Highlights
No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Metastatic Squamous Neck Cancer With Occult Primary when undergoing chemotherapy or when you determine you have a genetic risk for developing Metastatic Squamous Neck Cancer With Occult Primary because of COL1A1 and COL2A1 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.
There is no one answer to this question for cancers such as Metastatic Squamous Neck Cancer With Occult Primary which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.
In short – the process to answer questions like “Should I Avoid eating fruit Lichee” or “Include fruit Currant in my diet” or “Should I reduce consumption of vegetable Bell Pepper” or “Can I take Dim and Vitamin E supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.
RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO METASTATIC SQUAMOUS NECK CANCER WITH OCCULT PRIMARY, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.
The overall objective of personalized nutrition for Metastatic Squamous Neck Cancer With Occult Primary is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.
RECOMMENDATION: UPDATE YOUR NUTRITION FOR METASTATIC SQUAMOUS NECK CANCER WITH OCCULT PRIMARY, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.
About Metastatic Squamous Neck Cancer With Occult Primary
cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.
Following key highlights are derived from clinical data for Metastatic Squamous Neck Cancer With Occult Primary from cBioPortal. The top genes with mutations and other abnormalities for Metastatic Squamous Neck Cancer With Occult Primary include genes TP53, COL1A1, COL2A1, CREB1 and ETS1. The occurrence frequency distribution for these genes respectively is 55.6%, 33.3%, 33.3%, 33.3% and 33.3%. These tumor genetic details of Metastatic Squamous Neck Cancer With Occult Primary are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Metastatic Squamous Neck Cancer With Occult Primary.
Significance of Nutrition for Metastatic Squamous Neck Cancer With Occult Primary
All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Metastatic Squamous Neck Cancer With Occult Primary. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.
For example Lichee includes active ingredients Oleic Acid, Beta-sitosterol, Vitamin C, Linolenic Acid, Linoleic Acid and others. And Currant contains active ingredients Quercetin, Oleic Acid, Beta-sitosterol, Gallic Acid, Myricetin and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.
For cancers like Metastatic Squamous Neck Cancer With Occult Primary, activation or inhibition of selected biochemical pathways like Apoptosis, Angiogenesis, PI3K-AKT-MTOR Signaling, MAPK Signaling plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Metastatic Squamous Neck Cancer With Occult Primary, while eating some other foods and supplements may not be recommended.
One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.
RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR METASTATIC SQUAMOUS NECK CANCER WITH OCCULT PRIMARY – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.
Foods for Metastatic Squamous Neck Cancer With Occult Primary undergoing chemotherapy treatment
In Metastatic Squamous Neck Cancer With Occult Primary – the genes TP53, COL1A1, COL2A1, CREB1 and ETS1 have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Metastatic Squamous Neck Cancer With Occult Primary are Apoptosis, Angiogenesis, PI3K-AKT-MTOR Signaling and others. Trabectedin is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Apoptosis, Angiogenesis, PI3K-AKT-MTOR Signaling so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.
RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.
Eat more pulses, Common Pea or Adzuki Bean?
Pulses are an important part of many diets. The active ingredients contained in Common Pea are Lupeol, Daidzein, Oleic Acid, Beta-sitosterol, Kaempferol among others. While the active ingredients contained in Adzuki Bean are Isoliquiritigenin, Glucaric Acid, Genistein, Folic Acid and others.
Beta-sitosterol can manipulate biochemical pathways NFKB Signaling, Cell Cycle and Cell Survival. Vitamin C has biological action on biochemical pathways MYC Signaling, P53 Signaling and PI3K-AKT-MTOR Signaling.
Isoliquiritigenin can manipulate biochemical pathways DNA Repair. Genistein has biological action on biochemical pathways DNA Repair. And so on.
When treating Metastatic Squamous Neck Cancer With Occult Primary with chemotherapy Trabectedin – Foods like Common Pea are recommended compared to Adzuki Bean. This is because the active ingredients Isoliquiritigenin and Genistein in Adzuki Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin C contained in Common Pea support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: COMMON PEA IS RECOMMENDED OVER ADZUKI BEAN FOR METASTATIC SQUAMOUS NECK CANCER WITH OCCULT PRIMARY ON TREATMENT WITH CHEMOTHERAPY TRABECTEDIN FOR SOME CONDITIONS.
