Which Foods are Recommended for Spindle Cell Sarcoma?

Highlights

No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Spindle Cell Sarcoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Spindle Cell Sarcoma because of HNF1A and MED12 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.

There is no one answer to this question for cancers such as Spindle Cell Sarcoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.

In short – the process to answer questions like “Should I Avoid eating fruit Jackfruit” or “Include fruit Pomegranate in my diet” or “Should I reduce consumption of vegetable Beetroot” or “Can I take Chanca Piedra and Baicalin supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.

RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO SPINDLE CELL SARCOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.

The overall objective of personalized nutrition for Spindle Cell Sarcoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.

RECOMMENDATION: UPDATE YOUR NUTRITION FOR SPINDLE CELL SARCOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.

About Spindle Cell Sarcoma

cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.

Following key highlights are derived from clinical data for Spindle Cell Sarcoma from cBioPortal. 60.0% of males and 40.0% of females were the distribution of gender in these clinical studies. From a patient sample size of 15; the top genes with mutations and other abnormalities for Spindle Cell Sarcoma include genes ATRX, TERT, HNF1A, MED12 and MACC1. The occurrence frequency distribution for these genes respectively is 18.2%, 18.2%, 18.2%, 18.2% and 9.1%. These tumor genetic details of Spindle Cell Sarcoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Spindle Cell Sarcoma.

Significance of Nutrition for Spindle Cell Sarcoma

All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Spindle Cell Sarcoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.

For example Jackfruit includes active ingredients Betulinic Acid, Beta-sitosterol, Oleic Acid, Linolenic Acid, Stigmasterol and others. And Pomegranate contains active ingredients Corilagin, Betulinic Acid, Beta-sitosterol, Vitamin C, Epigallocatechin Gallate and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.

For cancers like Spindle Cell Sarcoma, activation or inhibition of selected biochemical pathways like TGFB Signaling, PI3K-AKT-MTOR Signaling, Apoptosis, RAS-RAF Signaling plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Spindle Cell Sarcoma, while eating some other foods and supplements may not be recommended.

One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.

RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR SPINDLE CELL SARCOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.

Foods for Spindle Cell Sarcoma undergoing chemotherapy treatment

In Spindle Cell Sarcoma – the genes ATRX, TERT, HNF1A, MED12 and MACC1 have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Spindle Cell Sarcoma are TGFB Signaling, PI3K-AKT-MTOR Signaling, Apoptosis and others. Docetaxel is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers TGFB Signaling, PI3K-AKT-MTOR Signaling, Apoptosis so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.

RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.

Eat more pulses, Common Pea or Yellow Wax Bean?

Pulses are an important part of many diets. The active ingredients contained in Common Pea are Lupeol, Daidzein, Beta-sitosterol, Oleic Acid, Linolenic Acid among others. While the active ingredients contained in Yellow Wax Bean are Vitamin C, Cianidanol, Ferulic Acid, Butyric Acid, Vitamin A and others.

Beta-sitosterol can manipulate biochemical pathways Apoptosis, Microtubule Dynamics and MYC Signaling. Vitamin C has biological action on biochemical pathways WNT Beta Catenin Signaling, PI3K-AKT-MTOR Signaling and MYC Signaling.

Palmitic Acid can manipulate biochemical pathways WNT Beta Catenin Signaling, TGFB Signaling and Microtubule Dynamics. Folic Acid has biological action on biochemical pathways MYC Signaling, Apoptosis and PI3K-AKT-MTOR Signaling. And so on.

When treating Spindle Cell Sarcoma with chemotherapy Docetaxel – Foods like Common Pea are recommended compared to Yellow Wax Bean. This is because the active ingredients Palmitic Acid and Folic Acid in Yellow Wax Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin C contained in Common Pea support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: COMMON PEA IS RECOMMENDED OVER YELLOW WAX BEAN FOR SPINDLE CELL SARCOMA ON TREATMENT WITH CHEMOTHERAPY DOCETAXEL FOR SOME CONDITIONS.

Eat more vegetables, Lettuce or Beetroot?

Vegetables are an important part of many diets. The active ingredients contained in Lettuce are Beta-sitosterol, Oleic Acid, Linolenic Acid, Quercetin, Vitamin C among others. While the active ingredients contained in Beetroot are Beta-sitosterol, Oleic Acid, Vitamin E, Linolenic Acid, Vitamin C and others.

