Which Foods are Recommended for Uterine Endometrioid Carcinoma?

Highlights

No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Uterine Endometrioid Carcinoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Uterine Endometrioid Carcinoma because of ZFHX3 and RYR1 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.

There is no one answer to this question for cancers such as Uterine Endometrioid Carcinoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.

In short – the process to answer questions like “Should I Avoid eating fruit Lingonberry” or “Include fruit Nance in my diet” or “Should I reduce consumption of vegetable Swede” or “Can I take Dim and Silymarin supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.

RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO UTERINE ENDOMETRIOID CARCINOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.

The overall objective of personalized nutrition for Uterine Endometrioid Carcinoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.

RECOMMENDATION: UPDATE YOUR NUTRITION FOR UTERINE ENDOMETRIOID CARCINOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.

About Uterine Endometrioid Carcinoma

cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.

Following key highlights are derived from clinical data for Uterine Endometrioid Carcinoma from cBioPortal. The patients enrolled in the studies for Uterine Endometrioid Carcinoma are in ages between 31 to 90 with an average age of 62.From a patient sample size of 1383; the top genes with mutations and other abnormalities for Uterine Endometrioid Carcinoma include genes MUC16, ZFHX3, RYR2, RYR1 and RYR3. The occurrence frequency distribution for these genes respectively is 4.4%, 4.0%, 3.5%, 3.1% and 3.1%. These tumor genetic details of Uterine Endometrioid Carcinoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Uterine Endometrioid Carcinoma.

Significance of Nutrition for Uterine Endometrioid Carcinoma

All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Uterine Endometrioid Carcinoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.

For example Lingonberry includes active ingredients Quercetin, Hyperoside, Caffeic Acid, Linolenic Acid, Resveratrol and others. And Nance contains active ingredients Betulin, Vitamin C, Vitamin A and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.

For cancers like Uterine Endometrioid Carcinoma, activation or inhibition of selected biochemical pathways like Apoptosis, C-type Lectin Receptor Signaling, Small Molecule Transport, Focal Adhesion plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Uterine Endometrioid Carcinoma, while eating some other foods and supplements may not be recommended.

One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.

RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR UTERINE ENDOMETRIOID CARCINOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.

Foods for Uterine Endometrioid Carcinoma undergoing chemotherapy treatment

In Uterine Endometrioid Carcinoma – the genes MUC16, ZFHX3, RYR2, RYR1 and RYR3 have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Uterine Endometrioid Carcinoma are Apoptosis, C-type Lectin Receptor Signaling, Phospholipase Signaling and others. Carboplatin is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Apoptosis, C-type Lectin Receptor Signaling, Phospholipase Signaling so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.

RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.

Eat more pulses, Common Pea or Pigeon Pea?

Pulses are an important part of many diets. The active ingredients contained in Common Pea are Lupeol, Daidzein, Linolenic Acid, Beta-sitosterol, Oleic Acid among others. While the active ingredients contained in Pigeon Pea are Linolenic Acid, Oleic Acid, Vitamin C, Genistein, Linoleic Acid and others.

Beta-sitosterol can manipulate biochemical pathways NFKB Signaling, Apoptosis and Cell Cycle. Vitamin C has biological action on biochemical pathways MYC Signaling, WNT Beta Catenin Signaling and P53 Signaling.

Genistein can manipulate biochemical pathways DNA Repair and Oxidative Stress. Linolenic Acid has biological action on biochemical pathways Vitamin D Signaling and Oxidative Stress. And so on.

When treating Uterine Endometrioid Carcinoma with chemotherapy Carboplatin – Foods like Common Pea are recommended compared to Pigeon Pea. This is because the active ingredients Genistein and Linolenic Acid in Pigeon Pea interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin C contained in Common Pea support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: COMMON PEA IS RECOMMENDED OVER PIGEON PEA FOR UTERINE ENDOMETRIOID CARCINOMA ON TREATMENT WITH CHEMOTHERAPY CARBOPLATIN FOR SOME CONDITIONS.

Eat more vegetables, Cassava or Swede?

Vegetables are an important part of many diets. The active ingredients contained in Cassava are Linolenic Acid, Beta-sitosterol, Oleic Acid, Vitamin C, Linoleic Acid among others. While the active ingredients contained in Swede are Lycopene, Linolenic Acid, Oleic Acid, Linoleic Acid, Folic Acid and others.

