Which Foods are Recommended for Esophageal Adenocarcinoma?

Highlights

No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Esophageal Adenocarcinoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Esophageal Adenocarcinoma because of FAT3 and LAMA1 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.

There is no one answer to this question for cancers such as Esophageal Adenocarcinoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.

In short – the process to answer questions like “Should I Avoid eating fruit Roselle” or “Include fruit Saskatoon Berry in my diet” or “Should I reduce consumption of vegetable Carob” or “Can I take Neem Extract and Alpha Lipoic Acid supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.

RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO ESOPHAGEAL ADENOCARCINOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.

The overall objective of personalized nutrition for Esophageal Adenocarcinoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.

RECOMMENDATION: UPDATE YOUR NUTRITION FOR ESOPHAGEAL ADENOCARCINOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.

About Esophageal Adenocarcinoma

cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.

Following key highlights are derived from clinical data for Esophageal Adenocarcinoma from cBioPortal. The patients enrolled in the studies for Esophageal Adenocarcinoma are in ages between 32 to 88 with an average age of 70. 85.4% of males and 14.6% of females were the distribution of gender in these clinical studies. From a patient sample size of 1314; the top genes with mutations and other abnormalities for Esophageal Adenocarcinoma include genes TP53, MUC16, FAT3, LAMA1 and FAT4. The occurrence frequency distribution for these genes respectively is 10.4%, 4.0%, 2.3%, 2.1% and 2.1%. These tumor genetic details of Esophageal Adenocarcinoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Esophageal Adenocarcinoma.

Significance of Nutrition for Esophageal Adenocarcinoma

All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Esophageal Adenocarcinoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.

For example Roselle includes active ingredients Vitamin E, Beta-sitosterol, Linolenic Acid, Vitamin C, Oleic Acid and others. And Saskatoon Berry contains active ingredients Quercetin, Delphinidin and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.

For cancers like Esophageal Adenocarcinoma, activation or inhibition of selected biochemical pathways like Apoptosis, Cell Cycle, PI3K-AKT-MTOR Signaling, MAPK Signaling plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Esophageal Adenocarcinoma, while eating some other foods and supplements may not be recommended.

One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.

RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR ESOPHAGEAL ADENOCARCINOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.

Foods for Esophageal Adenocarcinoma undergoing chemotherapy treatment

In Esophageal Adenocarcinoma – the genes TP53, MUC16, FAT3, LAMA1 and FAT4 have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Esophageal Adenocarcinoma are Apoptosis, Cell Cycle, Extracellular Matrix Remodelling and others. Docetaxel is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Apoptosis, Cell Cycle, Extracellular Matrix Remodelling so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.

RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.

Eat more pulses, Common Pea or Lima Bean?

Pulses are an important part of many diets. The active ingredients contained in Common Pea are Lupeol, Daidzein, Beta-sitosterol, Kaempferol, Linolenic Acid among others. While the active ingredients contained in Lima Bean are Genistein, Vitamin C, Oleic Acid, Vitamin A, Linoleic Acid and others.

Beta-sitosterol can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and Glucocorticoid Signaling. Vitamin C has biological action on biochemical pathways Carbohydrate Metabolism, Apoptosis and Adherens junction.

Genistein can manipulate biochemical pathways Nutrient sensing. Vitamin A has biological action on biochemical pathways NFKB Signaling and Focal Adhesion. And so on.

When treating Esophageal Adenocarcinoma with chemotherapy Docetaxel – Foods like Common Pea are recommended compared to Lima Bean. This is because the active ingredients Genistein and Vitamin A in Lima Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin C contained in Common Pea support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: COMMON PEA IS RECOMMENDED OVER LIMA BEAN FOR ESOPHAGEAL ADENOCARCINOMA ON TREATMENT WITH CHEMOTHERAPY DOCETAXEL FOR SOME CONDITIONS.

Eat more vegetables, Kohlrabi or Carob?

Vegetables are an important part of many diets. The active ingredients contained in Kohlrabi are Beta-sitosterol, Brassinin, Kaempferol, Linolenic Acid, Indole-3-carbinol among others. While the active ingredients contained in Carob are Quercetin, Myricetin, Gallic Acid, Phloroglucinol, Palmitic Acid and others.

Brassinin can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and Apoptosis. Vitamin C has biological action on biochemical pathways Carbohydrate Metabolism, Adherens junction and Growth Factor Signaling.

