Which Foods are Recommended for Pseudomyxoma Peritonei?

Highlights

No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Pseudomyxoma Peritonei when undergoing chemotherapy or when you determine you have a genetic risk for developing Pseudomyxoma Peritonei because of GNAS and TGFBR2 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.

There is no one answer to this question for cancers such as Pseudomyxoma Peritonei which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.

In short – the process to answer questions like “Should I Avoid eating fruit Cranberry” or “Include fruit Apple in my diet” or “Should I reduce consumption of vegetable Chayote” or “Can I take Thunder God and Dim supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.

RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO PSEUDOMYXOMA PERITONEI, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.

The overall objective of personalized nutrition for Pseudomyxoma Peritonei is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.

RECOMMENDATION: UPDATE YOUR NUTRITION FOR PSEUDOMYXOMA PERITONEI, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.

About Pseudomyxoma Peritonei

cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.

Following key highlights are derived from clinical data for Pseudomyxoma Peritonei from cBioPortal. The top genes with mutations and other abnormalities for Pseudomyxoma Peritonei include genes KRAS, GNAS, TP53, TGFBR2 and ARHGEF12. The occurrence frequency distribution for these genes respectively is 72.8%, 44.7%, 25.2%, 9.2% and 9.1%. These tumor genetic details of Pseudomyxoma Peritonei are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Pseudomyxoma Peritonei.

Pseudomyxoma peritonei (PMP) often called “jelly-belly”, is a rare malignant growth characterized by the progressive accumulation of mucus-secreting (mucinous) tumor cells within the abdominal cavity and pelvis. PMP develops when a small growth (polyp) in the appendix bursts through the wall of the appendix and spreads mucus-producing cancer cells throughout the abdominal cavity. Common symptoms of PMP include increasing abdominal size and abdominal discomfort due to pressure on internal organs due to accumulation of large amounts of mucinous tumor. PMP is a slow growing cancer, patients may live for many years with active disease and worsening symptoms. Treatment includes cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (HIPEC), which can lead to an overall 10-year survival rate of ~63%. Supportive care with the right nutrition (foods and natural supplements) can also help improve the well-being of the patients’ with pseudomyxoma peritonei (PMP). (Ref: Patrick-Brown TDJH, Ann Surg Oncol., 2021; https://rarediseases.org/rare-diseases/pseudomyxoma-peritonei/)

Significance of Nutrition for Pseudomyxoma Peritonei

All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Pseudomyxoma Peritonei. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.

For example Cranberry includes active ingredients Quercetin, Ellagic Acid, Myricetin, Resveratrol, Hyperoside and others. And Apple contains active ingredients Phloretin, Modified Citrus Pectin, Fisetin, Rhamnetin, Cianidanol and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.

For cancers like Pseudomyxoma Peritonei, activation or inhibition of selected biochemical pathways like Apoptosis, MAPK Signaling, PI3K-AKT-MTOR Signaling, RAS-RAF Signaling plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Pseudomyxoma Peritonei, while eating some other foods and supplements may not be recommended.

One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.

RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR PSEUDOMYXOMA PERITONEI – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.

Foods for Pseudomyxoma Peritonei undergoing chemotherapy treatment

In Pseudomyxoma Peritonei – the genes KRAS, GNAS, TP53, TGFBR2 and ARHGEF12 have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Pseudomyxoma Peritonei are Apoptosis, MAPK Signaling, Notch Signaling and others. Oxaliplatin is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Apoptosis, MAPK Signaling, Notch Signaling so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.

RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.

Eat more pulses, Common Pea or Lima Bean?

Pulses are an important part of many diets. The active ingredients contained in Common Pea are Lupeol, Daidzein, Beta-sitosterol, Linolenic Acid, Vitamin C among others. While the active ingredients contained in Lima Bean are Vitamin C, Oleic Acid, Vitamin A, Linoleic Acid, Genistein and others.

Beta-sitosterol can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and Apoptosis. Vitamin C has biological action on biochemical pathways Cell Cycle, WNT Beta Catenin Signaling and MAPK Signaling.

Genistein can manipulate biochemical pathways DNA Repair and Oxidative Stress. Oleic Acid has biological action on biochemical pathways Epithelial to Mesenchymal Transition. And so on.

When treating Pseudomyxoma Peritonei with chemotherapy Oxaliplatin – Foods like Common Pea are recommended compared to Lima Bean. This is because the active ingredients Genistein and Oleic Acid in Lima Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin C contained in Common Pea support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: COMMON PEA IS RECOMMENDED OVER LIMA BEAN FOR PSEUDOMYXOMA PERITONEI ON TREATMENT WITH CHEMOTHERAPY OXALIPLATIN FOR SOME CONDITIONS.

Eat more vegetables, Cabbage or Chayote?

