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What Foods are Recommended for Cancer?
is a very common question. Personalized Nutrition Plans are foods and supplements which are personalized to a cancer indication, genes, any treatments and lifestyle conditions.

Which Foods are Recommended for Esophageal Squamous Cell Carcinoma?

Aug 27, 2022

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Highlights

No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Esophageal Squamous Cell Carcinoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Esophageal Squamous Cell Carcinoma because of ROS1 and NCOR1 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.

There is no one answer to this question for cancers such as Esophageal Squamous Cell Carcinoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.

In short – the process to answer questions like “Should I Avoid eating fruit Peach” or “Include fruit Papaya in my diet” or “Should I reduce consumption of vegetable Beetroot” or “Can I take Birch and Vitamin E supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.

RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO ESOPHAGEAL SQUAMOUS CELL CARCINOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.

The overall objective of personalized nutrition for Esophageal Squamous Cell Carcinoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.

RECOMMENDATION: UPDATE YOUR NUTRITION FOR ESOPHAGEAL SQUAMOUS CELL CARCINOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.



About Esophageal Squamous Cell Carcinoma

cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.

Following key highlights are derived from clinical data for Esophageal Squamous Cell Carcinoma from cBioPortal. The patients enrolled in the studies for Esophageal Squamous Cell Carcinoma are in ages between 34 to 88 with an average age of 60. 79.4% of males and 20.6% of females were the distribution of gender in these clinical studies. From a patient sample size of 827; the top genes with mutations and other abnormalities for Esophageal Squamous Cell Carcinoma include genes TP53, KMT2D, ROS1, NCOR1 and MUC16. The occurrence frequency distribution for these genes respectively is 10.5%, 3.2%, 3.0%, 2.7% and 2.5%. These tumor genetic details of Esophageal Squamous Cell Carcinoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Esophageal Squamous Cell Carcinoma.

Significance of Nutrition for Esophageal Squamous Cell Carcinoma

All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Esophageal Squamous Cell Carcinoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.

For example Peach includes active ingredients Beta-sitosterol, Fisetin, Linolenic Acid, Vitamin C, Oleic Acid and others. And Papaya contains active ingredients Benzyl Isothiocyanate, Lycopene, Beta-sitosterol, Linalool, Linolenic Acid and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.

For cancers like Esophageal Squamous Cell Carcinoma, activation or inhibition of selected biochemical pathways like Cell Cycle, Growth Factor Signaling, PI3K-AKT-MTOR Signaling, MAPK Signaling plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Esophageal Squamous Cell Carcinoma, while eating some other foods and supplements may not be recommended.

One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.

For cancers like Esophageal Squamous Cell Carcinoma, activation or inhibition of selected biochemical pathways like Cell Cycle, Growth Factor Signaling, PI3K-AKT-MTOR Signaling, MAPK Signaling plays an important role in driving cancer growth.

RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR ESOPHAGEAL SQUAMOUS CELL CARCINOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.

Foods for Esophageal Squamous Cell Carcinoma undergoing chemotherapy treatment

In Esophageal Squamous Cell Carcinoma – the genes TP53, KMT2D, ROS1, NCOR1 and MUC16 have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Esophageal Squamous Cell Carcinoma are Cell Cycle, Growth Factor Signaling, MAPK Signaling and others. Irinotecan is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Cell Cycle, Growth Factor Signaling, MAPK Signaling so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.

RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.

Eat more pulses, Common Pea or Pigeon Pea?

Pulses are an important part of many diets. The active ingredients contained in Common Pea are Lupeol, Daidzein, Beta-sitosterol, Delphinidin, Linolenic Acid among others. While the active ingredients contained in Pigeon Pea are Linolenic Acid, Vitamin C, Oleic Acid, Genistein, Vitamin A and others.

Beta-sitosterol can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and Apoptosis. Vitamin C has biological action on biochemical pathways Growth Factor Signaling, Cell Cycle and MYC Signaling.

Genistein can manipulate biochemical pathways Vitamin Metabolism, DNA Repair and Nutrient sensing. Linolenic Acid has biological action on biochemical pathways Vitamin Metabolism. And so on.

When treating Esophageal Squamous Cell Carcinoma with chemotherapy Irinotecan – Foods like Common Pea are recommended compared to Pigeon Pea. This is because the active ingredients Genistein and Linolenic Acid in Pigeon Pea interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin C contained in Common Pea support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: COMMON PEA IS RECOMMENDED OVER PIGEON PEA FOR ESOPHAGEAL SQUAMOUS CELL CARCINOMA ON TREATMENT WITH CHEMOTHERAPY IRINOTECAN FOR SOME CONDITIONS.