Palmitic Acid can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and Extracellular Matrix Remodelling. Folic Acid has biological action on biochemical pathways Apoptosis, Growth Factor Signaling and JAK-STAT Signaling. And so on.

When treating Esophageal Adenocarcinoma with chemotherapy Docetaxel – Foods like Kohlrabi are recommended compared to Carob. This is because the active ingredients Palmitic Acid and Folic Acid in Carob interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Brassinin and Vitamin C contained in Kohlrabi support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: KOHLRABI IS RECOMMENDED OVER CAROB FOR ESOPHAGEAL ADENOCARCINOMA ON TREATMENT WITH CHEMOTHERAPY DOCETAXEL FOR SOME CONDITIONS.

Eat more fruits, Saskatoon Berry or Roselle?

Fruits are an important part of many diets. The active ingredients contained in Saskatoon Berry are Quercetin, Delphinidin among others. While the active ingredients contained in Roselle are Vitamin E, Beta-sitosterol, Linolenic Acid, Vitamin C, Oleic Acid and others.

Delphinidin can manipulate biochemical pathways NFKB Signaling, Growth Factor Signaling and MYC Signaling. Quercetin has biological action on biochemical pathways Microtubule Dynamics, TGFB Signaling and Cell Survival.

Lutein can manipulate biochemical pathways NFKB Signaling. Vitamin A has biological action on biochemical pathways Focal Adhesion and NFKB Signaling. And so on.

When treating Esophageal Adenocarcinoma with chemotherapy Docetaxel – Foods like Saskatoon Berry are recommended compared to Roselle. This is because the active ingredients Lutein and Vitamin A in Roselle interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Delphinidin and Quercetin contained in Saskatoon Berry support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: SASKATOON BERRY IS RECOMMENDED OVER ROSELLE FOR ESOPHAGEAL ADENOCARCINOMA ON TREATMENT WITH CHEMOTHERAPY DOCETAXEL FOR SOME CONDITIONS.

Eat more nuts, Pine Nut or Pumpkin Seeds?

Nuts are an important part of many diets. The active ingredients contained in Pine Nut are Vitamin E, Beta-sitosterol, Linolenic Acid, Oleic Acid, Vitamin A among others. While the active ingredients contained in Pumpkin Seeds are Beta-sitosterol, Linolenic Acid, Salicylic Acid, Cucurbitacin I, Gamma-linolenic Acid and others.

Beta-sitosterol can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and Glucocorticoid Signaling. Vitamin K has biological action on biochemical pathways Cell Cycle, MYC Signaling and PI3K-AKT-MTOR Signaling.

Lecithin can manipulate biochemical pathways NFKB Signaling, Chemokine Signaling and JAK-STAT Signaling. Salicylic Acid has biological action on biochemical pathways Nutrient sensing. And so on.

When treating Esophageal Adenocarcinoma with chemotherapy Docetaxel – Foods like Pine Nut are recommended compared to Pumpkin Seeds. This is because the active ingredients Lecithin and Salicylic Acid in Pumpkin Seeds interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin K contained in Pine Nut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: PINE NUT IS RECOMMENDED OVER PUMPKIN SEEDS FOR ESOPHAGEAL ADENOCARCINOMA ON TREATMENT WITH CHEMOTHERAPY DOCETAXEL FOR SOME CONDITIONS.

Foods for Genetic Risk of Esophageal Adenocarcinoma

One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. FAT3 and LAMA1 are two genes whose abnormalities are risk factors for Esophageal Adenocarcinoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Esophageal Adenocarcinoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Esophageal Adenocarcinoma gene FAT3 has causative impact on biological pathways like Adherens junction. And LAMA1 has a causative impact on biological pathways like Extracellular Matrix Remodelling, Epithelial to Mesenchymal Transition and Focal Adhesion. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like FAT3 and LAMA1 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes FAT3 and LAMA1 should be avoided.

Eat more pulses, Scarlet Bean or Common Bean?

The active ingredients contained in Scarlet Bean are Beta-sitosterol, Oleic Acid, Vitamin C, Linolenic Acid, Stigmasterol among others. While the active ingredients contained in Common Bean are Apigenin, Esculin, Oleic Acid, Vitamin C, Linolenic Acid and others.

