Which Foods are Recommended for Pheochromocytoma And Paraganglioma?

Highlights

No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Pheochromocytoma And Paraganglioma when undergoing chemotherapy or when you determine you have a genetic risk for developing Pheochromocytoma And Paraganglioma because of EPAS1 and AWAT1 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.

There is no one answer to this question for cancers such as Pheochromocytoma And Paraganglioma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.

In short – the process to answer questions like “Should I Avoid eating fruit Date” or “Include fruit Pitanga in my diet” or “Should I reduce consumption of vegetable Celery” or “Can I take Dan Shen and Angelica supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.

RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO PHEOCHROMOCYTOMA AND PARAGANGLIOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.

The overall objective of personalized nutrition for Pheochromocytoma And Paraganglioma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.

RECOMMENDATION: UPDATE YOUR NUTRITION FOR PHEOCHROMOCYTOMA AND PARAGANGLIOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.

About Pheochromocytoma And Paraganglioma

cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.

Following key highlights are derived from clinical data for Pheochromocytoma And Paraganglioma from cBioPortal. The patients enrolled in the studies for Pheochromocytoma And Paraganglioma are in ages between 19 to 83 with an average age of 46. 45.0% of males and 55.0% of females were the distribution of gender in these clinical studies. From a patient sample size of 366; the top genes with mutations and other abnormalities for Pheochromocytoma And Paraganglioma include genes EPAS1, AWAT1, POLR1A, ATRX and ACER2. The occurrence frequency distribution for these genes respectively is 6.5%, 3.2%, 3.2%, 3.2% and 1.6%. These tumor genetic details of Pheochromocytoma And Paraganglioma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Pheochromocytoma And Paraganglioma.

Significance of Nutrition for Pheochromocytoma And Paraganglioma

All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Pheochromocytoma And Paraganglioma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.

For example Date includes active ingredients Quercetin, Apigenin, Vitamin C, Lupeol, Gallic Acid and others. And Pitanga contains active ingredients Quercetin, Vitamin C, Vitamin A and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.

For cancers like Pheochromocytoma And Paraganglioma, activation or inhibition of selected biochemical pathways like Epithelial to Mesenchymal Transition, MAPK Signaling, Small Molecule Transport, Post Translation Modification plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Pheochromocytoma And Paraganglioma, while eating some other foods and supplements may not be recommended.

One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.

RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR PHEOCHROMOCYTOMA AND PARAGANGLIOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.

Foods for Pheochromocytoma And Paraganglioma undergoing chemotherapy treatment

In Pheochromocytoma And Paraganglioma – the genes EPAS1, AWAT1, POLR1A, ATRX and ACER2 have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Pheochromocytoma And Paraganglioma are Epithelial to Mesenchymal Transition, MAPK Signaling, Carbohydrate Metabolism and others. Vincristine is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Epithelial to Mesenchymal Transition, MAPK Signaling, Carbohydrate Metabolism so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.

RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.

Eat more pulses, Mung Bean or Soy Bean?

Pulses are an important part of many diets. The active ingredients contained in Mung Bean are Quercetin, Vitamin C, Kaempferol, Linolenic Acid, Genistein among others. While the active ingredients contained in Soy Bean are Quercetin, Fisetin, 7-8-dihydroxyflavone, Vitamin E, Vitamin C and others.

Quercetin can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Carbohydrate Metabolism and Cell Cycle. Vitamin C has biological action on biochemical pathways MAPK Signaling, Hypoxia and RAS-RAF Signaling.

Lecithin can manipulate biochemical pathways MAPK Signaling. Fisetin has biological action on biochemical pathways Epithelial to Mesenchymal Transition. And so on.

When treating Pheochromocytoma And Paraganglioma with chemotherapy Vincristine – Foods like Mung Bean are recommended compared to Soy Bean. This is because the active ingredients Lecithin and Fisetin in Soy Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Quercetin and Vitamin C contained in Mung Bean support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: MUNG BEAN IS RECOMMENDED OVER SOY BEAN FOR PHEOCHROMOCYTOMA AND PARAGANGLIOMA ON TREATMENT WITH CHEMOTHERAPY VINCRISTINE FOR SOME CONDITIONS.

