Highlights
No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Diffuse Large B-cell Lymphoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Diffuse Large B-cell Lymphoma because of MYD88 and PIM1 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.
There is no one answer to this question for cancers such as Diffuse Large B-cell Lymphoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.
In short – the process to answer questions like “Should I Avoid eating fruit Cranberry” or “Include fruit Nectarine in my diet” or “Should I reduce consumption of vegetable Purslane” or “Can I take Dim and Neem Extract supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.
RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO DIFFUSE LARGE B-CELL LYMPHOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.
The overall objective of personalized nutrition for Diffuse Large B-cell Lymphoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.
RECOMMENDATION: UPDATE YOUR NUTRITION FOR DIFFUSE LARGE B-CELL LYMPHOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.
About Diffuse Large B-cell Lymphoma
cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.
Following key highlights are derived from clinical data for Diffuse Large B-cell Lymphoma from cBioPortal. The patients enrolled in the studies for Diffuse Large B-cell Lymphoma are in ages between 8 to 85 with an average age of 58. 55.6% of males and 44.4% of females were the distribution of gender in these clinical studies. From a patient sample size of 1565; the top genes with mutations and other abnormalities for Diffuse Large B-cell Lymphoma include genes KMT2D, MYD88, PIM1, CREBBP and SPEN. The occurrence frequency distribution for these genes respectively is 18.2%, 12.6%, 10.8%, 8.5% and 7.4%. These tumor genetic details of Diffuse Large B-cell Lymphoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Diffuse Large B-cell Lymphoma.
Diffuse large B-cell lymphoma (DLBCL) is the most common and most aggressive subtype of non-Hodgkin’s lymphoma. DLBCLs have a rapid growth rate and present as masses infiltrating tissues or obstructing organs. This is a heterogeneous b-cell lymphoma with subtypes based on cell of origin and or genomics. The key subtypes with different underlying molecular and genomic characteristics include GCB (germinal center b-cell subtype) and non-GCB that include the ABC (activated b-cell subtype) and some that are unclassified or not otherwise specified (NOS) subtype, that include an array of DLBCL variants. DLBCL is diagnosed most frequently in older adults above 60 years of age, except for primary mediastinal DLBCL variant, which affects mostly females in their lates 20s or early 30s. Signs and symptoms of DLBCL include pain in an enlarged lymph node or organ, fever, drenching night sweats, weight loss, generalized pruritus, anorexia, fatigue, chest discomfort and shortness of breath. The standard of care treatment for DLBCL is a combination regimen of chemotherapy and immunotherapy called R-CHOP (rituximab plus cyclophosphamide, doxorubicin, vincristine and prednisone). Other later line treatment options include hematopoietic stem cell transplantation, chimeric T-cell (CAR-T) therapy and other targeted drugs. 5-year survival rate for non-Hodgkin lymphoma is ~73%, however, women and patients younger than 65 years have a better survival outcome. Treatment plan personalized to the stage and variant of the DLBCL subtype along with the right nutrition (food and natural supplements) can help improve the well-being of patients with DLBCL. (Ref: https://emedicine.medscape.com/article/202969-overview#showall; https://www.ncbi.nlm.nih.gov/books/NBK557796/)
Significance of Nutrition for Diffuse Large B-cell Lymphoma
All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Diffuse Large B-cell Lymphoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.
For example Cranberry includes active ingredients Quercetin, Ellagic Acid, Myricetin, Resveratrol, Caffeic Acid and others. And Nectarine contains active ingredients Chlorogenic Acid, Vitamin A and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.
For cancers like Diffuse Large B-cell Lymphoma, activation or inhibition of selected biochemical pathways like Oncogenic Cancer Epigenetics, Chromatin Remodeling, PI3K-AKT-MTOR Signaling, NFKB Signaling plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Diffuse Large B-cell Lymphoma, while eating some other foods and supplements may not be recommended.
One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.
RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR DIFFUSE LARGE B-CELL LYMPHOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.
Foods for Diffuse Large B-cell Lymphoma undergoing chemotherapy treatment
In Diffuse Large B-cell Lymphoma – the genes KMT2D, MYD88, PIM1, CREBBP and SPEN have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Diffuse Large B-cell Lymphoma are Oncogenic Cancer Epigenetics, Chromatin Remodeling, MAPK Signaling and others. Doxorubicin is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Oncogenic Cancer Epigenetics, Chromatin Remodeling, MAPK Signaling so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.
RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.
Eat more pulses, Common Pea or Lima Bean?
