Which Foods are Recommended for Thymic Neuroendocrine?

Highlights

No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Thymic Neuroendocrine when undergoing chemotherapy or when you determine you have a genetic risk for developing Thymic Neuroendocrine because of MEN1 and GSK3B gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.

There is no one answer to this question for cancers such as Thymic Neuroendocrine which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.

In short – the process to answer questions like “Should I Avoid eating fruit Pummelo” or “Include fruit Saskatoon Berry in my diet” or “Should I reduce consumption of vegetable Spinach” or “Can I take Vitamin D3 and Cissus supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.

RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO THYMIC NEUROENDOCRINE, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.

The overall objective of personalized nutrition for Thymic Neuroendocrine is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.

RECOMMENDATION: UPDATE YOUR NUTRITION FOR THYMIC NEUROENDOCRINE, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.

About Thymic Neuroendocrine

cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.

Following key highlights are derived from clinical data for Thymic Neuroendocrine from cBioPortal. The patients enrolled in the studies for Thymic Neuroendocrine are in ages between 66 to 66 with an average age of 66.From a patient sample size of 1; the top genes with mutations and other abnormalities for Thymic Neuroendocrine include genes MEN1, GSK3B, APC, CTNNB1 and MYC. The occurrence frequency distribution for these genes respectively is 90.0%, 55.0%, 45.0%, 35.0% and 30.0%. These tumor genetic details of Thymic Neuroendocrine are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Thymic Neuroendocrine.

Significance of Nutrition for Thymic Neuroendocrine

All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Thymic Neuroendocrine. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.

For example Pummelo includes active ingredients Naringin, Beta-sitosterol, Vitamin C, Naringenin, Oleic Acid and others. And Saskatoon Berry contains active ingredients Quercetin, Delphinidin and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.

For cancers like Thymic Neuroendocrine, activation or inhibition of selected biochemical pathways like Cell Cycle, MAPK Signaling, PI3K-AKT-MTOR Signaling, DNA Repair plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Thymic Neuroendocrine, while eating some other foods and supplements may not be recommended.

One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.

RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR THYMIC NEUROENDOCRINE – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.

Foods for Thymic Neuroendocrine undergoing chemotherapy treatment

In Thymic Neuroendocrine – the genes MEN1, GSK3B, APC, CTNNB1 and MYC have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Thymic Neuroendocrine are Cell Cycle, MAPK Signaling, PI3K-AKT-MTOR Signaling and others. Octreotide is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Cell Cycle, MAPK Signaling, PI3K-AKT-MTOR Signaling so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.

RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.

Eat more pulses, Common Pea or Fava Bean?

Pulses are an important part of many diets. The active ingredients contained in Common Pea are Kaempferol, Daidzein, Lupeol, Genistein, Delphinidin among others. While the active ingredients contained in Fava Bean are Quercetin, Kaempferol, Daidzein, Butein, Genistein and others.

Beta-sitosterol can manipulate biochemical pathways Cell Cycle, WNT Beta Catenin Signaling and PI3K-AKT-MTOR Signaling. Vitamin C has biological action on biochemical pathways Growth Factor Signaling, MAPK Signaling and Oncogenic Cancer Epigenetics.

Epicatechin can manipulate biochemical pathways Angiogenesis. Linoleic Acid has biological action on biochemical pathways Growth Factor Signaling and Angiogenesis. And so on.

When treating Thymic Neuroendocrine with chemotherapy Octreotide – Foods like Common Pea are recommended compared to Fava Bean. This is because the active ingredients Epicatechin and Linoleic Acid in Fava Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin C contained in Common Pea support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: COMMON PEA IS RECOMMENDED OVER FAVA BEAN FOR THYMIC NEUROENDOCRINE ON TREATMENT WITH CHEMOTHERAPY OCTREOTIDE FOR SOME CONDITIONS.

Eat more vegetables, Brussels Sprout or Spinach?

Vegetables are an important part of many diets. The active ingredients contained in Brussels Sprout are Indole-3-carbinol, Beta-sitosterol, Vitamin C, Oleic Acid, Linolenic Acid among others. While the active ingredients contained in Spinach are Quercetin, Apigenin, Kaempferol, Beta-sitosterol, Vitamin C and others.

Indole-3-carbinol can manipulate biochemical pathways Growth Factor Signaling, Cell Cycle and JAK-STAT Signaling. Vitamin C has biological action on biochemical pathways WNT Beta Catenin Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling.

