Highlights
No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Renal Non-clear Cell Carcinoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Renal Non-clear Cell Carcinoma because of MET and MUC4 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.
There is no one answer to this question for cancers such as Renal Non-clear Cell Carcinoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.
In short – the process to answer questions like “Should I Avoid eating fruit Strawberry” or “Include fruit Rowanberry in my diet” or “Should I reduce consumption of vegetable Olive” or “Can I take Cissus and Turmeric supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.
RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO RENAL NON-CLEAR CELL CARCINOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.
The overall objective of personalized nutrition for Renal Non-clear Cell Carcinoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.
RECOMMENDATION: UPDATE YOUR NUTRITION FOR RENAL NON-CLEAR CELL CARCINOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.
About Renal Non-clear Cell Carcinoma
cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.
Following key highlights are derived from clinical data for Renal Non-clear Cell Carcinoma from cBioPortal. The patients enrolled in the studies for Renal Non-clear Cell Carcinoma are in ages between 25 to 88 with an average age of 60. 63.4% of males and 36.6% of females were the distribution of gender in these clinical studies. From a patient sample size of 147; the top genes with mutations and other abnormalities for Renal Non-clear Cell Carcinoma include genes TP53, MET, MUC4, SPEN and ARID1A. The occurrence frequency distribution for these genes respectively is 7.9%, 7.2%, 6.5%, 4.3% and 4.3%. These tumor genetic details of Renal Non-clear Cell Carcinoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Renal Non-clear Cell Carcinoma.
Significance of Nutrition for Renal Non-clear Cell Carcinoma
All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Renal Non-clear Cell Carcinoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.
For example Strawberry includes active ingredients Ellagic Acid, Fisetin, Vitamin C, Linolenic Acid, Lupeol and others. And Rowanberry contains active ingredients Quercetin, Chlorogenic Acid and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.
For cancers like Renal Non-clear Cell Carcinoma, activation or inhibition of selected biochemical pathways like Angiogenesis, Hypoxia, PI3K-AKT-MTOR Signaling, MAPK Signaling plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Renal Non-clear Cell Carcinoma, while eating some other foods and supplements may not be recommended.
One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.
RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR RENAL NON-CLEAR CELL CARCINOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.
Foods for Renal Non-clear Cell Carcinoma undergoing chemotherapy treatment
In Renal Non-clear Cell Carcinoma – the genes TP53, MET, MUC4, SPEN and ARID1A have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Renal Non-clear Cell Carcinoma are Angiogenesis, Hypoxia, Extracellular Matrix Remodelling and others. Bevacizumab is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Angiogenesis, Hypoxia, Extracellular Matrix Remodelling so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.
RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.
Eat more pulses, Adzuki Bean or Common Bean?
Pulses are an important part of many diets. The active ingredients contained in Adzuki Bean are Isoliquiritigenin, Glucaric Acid, Genistein, Folic Acid among others. While the active ingredients contained in Common Bean are Apigenin, Kaempferol, Vitamin C, Linolenic Acid, Gamma-linolenic Acid and others.
Glucaric Acid can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Extracellular Matrix Remodelling and MYC Signaling. Isoliquiritigenin has biological action on biochemical pathways Chemokine Signaling, Growth Factor Signaling and TGFB Signaling.
Vitamin A can manipulate biochemical pathways Extracellular Matrix Remodelling, Notch Signaling and Focal Adhesion. Apigenin has biological action on biochemical pathways Epithelial to Mesenchymal Transition, TGFB Signaling and PI3K-AKT-MTOR Signaling. And so on.
When treating Renal Non-clear Cell Carcinoma with chemotherapy Bevacizumab – Foods like Adzuki Bean are recommended compared to Common Bean. This is because the active ingredients Vitamin A and Apigenin in Common Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Glucaric Acid and Isoliquiritigenin contained in Adzuki Bean support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: ADZUKI BEAN IS RECOMMENDED OVER COMMON BEAN FOR RENAL NON-CLEAR CELL CARCINOMA ON TREATMENT WITH CHEMOTHERAPY BEVACIZUMAB FOR SOME CONDITIONS.
