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What Foods are Recommended for Cancer?
is a very common question. Personalized Nutrition Plans are foods and supplements which are personalized to a cancer indication, genes, any treatments and lifestyle conditions.

Foods for Uterine Endometrioid Carcinoma!

Aug 2, 2023

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Introduction

Foods for Uterine Endometrioid Carcinoma should be personalized for each individual and also must adapt when cancer treatment or tumor genetic change. The personalization and adaptation must consider all the active ingredients or bioactives contained in different foods with respect to cancer tissue biology, genetics, treatments, lifestyle conditions and diet preferences. Hence while nutrition is one of the very important decisions for a cancer patient and individual at risk of cancer to make – how to choose foods to eat is not an easy task.



For Uterine Endometrioid Carcinoma does it matter what vegetables, fruits, nuts, seeds one eats?

A very common nutrition question asked by cancer patients and individuals at-genetic risk of cancer is – for cancers like Uterine Endometrioid Carcinoma does it matter what foods I eat and which I do not? Or if I follow a plant-based diet is that enough for cancer like Uterine Endometrioid Carcinoma?

For example does it matter if vegetable Globe Artichoke is consumed more compared to Kohlrabi? Does it make any difference if fruit Durian is preferred over Black Mulberry? Also if similar choices are made for nuts/seeds like Butternut over Chestnut and for pulses like Broad Bean over Lima Bean. And if what I eat matters – then how does one identify foods which are recommended for Uterine Endometrioid Carcinoma and is it the same answer for everyone with the same diagnosis or genetic risk?

Yes! Foods you eat matters for Uterine Endometrioid Carcinoma!

Food recommendations may not be the same for everyone and can be different even for the same diagnosis and genetic risk.

All cancers like Uterine Endometrioid Carcinoma can be characterized by a unique set of biochemical pathways - the signature pathways of Uterine Endometrioid Carcinoma. Biochemical pathways like Cell Cycle, Cell Cycle Checkpoints, Small Molecule Transport, Focal Adhesion are part of the signature definition of Uterine Endometrioid Carcinoma.

All foods (vegetables, fruits, nuts, seeds, pulses, oils etc.) and nutritional supplements are made up of more than one active molecular ingredient or bio-actives in different proportions and quantities. Each active ingredient has a unique mechanism of action – which can be activation or inhibition of different biochemical pathways. Simply stated foods and supplements which are recommended are those which do not cause an increase of molecular drivers of cancer but reduce them. Else those foods should not be recommended. Foods contain multiple active ingredients – hence when evaluating foods and supplements you need to consider the impact of all active ingredients cumulatively rather than individually.

For example Durian contains active ingredients Apigenin, Curcumin, Isoliquiritigenin, Formononetin, Lycopene. And Black Mulberry contains active ingredients Quercetin, Apigenin, Curcumin, Isoliquiritigenin, Formononetin and possibly others.

A common mistake made when deciding and choosing foods to eat for Uterine Endometrioid Carcinoma – is to evaluate only selected active ingredients contained in foods and ignore the rest. Because different active ingredients contained in foods may have opposing effects on cancer drivers – you cannot cherry pick active ingredients in foods and supplements for making a nutrition decision for Uterine Endometrioid Carcinoma.

YES – FOOD CHOICES MATTER FOR CANCER. NUTRITION DECISIONS MUST CONSIDER ALL ACTIVE INGREDIENTS OF FOODS.

Skills Needed for Nutrition Personalization for Uterine Endometrioid Carcinoma?

Personalized nutrition for cancers like Uterine Endometrioid Carcinoma consists of recommended foods / supplements; not recommended foods / supplements with example recipes which prioritize use of recommended foods. An example of personalized nutrition can be seen at this link.

Deciding which foods are recommended or not is extremely complicated, requiring expertise in Uterine Endometrioid Carcinoma biology, food science, genetics, biochemistry along with good understanding of how cancer treatments work and associated vulnerabilities by which the treatments could stop being effective.

MINIMUM KNOWLEDGE EXPERTISE NEEDED FOR NUTRITION PERSONALIZATION FOR CANCER ARE: CANCER BIOLOGY, FOOD SCIENCE, CANCER TREATMENTS AND GENETICS.

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.

Characteristics of cancers like Uterine Endometrioid Carcinoma

All cancers like Uterine Endometrioid Carcinoma can be characterized by a unique set of biochemical pathways – the signature pathways of Uterine Endometrioid Carcinoma. Biochemical pathways like Cell Cycle, Cell Cycle Checkpoints, Small Molecule Transport, Focal Adhesion are part of the signature definition of Uterine Endometrioid Carcinoma. Each individual’s cancer genetics can be different and hence their specific cancer signature could be unique.

The treatments which are effective for Uterine Endometrioid Carcinoma need to be cognizant of the associated signature biochemical pathways for each cancer patient and individual at genetic risk. Therefore different treatments with different mechanisms of actions are effective for different patients. Similarly and for the same reasons foods and supplements need to be personalized for each individual. Hence some foods and supplements are recommended for Uterine Endometrioid Carcinoma when taking cancer treatment Anastrozole, and some foods and supplements are not recommended.

