Foods for Spindle Cell Sarcoma!

Introduction

Foods for Spindle Cell Sarcoma should be personalized for each individual and also must adapt when cancer treatment or tumor genetic change. The personalization and adaptation must consider all the active ingredients or bioactives contained in different foods with respect to cancer tissue biology, genetics, treatments, lifestyle conditions and diet preferences. Hence while nutrition is one of the very important decisions for a cancer patient and individual at risk of cancer to make – how to choose foods to eat is not an easy task.

Spindle Cell Sarcoma, a type of cancer characterized by spindle-shaped tumor cells, can occur in both humans and dogs, with varying prognosis and survival rates. In dogs, spindle cell sarcoma presents unique challenges in diagnosis and treatment. The pathology outlines of spindle cell sarcoma are crucial for accurate diagnosis, often confirmed by an IHC (immunohistochemistry) panel. Radiology, including CT scans and MRIs, is essential for detecting spindle cell sarcoma in the lung and other locations, helping to assess the extent of metastasis. The treatment of spindle cell sarcoma involves surgery, chemotherapy, and sometimes radiation therapy, depending on the tumor’s location and stage. While the potential for a cure varies, early detection and aggressive treatment can improve outcomes. The ICD-10 coding system categorizes spindle cell sarcoma for healthcare tracking. Understanding what spindle cell sarcoma is, particularly in dogs, is important for pet owners and veterinarians alike. Symptoms (sintomas) can vary based on the tumor’s size and location, emphasizing the need for awareness and timely medical intervention.

For Spindle Cell Sarcoma does it matter what vegetables, fruits, nuts, seeds one eats?

A very common nutrition question asked by cancer patients and individuals at-genetic risk of cancer is – for cancers like Spindle Cell Sarcoma does it matter what foods I eat and which I do not? Or if I follow a plant-based diet is that enough for cancer like Spindle Cell Sarcoma?

For example does it matter if vegetable Red Bell Pepper is consumed more compared to Shallot? Does it make any difference if fruit Alaska Blueberry is preferred over Sour Cherry? Also if similar choices are made for nuts/seeds like Common Walnut over Chestnut and for pulses like Yardlong Bean over Catjang Pea. And if what I eat matters – then how does one identify foods which are recommended for Spindle Cell Sarcoma and is it the same answer for everyone with the same diagnosis or genetic risk?

Yes! Foods you eat matters for Spindle Cell Sarcoma!

Food recommendations may not be the same for everyone and can be different even for the same diagnosis and genetic risk.

All foods (vegetables, fruits, nuts, seeds, pulses, oils etc.) and nutritional supplements are made up of more than one active molecular ingredient or bio-actives in different proportions and quantities. Each active ingredient has a unique mechanism of action – which can be activation or inhibition of different biochemical pathways. Simply stated foods and supplements which are recommended are those which do not cause an increase of molecular drivers of cancer but reduce them. Else those foods should not be recommended. Foods contain multiple active ingredients – hence when evaluating foods and supplements you need to consider the impact of all active ingredients cumulatively rather than individually.

For example Alaska Blueberry contains active ingredients Curcumin, Formononetin, Daidzein, Lupeol, Apigenin. And Sour Cherry contains active ingredients Curcumin, Formononetin, Daidzein, Lupeol, Apigenin and possibly others.

A common mistake made when deciding and choosing foods to eat for Spindle Cell Sarcoma – is to evaluate only selected active ingredients contained in foods and ignore the rest. Because different active ingredients contained in foods may have opposing effects on cancer drivers – you cannot cherry pick active ingredients in foods and supplements for making a nutrition decision for Spindle Cell Sarcoma.

YES – FOOD CHOICES MATTER FOR CANCER. NUTRITION DECISIONS MUST CONSIDER ALL ACTIVE INGREDIENTS OF FOODS.

Skills Needed for Nutrition Personalization for Spindle Cell Sarcoma?

Personalized nutrition for cancers like Spindle Cell Sarcoma consists of recommended foods / supplements; not recommended foods / supplements with example recipes which prioritize use of recommended foods. An example of personalized nutrition can be seen at this link.

Deciding which foods are recommended or not is extremely complicated, requiring expertise in Spindle Cell Sarcoma biology, food science, genetics, biochemistry along with good understanding of how cancer treatments work and associated vulnerabilities by which the treatments could stop being effective.

MINIMUM KNOWLEDGE EXPERTISE NEEDED FOR NUTRITION PERSONALIZATION FOR CANCER ARE: CANCER BIOLOGY, FOOD SCIENCE, CANCER TREATMENTS AND GENETICS.

Characteristics of cancers like Spindle Cell Sarcoma

All cancers like Spindle Cell Sarcoma can be characterized by a unique set of biochemical pathways – the signature pathways of Spindle Cell Sarcoma. Biochemical pathways like Apoptosis, Microtubule Dynamics, TGFB Signaling, PI3K-AKT-MTOR Signaling are part of the signature definition of Spindle Cell Sarcoma. Each individual’s cancer genetics can be different and hence their specific cancer signature could be unique.