Eat more vegetables, Giant Butterbur or Celery?

Vegetables are an important part of many diets. The active ingredients contained in Giant Butterbur are Vitamin C, Kaempferol, Melatonin, Beta-sitosterol, Vitamin A among others. While the active ingredients contained in Celery are Quercetin, Apigenin, Luteolin, Vitamin C, Kaempferol and others.

Vitamin C can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Carbohydrate Metabolism and Cell Cycle. Kaempferol has biological action on biochemical pathways MAPK Signaling, Hypoxia and RAS-RAF Signaling.

Chrysin can manipulate biochemical pathways Epithelial to Mesenchymal Transition. Cynaroside has biological action on biochemical pathways MAPK Signaling. And so on.

When treating Pheochromocytoma And Paraganglioma with chemotherapy Vincristine – Foods like Giant Butterbur are recommended compared to Celery. This is because the active ingredients Chrysin and Cynaroside in Celery interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Kaempferol contained in Giant Butterbur support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: GIANT BUTTERBUR IS RECOMMENDED OVER CELERY FOR PHEOCHROMOCYTOMA AND PARAGANGLIOMA ON TREATMENT WITH CHEMOTHERAPY VINCRISTINE FOR SOME CONDITIONS.

Eat more fruits, Pitanga or Date?

Fruits are an important part of many diets. The active ingredients contained in Pitanga are Quercetin, Vitamin C, Vitamin A among others. While the active ingredients contained in Date are Quercetin, Apigenin, Vitamin C, Lupeol, Gallic Acid and others.

Vitamin C can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Carbohydrate Metabolism and Cell Cycle. Quercetin has biological action on biochemical pathways MAPK Signaling, Hypoxia and RAS-RAF Signaling.

Apigenin can manipulate biochemical pathways Epithelial to Mesenchymal Transition. Oleic Acid has biological action on biochemical pathways Epithelial to Mesenchymal Transition. And so on.

When treating Pheochromocytoma And Paraganglioma with chemotherapy Vincristine – Foods like Pitanga are recommended compared to Date. This is because the active ingredients Apigenin and Oleic Acid in Date interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Quercetin contained in Pitanga support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: PITANGA IS RECOMMENDED OVER DATE FOR PHEOCHROMOCYTOMA AND PARAGANGLIOMA ON TREATMENT WITH CHEMOTHERAPY VINCRISTINE FOR SOME CONDITIONS.

Eat more nuts, Almond or Macadamia Nut?

Nuts are an important part of many diets. The active ingredients contained in Almond are Quercetin, Salicylic Acid, Vitamin E, Linolenic Acid, Beta-sitosterol among others. While the active ingredients contained in Macadamia Nut are Beta-sitosterol, Lauric Acid, Palmitic Acid, Folic Acid, Myristic Acid and others.

Beta-sitosterol can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Cell Cycle and Hypoxia. Quercetin has biological action on biochemical pathways Carbohydrate Metabolism, MAPK Signaling and RAS-RAF Signaling.

Lauric Acid can manipulate biochemical pathways MAPK Signaling. Palmitic Acid has biological action on biochemical pathways Epithelial to Mesenchymal Transition and MAPK Signaling. And so on.

When treating Pheochromocytoma And Paraganglioma with chemotherapy Vincristine – Foods like Almond are recommended compared to Macadamia Nut. This is because the active ingredients Lauric Acid and Palmitic Acid in Macadamia Nut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Quercetin contained in Almond support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: ALMOND IS RECOMMENDED OVER MACADAMIA NUT FOR PHEOCHROMOCYTOMA AND PARAGANGLIOMA ON TREATMENT WITH CHEMOTHERAPY VINCRISTINE FOR SOME CONDITIONS.