Sources like cBioPortal and many others provide population representative patient anonymized data from clinical trials for all cancer indications. This data consists of clinical trial study details like sample size / number of patients, age groups, gender, ethnicity, treatments, tumor site and any genetic mutations.

MUC16, ZFHX3, RYR2, RYR1 and RYR3 are the top ranked reported genes for Uterine Endometrioid Carcinoma. MUC16 is reported in 4.4 % of the representative patients across all clinical trials. And ZFHX3 is reported in 4.0 %. The combined population patient data cover ages from 31 to 90. 0.0 % of the patient data are identified as men. The Uterine Endometrioid Carcinoma biology along with reported genetics together define the population represented signature biochemical pathways for this cancer. If the individual cancer tumor genetics or genes contributing to the risk are also known then that should also be used for nutrition personalization.

NUTRITION CHOICES SHOULD MATCH WITH EACH INDIVIDUAL’S CANCER SIGNATURE.

Foods for Uterine Endometrioid Carcinoma!

Food and Supplements for Uterine Endometrioid Carcinoma

For Cancer Patients

Cancer patients on treatment or on palliative care need to make decisions on food and supplements – for the needed dietary calories, for managing any treatment side effects and also for improved cancer management. All plant-based foods are not equal and choosing and prioritizing foods which are personalized and customized to ongoing cancer treatment is important and complicated. Here are some examples providing guidelines for making nutrition decisions.

Choose Vegetable GLOBE ARTICHOKE or KOHLRABI?

Vegetable Globe Artichoke contains many active ingredients or bioactives such as Apigenin, Curcumin, Isoliquiritigenin, Formononetin, Genistein. These active ingredients manipulate various biochemical pathways like Cell Cycle, Epithelial to Mesenchymal Transition, Amino Acid Metabolism and Microtubule Dynamics and others. Globe Artichoke is recommended for Uterine Endometrioid Carcinoma when ongoing cancer treatment is Anastrozole. This is because Globe Artichoke modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Anastrozole.

Some of the active ingredients or bioactives in vegetable Kohlrabi are Quercetin, Curcumin, Isoliquiritigenin, Formononetin, Genistein. These active ingredients manipulate various biochemical pathways like Cell Cycle, WNT Beta Catenin Signaling, PI3K-AKT-MTOR Signaling and Cell Cycle Checkpoints and others. Kohlrabi is not recommended for Uterine Endometrioid Carcinoma when ongoing cancer treatment is Anastrozole because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

VEGETABLE GLOBE ARTICHOKE IS RECOMMENDED OVER KOHLRABI FOR Uterine Endometrioid Carcinoma AND TREATMENT Anastrozole.

Choose Fruit BLACK MULBERRY or DURIAN?

Fruit Black Mulberry contains many active ingredients or bioactives such as Quercetin, Apigenin, Curcumin, Isoliquiritigenin, Formononetin. These active ingredients manipulate various biochemical pathways like Cell Cycle, Adherens junction, Growth Factor Signaling and Epithelial to Mesenchymal Transition and others. Black Mulberry is recommended for Uterine Endometrioid Carcinoma when ongoing cancer treatment is Anastrozole. This is because Black Mulberry modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Anastrozole.

Some of the active ingredients or bioactives in fruit Durian are Apigenin, Curcumin, Isoliquiritigenin, Formononetin, Lycopene. These active ingredients manipulate various biochemical pathways like Cell Cycle, TGFB Signaling, Cell Cycle Checkpoints and Oncogenic Cancer Epigenetics and others. Durian is not recommended for Uterine Endometrioid Carcinoma when ongoing cancer treatment is Anastrozole because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

FRUIT BLACK MULBERRY IS RECOMMENDED OVER DURIAN FOR Uterine Endometrioid Carcinoma AND TREATMENT Anastrozole.

Choose Nut BUTTERNUT or CHESTNUT?

Butternut contains many active ingredients or bioactives such as Apigenin, Curcumin, Isoliquiritigenin, Formononetin, Lycopene. These active ingredients manipulate various biochemical pathways like Reproductive Hormone Signaling and others. Butternut is recommended for Uterine Endometrioid Carcinoma when ongoing cancer treatment is Anastrozole. This is because Butternut modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Anastrozole.

Some of the active ingredients or bioactives in Chestnut are Ellagic Acid, Apigenin, Curcumin, Isoliquiritigenin, Formononetin. These active ingredients manipulate various biochemical pathways like Cell Cycle, Epithelial to Mesenchymal Transition and Cell Cycle Checkpoints and others. Chestnut is not recommended for Uterine Endometrioid Carcinoma when ongoing cancer treatment is Anastrozole because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

BUTTERNUT IS RECOMMENDED OVER CHESTNUT FOR Uterine Endometrioid Carcinoma AND TREATMENT Anastrozole.

