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What Foods are Recommended for Cancer?
is a very common question. Personalized Nutrition Plans are foods and supplements which are personalized to a cancer indication, genes, any treatments and lifestyle conditions.

Which Foods are Recommended for Acute Myeloid Leukemia?

Aug 30, 2022

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Highlights

No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Acute Myeloid Leukemia when undergoing chemotherapy or when you determine you have a genetic risk for developing Acute Myeloid Leukemia because of NPM1 and IDH2 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.

There is no one answer to this question for cancers such as Acute Myeloid Leukemia which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.

In short – the process to answer questions like “Should I Avoid eating fruit Lingonberry” or “Include fruit Nance in my diet” or “Should I reduce consumption of vegetable Jute” or “Can I take Neem Extract and Thunder God supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.

RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO ACUTE MYELOID LEUKEMIA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.

The overall objective of personalized nutrition for Acute Myeloid Leukemia is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.

RECOMMENDATION: UPDATE YOUR NUTRITION FOR ACUTE MYELOID LEUKEMIA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.



About Acute Myeloid Leukemia

cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.

Following key highlights are derived from clinical data for Acute Myeloid Leukemia from cBioPortal. The patients enrolled in the studies for Acute Myeloid Leukemia are in ages between 1 to 88 with an average age of 14. 53.5% of males and 46.5% of females were the distribution of gender in these clinical studies. From a patient sample size of 4560; the top genes with mutations and other abnormalities for Acute Myeloid Leukemia include genes NPM1, IDH2, CEBPA, WT1 and PTPN11. The occurrence frequency distribution for these genes respectively is 13.0%, 5.1%, 3.1%, 3.1% and 2.4%. These tumor genetic details of Acute Myeloid Leukemia are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Acute Myeloid Leukemia.

Significance of Nutrition for Acute Myeloid Leukemia

All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Acute Myeloid Leukemia. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.

For example Lingonberry includes active ingredients Resveratrol, Quercetin, Caffeic Acid, Linolenic Acid, Hyperoside and others. And Nance contains active ingredients Vitamin C, Vitamin A, Betulin and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.

For cancers like Acute Myeloid Leukemia, activation or inhibition of selected biochemical pathways like Oncogenic Cancer Epigenetics, Chromatin Remodeling, MAPK Signaling, Focal Adhesion plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Acute Myeloid Leukemia, while eating some other foods and supplements may not be recommended.

One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.

For cancers like Acute Myeloid Leukemia, activation or inhibition of selected biochemical pathways like Oncogenic Cancer Epigenetics, Chromatin Remodeling, MAPK Signaling, Focal Adhesion plays an important role in driving cancer growth.

RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR ACUTE MYELOID LEUKEMIA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.

Foods for Acute Myeloid Leukemia undergoing chemotherapy treatment

In Acute Myeloid Leukemia – the genes NPM1, IDH2, CEBPA, WT1 and PTPN11 have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Acute Myeloid Leukemia are Oncogenic Cancer Epigenetics, Chromatin Remodeling, Microtubule Dynamics and others. Cytarabine is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Oncogenic Cancer Epigenetics, Chromatin Remodeling, Microtubule Dynamics so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.

RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.

Eat more pulses, Scarlet Bean or Pigeon Pea?

Pulses are an important part of many diets. The active ingredients contained in Scarlet Bean are Beta-sitosterol, Linolenic Acid, Vitamin C, Liquiritigenin, Stigmasterol among others. While the active ingredients contained in Pigeon Pea are Linolenic Acid, Vitamin C, Vitamin A, Oleic Acid, Linoleic Acid and others.

Beta-sitosterol can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and Apoptosis. Vitamin C has biological action on biochemical pathways Adherens junction, MYC Signaling and WNT Beta Catenin Signaling.

Genistein can manipulate biochemical pathways Oxidative Stress. Linolenic Acid has biological action on biochemical pathways Vitamin D Signaling and Oxidative Stress. And so on.

When treating Acute Myeloid Leukemia with chemotherapy Cytarabine – Foods like Scarlet Bean are recommended compared to Pigeon Pea. This is because the active ingredients Genistein and Linolenic Acid in Pigeon Pea interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin C contained in Scarlet Bean support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: SCARLET BEAN IS RECOMMENDED OVER PIGEON PEA FOR ACUTE MYELOID LEUKEMIA ON TREATMENT WITH CHEMOTHERAPY CYTARABINE FOR SOME CONDITIONS.

Eat more vegetables, Turnip or Jute?

Vegetables are an important part of many diets. The active ingredients contained in Turnip are Sulforaphane, Vitamin C, Vitamin A, Indole-3-carbinol, Vitamin K among others. While the active ingredients contained in Jute are Quercetin, Linolenic Acid, Kaempferol, Vitamin C, Vitamin B3 and others.