Foods for Genetic Risk of Pheochromocytoma And Paraganglioma

One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. EPAS1 and AWAT1 are two genes whose abnormalities are risk factors for Pheochromocytoma And Paraganglioma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Pheochromocytoma And Paraganglioma can be used as a guide for coming up with a recommended personalized nutrition plan. For Pheochromocytoma And Paraganglioma gene EPAS1 has causative impact on biological pathways like Hypoxia and Post Translation Modification. And AWAT1 has a causative impact on biological pathways like Lipid Metabolism. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like EPAS1 and AWAT1 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes EPAS1 and AWAT1 should be avoided.

Eat more pulses, Fava Bean or Hyacinth Bean?

The active ingredients contained in Fava Bean are Quercetin, Caffeic Acid, Vitamin C, Genistein, Beta-sitosterol among others. While the active ingredients contained in Hyacinth Bean are Vitamin C, Genistein, Palmitic Acid, Folic Acid, Myristic Acid and others.

Quercetin can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Small Molecule Transport and TGFB Signaling. Caffeic Acid has biological action on biochemical pathways Post Translation Modification, EPHRIN Signaling and Epithelial to Mesenchymal Transition.

Palmitic Acid can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Small Molecule Transport and Post Translation Modification. Myristic Acid has biological action on biochemical pathways RAS-RAF Signaling and Post Translation Modification. And so on.

For genetic risk of Pheochromocytoma And Paraganglioma due to abnormalities in genes EPAS1 and AWAT1 – Foods like Fava Bean are recommended compared to Hyacinth Bean. This is because the active ingredients Palmitic Acid and Myristic Acid in Hyacinth Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Quercetin and Caffeic Acid contained in Fava Bean together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: FAVA BEAN IS RECOMMENDED OVER HYACINTH BEAN FOR REDUCING THE GENETIC RISK OF PHEOCHROMOCYTOMA AND PARAGANGLIOMA DUE TO GENES EPAS1 AND AWAT1

Eat more vegetables, Arrowroot or Cucumber?

The active ingredients contained in Arrowroot are Quercetin, Protocatechuic Acid, Beta-carotene, Chlorogenic Acid, Vitamin C among others. While the active ingredients contained in Cucumber are Caffeic Acid, Vitamin C, Lupeol, Beta-sitosterol, Cucurbitacin E and others.

Quercetin can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Small Molecule Transport and TGFB Signaling. Protocatechuic Acid has biological action on biochemical pathways RAS-RAF Signaling, EPHRIN Signaling and Epithelial to Mesenchymal Transition.

Fisetin can manipulate biochemical pathways Epithelial to Mesenchymal Transition. Cucurbitacin I has biological action on biochemical pathways EPHRIN Signaling. And so on.

For genetic risk of Pheochromocytoma And Paraganglioma due to abnormalities in genes EPAS1 and AWAT1 – Foods like Arrowroot are recommended compared to Cucumber. This is because the active ingredients Fisetin and Cucurbitacin I in Cucumber further promote the effects of genes on the biochemical pathways. While the active ingredients Quercetin and Protocatechuic Acid contained in Arrowroot together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: ARROWROOT IS RECOMMENDED OVER CUCUMBER FOR REDUCING THE GENETIC RISK OF PHEOCHROMOCYTOMA AND PARAGANGLIOMA DUE TO GENES EPAS1 AND AWAT1

Eat more fruits, Huckleberry or Guava?

The active ingredients contained in Huckleberry are Quercetin, Caffeic Acid, Delphinidin, Chlorogenic Acid, Vitamin C among others. While the active ingredients contained in Guava are Myricetin, Maslinic Acid, Corosolic Acid, Modified Citrus Pectin, Vitamin C and others.

Quercetin can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Small Molecule Transport and TGFB Signaling. Caffeic Acid has biological action on biochemical pathways Post Translation Modification, EPHRIN Signaling and Epithelial to Mesenchymal Transition.

Lycopene can manipulate biochemical pathways Small Molecule Transport, Calcium Signaling and Post Translation Modification. Oleic Acid has biological action on biochemical pathways Epithelial to Mesenchymal Transition. And so on.