Eat more vegetables, Cassava or Beetroot?

Vegetables are an important part of many diets. The active ingredients contained in Cassava are Beta-sitosterol, Linolenic Acid, Vitamin C, Oleic Acid, Vitamin A among others. While the active ingredients contained in Beetroot are Vitamin E, Beta-sitosterol, Linolenic Acid, Vitamin C, Oleic Acid and others.

Vitamin C can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Apoptosis and Growth Factor Signaling. Beta-sitosterol has biological action on biochemical pathways NFKB Signaling, DNA Repair and Cell Cycle.

Trans-trans-farnesol can manipulate biochemical pathways Nutrient sensing. Citric Acid has biological action on biochemical pathways Vitamin Metabolism. And so on.

When treating Esophageal Squamous Cell Carcinoma with chemotherapy Irinotecan – Foods like Cassava are recommended compared to Beetroot. This is because the active ingredients Trans-trans-farnesol and Citric Acid in Beetroot interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Beta-sitosterol contained in Cassava support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: CASSAVA IS RECOMMENDED OVER BEETROOT FOR ESOPHAGEAL SQUAMOUS CELL CARCINOMA ON TREATMENT WITH CHEMOTHERAPY IRINOTECAN FOR SOME CONDITIONS.

Which Foods are Recommended for Esophageal Squamous Cell Carcinoma?

Eat more fruits, Papaya or Peach?

Fruits are an important part of many diets. The active ingredients contained in Papaya are Benzyl Isothiocyanate, Lycopene, Beta-sitosterol, Linalool, Linolenic Acid among others. While the active ingredients contained in Peach are Beta-sitosterol, Fisetin, Linolenic Acid, Vitamin C, Oleic Acid and others.

Lycopene can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and Apoptosis. Zeaxanthin has biological action on biochemical pathways DNA Repair, JAK-STAT Signaling and Cell Cycle.

Citric Acid can manipulate biochemical pathways Vitamin Metabolism. Fisetin has biological action on biochemical pathways Epithelial to Mesenchymal Transition, WNT Beta Catenin Signaling and MYC Signaling. And so on.

When treating Esophageal Squamous Cell Carcinoma with chemotherapy Irinotecan – Foods like Papaya are recommended compared to Peach. This is because the active ingredients Citric Acid and Fisetin in Peach interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Lycopene and Zeaxanthin contained in Papaya support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: PAPAYA IS RECOMMENDED OVER PEACH FOR ESOPHAGEAL SQUAMOUS CELL CARCINOMA ON TREATMENT WITH CHEMOTHERAPY IRINOTECAN FOR SOME CONDITIONS.

Eat more nuts, Pecan Nut or Acorn?

Nuts are an important part of many diets. The active ingredients contained in Pecan Nut are Vitamin E, Delphinidin, Cianidanol, Linolenic Acid, Oleic Acid among others. While the active ingredients contained in Acorn are Quercetin, Beta-sitosterol, Gallic Acid, Beta-carotene, Vitamin C and others.

Vitamin E can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and Apoptosis. Delphinidin has biological action on biochemical pathways DNA Repair, Growth Factor Signaling and MYC Signaling.

Quercetin can manipulate biochemical pathways Vitamin Metabolism. Gallic Acid has biological action on biochemical pathways Vitamin Metabolism. And so on.

When treating Esophageal Squamous Cell Carcinoma with chemotherapy Irinotecan – Foods like Pecan Nut are recommended compared to Acorn. This is because the active ingredients Quercetin and Gallic Acid in Acorn interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin E and Delphinidin contained in Pecan Nut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: PECAN NUT IS RECOMMENDED OVER ACORN FOR ESOPHAGEAL SQUAMOUS CELL CARCINOMA ON TREATMENT WITH CHEMOTHERAPY IRINOTECAN FOR SOME CONDITIONS.

Foods for Genetic Risk of Esophageal Squamous Cell Carcinoma

One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. ROS1 and NCOR1 are two genes whose abnormalities are risk factors for Esophageal Squamous Cell Carcinoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Esophageal Squamous Cell Carcinoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Esophageal Squamous Cell Carcinoma gene ROS1 has causative impact on biological pathways like PI3K-AKT-MTOR Signaling, RAS-RAF Signaling and MAPK Signaling. And NCOR1 has a causative impact on biological pathways like Androgen Signaling, Oncogenic Cancer Epigenetics and Growth Factor Signaling. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like ROS1 and NCOR1 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes ROS1 and NCOR1 should be avoided.

Eat more pulses, Scarlet Bean or Chickpea?