Sulforaphane can manipulate biochemical pathways NFKB Signaling, Oxidative Stress and Microtubule Dynamics. Vitamin A has biological action on biochemical pathways Epithelial to Mesenchymal Transition, Adherens junction and TWEAK Signaling.

Quercetin can manipulate biochemical pathways Oxidative Stress. Kaempferol has biological action on biochemical pathways Oxidative Stress. And so on.

When treating Acute Myeloid Leukemia with chemotherapy Cytarabine – Foods like Turnip are recommended compared to Jute. This is because the active ingredients Quercetin and Kaempferol in Jute interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Sulforaphane and Vitamin A contained in Turnip support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: TURNIP IS RECOMMENDED OVER JUTE FOR ACUTE MYELOID LEUKEMIA ON TREATMENT WITH CHEMOTHERAPY CYTARABINE FOR SOME CONDITIONS.

Which Foods are Recommended for Acute Myeloid Leukemia?

Eat more fruits, Nance or Lingonberry?

Fruits are an important part of many diets. The active ingredients contained in Nance are Vitamin C, Vitamin A, Betulin among others. While the active ingredients contained in Lingonberry are Resveratrol, Quercetin, Caffeic Acid, Linolenic Acid, Hyperoside and others.

Vitamin C can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and Adherens junction. Vitamin A has biological action on biochemical pathways Oxidative Stress, TWEAK Signaling and MYC Signaling.

Resveratrol can manipulate biochemical pathways Oncogenic Cancer Epigenetics. Quercetin has biological action on biochemical pathways Oxidative Stress. And so on.

When treating Acute Myeloid Leukemia with chemotherapy Cytarabine – Foods like Nance are recommended compared to Lingonberry. This is because the active ingredients Resveratrol and Quercetin in Lingonberry interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Vitamin A contained in Nance support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: NANCE IS RECOMMENDED OVER LINGONBERRY FOR ACUTE MYELOID LEUKEMIA ON TREATMENT WITH CHEMOTHERAPY CYTARABINE FOR SOME CONDITIONS.

Eat more nuts, Pine Nut or Cashew Nut?

Nuts are an important part of many diets. The active ingredients contained in Pine Nut are Beta-sitosterol, Vitamin E, Linolenic Acid, Vitamin A, Oleic Acid among others. While the active ingredients contained in Cashew Nut are Butyric Acid, Beta-sitosterol, Vitamin C, Gallic Acid, Vitamin K and others.

Beta-sitosterol can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and Apoptosis. Vitamin K has biological action on biochemical pathways TWEAK Signaling, MYC Signaling and Vitamin D Signaling.

Myristic Acid can manipulate biochemical pathways Apoptosis, MYC Signaling and MAPK Signaling. Lauric Acid has biological action on biochemical pathways NFKB Signaling, TWEAK Signaling and PI3K-AKT-MTOR Signaling. And so on.

When treating Acute Myeloid Leukemia with chemotherapy Cytarabine – Foods like Pine Nut are recommended compared to Cashew Nut. This is because the active ingredients Myristic Acid and Lauric Acid in Cashew Nut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin K contained in Pine Nut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: PINE NUT IS RECOMMENDED OVER CASHEW NUT FOR ACUTE MYELOID LEUKEMIA ON TREATMENT WITH CHEMOTHERAPY CYTARABINE FOR SOME CONDITIONS.

Foods for Genetic Risk of Acute Myeloid Leukemia

One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. NPM1 and IDH2 are two genes whose abnormalities are risk factors for Acute Myeloid Leukemia. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Acute Myeloid Leukemia can be used as a guide for coming up with a recommended personalized nutrition plan. For Acute Myeloid Leukemia gene NPM1 has causative impact on biological pathways like DNA Repair and Growth Factor Signaling. And IDH2 has a causative impact on biological pathways like Oncogenic Cancer Epigenetics, Glutathione Metabolism and Hypoxia. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like NPM1 and IDH2 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes NPM1 and IDH2 should be avoided.

Eat more pulses, Common Pea or Soy Bean?

The active ingredients contained in Common Pea are Vitamin C, Lupeol, Daidzein, Linolenic Acid, Beta-sitosterol among others. While the active ingredients contained in Soy Bean are Vitamin C, Lupeol, Vitamin E, Daidzein, Linolenic Acid and others.

Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and Cell Cycle Checkpoints. Beta-sitosterol has biological action on biochemical pathways Oncogenic Cancer Epigenetics, Hypoxia and Apoptosis.

Aescin can manipulate biochemical pathways Cell Cycle Checkpoints. Lecithin has biological action on biochemical pathways MYC Signaling. And so on.