For genetic risk of Pheochromocytoma And Paraganglioma due to abnormalities in genes EPAS1 and AWAT1 – Foods like Huckleberry are recommended compared to Guava. This is because the active ingredients Lycopene and Oleic Acid in Guava further promote the effects of genes on the biochemical pathways. While the active ingredients Quercetin and Caffeic Acid contained in Huckleberry together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: HUCKLEBERRY IS RECOMMENDED OVER GUAVA FOR REDUCING THE GENETIC RISK OF PHEOCHROMOCYTOMA AND PARAGANGLIOMA DUE TO GENES EPAS1 AND AWAT1

Eat more nuts, Acorn or Cashew Nut?

The active ingredients contained in Acorn are Quercetin, Beta-carotene, Vitamin C, Gallic Acid, Beta-sitosterol among others. While the active ingredients contained in Cashew Nut are Vitamin C, Beta-sitosterol, Gallic Acid, Vitamin K, Palmitic Acid and others.

Quercetin can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Small Molecule Transport and TGFB Signaling. Beta-carotene has biological action on biochemical pathways Calcium Signaling and Epithelial to Mesenchymal Transition.

Palmitic Acid can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Small Molecule Transport and Post Translation Modification. Myristic Acid has biological action on biochemical pathways RAS-RAF Signaling and Post Translation Modification. And so on.

For genetic risk of Pheochromocytoma And Paraganglioma due to abnormalities in genes EPAS1 and AWAT1 – Foods like Acorn are recommended compared to Cashew Nut. This is because the active ingredients Palmitic Acid and Myristic Acid in Cashew Nut further promote the effects of genes on the biochemical pathways. While the active ingredients Quercetin and Beta-carotene contained in Acorn together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: ACORN IS RECOMMENDED OVER CASHEW NUT FOR REDUCING THE GENETIC RISK OF PHEOCHROMOCYTOMA AND PARAGANGLIOMA DUE TO GENES EPAS1 AND AWAT1

In Summary

An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.

“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.

The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.

You can get started NOW and design a personalized nutrition plan for Pheochromocytoma And Paraganglioma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

References

• Msk Impact 2017
• Cancer therapy shapes the fitness landscape of clonal hematopoiesis.
• Vasorelaxant effect of flavonoids through calmodulin inhibition: Ex vivo, in vitro, and in silico approaches.
• Mucocutaneous lymph node syndrome (Kawasaki syndrome): a case report.
• The recruitment of Raf-1 to membranes is mediated by direct interaction with phosphatidic acid and is independent of association with Ras.
• Crystal structure of a human cyclin-dependent kinase 6 complex with a flavonol inhibitor, fisetin.
• Oleic acid-induced ANGPTL4 enhances head and neck squamous cell carcinoma anoikis resistance and metastasis via up-regulation of fibronectin.
• Flavonoids as receptor tyrosine kinase FLT3 inhibitors.
• Luteoloside Inhibits Proliferation and Promotes Intrinsic and Extrinsic Pathway-Mediated Apoptosis Involving MAPK and mTOR Signaling Pathways in Human Cervical Cancer Cells.
• β-Sitosterol and Gemcitabine Exhibit Synergistic Anti-pancreatic Cancer Activity by Modulating Apoptosis and Inhibiting Epithelial-Mesenchymal Transition by Deactivating Akt/GSK-3β Signaling.
• Clinical pharmacodynamics of antihistamines.
• Targeting metastasis-initiating cells through the fatty acid receptor CD36.
• Synthesis and structure-activity relationship analysis of caffeic acid amides as selective matrix metalloproteinase inhibitors.
• Functional Expression and Characterization of Human Myristoylated-Arf1 in Nanodisc Membrane Mimetics.
• Lycopene and bone: an in vitro investigation and a pilot prospective clinical study.
• Protocatechuic acid inhibits lung cancer cells by modulating FAK, MAPK, and NF-κB pathways.
• Binding studies and biological evaluation of β-carotene as a potential inhibitor of human calcium/calmodulin-dependent protein kinase IV.
• HyperFoods: Machine intelligent mapping of cancer-beating molecules in foods.
• Fisetin: a dietary antioxidant for health promotion.