Eat more vegetables, Kohlrabi or Olive?
Vegetables are an important part of many diets. The active ingredients contained in Kohlrabi are Kaempferol, Vitamin C, Linolenic Acid, Beta-sitosterol, Brassinin among others. While the active ingredients contained in Olive are Quercetin, Caffeic Acid, Betulinic Acid, Hydroxytyrosol, Protocatechuic Acid and others.
Vitamin C can manipulate biochemical pathways Epithelial to Mesenchymal Transition, MYC Signaling and WNT Beta Catenin Signaling. Brassinin has biological action on biochemical pathways Extracellular Matrix Remodelling, Chemokine Signaling and MAPK Signaling.
Caffeic Acid can manipulate biochemical pathways TGFB Signaling. Lupeol has biological action on biochemical pathways Cytoskeletal Dynamics. And so on.
When treating Renal Non-clear Cell Carcinoma with chemotherapy Bevacizumab – Foods like Kohlrabi are recommended compared to Olive. This is because the active ingredients Caffeic Acid and Lupeol in Olive interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Brassinin contained in Kohlrabi support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: KOHLRABI IS RECOMMENDED OVER OLIVE FOR RENAL NON-CLEAR CELL CARCINOMA ON TREATMENT WITH CHEMOTHERAPY BEVACIZUMAB FOR SOME CONDITIONS.
Eat more fruits, Rowanberry or Strawberry?
Fruits are an important part of many diets. The active ingredients contained in Rowanberry are Quercetin, Chlorogenic Acid among others. While the active ingredients contained in Strawberry are Ellagic Acid, Fisetin, Vitamin C, Linolenic Acid, Lupeol and others.
Chlorogenic Acid can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Extracellular Matrix Remodelling and Chemokine Signaling. Quercetin has biological action on biochemical pathways Growth Factor Signaling, TGFB Signaling and EPHRIN Signaling.
Fisetin can manipulate biochemical pathways Epithelial to Mesenchymal Transition, WNT Beta Catenin Signaling and MYC Signaling. Ellagic Acid has biological action on biochemical pathways Epithelial to Mesenchymal Transition, WNT Beta Catenin Signaling and MYC Signaling. And so on.
When treating Renal Non-clear Cell Carcinoma with chemotherapy Bevacizumab – Foods like Rowanberry are recommended compared to Strawberry. This is because the active ingredients Fisetin and Ellagic Acid in Strawberry interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Chlorogenic Acid and Quercetin contained in Rowanberry support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: ROWANBERRY IS RECOMMENDED OVER STRAWBERRY FOR RENAL NON-CLEAR CELL CARCINOMA ON TREATMENT WITH CHEMOTHERAPY BEVACIZUMAB FOR SOME CONDITIONS.
Eat more nuts, Pine Nut or Peanut?
Nuts are an important part of many diets. The active ingredients contained in Pine Nut are Vitamin E, Linolenic Acid, Beta-sitosterol, Oleic Acid, Vitamin A among others. While the active ingredients contained in Peanut are Quercetin, Vitamin E, Vitamin C, Vanillic Acid, Linolenic Acid and others.
Beta-sitosterol can manipulate biochemical pathways Epithelial to Mesenchymal Transition, MYC Signaling and WNT Beta Catenin Signaling. Vitamin K has biological action on biochemical pathways PI3K-AKT-MTOR Signaling and MYC Signaling.
Vitamin A can manipulate biochemical pathways Extracellular Matrix Remodelling, Notch Signaling and Focal Adhesion. Lecithin has biological action on biochemical pathways Chemokine Signaling, Cytoskeletal Dynamics and MYC Signaling. And so on.