Vitamin C can manipulate biochemical pathways Apoptosis, Cell Cycle and MYC Signaling. Beta-sitosterol has biological action on biochemical pathways NFKB Signaling, Cell Survival and WNT Beta Catenin Signaling.

Lycopene can manipulate biochemical pathways Oxidative Stress. Linolenic Acid has biological action on biochemical pathways Vitamin D Signaling and Oxidative Stress. And so on.

When treating Uterine Endometrioid Carcinoma with chemotherapy Carboplatin – Foods like Cassava are recommended compared to Swede. This is because the active ingredients Lycopene and Linolenic Acid in Swede interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Beta-sitosterol contained in Cassava support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: CASSAVA IS RECOMMENDED OVER SWEDE FOR UTERINE ENDOMETRIOID CARCINOMA ON TREATMENT WITH CHEMOTHERAPY CARBOPLATIN FOR SOME CONDITIONS.

Eat more fruits, Nance or Lingonberry?

Fruits are an important part of many diets. The active ingredients contained in Nance are Betulin, Vitamin C, Vitamin A among others. While the active ingredients contained in Lingonberry are Quercetin, Hyperoside, Caffeic Acid, Linolenic Acid, Resveratrol and others.

Vitamin C can manipulate biochemical pathways Apoptosis, Cell Cycle and MYC Signaling. Betulin has biological action on biochemical pathways Extracellular Matrix Remodelling, Cell Survival and MAPK Signaling.

Quercetin can manipulate biochemical pathways Oxidative Stress. Hyperoside has biological action on biochemical pathways Oxidative Stress. And so on.

When treating Uterine Endometrioid Carcinoma with chemotherapy Carboplatin – Foods like Nance are recommended compared to Lingonberry. This is because the active ingredients Quercetin and Hyperoside in Lingonberry interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Betulin contained in Nance support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: NANCE IS RECOMMENDED OVER LINGONBERRY FOR UTERINE ENDOMETRIOID CARCINOMA ON TREATMENT WITH CHEMOTHERAPY CARBOPLATIN FOR SOME CONDITIONS.

Eat more nuts, Pecan Nut or Acorn?

Nuts are an important part of many diets. The active ingredients contained in Pecan Nut are Vitamin E, Linolenic Acid, Oleic Acid, Cianidanol, Linoleic Acid among others. While the active ingredients contained in Acorn are Quercetin, Gallic Acid, Beta-sitosterol, Beta-carotene, Vitamin C and others.

Vitamin E can manipulate biochemical pathways NFKB Signaling, Apoptosis and Extracellular Matrix Remodelling. Cianidanol has biological action on biochemical pathways DNA Repair, Cell Survival and MYC Signaling.

Quercetin can manipulate biochemical pathways Oxidative Stress. Gallic Acid has biological action on biochemical pathways Vitamin D Signaling and Oxidative Stress. And so on.

When treating Uterine Endometrioid Carcinoma with chemotherapy Carboplatin – Foods like Pecan Nut are recommended compared to Acorn. This is because the active ingredients Quercetin and Gallic Acid in Acorn interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin E and Cianidanol contained in Pecan Nut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: PECAN NUT IS RECOMMENDED OVER ACORN FOR UTERINE ENDOMETRIOID CARCINOMA ON TREATMENT WITH CHEMOTHERAPY CARBOPLATIN FOR SOME CONDITIONS.

Foods for Genetic Risk of Uterine Endometrioid Carcinoma

One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. ZFHX3 and RYR1 are two genes whose abnormalities are risk factors for Uterine Endometrioid Carcinoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Uterine Endometrioid Carcinoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Uterine Endometrioid Carcinoma gene ZFHX3 has causative impact on biological pathways like . And RYR1 has a causative impact on biological pathways like G-protein-coupled Receptor Signaling and G-protein-coupled Receptor Signaling. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like ZFHX3 and RYR1 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes ZFHX3 and RYR1 should be avoided.

Eat more pulses, Scarlet Bean or Soy Bean?

The active ingredients contained in Scarlet Bean are Beta-sitosterol, Oleic Acid, Vitamin C, Linolenic Acid, Stigmasterol among others. While the active ingredients contained in Soy Bean are Lupeol, Daidzein, Vitamin E, Beta-sitosterol, Oleic Acid and others.

