Highlights
No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Sinonasal Squamous Cell Carcinoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Sinonasal Squamous Cell Carcinoma because of JAK2 and MYCN gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.
There is no one answer to this question for cancers such as Sinonasal Squamous Cell Carcinoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.
In short – the process to answer questions like “Should I Avoid eating fruit Coconut” or “Include fruit Naranjilla in my diet” or “Should I reduce consumption of vegetable Yam” or “Can I take Caffeine and Alpha Lipoic Acid supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.
RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO SINONASAL SQUAMOUS CELL CARCINOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.
The overall objective of personalized nutrition for Sinonasal Squamous Cell Carcinoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.
RECOMMENDATION: UPDATE YOUR NUTRITION FOR SINONASAL SQUAMOUS CELL CARCINOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.
About Sinonasal Squamous Cell Carcinoma
cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.
Following key highlights are derived from clinical data for Sinonasal Squamous Cell Carcinoma from cBioPortal. The patients enrolled in the studies for Sinonasal Squamous Cell Carcinoma are in ages between 35 to 76 with an average age of 56. 83.3% of males and 16.7% of females were the distribution of gender in these clinical studies. From a patient sample size of 19; the top genes with mutations and other abnormalities for Sinonasal Squamous Cell Carcinoma include genes KMT2D, TP53, JAK2, MYCN and NTRK3. The occurrence frequency distribution for these genes respectively is 16.7%, 16.7%, 8.3%, 8.3% and 8.3%. These tumor genetic details of Sinonasal Squamous Cell Carcinoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Sinonasal Squamous Cell Carcinoma.
Significance of Nutrition for Sinonasal Squamous Cell Carcinoma
All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Sinonasal Squamous Cell Carcinoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.
For example Coconut includes active ingredients Vitamin E, Beta-sitosterol, Capric Acid, Palmitic Acid, Lauric Acid and others. And Naranjilla contains active ingredients Beta-carotene, Zeaxanthin, Vitamin A and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.
For cancers like Sinonasal Squamous Cell Carcinoma, activation or inhibition of selected biochemical pathways like Cytoskeletal Dynamics, DNA Repair, PI3K-AKT-MTOR Signaling, Extracellular Matrix Remodelling plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Sinonasal Squamous Cell Carcinoma, while eating some other foods and supplements may not be recommended.
One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.
RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR SINONASAL SQUAMOUS CELL CARCINOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.
Foods for Sinonasal Squamous Cell Carcinoma undergoing chemotherapy treatment
In Sinonasal Squamous Cell Carcinoma – the genes KMT2D, TP53, JAK2, MYCN and NTRK3 have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Sinonasal Squamous Cell Carcinoma are Cytoskeletal Dynamics, DNA Repair, JAK-STAT Signaling and others. Radiation is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Cytoskeletal Dynamics, DNA Repair, JAK-STAT Signaling so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.
RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.
Eat more pulses, Common Pea or Fava Bean?
Pulses are an important part of many diets. The active ingredients contained in Common Pea are Daidzein, Lupeol, Beta-sitosterol, Oleic Acid, Vitamin C among others. While the active ingredients contained in Fava Bean are Daidzein, Butein, Beta-sitosterol, Oleic Acid, Caffeic Acid and others.
Beta-sitosterol can manipulate biochemical pathways MYC Signaling, NFKB Signaling and Oxidative Stress. Vitamin C has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, MYC Signaling and Oxidative Stress.
Caffeic Acid can manipulate biochemical pathways TGFB Signaling. Quercetin has biological action on biochemical pathways Oxidative Stress. And so on.
When treating Sinonasal Squamous Cell Carcinoma with chemotherapy Radiation – Foods like Common Pea are recommended compared to Fava Bean. This is because the active ingredients Caffeic Acid and Quercetin in Fava Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin C contained in Common Pea support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: COMMON PEA IS RECOMMENDED OVER FAVA BEAN FOR SINONASAL SQUAMOUS CELL CARCINOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Eat more vegetables, Cabbage or Yam?
Vegetables are an important part of many diets. The active ingredients contained in Cabbage are Benzyl Isothiocyanate, Isorhamnetin, Brassinin, Beta-sitosterol, Vitamin C among others. While the active ingredients contained in Yam are Beta-sitosterol, Oleic Acid, Vitamin C, Linolenic Acid, Dioscin and others.