When treating Renal Non-clear Cell Carcinoma with chemotherapy Bevacizumab – Foods like Pine Nut are recommended compared to Peanut. This is because the active ingredients Vitamin A and Lecithin in Peanut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin K contained in Pine Nut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: PINE NUT IS RECOMMENDED OVER PEANUT FOR RENAL NON-CLEAR CELL CARCINOMA ON TREATMENT WITH CHEMOTHERAPY BEVACIZUMAB FOR SOME CONDITIONS.
Foods for Genetic Risk of Renal Non-clear Cell Carcinoma
One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. MET and MUC4 are two genes whose abnormalities are risk factors for Renal Non-clear Cell Carcinoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Renal Non-clear Cell Carcinoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Renal Non-clear Cell Carcinoma gene MET has causative impact on biological pathways like Adherens junction, Cytoskeletal Dynamics and MAPK Signaling. And MUC4 has a causative impact on biological pathways like Post Translation Modification. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like MET and MUC4 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes MET and MUC4 should be avoided.
Eat more pulses, Scarlet Bean or Chickpea?
The active ingredients contained in Scarlet Bean are Beta-sitosterol, Oleic Acid, Vitamin C, Linolenic Acid, Stigmasterol among others. While the active ingredients contained in Chickpea are Oleic Acid, Linolenic Acid, Genistein, Vitamin A, Folic Acid and others.
Beta-sitosterol can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Vitamin C has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and RAS-RAF Signaling.
Vitamin A can manipulate biochemical pathways PI3K-AKT-MTOR Signaling and Extracellular Matrix Remodelling. Folic Acid has biological action on biochemical pathways Apoptosis, Growth Factor Signaling and MYC Signaling. And so on.
For genetic risk of Renal Non-clear Cell Carcinoma due to abnormalities in genes MET and MUC4 – Foods like Scarlet Bean are recommended compared to Chickpea. This is because the active ingredients Vitamin A and Folic Acid in Chickpea further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin C contained in Scarlet Bean together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: SCARLET BEAN IS RECOMMENDED OVER CHICKPEA FOR REDUCING THE GENETIC RISK OF RENAL NON-CLEAR CELL CARCINOMA DUE TO GENES MET AND MUC4
Eat more vegetables, Eggplant or Celery?
The active ingredients contained in Eggplant are Beta-sitosterol, Oleic Acid, Vitamin C, Linolenic Acid, Delphinidin among others. While the active ingredients contained in Celery are Apigenin, Quercetin, Oleic Acid, Vitamin C, Linolenic Acid and others.
Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Delphinidin has biological action on biochemical pathways Extracellular Matrix Remodelling, Growth Factor Signaling and PI3K-AKT-MTOR Signaling.
Luteolin can manipulate biochemical pathways MYC Signaling. Chrysin has biological action on biochemical pathways MYC Signaling. And so on.
For genetic risk of Renal Non-clear Cell Carcinoma due to abnormalities in genes MET and MUC4 – Foods like Eggplant are recommended compared to Celery. This is because the active ingredients Luteolin and Chrysin in Celery further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Delphinidin contained in Eggplant together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: EGGPLANT IS RECOMMENDED OVER CELERY FOR REDUCING THE GENETIC RISK OF RENAL NON-CLEAR CELL CARCINOMA DUE TO GENES MET AND MUC4
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
Eat more fruits, Avocado or Huckleberry?
The active ingredients contained in Avocado are Quercetin, Beta-sitosterol, Oleic Acid, Vitamin C, Linolenic Acid among others. While the active ingredients contained in Huckleberry are Quercetin, Resveratrol, Vitamin C, Ferulic Acid, P-coumaric Acid and others.
Beta-sitosterol can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Quercetin has biological action on biochemical pathways Extracellular Matrix Remodelling, Growth Factor Signaling and Cell Cycle Checkpoints.
Resveratrol can manipulate biochemical pathways P53 Signaling. Pelargonidin has biological action on biochemical pathways MYC Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling. And so on.