Eat more vegetables, Cabbage or Bell Pepper?
Vegetables are an important part of many diets. The active ingredients contained in Cabbage are Quercetin, Benzyl Isothiocyanate, Isorhamnetin, Brassinin, Beta-sitosterol among others. While the active ingredients contained in Bell Pepper are Vitamin E, Isorhamnetin, Capsaicin, Oleic Acid, Vitamin C and others.
Vitamin C can manipulate biochemical pathways Cell Cycle, MYC Signaling and P53 Signaling. Glucaric Acid has biological action on biochemical pathways NFKB Signaling, Apoptosis and Cell Survival.
Capsaicin can manipulate biochemical pathways DNA Repair. Folic Acid has biological action on biochemical pathways MYC Signaling, P53 Signaling and PI3K-AKT-MTOR Signaling. And so on.
When treating Metastatic Squamous Neck Cancer With Occult Primary with chemotherapy Trabectedin – Foods like Cabbage are recommended compared to Bell Pepper. This is because the active ingredients Capsaicin and Folic Acid in Bell Pepper interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Glucaric Acid contained in Cabbage support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: CABBAGE IS RECOMMENDED OVER BELL PEPPER FOR METASTATIC SQUAMOUS NECK CANCER WITH OCCULT PRIMARY ON TREATMENT WITH CHEMOTHERAPY TRABECTEDIN FOR SOME CONDITIONS.
Eat more fruits, Currant or Lichee?
Fruits are an important part of many diets. The active ingredients contained in Currant are Quercetin, Oleic Acid, Beta-sitosterol, Gallic Acid, Myricetin among others. While the active ingredients contained in Lichee are Oleic Acid, Beta-sitosterol, Vitamin C, Linolenic Acid, Linoleic Acid and others.
Vitamin C can manipulate biochemical pathways Cell Cycle, MYC Signaling and P53 Signaling. Cianidanol has biological action on biochemical pathways NFKB Signaling, Apoptosis and Cell Survival.
Linoleic Acid can manipulate biochemical pathways Angiogenesis. Folic Acid has biological action on biochemical pathways MYC Signaling, P53 Signaling and PI3K-AKT-MTOR Signaling. And so on.
When treating Metastatic Squamous Neck Cancer With Occult Primary with chemotherapy Trabectedin – Foods like Currant are recommended compared to Lichee. This is because the active ingredients Linoleic Acid and Folic Acid in Lichee interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Cianidanol contained in Currant support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: CURRANT IS RECOMMENDED OVER LICHEE FOR METASTATIC SQUAMOUS NECK CANCER WITH OCCULT PRIMARY ON TREATMENT WITH CHEMOTHERAPY TRABECTEDIN FOR SOME CONDITIONS.
Eat more nuts, Pecan Nut or Pumpkin Seeds?
Nuts are an important part of many diets. The active ingredients contained in Pecan Nut are Vitamin E, Oleic Acid, Cianidanol, Linolenic Acid, Delphinidin among others. While the active ingredients contained in Pumpkin Seeds are Oleic Acid, Beta-sitosterol, Linolenic Acid, Gamma-linolenic Acid, Salicylic Acid and others.
Vitamin E can manipulate biochemical pathways NFKB Signaling, Apoptosis and DNA Repair. Cianidanol has biological action on biochemical pathways Cell Survival, MYC Signaling and P53 Signaling.
Lecithin can manipulate biochemical pathways MYC Signaling, NFKB Signaling and Angiogenesis. Cucurbitacin I has biological action on biochemical pathways MYC Signaling and NFKB Signaling. And so on.
When treating Metastatic Squamous Neck Cancer With Occult Primary with chemotherapy Trabectedin – Foods like Pecan Nut are recommended compared to Pumpkin Seeds. This is because the active ingredients Lecithin and Cucurbitacin I in Pumpkin Seeds interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin E and Cianidanol contained in Pecan Nut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: PECAN NUT IS RECOMMENDED OVER PUMPKIN SEEDS FOR METASTATIC SQUAMOUS NECK CANCER WITH OCCULT PRIMARY ON TREATMENT WITH CHEMOTHERAPY TRABECTEDIN FOR SOME CONDITIONS.