The treatments which are effective for Spindle Cell Sarcoma need to be cognizant of the associated signature biochemical pathways for each cancer patient and individual at genetic risk. Therefore different treatments with different mechanisms of actions are effective for different patients. Similarly and for the same reasons foods and supplements need to be personalized for each individual. Hence some foods and supplements are recommended for Spindle Cell Sarcoma when taking cancer treatment Vinorelbine, and some foods and supplements are not recommended.

Sources like cBioPortal and many others provide population representative patient anonymized data from clinical trials for all cancer indications. This data consists of clinical trial study details like sample size / number of patients, age groups, gender, ethnicity, treatments, tumor site and any genetic mutations.

ATRX, TERT, HNF1A, MED12 and MACC1 are the top ranked reported genes for Spindle Cell Sarcoma. ATRX is reported in 18.2 % of the representative patients across all clinical trials. And TERT is reported in 18.2 %. The combined population patient data cover ages from to . 60.0 % of the patient data are identified as men. The Spindle Cell Sarcoma biology along with reported genetics together define the population represented signature biochemical pathways for this cancer. If the individual cancer tumor genetics or genes contributing to the risk are also known then that should also be used for nutrition personalization.

NUTRITION CHOICES SHOULD MATCH WITH EACH INDIVIDUAL’S CANCER SIGNATURE.

Food and Supplements for Spindle Cell Sarcoma

For Cancer Patients

Cancer patients on treatment or on palliative care need to make decisions on food and supplements – for the needed dietary calories, for managing any treatment side effects and also for improved cancer management. All plant-based foods are not equal and choosing and prioritizing foods which are personalized and customized to ongoing cancer treatment is important and complicated. Here are some examples providing guidelines for making nutrition decisions.

Choose Vegetable RED BELL PEPPER or SHALLOT?

Vegetable Red Bell Pepper contains many active ingredients or bioactives such as Curcumin, Formononetin, Daidzein, Lupeol, Lycopene. These active ingredients manipulate various biochemical pathways like Apoptosis and PI3K-AKT-MTOR Signaling and others. Red Bell Pepper is recommended for Spindle Cell Sarcoma when ongoing cancer treatment is Vinorelbine. This is because Red Bell Pepper modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Vinorelbine.

Some of the active ingredients or bioactives in vegetable Shallot are Curcumin, Formononetin, Daidzein, Lupeol, Apigenin. These active ingredients manipulate various biochemical pathways like Microtubule Dynamics and PI3K-AKT-MTOR Signaling and others. Shallot is not recommended for Spindle Cell Sarcoma when ongoing cancer treatment is Vinorelbine because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

VEGETABLE RED BELL PEPPER IS RECOMMENDED OVER SHALLOT FOR Spindle Cell Sarcoma AND TREATMENT Vinorelbine.

Choose Fruit SOUR CHERRY or ALASKA BLUEBERRY?

Fruit Sour Cherry contains many active ingredients or bioactives such as Curcumin, Formononetin, Daidzein, Lupeol, Apigenin. These active ingredients manipulate various biochemical pathways like Apoptosis, PI3K-AKT-MTOR Signaling and Microtubule Dynamics and others. Sour Cherry is recommended for Spindle Cell Sarcoma when ongoing cancer treatment is Vinorelbine. This is because Sour Cherry modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Vinorelbine.

Some of the active ingredients or bioactives in fruit Alaska Blueberry are Curcumin, Formononetin, Daidzein, Lupeol, Apigenin. These active ingredients manipulate various biochemical pathways like Microtubule Dynamics and PI3K-AKT-MTOR Signaling and others. Alaska Blueberry is not recommended for Spindle Cell Sarcoma when ongoing cancer treatment is Vinorelbine because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

FRUIT SOUR CHERRY IS RECOMMENDED OVER ALASKA BLUEBERRY FOR Spindle Cell Sarcoma AND TREATMENT Vinorelbine.

Choose Nut COMMON WALNUT or CHESTNUT?

Common Walnut contains many active ingredients or bioactives such as Curcumin, Juglone, Daidzein, Formononetin, Lupeol. These active ingredients manipulate various biochemical pathways like Apoptosis and Microtubule Dynamics and others. Common Walnut is recommended for Spindle Cell Sarcoma when ongoing cancer treatment is Vinorelbine. This is because Common Walnut modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Vinorelbine.

Some of the active ingredients or bioactives in Chestnut are Curcumin, Daidzein, Formononetin, Lupeol, Apigenin. These active ingredients manipulate various biochemical pathways like Microtubule Dynamics and others. Chestnut is not recommended for Spindle Cell Sarcoma when ongoing cancer treatment is Vinorelbine because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

COMMON WALNUT IS RECOMMENDED OVER CHESTNUT FOR Spindle Cell Sarcoma AND TREATMENT Vinorelbine.

For Individuals with Genetic Risk of Cancer

The question asked by individuals who have genetic risk of Spindle Cell Sarcoma or familial history is “What Should I Eat Differently from Before?” and how they should choose foods and supplements to manage risks of the disease. Since for cancer risk there is nothing actionable in terms of treatment – decisions of foods and supplements become important and one of the very few actionable things which can be done. All plant-based foods are not equal and based on identified genetics and pathway signature – the choices of food and supplements should be personalized.