Vitamin C can manipulate biochemical pathways MYC Signaling, Oxidative Stress and PI3K-AKT-MTOR Signaling. Glucaric Acid has biological action on biochemical pathways NFKB Signaling, MYC Signaling and PI3K-AKT-MTOR Signaling.
Citric Acid can manipulate biochemical pathways Oxidative Stress. Dioscin has biological action on biochemical pathways NFKB Signaling and Oxidative Stress. And so on.
When treating Sinonasal Squamous Cell Carcinoma with chemotherapy Radiation – Foods like Cabbage are recommended compared to Yam. This is because the active ingredients Citric Acid and Dioscin in Yam interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Glucaric Acid contained in Cabbage support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: CABBAGE IS RECOMMENDED OVER YAM FOR SINONASAL SQUAMOUS CELL CARCINOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Eat more fruits, Naranjilla or Coconut?
Fruits are an important part of many diets. The active ingredients contained in Naranjilla are Beta-carotene, Zeaxanthin, Vitamin A among others. While the active ingredients contained in Coconut are Vitamin E, Beta-sitosterol, Capric Acid, Palmitic Acid, Lauric Acid and others.
Beta-carotene can manipulate biochemical pathways NFKB Signaling, DNA Repair and TGFB Signaling. Vitamin A has biological action on biochemical pathways MYC Signaling, PI3K-AKT-MTOR Signaling and Oxidative Stress.
Palmitic Acid can manipulate biochemical pathways NFKB Signaling and TGFB Signaling. Lauric Acid has biological action on biochemical pathways MYC Signaling, PI3K-AKT-MTOR Signaling and NFKB Signaling. And so on.
When treating Sinonasal Squamous Cell Carcinoma with chemotherapy Radiation – Foods like Naranjilla are recommended compared to Coconut. This is because the active ingredients Palmitic Acid and Lauric Acid in Coconut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-carotene and Vitamin A contained in Naranjilla support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: NARANJILLA IS RECOMMENDED OVER COCONUT FOR SINONASAL SQUAMOUS CELL CARCINOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Eat more nuts, Cashew Nut or Pumpkin Seeds?
Nuts are an important part of many diets. The active ingredients contained in Cashew Nut are Beta-sitosterol, Vitamin C, Butyric Acid, Palmitic Acid, Lauric Acid among others. While the active ingredients contained in Pumpkin Seeds are Cucurbitacin I, Beta-sitosterol, Oleic Acid, Stigmasterol, Salicylic Acid and others.
Beta-sitosterol can manipulate biochemical pathways MYC Signaling, NFKB Signaling and Oxidative Stress. Vitamin C has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, MYC Signaling and Oxidative Stress.
Gamma-linolenic Acid can manipulate biochemical pathways Oxidative Stress. Lecithin has biological action on biochemical pathways MYC Signaling, NFKB Signaling and JAK-STAT Signaling. And so on.
When treating Sinonasal Squamous Cell Carcinoma with chemotherapy Radiation – Foods like Cashew Nut are recommended compared to Pumpkin Seeds. This is because the active ingredients Gamma-linolenic Acid and Lecithin in Pumpkin Seeds interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin C contained in Cashew Nut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: CASHEW NUT IS RECOMMENDED OVER PUMPKIN SEEDS FOR SINONASAL SQUAMOUS CELL CARCINOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Foods for Genetic Risk of Sinonasal Squamous Cell Carcinoma
One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. JAK2 and MYCN are two genes whose abnormalities are risk factors for Sinonasal Squamous Cell Carcinoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Sinonasal Squamous Cell Carcinoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Sinonasal Squamous Cell Carcinoma gene JAK2 has causative impact on biological pathways like AGE-RAGE Signaling, Chemokine Signaling and Hematopoiesis. And MYCN has a causative impact on biological pathways like Focal Adhesion and Cell Cycle. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like JAK2 and MYCN should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes JAK2 and MYCN should be avoided.
Eat more pulses, Scarlet Bean or Lentils?