Foods for Genetic Risk of Metastatic Squamous Neck Cancer With Occult Primary
One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. COL1A1 and COL2A1 are two genes whose abnormalities are risk factors for Metastatic Squamous Neck Cancer With Occult Primary. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Metastatic Squamous Neck Cancer With Occult Primary can be used as a guide for coming up with a recommended personalized nutrition plan. For Metastatic Squamous Neck Cancer With Occult Primary gene COL1A1 has causative impact on biological pathways like Extracellular Matrix Remodelling, Epithelial to Mesenchymal Transition and Focal Adhesion. And COL2A1 has a causative impact on biological pathways like Extracellular Matrix Remodelling, Focal Adhesion and PI3K-AKT-MTOR Signaling. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like COL1A1 and COL2A1 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes COL1A1 and COL2A1 should be avoided.
Eat more pulses, Hyacinth Bean or Moth Bean?
The active ingredients contained in Hyacinth Bean are Palmitic Acid, Vitamin C, Genistein, Folic Acid, Myristic Acid among others. While the active ingredients contained in Moth Bean are Beta-sitosterol, Linolenic Acid, Stigmasterol, Oleic Acid, Linoleic Acid and others.
Palmitic Acid can manipulate biochemical pathways Apoptosis, Growth Factor Signaling and MYC Signaling. Vitamin C has biological action on biochemical pathways P53 Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling.
Vitamin A can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Linoleic Acid has biological action on biochemical pathways Extracellular Matrix Remodelling. And so on.
For genetic risk of Metastatic Squamous Neck Cancer With Occult Primary due to abnormalities in genes COL1A1 and COL2A1 – Foods like Hyacinth Bean are recommended compared to Moth Bean. This is because the active ingredients Vitamin A and Linoleic Acid in Moth Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Palmitic Acid and Vitamin C contained in Hyacinth Bean together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: HYACINTH BEAN IS RECOMMENDED OVER MOTH BEAN FOR REDUCING THE GENETIC RISK OF METASTATIC SQUAMOUS NECK CANCER WITH OCCULT PRIMARY DUE TO GENES COL1A1 AND COL2A1
Eat more vegetables, Cassava or Wild Leek?
The active ingredients contained in Cassava are Beta-sitosterol, Linolenic Acid, Vitamin C, Oleic Acid, Linoleic Acid among others. While the active ingredients contained in Wild Leek are Vitamin C, Vitamin K, Vitamin A, Folic Acid and others.
Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Beta-sitosterol has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and Apoptosis.
Vitamin A can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. And so on.
For genetic risk of Metastatic Squamous Neck Cancer With Occult Primary due to abnormalities in genes COL1A1 and COL2A1 – Foods like Cassava are recommended compared to Wild Leek. This is because the active ingredients Vitamin A and Folic Acid in Wild Leek further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Cassava together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: CASSAVA IS RECOMMENDED OVER WILD LEEK FOR REDUCING THE GENETIC RISK OF METASTATIC SQUAMOUS NECK CANCER WITH OCCULT PRIMARY DUE TO GENES COL1A1 AND COL2A1
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
Eat more fruits, Feijoa or Huckleberry?
The active ingredients contained in Feijoa are Vitamin C, Lycopene, Casuarinin, Folic Acid among others. While the active ingredients contained in Huckleberry are Resveratrol, Ferulic Acid, Vitamin C, P-coumaric Acid, Quercetin and others.
Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Lycopene has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and Apoptosis.
Resveratrol can manipulate biochemical pathways P53 Signaling. Pelargonidin has biological action on biochemical pathways MYC Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling. And so on.