Apigenin can manipulate biochemical pathways WNT Beta Catenin Signaling. Linoleic Acid has biological action on biochemical pathways Growth Factor Signaling and Angiogenesis. And so on.

When treating Thymic Neuroendocrine with chemotherapy Octreotide – Foods like Brussels Sprout are recommended compared to Spinach. This is because the active ingredients Apigenin and Linoleic Acid in Spinach interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Indole-3-carbinol and Vitamin C contained in Brussels Sprout support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: BRUSSELS SPROUT IS RECOMMENDED OVER SPINACH FOR THYMIC NEUROENDOCRINE ON TREATMENT WITH CHEMOTHERAPY OCTREOTIDE FOR SOME CONDITIONS.

Eat more fruits, Saskatoon Berry or Pummelo?

Fruits are an important part of many diets. The active ingredients contained in Saskatoon Berry are Quercetin, Delphinidin among others. While the active ingredients contained in Pummelo are Naringin, Beta-sitosterol, Vitamin C, Naringenin, Oleic Acid and others.

Delphinidin can manipulate biochemical pathways Growth Factor Signaling, Angiogenesis and MAPK Signaling. Quercetin has biological action on biochemical pathways JAK-STAT Signaling, Cell Cycle and WNT Beta Catenin Signaling.

Naringetol can manipulate biochemical pathways WNT Beta Catenin Signaling. Hesperetin has biological action on biochemical pathways WNT Beta Catenin Signaling. And so on.

When treating Thymic Neuroendocrine with chemotherapy Octreotide – Foods like Saskatoon Berry are recommended compared to Pummelo. This is because the active ingredients Naringetol and Hesperetin in Pummelo interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Delphinidin and Quercetin contained in Saskatoon Berry support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: SASKATOON BERRY IS RECOMMENDED OVER PUMMELO FOR THYMIC NEUROENDOCRINE ON TREATMENT WITH CHEMOTHERAPY OCTREOTIDE FOR SOME CONDITIONS.

Eat more nuts, Almond or Pumpkin Seeds?

Nuts are an important part of many diets. The active ingredients contained in Almond are Quercetin, Vitamin E, Beta-sitosterol, Salicylic Acid, Oleic Acid among others. While the active ingredients contained in Pumpkin Seeds are Beta-sitosterol, Salicylic Acid, Cucurbitacin I, Gamma-linolenic Acid, Oleic Acid and others.

Beta-sitosterol can manipulate biochemical pathways Cell Cycle, WNT Beta Catenin Signaling and PI3K-AKT-MTOR Signaling. Quercetin has biological action on biochemical pathways Growth Factor Signaling, JAK-STAT Signaling and MAPK Signaling.

Lecithin can manipulate biochemical pathways Angiogenesis, MAPK Signaling and PI3K-AKT-MTOR Signaling. Linoleic Acid has biological action on biochemical pathways Growth Factor Signaling and Angiogenesis. And so on.

When treating Thymic Neuroendocrine with chemotherapy Octreotide – Foods like Almond are recommended compared to Pumpkin Seeds. This is because the active ingredients Lecithin and Linoleic Acid in Pumpkin Seeds interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Quercetin contained in Almond support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: ALMOND IS RECOMMENDED OVER PUMPKIN SEEDS FOR THYMIC NEUROENDOCRINE ON TREATMENT WITH CHEMOTHERAPY OCTREOTIDE FOR SOME CONDITIONS.

Foods for Genetic Risk of Thymic Neuroendocrine

One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. MEN1 and GSK3B are two genes whose abnormalities are risk factors for Thymic Neuroendocrine. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Thymic Neuroendocrine can be used as a guide for coming up with a recommended personalized nutrition plan. For Thymic Neuroendocrine gene MEN1 has causative impact on biological pathways like Oncogenic Cancer Epigenetics and DNA Repair. And GSK3B has a causative impact on biological pathways like CRMP Signaling and Epithelial to Mesenchymal Transition. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like MEN1 and GSK3B should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes MEN1 and GSK3B should be avoided.

Eat more pulses, Mung Bean or Lima Bean?

The active ingredients contained in Mung Bean are Quercetin, Vitamin A, Vitamin C, Linolenic Acid, Glucaric Acid among others. While the active ingredients contained in Lima Bean are Vitamin A, Vitamin C, Genistein, Oleic Acid, Linoleic Acid and others.

Quercetin can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Adherens junction and Microtubule Dynamics. Vitamin A has biological action on biochemical pathways WNT Beta Catenin Signaling, MYC Signaling and PI3K-AKT-MTOR Signaling.