Vitamin A can manipulate biochemical pathways Apoptosis, TGFB Signaling and MYC Signaling. Vitamin K has biological action on biochemical pathways PI3K-AKT-MTOR Signaling and MYC Signaling.

Linoleic Acid can manipulate biochemical pathways TGFB Signaling. Folic Acid has biological action on biochemical pathways MYC Signaling, Apoptosis and PI3K-AKT-MTOR Signaling. And so on.

When treating Spindle Cell Sarcoma with chemotherapy Docetaxel – Foods like Lettuce are recommended compared to Beetroot. This is because the active ingredients Linoleic Acid and Folic Acid in Beetroot interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin A and Vitamin K contained in Lettuce support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: LETTUCE IS RECOMMENDED OVER BEETROOT FOR SPINDLE CELL SARCOMA ON TREATMENT WITH CHEMOTHERAPY DOCETAXEL FOR SOME CONDITIONS.

Eat more fruits, Pomegranate or Jackfruit?

Fruits are an important part of many diets. The active ingredients contained in Pomegranate are Corilagin, Betulinic Acid, Beta-sitosterol, Vitamin C, Epigallocatechin Gallate among others. While the active ingredients contained in Jackfruit are Betulinic Acid, Beta-sitosterol, Oleic Acid, Linolenic Acid, Stigmasterol and others.

Betulinic Acid can manipulate biochemical pathways MYC Signaling, WNT Beta Catenin Signaling and Apoptosis. Gallic Acid has biological action on biochemical pathways Microtubule Dynamics, TGFB Signaling and PI3K-AKT-MTOR Signaling.

Linoleic Acid can manipulate biochemical pathways TGFB Signaling. Folic Acid has biological action on biochemical pathways MYC Signaling, Apoptosis and PI3K-AKT-MTOR Signaling. And so on.

When treating Spindle Cell Sarcoma with chemotherapy Docetaxel – Foods like Pomegranate are recommended compared to Jackfruit. This is because the active ingredients Linoleic Acid and Folic Acid in Jackfruit interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Betulinic Acid and Gallic Acid contained in Pomegranate support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: POMEGRANATE IS RECOMMENDED OVER JACKFRUIT FOR SPINDLE CELL SARCOMA ON TREATMENT WITH CHEMOTHERAPY DOCETAXEL FOR SOME CONDITIONS.

Eat more nuts, Pecan Nut or Peanut?

Nuts are an important part of many diets. The active ingredients contained in Pecan Nut are Oleic Acid, Linolenic Acid, Vitamin E, Cianidanol, Linoleic Acid among others. While the active ingredients contained in Peanut are Beta-sitosterol, Oleic Acid, Linolenic Acid, Vitamin E, Rhamnetin and others.

Vitamin E can manipulate biochemical pathways MYC Signaling, Apoptosis and PI3K-AKT-MTOR Signaling. Cianidanol has biological action on biochemical pathways Microtubule Dynamics, MYC Signaling and Apoptosis.

Lecithin can manipulate biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. Linoleic Acid has biological action on biochemical pathways TGFB Signaling. And so on.

When treating Spindle Cell Sarcoma with chemotherapy Docetaxel – Foods like Pecan Nut are recommended compared to Peanut. This is because the active ingredients Lecithin and Linoleic Acid in Peanut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin E and Cianidanol contained in Pecan Nut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: PECAN NUT IS RECOMMENDED OVER PEANUT FOR SPINDLE CELL SARCOMA ON TREATMENT WITH CHEMOTHERAPY DOCETAXEL FOR SOME CONDITIONS.

Foods for Genetic Risk of Spindle Cell Sarcoma

One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. HNF1A and MED12 are two genes whose abnormalities are risk factors for Spindle Cell Sarcoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Spindle Cell Sarcoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Spindle Cell Sarcoma gene HNF1A has causative impact on biological pathways like . And MED12 has a causative impact on biological pathways like TGFB Signaling and Thyroid Hormone Signaling. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like HNF1A and MED12 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes HNF1A and MED12 should be avoided.

Eat more pulses, Scarlet Bean or Pigeon Pea?

The active ingredients contained in Scarlet Bean are Oleic Acid, Linolenic Acid, Vitamin C, Beta-sitosterol, Stigmasterol among others. While the active ingredients contained in Pigeon Pea are Oleic Acid, Linolenic Acid, Vitamin C, Genistein, Linoleic Acid and others.