The active ingredients contained in Scarlet Bean are Beta-sitosterol, Vitamin C, Linolenic Acid, Stigmasterol, Oleic Acid among others. While the active ingredients contained in Chickpea are Linolenic Acid, Oleic Acid, Genistein, Vitamin A, Folic Acid and others.

Beta-sitosterol can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Vitamin C has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and RAS-RAF Signaling.

Vitamin A can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. And so on.

For genetic risk of Esophageal Squamous Cell Carcinoma due to abnormalities in genes ROS1 and NCOR1 – Foods like Scarlet Bean are recommended compared to Chickpea. This is because the active ingredients Vitamin A and Folic Acid in Chickpea further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin C contained in Scarlet Bean together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: SCARLET BEAN IS RECOMMENDED OVER CHICKPEA FOR REDUCING THE GENETIC RISK OF ESOPHAGEAL SQUAMOUS CELL CARCINOMA DUE TO GENES ROS1 AND NCOR1

Eat more vegetables, Jicama or Chinese Mustard?

The active ingredients contained in Jicama are Vitamin C, Vitamin B3, Beta-carotene, Vitamin A, Folic Acid among others. While the active ingredients contained in Chinese Mustard are Quercetin, Indole-3-carbinol, Kaempferol, Isorhamnetin, Vitamin A and others.

Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Vitamin B3 has biological action on biochemical pathways Cell Cycle Checkpoints, MYC Signaling and P53 Signaling.

Vitamin A can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Quercetin has biological action on biochemical pathways DNA Repair. And so on.

For genetic risk of Esophageal Squamous Cell Carcinoma due to abnormalities in genes ROS1 and NCOR1 – Foods like Jicama are recommended compared to Chinese Mustard. This is because the active ingredients Vitamin A and Quercetin in Chinese Mustard further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Vitamin B3 contained in Jicama together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: JICAMA IS RECOMMENDED OVER CHINESE MUSTARD FOR REDUCING THE GENETIC RISK OF ESOPHAGEAL SQUAMOUS CELL CARCINOMA DUE TO GENES ROS1 AND NCOR1

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.

Eat more fruits, Kiwi or Kumquat?

The active ingredients contained in Kiwi are Quercetin, Vitamin C, Fisetin, Chlorogenic Acid, Vitamin A among others. While the active ingredients contained in Kumquat are Apigenin, Vitamin C, Linolenic Acid, Oleic Acid, Linoleic Acid and others.

Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Chlorogenic Acid has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, Extracellular Matrix Remodelling and MYC Signaling.

Vitamin A can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. And so on.

For genetic risk of Esophageal Squamous Cell Carcinoma due to abnormalities in genes ROS1 and NCOR1 – Foods like Kiwi are recommended compared to Kumquat. This is because the active ingredients Vitamin A and Folic Acid in Kumquat further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Chlorogenic Acid contained in Kiwi together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: KIWI IS RECOMMENDED OVER KUMQUAT FOR REDUCING THE GENETIC RISK OF ESOPHAGEAL SQUAMOUS CELL CARCINOMA DUE TO GENES ROS1 AND NCOR1

Eat more nuts, Pine Nut or Peanut?

The active ingredients contained in Pine Nut are Beta-sitosterol, Vitamin E, Linolenic Acid, Oleic Acid, Linoleic Acid among others. While the active ingredients contained in Peanut are Quercetin, Beta-sitosterol, Vitamin C, Vitamin E, Linolenic Acid and others.

Beta-sitosterol can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Vitamin K has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and MYC Signaling.

Quercetin can manipulate biochemical pathways DNA Repair. Vitamin A has biological action on biochemical pathways PI3K-AKT-MTOR Signaling. And so on.

For genetic risk of Esophageal Squamous Cell Carcinoma due to abnormalities in genes ROS1 and NCOR1 – Foods like Pine Nut are recommended compared to Peanut. This is because the active ingredients Quercetin and Vitamin A in Peanut further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin K contained in Pine Nut together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: PINE NUT IS RECOMMENDED OVER PEANUT FOR REDUCING THE GENETIC RISK OF ESOPHAGEAL SQUAMOUS CELL CARCINOMA DUE TO GENES ROS1 AND NCOR1


In Summary

An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.

“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.

The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.

You can get started NOW and design a personalized nutrition plan for Esophageal Squamous Cell Carcinoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

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References

Personalized Nutrition for Cancer!

Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.


Scientifically Reviewed by: Dr. Cogle

Christopher R. Cogle, M.D. is a tenured professor at the University of Florida, Chief Medical Officer of Florida Medicaid, and Director of the Florida Health Policy Leadership Academy at the Bob Graham Center for Public Service.

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