For genetic risk of Acute Myeloid Leukemia due to abnormalities in genes NPM1 and IDH2 – Foods like Common Pea are recommended compared to Soy Bean. This is because the active ingredients Aescin and Lecithin in Soy Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Common Pea together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: COMMON PEA IS RECOMMENDED OVER SOY BEAN FOR REDUCING THE GENETIC RISK OF ACUTE MYELOID LEUKEMIA DUE TO GENES NPM1 AND IDH2

Eat more vegetables, Cassava or Heart Of Palm?

The active ingredients contained in Cassava are Vitamin C, Linolenic Acid, Beta-sitosterol, Oleic Acid, Linoleic Acid among others. While the active ingredients contained in Heart Of Palm are Vitamin C, Palmitic Acid, Vitamin A, Folic Acid and others.

Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and Cell Cycle Checkpoints. Beta-sitosterol has biological action on biochemical pathways Oncogenic Cancer Epigenetics, Hypoxia and Apoptosis.

Palmitic Acid can manipulate biochemical pathways Oncogenic Cancer Epigenetics, mRNA Splicing and Energy Metabolism. Folic Acid has biological action on biochemical pathways MYC Signaling, Cell Cycle Checkpoints and Apoptosis. And so on.

For genetic risk of Acute Myeloid Leukemia due to abnormalities in genes NPM1 and IDH2 – Foods like Cassava are recommended compared to Heart Of Palm. This is because the active ingredients Palmitic Acid and Folic Acid in Heart Of Palm further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Cassava together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: CASSAVA IS RECOMMENDED OVER HEART OF PALM FOR REDUCING THE GENETIC RISK OF ACUTE MYELOID LEUKEMIA DUE TO GENES NPM1 AND IDH2

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.

Eat more fruits, Kiwi or Cranberry?

The active ingredients contained in Kiwi are Vitamin C, Quercetin, Vitamin A, Chlorogenic Acid, Fisetin among others. While the active ingredients contained in Cranberry are Vitamin C, Hyperoside, Quercetin, P-coumaric Acid, Resveratrol and others.

Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and Cell Cycle Checkpoints. Vitamin A has biological action on biochemical pathways Stem Cell Signaling, MYC Signaling and Cell Cycle Checkpoints.

Ellagic Acid can manipulate biochemical pathways MYC Signaling and Stem Cell Signaling. Myricetin has biological action on biochemical pathways Oncogenic Cancer Epigenetics. And so on.

For genetic risk of Acute Myeloid Leukemia due to abnormalities in genes NPM1 and IDH2 – Foods like Kiwi are recommended compared to Cranberry. This is because the active ingredients Ellagic Acid and Myricetin in Cranberry further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Vitamin A contained in Kiwi together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: KIWI IS RECOMMENDED OVER CRANBERRY FOR REDUCING THE GENETIC RISK OF ACUTE MYELOID LEUKEMIA DUE TO GENES NPM1 AND IDH2

Eat more nuts, Pecan Nut or Peanut?

The active ingredients contained in Pecan Nut are Vitamin E, Linolenic Acid, Cianidanol, Oleic Acid, Linoleic Acid among others. While the active ingredients contained in Peanut are Vitamin C, Vitamin E, Linolenic Acid, Beta-sitosterol, Rhamnetin and others.

Vitamin E can manipulate biochemical pathways Apoptosis, Cell Cycle Checkpoints and Hypoxia. Cianidanol has biological action on biochemical pathways MYC Signaling, Apoptosis and Cell Cycle Checkpoints.

Lecithin can manipulate biochemical pathways MYC Signaling. Folic Acid has biological action on biochemical pathways Cell Cycle Checkpoints, Apoptosis and MYC Signaling. And so on.

For genetic risk of Acute Myeloid Leukemia due to abnormalities in genes NPM1 and IDH2 – Foods like Pecan Nut are recommended compared to Peanut. This is because the active ingredients Lecithin and Folic Acid in Peanut further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin E and Cianidanol contained in Pecan Nut together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: PECAN NUT IS RECOMMENDED OVER PEANUT FOR REDUCING THE GENETIC RISK OF ACUTE MYELOID LEUKEMIA DUE TO GENES NPM1 AND IDH2


In Summary

An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.

“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.

The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.

You can get started NOW and design a personalized nutrition plan for Acute Myeloid Leukemia by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

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References

Personalized Nutrition for Cancer!

Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.


Scientifically Reviewed by: Dr. Cogle

Christopher R. Cogle, M.D. is a tenured professor at the University of Florida, Chief Medical Officer of Florida Medicaid, and Director of the Florida Health Policy Leadership Academy at the Bob Graham Center for Public Service.

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