Pulses are an important part of many diets. The active ingredients contained in Common Pea are Lupeol, Beta-sitosterol, Daidzein, Linolenic Acid, Oleic Acid among others. While the active ingredients contained in Lima Bean are Oleic Acid, Vitamin C, Genistein, Linoleic Acid, Vitamin A and others.
Beta-sitosterol can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and Apoptosis. Vitamin C has biological action on biochemical pathways Oxidative Stress, MYC Signaling and WNT Beta Catenin Signaling.
Genistein can manipulate biochemical pathways DNA Repair and Oxidative Stress. Oleic Acid has biological action on biochemical pathways Epithelial to Mesenchymal Transition and Oncogenic Cancer Epigenetics. And so on.
When treating Diffuse Large B-cell Lymphoma with chemotherapy Doxorubicin – Foods like Common Pea are recommended compared to Lima Bean. This is because the active ingredients Genistein and Oleic Acid in Lima Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin C contained in Common Pea support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: COMMON PEA IS RECOMMENDED OVER LIMA BEAN FOR DIFFUSE LARGE B-CELL LYMPHOMA ON TREATMENT WITH CHEMOTHERAPY DOXORUBICIN FOR SOME CONDITIONS.
Eat more vegetables, Cassava or Purslane?
Vegetables are an important part of many diets. The active ingredients contained in Cassava are Beta-sitosterol, Linolenic Acid, Oleic Acid, Vitamin C, Linoleic Acid among others. While the active ingredients contained in Purslane are Linolenic Acid, Oleic Acid, Vitamin C, Linoleic Acid, Vitamin A and others.
Vitamin C can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Apoptosis and Oxidative Stress. Beta-sitosterol has biological action on biochemical pathways NFKB Signaling, Chromatin Remodeling and DNA Repair.
Citric Acid can manipulate biochemical pathways Oxidative Stress. Linolenic Acid has biological action on biochemical pathways Vitamin D Signaling and Oxidative Stress. And so on.
When treating Diffuse Large B-cell Lymphoma with chemotherapy Doxorubicin – Foods like Cassava are recommended compared to Purslane. This is because the active ingredients Citric Acid and Linolenic Acid in Purslane interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Beta-sitosterol contained in Cassava support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: CASSAVA IS RECOMMENDED OVER PURSLANE FOR DIFFUSE LARGE B-CELL LYMPHOMA ON TREATMENT WITH CHEMOTHERAPY DOXORUBICIN FOR SOME CONDITIONS.
Eat more fruits, Nectarine or Cranberry?
Fruits are an important part of many diets. The active ingredients contained in Nectarine are Chlorogenic Acid, Vitamin A among others. While the active ingredients contained in Cranberry are Quercetin, Ellagic Acid, Myricetin, Resveratrol, Caffeic Acid and others.
Chlorogenic Acid can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and Apoptosis. Vitamin A has biological action on biochemical pathways Oxidative Stress, MYC Signaling and WNT Beta Catenin Signaling.
Quercetin can manipulate biochemical pathways Oxidative Stress and Hypoxia. Ellagic Acid has biological action on biochemical pathways Epithelial to Mesenchymal Transition, MYC Signaling and WNT Beta Catenin Signaling. And so on.
When treating Diffuse Large B-cell Lymphoma with chemotherapy Doxorubicin – Foods like Nectarine are recommended compared to Cranberry. This is because the active ingredients Quercetin and Ellagic Acid in Cranberry interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Chlorogenic Acid and Vitamin A contained in Nectarine support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: NECTARINE IS RECOMMENDED OVER CRANBERRY FOR DIFFUSE LARGE B-CELL LYMPHOMA ON TREATMENT WITH CHEMOTHERAPY DOXORUBICIN FOR SOME CONDITIONS.
Eat more nuts, Pecan Nut or Acorn?
Nuts are an important part of many diets. The active ingredients contained in Pecan Nut are Vitamin E, Linolenic Acid, Oleic Acid, Cianidanol, Linoleic Acid among others. While the active ingredients contained in Acorn are Quercetin, Beta-sitosterol, Gallic Acid, Beta-carotene, Vitamin C and others.
Vitamin E can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and Apoptosis. Cianidanol has biological action on biochemical pathways DNA Repair, Cell Survival and MYC Signaling.
Quercetin can manipulate biochemical pathways Oxidative Stress and Hypoxia. Gallic Acid has biological action on biochemical pathways Vitamin D Signaling and Oxidative Stress. And so on.