For genetic risk of Renal Non-clear Cell Carcinoma due to abnormalities in genes MET and MUC4 – Foods like Avocado are recommended compared to Huckleberry. This is because the active ingredients Resveratrol and Pelargonidin in Huckleberry further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Quercetin contained in Avocado together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: AVOCADO IS RECOMMENDED OVER HUCKLEBERRY FOR REDUCING THE GENETIC RISK OF RENAL NON-CLEAR CELL CARCINOMA DUE TO GENES MET AND MUC4
Eat more nuts, Almond or Acorn?
The active ingredients contained in Almond are Quercetin, Vitamin E, Beta-sitosterol, Oleic Acid, Linolenic Acid among others. While the active ingredients contained in Acorn are Quercetin, Beta-sitosterol, Vitamin C, Quercitrin, Vitamin B3 and others.
Beta-sitosterol can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Quercetin has biological action on biochemical pathways Extracellular Matrix Remodelling, Growth Factor Signaling and Cell Cycle Checkpoints.
Vitamin B3 can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Beta-carotene has biological action on biochemical pathways PI3K-AKT-MTOR Signaling. And so on.
For genetic risk of Renal Non-clear Cell Carcinoma due to abnormalities in genes MET and MUC4 – Foods like Almond are recommended compared to Acorn. This is because the active ingredients Vitamin B3 and Beta-carotene in Acorn further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Quercetin contained in Almond together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: ALMOND IS RECOMMENDED OVER ACORN FOR REDUCING THE GENETIC RISK OF RENAL NON-CLEAR CELL CARCINOMA DUE TO GENES MET AND MUC4
In Summary
An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.
“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.
The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.
You can get started NOW and design a personalized nutrition plan for Renal Non-clear Cell Carcinoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
References
- Nccrcc Genentech 2014
- Spectrum of diverse genomic alterations define non-clear cell renal carcinoma subtypes.
- Preventive effects of butyric acid, nicotinamide, calcium glucarate alone or in combination during the 7, 12-dimethylbenz (a) anthracene induced mouse skin tumorigenesis via modulation of K-Ras-PI3K-AKTpathway and associated micro RNAs.
- Effects of isoliquiritigenin on ovarian cancer cells.
- Vitamin A regulates Akt signaling through the phospholipid fatty acid composition.
- Crystal structure of a human cyclin-dependent kinase 6 complex with a flavonol inhibitor, fisetin.
- Chlorogenic acid inhibits proliferation and induces apoptosis in A498 human kidney cancer cells via inactivating PI3K/Akt/mTOR signalling pathway.
- Identification of ellagic acid as potent inhibitor of protein kinase CK2: a successful example of a virtual screening application.
- Vitamin C enhances epigenetic modifications induced by 5-azacytidine and cell cycle arrest in the hepatocellular carcinoma cell lines HLE and Huh7.
- Brassinin inhibits STAT3 signaling pathway through modulation of PIAS-3 and SOCS-3 expression and sensitizes human lung cancer xenograft in nude mice to paclitaxel.
- Synthesis and structure-activity relationship analysis of caffeic acid amides as selective matrix metalloproteinase inhibitors.
- Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors.
- β-Sitosterol targets Trx/Trx1 reductase to induce apoptosis in A549 cells via ROS mediated mitochondrial dysregulation and p53 activation.
- Research progress on the anticancer effects of vitamin K2.
- New concepts in phospholipase D signaling in inflammation and cancer.
- Effects of folate deficiency on gene expression in the apoptosis and cancer pathways in colon cancer cells.
- Resveratrol, a remarkable inhibitor of ribonucleotide reductase.
- Pelargonidin suppresses adipogenesis in 3T3-L1 cells through inhibition of PPAR-γ signaling pathway.
- Delphinidin inhibits cell proliferation and invasion via modulation of Met receptor phosphorylation.
- Modulation of Sirt1 by resveratrol and nicotinamide alters proliferation and differentiation of pig preadipocytes.
- β-carotene Inhibits Expression of c-Myc and Cyclin E in Helicobacter pylori-infected Gastric Epithelial Cells.
- HyperFoods: Machine intelligent mapping of cancer-beating molecules in foods.
- Fisetin: a dietary antioxidant for health promotion.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.