Vegetables are an important part of many diets. The active ingredients contained in Cabbage are Quercetin, Benzyl Isothiocyanate, Beta-sitosterol, Isorhamnetin, Indole-3-carbinol among others. While the active ingredients contained in Chayote are Linolenic Acid, Vitamin C, Oleic Acid, Linoleic Acid, Citric Acid and others.

Vitamin C can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Apoptosis and Cell Cycle. Glucaric Acid has biological action on biochemical pathways NFKB Signaling, Cell Survival and MAPK Signaling.

Citric Acid can manipulate biochemical pathways Oxidative Stress. Linolenic Acid has biological action on biochemical pathways Oxidative Stress. And so on.

When treating Pseudomyxoma Peritonei with chemotherapy Oxaliplatin – Foods like Cabbage are recommended compared to Chayote. This is because the active ingredients Citric Acid and Linolenic Acid in Chayote interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Glucaric Acid contained in Cabbage support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: CABBAGE IS RECOMMENDED OVER CHAYOTE FOR PSEUDOMYXOMA PERITONEI ON TREATMENT WITH CHEMOTHERAPY OXALIPLATIN FOR SOME CONDITIONS.

Eat more fruits, Apple or Cranberry?

Fruits are an important part of many diets. The active ingredients contained in Apple are Phloretin, Modified Citrus Pectin, Fisetin, Rhamnetin, Cianidanol among others. While the active ingredients contained in Cranberry are Quercetin, Ellagic Acid, Myricetin, Resveratrol, Hyperoside and others.

Glucaric Acid can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and Apoptosis. Phloretin has biological action on biochemical pathways JAK-STAT Signaling, Cell Cycle and Cell Survival.

Quercetin can manipulate biochemical pathways Oxidative Stress. Ellagic Acid has biological action on biochemical pathways Epithelial to Mesenchymal Transition and WNT Beta Catenin Signaling. And so on.

When treating Pseudomyxoma Peritonei with chemotherapy Oxaliplatin – Foods like Apple are recommended compared to Cranberry. This is because the active ingredients Quercetin and Ellagic Acid in Cranberry interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Glucaric Acid and Phloretin contained in Apple support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: APPLE IS RECOMMENDED OVER CRANBERRY FOR PSEUDOMYXOMA PERITONEI ON TREATMENT WITH CHEMOTHERAPY OXALIPLATIN FOR SOME CONDITIONS.

Eat more nuts, Pecan Nut or Acorn?

Nuts are an important part of many diets. The active ingredients contained in Pecan Nut are Vitamin E, Linolenic Acid, Oleic Acid, Cianidanol, Delphinidin among others. While the active ingredients contained in Acorn are Quercetin, Beta-sitosterol, Vitamin C, Beta-carotene, Gallic Acid and others.

Vitamin E can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and Apoptosis. Cianidanol has biological action on biochemical pathways Cell Survival, RUNX Signaling and MAPK Signaling.

Quercetin can manipulate biochemical pathways Oxidative Stress. Beta-carotene has biological action on biochemical pathways MAPK Signaling and Notch Signaling. And so on.

When treating Pseudomyxoma Peritonei with chemotherapy Oxaliplatin – Foods like Pecan Nut are recommended compared to Acorn. This is because the active ingredients Quercetin and Beta-carotene in Acorn interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin E and Cianidanol contained in Pecan Nut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: PECAN NUT IS RECOMMENDED OVER ACORN FOR PSEUDOMYXOMA PERITONEI ON TREATMENT WITH CHEMOTHERAPY OXALIPLATIN FOR SOME CONDITIONS.

Foods for Genetic Risk of Pseudomyxoma Peritonei

One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. GNAS and TGFBR2 are two genes whose abnormalities are risk factors for Pseudomyxoma Peritonei. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Pseudomyxoma Peritonei can be used as a guide for coming up with a recommended personalized nutrition plan. For Pseudomyxoma Peritonei gene GNAS has causative impact on biological pathways like G-protein-coupled Receptor Signaling, Reproductive Hormone Signaling and Gonadotropin-releasing hormone. And TGFBR2 has a causative impact on biological pathways like TGFB Signaling, Extracellular Matrix Remodelling and Inflammation. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like GNAS and TGFBR2 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes GNAS and TGFBR2 should be avoided.

Eat more pulses, Winged Bean or Black-eyed Pea?

The active ingredients contained in Winged Bean are Betulinic Acid, Oleic Acid, Linolenic Acid, Vitamin C, Isovitexin among others. While the active ingredients contained in Black-eyed Pea are Daidzein, Oleic Acid, Linolenic Acid, Vitamin C, Genistein and others.