Beta-sitosterol can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Vitamin C has biological action on biochemical pathways Cell Cycle Checkpoints, MAPK Signaling and PI3K-AKT-MTOR Signaling.

Aescin can manipulate biochemical pathways Cell Cycle Checkpoints. Lecithin has biological action on biochemical pathways MYC Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling. And so on.

For genetic risk of Uterine Endometrioid Carcinoma due to abnormalities in genes ZFHX3 and RYR1 – Foods like Scarlet Bean are recommended compared to Soy Bean. This is because the active ingredients Aescin and Lecithin in Soy Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin C contained in Scarlet Bean together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: SCARLET BEAN IS RECOMMENDED OVER SOY BEAN FOR REDUCING THE GENETIC RISK OF UTERINE ENDOMETRIOID CARCINOMA DUE TO GENES ZFHX3 AND RYR1

Eat more vegetables, Jicama or Carrot?

The active ingredients contained in Jicama are Vitamin C, Vitamin B3, Beta-carotene, Vitamin A, Folic Acid among others. While the active ingredients contained in Carrot are D-limonene, Lupeol, Linalool, Vitamin E, Beta-sitosterol and others.

Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Vitamin B3 has biological action on biochemical pathways Cell Cycle Checkpoints, MYC Signaling and P53 Signaling.

Gamma-linolenic Acid can manipulate biochemical pathways Complement Cascade. Beta-carotene has biological action on biochemical pathways MAPK Signaling and PI3K-AKT-MTOR Signaling. And so on.

For genetic risk of Uterine Endometrioid Carcinoma due to abnormalities in genes ZFHX3 and RYR1 – Foods like Jicama are recommended compared to Carrot. This is because the active ingredients Gamma-linolenic Acid and Beta-carotene in Carrot further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Vitamin B3 contained in Jicama together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: JICAMA IS RECOMMENDED OVER CARROT FOR REDUCING THE GENETIC RISK OF UTERINE ENDOMETRIOID CARCINOMA DUE TO GENES ZFHX3 AND RYR1

Eat more fruits, Jujube or Strawberry Guava?

The active ingredients contained in Jujube are Beta-sitosterol, Oleic Acid, Vitamin C, Linolenic Acid, Linoleic Acid among others. While the active ingredients contained in Strawberry Guava are Oleic Acid, Quercetin, Vitamin C, Linolenic Acid, Linoleic Acid and others.

Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Beta-sitosterol has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and Apoptosis.

Quercetin can manipulate biochemical pathways Complement Cascade. Vitamin A has biological action on biochemical pathways PI3K-AKT-MTOR Signaling. And so on.

For genetic risk of Uterine Endometrioid Carcinoma due to abnormalities in genes ZFHX3 and RYR1 – Foods like Jujube are recommended compared to Strawberry Guava. This is because the active ingredients Quercetin and Vitamin A in Strawberry Guava further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Jujube together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: JUJUBE IS RECOMMENDED OVER STRAWBERRY GUAVA FOR REDUCING THE GENETIC RISK OF UTERINE ENDOMETRIOID CARCINOMA DUE TO GENES ZFHX3 AND RYR1

Eat more nuts, Pine Nut or Peanut?

The active ingredients contained in Pine Nut are Vitamin E, Beta-sitosterol, Oleic Acid, Linolenic Acid, Linoleic Acid among others. While the active ingredients contained in Peanut are Vitamin E, Beta-sitosterol, Oleic Acid, Quercetin, Vitamin C and others.

Beta-sitosterol can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Vitamin K has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and MYC Signaling.

Quercetin can manipulate biochemical pathways Complement Cascade. Vitamin A has biological action on biochemical pathways PI3K-AKT-MTOR Signaling. And so on.

For genetic risk of Uterine Endometrioid Carcinoma due to abnormalities in genes ZFHX3 and RYR1 – Foods like Pine Nut are recommended compared to Peanut. This is because the active ingredients Quercetin and Vitamin A in Peanut further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin K contained in Pine Nut together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: PINE NUT IS RECOMMENDED OVER PEANUT FOR REDUCING THE GENETIC RISK OF UTERINE ENDOMETRIOID CARCINOMA DUE TO GENES ZFHX3 AND RYR1

In Summary

An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.

“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.

The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.

You can get started NOW and design a personalized nutrition plan for Uterine Endometrioid Carcinoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

References

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