For genetic risk of Metastatic Squamous Neck Cancer With Occult Primary due to abnormalities in genes COL1A1 and COL2A1 – Foods like Feijoa are recommended compared to Huckleberry. This is because the active ingredients Resveratrol and Pelargonidin in Huckleberry further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Lycopene contained in Feijoa together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: FEIJOA IS RECOMMENDED OVER HUCKLEBERRY FOR REDUCING THE GENETIC RISK OF METASTATIC SQUAMOUS NECK CANCER WITH OCCULT PRIMARY DUE TO GENES COL1A1 AND COL2A1
Eat more nuts, Hazelnut or Macadamia Nut?
The active ingredients contained in Hazelnut are Vitamin E, Linolenic Acid, Oleic Acid, Quercetin, Linoleic Acid among others. While the active ingredients contained in Macadamia Nut are Beta-sitosterol, Palmitic Acid, Lauric Acid, Folic Acid, Myristic Acid and others.
Vitamin E can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Quercetin has biological action on biochemical pathways Growth Factor Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling.
Lauric Acid can manipulate biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. Myristic Acid has biological action on biochemical pathways Apoptosis, P53 Signaling and Cell Cycle Checkpoints. And so on.
For genetic risk of Metastatic Squamous Neck Cancer With Occult Primary due to abnormalities in genes COL1A1 and COL2A1 – Foods like Hazelnut are recommended compared to Macadamia Nut. This is because the active ingredients Lauric Acid and Myristic Acid in Macadamia Nut further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin E and Quercetin contained in Hazelnut together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: HAZELNUT IS RECOMMENDED OVER MACADAMIA NUT FOR REDUCING THE GENETIC RISK OF METASTATIC SQUAMOUS NECK CANCER WITH OCCULT PRIMARY DUE TO GENES COL1A1 AND COL2A1
In Summary
An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.
“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.
The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.
You can get started NOW and design a personalized nutrition plan for Metastatic Squamous Neck Cancer With Occult Primary by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
References
- β-Sitosterol targets Trx/Trx1 reductase to induce apoptosis in A549 cells via ROS mediated mitochondrial dysregulation and p53 activation.
- Vitamin C enhances epigenetic modifications induced by 5-azacytidine and cell cycle arrest in the hepatocellular carcinoma cell lines HLE and Huh7.
- Bis(4-hydroxy-2H-chromen-2-one): synthesis and effects on leukemic cell lines proliferation and NF-κB regulation.
- BRCA1 and BRCA2 as molecular targets for phytochemicals indole-3-carbinol and genistein in breast and prostate cancer cells.
- (+)-Catechin inhibits tumour angiogenesis and regulates the production of nitric oxide and TNF-alpha in LPS-stimulated macrophages.
- Excess Linoleic Acid Increases Collagen I/III Ratio and Stiffens” the Heart Muscle Following High Fat Diets.”
- Effects of folate deficiency on gene expression in the apoptosis and cancer pathways in colon cancer cells.
- Induction of apoptosis by calcium D-glucarate in 7,12-dimethyl benz [a] anthracene-exposed mouse skin.
- Gamma- and delta-tocotrienols exert a more potent anticancer effect than alpha-tocopheryl succinate on breast cancer cell lines irrespective of HER-2/neu expression.
- New concepts in phospholipase D signaling in inflammation and cancer.
- Cucurbitacin-I induces hypertrophy in H9c2 cardiomyoblasts through activation of autophagy via MEK/ERK1/2 signaling pathway.
- Functional lipidomics: Palmitic acid impairs hepatocellular carcinoma development by modulating membrane fluidity and glucose metabolism.
- Vitamin A regulates Akt signaling through the phospholipid fatty acid composition.
- Lycopene metabolite, apo-10′-lycopenoic acid, inhibits diethylnitrosamine-initiated, high fat diet-promoted hepatic inflammation and tumorigenesis in mice.
- Resveratrol, a remarkable inhibitor of ribonucleotide reductase.
- Pelargonidin suppresses adipogenesis in 3T3-L1 cells through inhibition of PPAR-γ signaling pathway.
- Protein kinase and HDAC inhibitors from the endophytic fungus Epicoccum nigrum.
- Clinical pharmacodynamics of antihistamines.
- Saturated fatty acids modulate cell response to DNA damage: implication for their role in tumorigenesis.
- HyperFoods: Machine intelligent mapping of cancer-beating molecules in foods.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.