The active ingredients contained in Scarlet Bean are Stigmasterol, Oleic Acid, Vitamin C, Beta-sitosterol, Linolenic Acid among others. While the active ingredients contained in Lentils are Isoliquiritigenin, Ellagic Acid, Daidzein, Esculin, Oleic Acid and others.
Stigmasterol can manipulate biochemical pathways Cytokine Signaling, JAK-STAT Signaling and MAPK Signaling. Vitamin C has biological action on biochemical pathways WNT Beta Catenin Signaling, Oncogenic Cancer Epigenetics and PI3K-AKT-MTOR Signaling.
Ellagic Acid can manipulate biochemical pathways WNT Beta Catenin Signaling. Folic Acid has biological action on biochemical pathways JAK-STAT Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling. And so on.
For genetic risk of Sinonasal Squamous Cell Carcinoma due to abnormalities in genes JAK2 and MYCN – Foods like Scarlet Bean are recommended compared to Lentils. This is because the active ingredients Ellagic Acid and Folic Acid in Lentils further promote the effects of genes on the biochemical pathways. While the active ingredients Stigmasterol and Vitamin C contained in Scarlet Bean together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: SCARLET BEAN IS RECOMMENDED OVER LENTILS FOR REDUCING THE GENETIC RISK OF SINONASAL SQUAMOUS CELL CARCINOMA DUE TO GENES JAK2 AND MYCN
Eat more vegetables, Bitter Melon or Carob?
The active ingredients contained in Bitter Melon are Cucurbitacin I, Cucurbitacin E, Caffeic Acid, Oleic Acid, Vitamin C among others. While the active ingredients contained in Carob are Myricetin, Quercetin, Gallic Acid, Phloroglucinol, Folic Acid and others.
Vitamin C can manipulate biochemical pathways WNT Beta Catenin Signaling, Oncogenic Cancer Epigenetics and MAPK Signaling. Cucurbitacin I has biological action on biochemical pathways Cytokine Signaling, JAK-STAT Signaling and PI3K-AKT-MTOR Signaling.
Palmitic Acid can manipulate biochemical pathways WNT Beta Catenin Signaling, Oncogenic Cancer Epigenetics and MAPK Signaling. Myricetin has biological action on biochemical pathways Oncogenic Cancer Epigenetics. And so on.
For genetic risk of Sinonasal Squamous Cell Carcinoma due to abnormalities in genes JAK2 and MYCN – Foods like Bitter Melon are recommended compared to Carob. This is because the active ingredients Palmitic Acid and Myricetin in Carob further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Cucurbitacin I contained in Bitter Melon together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: BITTER MELON IS RECOMMENDED OVER CAROB FOR REDUCING THE GENETIC RISK OF SINONASAL SQUAMOUS CELL CARCINOMA DUE TO GENES JAK2 AND MYCN
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
Eat more fruits, Watermelon or Plum?
The active ingredients contained in Watermelon are Cucurbitacin E, Lycopene, Oleic Acid, Vitamin C, Linolenic Acid among others. While the active ingredients contained in Plum are Quercetin, Betulinic Acid, Chlorogenic Acid, Vitamin C, Beta-sitosterol and others.
Lycopene can manipulate biochemical pathways WNT Beta Catenin Signaling, JAK-STAT Signaling and MAPK Signaling. Cucurbitacin E has biological action on biochemical pathways Cytokine Signaling, PI3K-AKT-MTOR Signaling and WNT Beta Catenin Signaling.
Myristic Acid can manipulate biochemical pathways MAPK Signaling. Lauric Acid has biological action on biochemical pathways PI3K-AKT-MTOR Signaling and MAPK Signaling. And so on.
For genetic risk of Sinonasal Squamous Cell Carcinoma due to abnormalities in genes JAK2 and MYCN – Foods like Watermelon are recommended compared to Plum. This is because the active ingredients Myristic Acid and Lauric Acid in Plum further promote the effects of genes on the biochemical pathways. While the active ingredients Lycopene and Cucurbitacin E contained in Watermelon together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: WATERMELON IS RECOMMENDED OVER PLUM FOR REDUCING THE GENETIC RISK OF SINONASAL SQUAMOUS CELL CARCINOMA DUE TO GENES JAK2 AND MYCN
Eat more nuts, Almond or Acorn?