Oleic Acid can manipulate biochemical pathways Epithelial to Mesenchymal Transition. Linoleic Acid has biological action on biochemical pathways Epithelial to Mesenchymal Transition. And so on.

For genetic risk of Thymic Neuroendocrine due to abnormalities in genes MEN1 and GSK3B – Foods like Mung Bean are recommended compared to Lima Bean. This is because the active ingredients Oleic Acid and Linoleic Acid in Lima Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Quercetin and Vitamin A contained in Mung Bean together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: MUNG BEAN IS RECOMMENDED OVER LIMA BEAN FOR REDUCING THE GENETIC RISK OF THYMIC NEUROENDOCRINE DUE TO GENES MEN1 AND GSK3B

Eat more vegetables, Arugula or Celeriac?

The active ingredients contained in Arugula are Vitamin A, Esculin, Kaempferol, Vitamin K, Erysolin among others. While the active ingredients contained in Celeriac are Vitamin C, Linolenic Acid, Oleic Acid, Angelicin, Vitamin K and others.

Vitamin A can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Adherens junction and WNT Beta Catenin Signaling. Kaempferol has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, Microtubule Dynamics and WNT Beta Catenin Signaling.

Angelicin can manipulate biochemical pathways WNT Beta Catenin Signaling and Adherens junction. Oleic Acid has biological action on biochemical pathways Epithelial to Mesenchymal Transition. And so on.

For genetic risk of Thymic Neuroendocrine due to abnormalities in genes MEN1 and GSK3B – Foods like Arugula are recommended compared to Celeriac. This is because the active ingredients Angelicin and Oleic Acid in Celeriac further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin A and Kaempferol contained in Arugula together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: ARUGULA IS RECOMMENDED OVER CELERIAC FOR REDUCING THE GENETIC RISK OF THYMIC NEUROENDOCRINE DUE TO GENES MEN1 AND GSK3B

Eat more fruits, Pomegranate or Star Fruit?

The active ingredients contained in Pomegranate are Betulinic Acid, Beta-sitosterol, Corilagin, Vitamin C, Urolithin B among others. While the active ingredients contained in Star Fruit are Beta-sitosterol, Vitamin A, Vitamin C, Linolenic Acid, Oleic Acid and others.

Betulinic Acid can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Adherens junction and WNT Beta Catenin Signaling. Gallic Acid has biological action on biochemical pathways Extracellular Matrix Remodelling, Microtubule Dynamics and MYC Signaling.

Oleic Acid can manipulate biochemical pathways Epithelial to Mesenchymal Transition. Linoleic Acid has biological action on biochemical pathways Epithelial to Mesenchymal Transition. And so on.

For genetic risk of Thymic Neuroendocrine due to abnormalities in genes MEN1 and GSK3B – Foods like Pomegranate are recommended compared to Star Fruit. This is because the active ingredients Oleic Acid and Linoleic Acid in Star Fruit further promote the effects of genes on the biochemical pathways. While the active ingredients Betulinic Acid and Gallic Acid contained in Pomegranate together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: POMEGRANATE IS RECOMMENDED OVER STAR FRUIT FOR REDUCING THE GENETIC RISK OF THYMIC NEUROENDOCRINE DUE TO GENES MEN1 AND GSK3B

Eat more nuts, Pecan Nut or Peanut?

The active ingredients contained in Pecan Nut are Vitamin A, Vitamin E, Linolenic Acid, Oleic Acid, Cianidanol among others. While the active ingredients contained in Peanut are Beta-sitosterol, Quercetin, Vitamin A, Vitamin C, Vitamin E and others.

Vitamin A can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Adherens junction and WNT Beta Catenin Signaling. Vitamin E has biological action on biochemical pathways MYC Signaling, PI3K-AKT-MTOR Signaling and Epithelial to Mesenchymal Transition.

Lecithin can manipulate biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. Oleic Acid has biological action on biochemical pathways Epithelial to Mesenchymal Transition. And so on.

For genetic risk of Thymic Neuroendocrine due to abnormalities in genes MEN1 and GSK3B – Foods like Pecan Nut are recommended compared to Peanut. This is because the active ingredients Lecithin and Oleic Acid in Peanut further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin A and Vitamin E contained in Pecan Nut together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: PECAN NUT IS RECOMMENDED OVER PEANUT FOR REDUCING THE GENETIC RISK OF THYMIC NEUROENDOCRINE DUE TO GENES MEN1 AND GSK3B

In Summary

An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.

“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.

The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.

You can get started NOW and design a personalized nutrition plan for Thymic Neuroendocrine by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

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