When treating Diffuse Large B-cell Lymphoma with chemotherapy Doxorubicin – Foods like Pecan Nut are recommended compared to Acorn. This is because the active ingredients Quercetin and Gallic Acid in Acorn interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin E and Cianidanol contained in Pecan Nut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: PECAN NUT IS RECOMMENDED OVER ACORN FOR DIFFUSE LARGE B-CELL LYMPHOMA ON TREATMENT WITH CHEMOTHERAPY DOXORUBICIN FOR SOME CONDITIONS.
Foods for Genetic Risk of Diffuse Large B-cell Lymphoma
One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. MYD88 and PIM1 are two genes whose abnormalities are risk factors for Diffuse Large B-cell Lymphoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Diffuse Large B-cell Lymphoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Diffuse Large B-cell Lymphoma gene MYD88 has causative impact on biological pathways like Cytokine Signaling, Inflammation and Antigen Presentation. And PIM1 has a causative impact on biological pathways like Cytokine Signaling and JAK-STAT Signaling. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like MYD88 and PIM1 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes MYD88 and PIM1 should be avoided.
Eat more pulses, Scarlet Bean or Soy Bean?
The active ingredients contained in Scarlet Bean are Linolenic Acid, Vitamin C, Stigmasterol, Linoleic Acid, Liquiritigenin among others. While the active ingredients contained in Soy Bean are Quercetin, Ferulic Acid, Linolenic Acid, Vitamin E, Vitamin C and others.
Vitamin C can manipulate biochemical pathways MAPK Signaling, Oncogenic Cancer Epigenetics and Apoptosis. Stigmasterol has biological action on biochemical pathways Apoptosis and MAPK Signaling.
Lecithin can manipulate biochemical pathways NFKB Signaling and MAPK Signaling. Folic Acid has biological action on biochemical pathways Growth Factor Signaling, Apoptosis and MAPK Signaling. And so on.
For genetic risk of Diffuse Large B-cell Lymphoma due to abnormalities in genes MYD88 and PIM1 – Foods like Scarlet Bean are recommended compared to Soy Bean. This is because the active ingredients Lecithin and Folic Acid in Soy Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Stigmasterol contained in Scarlet Bean together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: SCARLET BEAN IS RECOMMENDED OVER SOY BEAN FOR REDUCING THE GENETIC RISK OF DIFFUSE LARGE B-CELL LYMPHOMA DUE TO GENES MYD88 AND PIM1
Eat more vegetables, Burdock or Carob?
The active ingredients contained in Burdock are Chlorogenic Acid, Linolenic Acid, Dehydrocostus Lactone, Lupeol, Arctigenin among others. While the active ingredients contained in Carob are Quercetin, Gallic Acid, Phloroglucinol, Myricetin, Palmitic Acid and others.
Chlorogenic Acid can manipulate biochemical pathways MAPK Signaling, Oncogenic Cancer Epigenetics and NFKB Signaling. Caffeic Acid has biological action on biochemical pathways NFKB Signaling and MAPK Signaling.
Palmitic Acid can manipulate biochemical pathways NFKB Signaling, Oncogenic Cancer Epigenetics and Chromatin Remodeling. Myricetin has biological action on biochemical pathways Oncogenic Cancer Epigenetics. And so on.
For genetic risk of Diffuse Large B-cell Lymphoma due to abnormalities in genes MYD88 and PIM1 – Foods like Burdock are recommended compared to Carob. This is because the active ingredients Palmitic Acid and Myricetin in Carob further promote the effects of genes on the biochemical pathways. While the active ingredients Chlorogenic Acid and Caffeic Acid contained in Burdock together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: BURDOCK IS RECOMMENDED OVER CAROB FOR REDUCING THE GENETIC RISK OF DIFFUSE LARGE B-CELL LYMPHOMA DUE TO GENES MYD88 AND PIM1
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
Eat more fruits, Raspberry or Plum?
The active ingredients contained in Raspberry are Ellagic Acid, Quercetin, Salicylic Acid, Gallic Acid, Vitamin C among others. While the active ingredients contained in Plum are Quercetin, Chlorogenic Acid, Melatonin, Vitamin C, Betulinic Acid and others.
Vitamin C can manipulate biochemical pathways MAPK Signaling, Oncogenic Cancer Epigenetics and Apoptosis. Salicylic Acid has biological action on biochemical pathways Histone/Protein Acetylation, NFKB Signaling and MAPK Signaling.
Myristic Acid can manipulate biochemical pathways Apoptosis, MAPK Signaling and Notch Signaling. Palmitic Acid has biological action on biochemical pathways NFKB Signaling, Oncogenic Cancer Epigenetics and Chromatin Remodeling. And so on.