Choose Vegetable GIANT BUTTERBUR or RADISH?

Vegetable Giant Butterbur contains many active ingredients or bioactives such as Curcumin, Apigenin, Formononetin, Lupeol, Lycopene. These active ingredients manipulate various biochemical pathways like TGFB Signaling, Stem Cell Signaling, P53 Signaling and MYC Signaling and others. Giant Butterbur is recommended for risk of Spindle Cell Sarcoma when associated genetic risk is ATRX. This is because Giant Butterbur increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in vegetable Radish are Curcumin, Apigenin, Quercetin, Formononetin, Lupeol. These active ingredients manipulate various biochemical pathways like TGFB Signaling, Stem Cell Signaling, PI3K-AKT-MTOR Signaling and MYC Signaling and others. Radish is not recommended when risk of Spindle Cell Sarcoma when associated genetic risk is ATRX because it increases the signature pathways of it.

VEGETABLE GIANT BUTTERBUR IS RECOMMENDED OVER RADISH FOR ATRX GENETIC RISK OF CANCER.

Choose Fruit NANCE or PUMMELO?

Fruit Nance contains many active ingredients or bioactives such as Curcumin, Apigenin, Formononetin, Lupeol, Daidzein. These active ingredients manipulate various biochemical pathways like Hypoxia, P53 Signaling and MYC Signaling and others. Nance is recommended for risk of Spindle Cell Sarcoma when associated genetic risk is ATRX. This is because Nance increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in fruit Pummelo are Curcumin, Apigenin, Quercetin, Formononetin, Lupeol. These active ingredients manipulate various biochemical pathways like TGFB Signaling, Stem Cell Signaling and Cell Cycle Checkpoints and others. Pummelo is not recommended when risk of Spindle Cell Sarcoma when associated genetic risk is ATRX because it increases the signature pathways of it.

FRUIT NANCE IS RECOMMENDED OVER PUMMELO FOR ATRX GENETIC RISK OF CANCER.

Choose Nut BUTTERNUT or EUROPEAN CHESTNUT?

Butternut contains many active ingredients or bioactives such as Curcumin, Apigenin, Formononetin, Lupeol, Lycopene. These active ingredients manipulate various biochemical pathways like TGFB Signaling, Hypoxia, P53 Signaling and MYC Signaling and others. Butternut is recommended for risk of Spindle Cell Sarcoma when associated genetic risk is ATRX. This is because Butternut increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in European Chestnut are Curcumin, Apigenin, Quercetin, Ellagic Acid, Formononetin. These active ingredients manipulate various biochemical pathways like TGFB Signaling and Stem Cell Signaling and others. European Chestnut is not recommended when risk of Spindle Cell Sarcoma when associated genetic risk is ATRX because it increases the signature pathways of it.

BUTTERNUT IS RECOMMENDED OVER EUROPEAN CHESTNUT FOR ATRX GENETIC RISK OF CANCER.

In Conclusion

Foods and Supplements chosen are important decisions for cancers like Spindle Cell Sarcoma. Spindle Cell Sarcoma patients and individuals with genetic-risk always have this question: “What foods and nutritional supplements are recommended for me and which are not?” There is a common belief which is a misconception that all plant-based foods could be beneficial or not but would not be harmful. Certain foods and supplements can interfere with cancer treatments or promote molecular pathway drivers of cancer.

There are different types of cancer indications like Spindle Cell Sarcoma, each with different tumor genetics with further genomic variations across each individual. Further every cancer treatment and chemotherapy has a unique mechanism of action. Each food like Red Bell Pepper contains various bioactives in different quantities, which have an impact on different and distinct sets of biochemical pathways. The definition of personalized nutrition is individualized food recommendations for the cancer indication, treatments, genetics, lifestyle and other factors. Nutrition personalization decisions for cancer require knowledge of cancer biology, food science and an understanding of different chemotherapy treatments. Finally when there are treatment changes or new genomics is identified – the nutrition personalization needs re-evaluation.

The addon nutrition personalization solution makes the decision making easy and removes all the guesswork in answering the question, “What foods should I choose or not choose for Spindle Cell Sarcoma?”. The addon multi-disciplinary team includes cancer physicians, clinical scientists, software engineers and data scientists.

References

• Pan Origimed 2020
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• In vitro and in vivo antitumor activity of neochlorogenic acid in human gastric carcinoma cells are complemented with ROS generation, loss of mitochondrial membrane potential and apoptosis induction.
• Triggering of transient receptor potential vanilloid type 1 (TRPV1) by capsaicin induces Fas/CD95-mediated apoptosis of urothelial cancer cells in an ATM-dependent manner.
• Mechanism of Juglone-Induced Cell Cycle Arrest and Apoptosis in Ishikawa Human Endometrial Cancer Cells.
• Melatonin and vitamin D3 synergistically down-regulate Akt and MDM2 leading to TGFβ-1-dependent growth inhibition of breast cancer cells.
• Formononetin suppresses the proliferation of human non-small cell lung cancer through induction of cell cycle arrest and apoptosis.