For Individuals with Genetic Risk of Cancer

The question asked by individuals who have genetic risk of Uterine Endometrioid Carcinoma or familial history is “What Should I Eat Differently from Before?” and how they should choose foods and supplements to manage risks of the disease. Since for cancer risk there is nothing actionable in terms of treatment – decisions of foods and supplements become important and one of the very few actionable things which can be done. All plant-based foods are not equal and based on identified genetics and pathway signature – the choices of food and supplements should be personalized.

Choose Vegetable GIANT BUTTERBUR or OLIVE?

Vegetable Giant Butterbur contains many active ingredients or bioactives such as Curcumin, Apigenin, Lupeol, Lycopene, Formononetin. These active ingredients manipulate various biochemical pathways like Stem Cell Signaling, P53 Signaling, Apoptosis and MYC Signaling and others. Giant Butterbur is recommended for risk of Uterine Endometrioid Carcinoma when associated genetic risk is MUC16. This is because Giant Butterbur increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in vegetable Olive are Curcumin, Lupeol, Formononetin, Quercetin, Beta-sitosterol. These active ingredients manipulate various biochemical pathways like Complement Cascade and Small Molecule Transport and others. Olive is not recommended when risk of Uterine Endometrioid Carcinoma when associated genetic risk is MUC16 because it increases the signature pathways of it.

VEGETABLE GIANT BUTTERBUR IS RECOMMENDED OVER OLIVE FOR MUC16 GENETIC RISK OF CANCER.

Choose Fruit JAVA PLUM or JAPANESE PERSIMMON?

Fruit Java Plum contains many active ingredients or bioactives such as Curcumin, Apigenin, Ellagic Acid, Lupeol, Lycopene. These active ingredients manipulate various biochemical pathways like Stem Cell Signaling, P53 Signaling, Apoptosis and Cell Cycle Checkpoints and others. Java Plum is recommended for risk of Uterine Endometrioid Carcinoma when associated genetic risk is MUC16. This is because Java Plum increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in fruit Japanese Persimmon are Curcumin, Apigenin, Lupeol, Formononetin, Daidzein. These active ingredients manipulate various biochemical pathways like Stem Cell Signaling and Small Molecule Transport and others. Japanese Persimmon is not recommended when risk of Uterine Endometrioid Carcinoma when associated genetic risk is MUC16 because it increases the signature pathways of it.

FRUIT JAVA PLUM IS RECOMMENDED OVER JAPANESE PERSIMMON FOR MUC16 GENETIC RISK OF CANCER.

Choose Nut COMMON HAZELNUT or BRAZIL NUT?

Common Hazelnut contains many active ingredients or bioactives such as Curcumin, Lupeol, Lycopene, Formononetin, Daidzein. These active ingredients manipulate various biochemical pathways like Stem Cell Signaling, P53 Signaling, Apoptosis and Cell Cycle Checkpoints and others. Common Hazelnut is recommended for risk of Uterine Endometrioid Carcinoma when associated genetic risk is MUC16. This is because Common Hazelnut increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in Brazil Nut are Curcumin, Ellagic Acid, Lupeol, Formononetin, Daidzein. These active ingredients manipulate various biochemical pathways like Stem Cell Signaling, PI3K-AKT-MTOR Signaling and MYC Signaling and others. Brazil Nut is not recommended when risk of Uterine Endometrioid Carcinoma when associated genetic risk is MUC16 because it increases the signature pathways of it.

COMMON HAZELNUT IS RECOMMENDED OVER BRAZIL NUT FOR MUC16 GENETIC RISK OF CANCER.


In Conclusion

Foods and Supplements chosen are important decisions for cancers like Uterine Endometrioid Carcinoma. Uterine Endometrioid Carcinoma patients and individuals with genetic-risk always have this question: “What foods and nutritional supplements are recommended for me and which are not?” There is a common belief which is a misconception that all plant-based foods could be beneficial or not but would not be harmful. Certain foods and supplements can interfere with cancer treatments or promote molecular pathway drivers of cancer.

There are different types of cancer indications like Uterine Endometrioid Carcinoma, each with different tumor genetics with further genomic variations across each individual. Further every cancer treatment and chemotherapy has a unique mechanism of action. Each food like Globe Artichoke contains various bioactives in different quantities, which have an impact on different and distinct sets of biochemical pathways. The definition of personalized nutrition is individualized food recommendations for the cancer indication, treatments, genetics, lifestyle and other factors. Nutrition personalization decisions for cancer require knowledge of cancer biology, food science and an understanding of different chemotherapy treatments. Finally when there are treatment changes or new genomics is identified – the nutrition personalization needs re-evaluation.

The addon nutrition personalization solution makes the decision making easy and removes all the guesswork in answering the question, “What foods should I choose or not choose for Uterine Endometrioid Carcinoma?”. The addon multi-disciplinary team includes cancer physicians, clinical scientists, software engineers and data scientists.


Personalized Nutrition for Cancer!

Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.

References

Scientifically Reviewed by: Dr. Cogle

Christopher R. Cogle, M.D. is a tenured professor at the University of Florida, Chief Medical Officer of Florida Medicaid, and Director of the Florida Health Policy Leadership Academy at the Bob Graham Center for Public Service.

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