4. This is because Pepper increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in vegetable Arrowhead are Apigenin, Curcumin, Lupeol, Daidzein, Beta-sitosterol. These active ingredients manipulate various biochemical pathways like DNA Repair, Oncogenic Histone Methylation and Cell Cycle Checkpoints and others. Arrowhead is not recommended when risk of Solitary Fibrous Tumor when associated genetic risk is BRD4 because it increases the signature pathways of it.

VEGETABLE PEPPER IS RECOMMENDED OVER ARROWHEAD FOR BRD4 GENETIC RISK OF CANCER.

Choose Fruit NANCE or PUMMELO?

Fruit Nance contains many active ingredients or bioactives such as Apigenin, Curcumin, Lupeol, Daidzein, Beta-sitosterol. These active ingredients manipulate various biochemical pathways like Cell Cycle, P53 Signaling, DNA Repair and Cell Cycle Checkpoints and others. Nance is recommended for risk of Solitary Fibrous Tumor when associated genetic risk is BRD4. This is because Nance increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in fruit Pummelo are Apigenin, Curcumin, Lupeol, Quercetin, Daidzein. These active ingredients manipulate various biochemical pathways like DNA Repair, Notch Signaling and Cell Cycle Checkpoints and others. Pummelo is not recommended when risk of Solitary Fibrous Tumor when associated genetic risk is BRD4 because it increases the signature pathways of it.

FRUIT NANCE IS RECOMMENDED OVER PUMMELO FOR BRD4 GENETIC RISK OF CANCER.

Choose Nut BUTTERNUT or FLAXSEED?

Butternut contains many active ingredients or bioactives such as Apigenin, Curcumin, Lupeol, Daidzein, Beta-sitosterol. These active ingredients manipulate various biochemical pathways like DNA Repair, Cell Cycle, Cell Cycle Checkpoints and MYC Signaling and others. Butternut is recommended for risk of Solitary Fibrous Tumor when associated genetic risk is BRD4. This is because Butternut increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in Flaxseed are Apigenin, Curcumin, Lupeol, Daidzein, Beta-sitosterol. These active ingredients manipulate various biochemical pathways like Oncogenic Histone Methylation, PI3K-AKT-MTOR Signaling and MYC Signaling and others. Flaxseed is not recommended when risk of Solitary Fibrous Tumor when associated genetic risk is BRD4 because it increases the signature pathways of it.

BUTTERNUT IS RECOMMENDED OVER FLAXSEED FOR BRD4 GENETIC RISK OF CANCER.

In Conclusion

Foods and Supplements chosen are important decisions for cancers like Solitary Fibrous Tumor. Solitary Fibrous Tumor patients and individuals with genetic-risk always have this question: “What foods and nutritional supplements are recommended for me and which are not?” There is a common belief which is a misconception that all plant-based foods could be beneficial or not but would not be harmful. Certain foods and supplements can interfere with cancer treatments or promote molecular pathway drivers of cancer.

There are different types of cancer indications like Solitary Fibrous Tumor, each with different tumor genetics with further genomic variations across each individual. Further every cancer treatment and chemotherapy has a unique mechanism of action. Each food like Kohlrabi contains various bioactives in different quantities, which have an impact on different and distinct sets of biochemical pathways. The definition of personalized nutrition is individualized food recommendations for the cancer indication, treatments, genetics, lifestyle and other factors. Nutrition personalization decisions for cancer require knowledge of cancer biology, food science and an understanding of different chemotherapy treatments. Finally when there are treatment changes or new genomics is identified – the nutrition personalization needs re-evaluation.

The addon nutrition personalization solution makes the decision making easy and removes all the guesswork in answering the question, “What foods should I choose or not choose for Solitary Fibrous Tumor?”. The addon multi-disciplinary team includes cancer physicians, clinical scientists, software engineers and data scientists.

References

• Pan Origimed 2020
• Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients.
• Evaluating the effects of ellagic acid on pSTAT3, pAKT, and pERK1/2 signaling pathways in prostate cancer PC3 cells.
• Brassinin Combined with Capsaicin Enhances Apoptotic and Anti-metastatic Effects in PC-3 Human Prostate Cancer Cells.
• Vitamin C enhances epigenetic modifications induced by 5-azacytidine and cell cycle arrest in the hepatocellular carcinoma cell lines HLE and Huh7.
• α-pinene regulates miR-221 and induces G₂/M phase cell cycle arrest in human hepatocellular carcinoma cells.
• Hesperetin, a potential therapy for carcinoid cancer.
• Davanzo B et al, Transl Gastroenterol Hepatol., 2018, doi: 10.21037/tgh.2018.11.02
• https://www.mayoclinic.org/diseases-conditions/solitary-fibrous-tumors/cdc-20395823
• https://emedicine.medscape.com/article/1255879-overview#a4