Betulinic Acid can manipulate biochemical pathways MYC Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling. Vitamin C has biological action on biochemical pathways RAS-RAF Signaling, MYC Signaling and MAPK Signaling.

Genistein can manipulate biochemical pathways G-protein-coupled Receptor Signaling. Beta-carotene has biological action on biochemical pathways MAPK Signaling. And so on.

For genetic risk of Pseudomyxoma Peritonei due to abnormalities in genes GNAS and TGFBR2 – Foods like Winged Bean are recommended compared to Black-eyed Pea. This is because the active ingredients Genistein and Beta-carotene in Black-eyed Pea further promote the effects of genes on the biochemical pathways. While the active ingredients Betulinic Acid and Vitamin C contained in Winged Bean together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: WINGED BEAN IS RECOMMENDED OVER BLACK-EYED PEA FOR REDUCING THE GENETIC RISK OF PSEUDOMYXOMA PERITONEI DUE TO GENES GNAS AND TGFBR2

Eat more vegetables, Jicama or Carob?

The active ingredients contained in Jicama are Vitamin C, Vitamin B3, Beta-carotene, Vitamin A, Folic Acid among others. While the active ingredients contained in Carob are Quercetin, Myricetin, Gallic Acid, Phloroglucinol, Palmitic Acid and others.

Vitamin C can manipulate biochemical pathways MYC Signaling, RAS-RAF Signaling and MAPK Signaling. Vitamin B3 has biological action on biochemical pathways PI3K-AKT-MTOR Signaling and MYC Signaling.

Palmitic Acid can manipulate biochemical pathways TGFB Signaling and MAPK Signaling. Quercetin has biological action on biochemical pathways G-protein-coupled Receptor Signaling. And so on.

For genetic risk of Pseudomyxoma Peritonei due to abnormalities in genes GNAS and TGFBR2 – Foods like Jicama are recommended compared to Carob. This is because the active ingredients Palmitic Acid and Quercetin in Carob further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Vitamin B3 contained in Jicama together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: JICAMA IS RECOMMENDED OVER CAROB FOR REDUCING THE GENETIC RISK OF PSEUDOMYXOMA PERITONEI DUE TO GENES GNAS AND TGFBR2

Eat more fruits, Orange or Peach?

The active ingredients contained in Orange are D-limonene, Modified Citrus Pectin, Linalool, Glucaric Acid, Delphinidin among others. While the active ingredients contained in Peach are Modified Citrus Pectin, Glucaric Acid, Oleic Acid, Beta-sitosterol, Caffeic Acid and others.

D-limonene can manipulate biochemical pathways Small Molecule Transport, MYC Signaling and MAPK Signaling. Glucaric Acid has biological action on biochemical pathways RAS-RAF Signaling, PI3K-AKT-MTOR Signaling and MYC Signaling.

Caffeic Acid can manipulate biochemical pathways TGFB Signaling. Fisetin has biological action on biochemical pathways MYC Signaling. And so on.

For genetic risk of Pseudomyxoma Peritonei due to abnormalities in genes GNAS and TGFBR2 – Foods like Orange are recommended compared to Peach. This is because the active ingredients Caffeic Acid and Fisetin in Peach further promote the effects of genes on the biochemical pathways. While the active ingredients D-limonene and Glucaric Acid contained in Orange together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: ORANGE IS RECOMMENDED OVER PEACH FOR REDUCING THE GENETIC RISK OF PSEUDOMYXOMA PERITONEI DUE TO GENES GNAS AND TGFBR2

Eat more nuts, Almond or Peanut?

The active ingredients contained in Almond are Quercetin, Vitamin E, Oleic Acid, Beta-sitosterol, Salicylic Acid among others. While the active ingredients contained in Peanut are Quercetin, Vitamin E, Oleic Acid, Beta-sitosterol, Linolenic Acid and others.

Beta-sitosterol can manipulate biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. Vitamin E has biological action on biochemical pathways MAPK Signaling, MYC Signaling and PI3K-AKT-MTOR Signaling.

Quercetin can manipulate biochemical pathways G-protein-coupled Receptor Signaling. Vitamin A has biological action on biochemical pathways TGFB Signaling and Extracellular Matrix Remodelling. And so on.

For genetic risk of Pseudomyxoma Peritonei due to abnormalities in genes GNAS and TGFBR2 – Foods like Almond are recommended compared to Peanut. This is because the active ingredients Quercetin and Vitamin A in Peanut further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin E contained in Almond together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: ALMOND IS RECOMMENDED OVER PEANUT FOR REDUCING THE GENETIC RISK OF PSEUDOMYXOMA PERITONEI DUE TO GENES GNAS AND TGFBR2

In Summary

An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.

“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.

The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.

You can get started NOW and design a personalized nutrition plan for Pseudomyxoma Peritonei by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

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