The active ingredients contained in Almond are Quercetin, Stigmasterol, Salicylic Acid, Vitamin E, Oleic Acid among others. While the active ingredients contained in Acorn are Quercetin, Gallic Acid, Vitamin C, Beta-sitosterol, Beta-carotene and others.
Beta-sitosterol can manipulate biochemical pathways WNT Beta Catenin Signaling, Oncogenic Cancer Epigenetics and PI3K-AKT-MTOR Signaling. Stigmasterol has biological action on biochemical pathways Cytokine Signaling, JAK-STAT Signaling and MAPK Signaling.
Vitamin B2 can manipulate biochemical pathways Oncogenic Cancer Epigenetics. Folic Acid has biological action on biochemical pathways JAK-STAT Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling. And so on.
For genetic risk of Sinonasal Squamous Cell Carcinoma due to abnormalities in genes JAK2 and MYCN – Foods like Almond are recommended compared to Acorn. This is because the active ingredients Vitamin B2 and Folic Acid in Acorn further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Stigmasterol contained in Almond together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: ALMOND IS RECOMMENDED OVER ACORN FOR REDUCING THE GENETIC RISK OF SINONASAL SQUAMOUS CELL CARCINOMA DUE TO GENES JAK2 AND MYCN
In Summary
An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.
“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.
The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.
You can get started NOW and design a personalized nutrition plan for Sinonasal Squamous Cell Carcinoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
References
- Msk Impact 2017
- Genomic correlates of response to immune checkpoint blockade in microsatellite-stable solid tumors.
- Paederia foetida induces anticancer activity by modulating chromatin modification enzymes and altering pro-inflammatory cytokine gene expression in human prostate cancer cells.
- The synergy of Vitamin C with decitabine activates TET2 in leukemic cells and significantly improves overall survival in elderly patients with acute myeloid leukemia.
- Synthesis and structure-activity relationship analysis of caffeic acid amides as selective matrix metalloproteinase inhibitors.
- Small-molecule inhibitors of NADPH oxidase 4.
- The effect of Pasteurella haemolytica cytotoxin on bovine polymorphonuclear leukocytes can be attenuated by beta-adrenoceptor antagonists.
- Retinol decreases beta-catenin protein levels in retinoic acid-resistant colon cancer cell lines.
- Functional lipidomics: Palmitic acid impairs hepatocellular carcinoma development by modulating membrane fluidity and glucose metabolism.
- Clinical pharmacodynamics of antihistamines.
- Preventive effects of butyric acid, nicotinamide, calcium glucarate alone or in combination during the 7, 12-dimethylbenz (a) anthracene induced mouse skin tumorigenesis via modulation of K-Ras-PI3K-AKTpathway and associated micro RNAs.
- Dioscin restores the activity of the anticancer agent adriamycin in multidrug-resistant human leukemia K562/adriamycin cells by down-regulating MDR1 via a mechanism involving NF-κB signaling inhibition.
- Research on Rett syndrome: strategy and preliminary results.
- Role of the lipid-regulated NF-κB/IL-6/STAT3 axis in alpha-naphthyl isothiocyanate-induced liver injury.
- Stigmasterol exhibits potent antitumor effects in human gastric cancer cells mediated via inhibition of cell migration, cell cycle arrest, mitochondrial mediated apoptosis and inhibition of JAK/STAT signalling pathway.
- Identification of ellagic acid as potent inhibitor of protein kinase CK2: a successful example of a virtual screening application.
- Folic acid mediates activation of the pro-oncogene STAT3 via the Folate Receptor alpha.
- Lycopene differentially induces quiescence and apoptosis in androgen-responsive and -independent prostate cancer cell lines.
- Cucurbitacin-E inhibits multiple cancer cells proliferation through attenuation of Wnt/β-catenin signaling.
- Sequence homology of surface membrane proteins of Babesia rodhaini.
- Cucurbitacin-I induces hypertrophy in H9c2 cardiomyoblasts through activation of autophagy via MEK/ERK1/2 signaling pathway.
- Methyl Donor Micronutrients that Modify DNA Methylation and Cancer Outcome.
- Promise of bitter melon (Momordica charantia) bioactives in cancer prevention and therapy.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.