Vitamin C can manipulate biochemical pathways Apoptosis, Growth Factor Signaling and MYC Signaling. Beta-sitosterol has biological action on biochemical pathways P53 Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling.

Linoleic Acid can manipulate biochemical pathways Growth Factor Signaling and TGFB Signaling. Folic Acid has biological action on biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. And so on.

For genetic risk of Spindle Cell Sarcoma due to abnormalities in genes HNF1A and MED12 – Foods like Scarlet Bean are recommended compared to Pigeon Pea. This is because the active ingredients Linoleic Acid and Folic Acid in Pigeon Pea further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Scarlet Bean together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: SCARLET BEAN IS RECOMMENDED OVER PIGEON PEA FOR REDUCING THE GENETIC RISK OF SPINDLE CELL SARCOMA DUE TO GENES HNF1A AND MED12

Eat more vegetables, Jicama or Carob?

The active ingredients contained in Jicama are Vitamin C, Vitamin B3, Beta-carotene, Vitamin A, Folic Acid among others. While the active ingredients contained in Carob are Quercetin, Myricetin, Palmitic Acid, Gallic Acid, Phloroglucinol and others.

Vitamin C can manipulate biochemical pathways Apoptosis, Growth Factor Signaling and MYC Signaling. Vitamin B3 has biological action on biochemical pathways P53 Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling.

Palmitic Acid can manipulate biochemical pathways Growth Factor Signaling, MAPK Signaling and TGFB Signaling. Folic Acid has biological action on biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. And so on.

For genetic risk of Spindle Cell Sarcoma due to abnormalities in genes HNF1A and MED12 – Foods like Jicama are recommended compared to Carob. This is because the active ingredients Palmitic Acid and Folic Acid in Carob further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Vitamin B3 contained in Jicama together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: JICAMA IS RECOMMENDED OVER CAROB FOR REDUCING THE GENETIC RISK OF SPINDLE CELL SARCOMA DUE TO GENES HNF1A AND MED12

Eat more fruits, Feijoa or Date?

The active ingredients contained in Feijoa are Lycopene, Vitamin C, Casuarinin, Folic Acid among others. While the active ingredients contained in Date are Apigenin, Protocatechuic Acid, Quercetin, Lupeol, Oleic Acid and others.

Vitamin C can manipulate biochemical pathways Apoptosis, Growth Factor Signaling and MYC Signaling. Lycopene has biological action on biochemical pathways P53 Signaling, Cell Cycle Checkpoints and MAPK Signaling.

Apigenin can manipulate biochemical pathways TGFB Signaling. Ferulic Acid has biological action on biochemical pathways Growth Factor Signaling. And so on.

For genetic risk of Spindle Cell Sarcoma due to abnormalities in genes HNF1A and MED12 – Foods like Feijoa are recommended compared to Date. This is because the active ingredients Apigenin and Ferulic Acid in Date further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Lycopene contained in Feijoa together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: FEIJOA IS RECOMMENDED OVER DATE FOR REDUCING THE GENETIC RISK OF SPINDLE CELL SARCOMA DUE TO GENES HNF1A AND MED12

Eat more nuts, Almond or Acorn?

The active ingredients contained in Almond are Quercetin, Vitamin E, Oleic Acid, Linolenic Acid, Beta-sitosterol among others. While the active ingredients contained in Acorn are Quercetin, Vitamin C, Beta-sitosterol, Gallic Acid, Quercitrin and others.

Beta-sitosterol can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Quercetin has biological action on biochemical pathways Growth Factor Signaling, TGFB Signaling and Cell Cycle Checkpoints.

Beta-carotene can manipulate biochemical pathways MAPK Signaling and PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. And so on.

For genetic risk of Spindle Cell Sarcoma due to abnormalities in genes HNF1A and MED12 – Foods like Almond are recommended compared to Acorn. This is because the active ingredients Beta-carotene and Folic Acid in Acorn further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Quercetin contained in Almond together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: ALMOND IS RECOMMENDED OVER ACORN FOR REDUCING THE GENETIC RISK OF SPINDLE CELL SARCOMA DUE TO GENES HNF1A AND MED12

In Summary

An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.

“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.

The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.

You can get started NOW and design a personalized nutrition plan for Spindle Cell Sarcoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

References

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