Beta-sitosterol can manipulate biochemical pathways Inositol Phosphate Signaling, Apoptosis and MYC Signaling. Vitamin C has biological action on biochemical pathways P53 Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling.

Pelargonidin can manipulate biochemical pathways MYC Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways Apoptosis, P53 Signaling and MYC Signaling. And so on.

For genetic risk of Esophageal Adenocarcinoma due to abnormalities in genes FAT3 and LAMA1 – Foods like Scarlet Bean are recommended compared to Common Bean. This is because the active ingredients Pelargonidin and Folic Acid in Common Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin C contained in Scarlet Bean together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: SCARLET BEAN IS RECOMMENDED OVER COMMON BEAN FOR REDUCING THE GENETIC RISK OF ESOPHAGEAL ADENOCARCINOMA DUE TO GENES FAT3 AND LAMA1

Eat more vegetables, Arugula or Celery?

The active ingredients contained in Arugula are Esculin, Vitamin A, Kaempferol, Vitamin K, Erysolin among others. While the active ingredients contained in Celery are Apigenin, Oleic Acid, Vitamin C, Linolenic Acid, Quercetin and others.

Kaempferol can manipulate biochemical pathways Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling. Vitamin K has biological action on biochemical pathways MYC Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling.

Luteolin can manipulate biochemical pathways MYC Signaling. Chrysin has biological action on biochemical pathways MYC Signaling. And so on.

For genetic risk of Esophageal Adenocarcinoma due to abnormalities in genes FAT3 and LAMA1 – Foods like Arugula are recommended compared to Celery. This is because the active ingredients Luteolin and Chrysin in Celery further promote the effects of genes on the biochemical pathways. While the active ingredients Kaempferol and Vitamin K contained in Arugula together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: ARUGULA IS RECOMMENDED OVER CELERY FOR REDUCING THE GENETIC RISK OF ESOPHAGEAL ADENOCARCINOMA DUE TO GENES FAT3 AND LAMA1

Eat more fruits, Feijoa or Cranberry?

The active ingredients contained in Feijoa are Lycopene, Vitamin C, Casuarinin, Folic Acid among others. While the active ingredients contained in Cranberry are Resveratrol, Ellagic Acid, Vitamin C, Hyperoside, Quercetin and others.

Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Lycopene has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and Apoptosis.

Resveratrol can manipulate biochemical pathways P53 Signaling. Ellagic Acid has biological action on biochemical pathways MYC Signaling. And so on.

For genetic risk of Esophageal Adenocarcinoma due to abnormalities in genes FAT3 and LAMA1 – Foods like Feijoa are recommended compared to Cranberry. This is because the active ingredients Resveratrol and Ellagic Acid in Cranberry further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Lycopene contained in Feijoa together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: FEIJOA IS RECOMMENDED OVER CRANBERRY FOR REDUCING THE GENETIC RISK OF ESOPHAGEAL ADENOCARCINOMA DUE TO GENES FAT3 AND LAMA1

Eat more nuts, Pecan Nut or Chestnut?

The active ingredients contained in Pecan Nut are Vitamin E, Oleic Acid, Cianidanol, Linolenic Acid, Linoleic Acid among others. While the active ingredients contained in Chestnut are Oleic Acid, Ellagic Acid, Vitamin C, Linolenic Acid, Quercetin and others.

Vitamin E can manipulate biochemical pathways Inositol Phosphate Signaling, Apoptosis and MYC Signaling. Cianidanol has biological action on biochemical pathways P53 Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling.

Ellagic Acid can manipulate biochemical pathways MYC Signaling. Folic Acid has biological action on biochemical pathways Apoptosis, P53 Signaling and Cell Cycle Checkpoints. And so on.

For genetic risk of Esophageal Adenocarcinoma due to abnormalities in genes FAT3 and LAMA1 – Foods like Pecan Nut are recommended compared to Chestnut. This is because the active ingredients Ellagic Acid and Folic Acid in Chestnut further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin E and Cianidanol contained in Pecan Nut together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: PECAN NUT IS RECOMMENDED OVER CHESTNUT FOR REDUCING THE GENETIC RISK OF ESOPHAGEAL ADENOCARCINOMA DUE TO GENES FAT3 AND LAMA1

In Summary

An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.

“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.

The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.

You can get started NOW and design a personalized nutrition plan for Esophageal Adenocarcinoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

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