For genetic risk of Diffuse Large B-cell Lymphoma due to abnormalities in genes MYD88 and PIM1 – Foods like Raspberry are recommended compared to Plum. This is because the active ingredients Myristic Acid and Palmitic Acid in Plum further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Salicylic Acid contained in Raspberry together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: RASPBERRY IS RECOMMENDED OVER PLUM FOR REDUCING THE GENETIC RISK OF DIFFUSE LARGE B-CELL LYMPHOMA DUE TO GENES MYD88 AND PIM1
Eat more nuts, Almond or Pumpkin Seeds?
The active ingredients contained in Almond are Quercetin, Salicylic Acid, Linolenic Acid, Vitamin E, Stigmasterol among others. While the active ingredients contained in Pumpkin Seeds are Salicylic Acid, Linolenic Acid, Stigmasterol, Linoleic Acid, Gamma-linolenic Acid and others.
Beta-sitosterol can manipulate biochemical pathways NFKB Signaling, Oncogenic Cancer Epigenetics and Apoptosis. Salicylic Acid has biological action on biochemical pathways Histone/Protein Acetylation, MAPK Signaling and NFKB Signaling.
Lecithin can manipulate biochemical pathways NFKB Signaling and MAPK Signaling. Cucurbitacin I has biological action on biochemical pathways NFKB Signaling. And so on.
For genetic risk of Diffuse Large B-cell Lymphoma due to abnormalities in genes MYD88 and PIM1 – Foods like Almond are recommended compared to Pumpkin Seeds. This is because the active ingredients Lecithin and Cucurbitacin I in Pumpkin Seeds further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Salicylic Acid contained in Almond together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: ALMOND IS RECOMMENDED OVER PUMPKIN SEEDS FOR REDUCING THE GENETIC RISK OF DIFFUSE LARGE B-CELL LYMPHOMA DUE TO GENES MYD88 AND PIM1
In Summary
An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.
“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.
The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.
You can get started NOW and design a personalized nutrition plan for Diffuse Large B-cell Lymphoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
References
- Dlbcl Dfci 2018
- Pan-cancer analysis of whole genomes.
- Paederia foetida induces anticancer activity by modulating chromatin modification enzymes and altering pro-inflammatory cytokine gene expression in human prostate cancer cells.
- The synergy of Vitamin C with decitabine activates TET2 in leukemic cells and significantly improves overall survival in elderly patients with acute myeloid leukemia.
- BRCA1 and BRCA2 as molecular targets for phytochemicals indole-3-carbinol and genistein in breast and prostate cancer cells.
- Oleic acid-induced ANGPTL4 enhances head and neck squamous cell carcinoma anoikis resistance and metastasis via up-regulation of fibronectin.
- [Effects of tizanidine, a central muscle relaxant, upon spinal reflexes].
- Retinol decreases beta-catenin protein levels in retinoic acid-resistant colon cancer cell lines.
- Structure-based virtual screening approach to the discovery of novel inhibitors of factor-inhibiting HIF-1: identification of new chelating groups for the active-site ferrous ion.
- Identification of ellagic acid as potent inhibitor of protein kinase CK2: a successful example of a virtual screening application.
- Alpha-linolenic acid confers protection on mice renal cells against cisplatin-induced nephrotoxicity.
- Anti-IL-1 alpha autoantibodies in patients with rheumatic diseases and in healthy subjects.
- (+)-Catechin inhibits tumour angiogenesis and regulates the production of nitric oxide and TNF-alpha in LPS-stimulated macrophages.
- Cardioprotective effect of gallic acid on cardiac troponin-T, cardiac marker enzymes, lipid peroxidation products and antioxidants in experimentally induced myocardial infarction in Wistar rats.
- Stigmasterol exhibits potent antitumor effects in human gastric cancer cells mediated via inhibition of cell migration, cell cycle arrest, mitochondrial mediated apoptosis and inhibition of JAK/STAT signalling pathway.
- The recruitment of Raf-1 to membranes is mediated by direct interaction with phosphatidic acid and is independent of association with Ras.
- Differential mRNA expression of insulin-like growth factor system during renal injury and hypertrophy.
- Salicylate, diflunisal and their metabolites inhibit CBP/p300 and exhibit anticancer activity.
- Saturated fatty acids modulate cell response to DNA damage: implication for their role in tumorigenesis.
- Functional lipidomics: Palmitic acid impairs hepatocellular carcinoma development by modulating membrane fluidity and glucose metabolism.
- Downregulation of inflammatory responses by novel caffeic acid ester derivative by inhibiting NF-kappa B.
- Activation of the NF-κB pathway by the STAT3 inhibitor JSI-124 in human glioblastoma cells.
- HyperFoods: Machine intelligent mapping of cancer-beating molecules in foods.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.